| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yin Sim Tor, Latifah Saiful Yazan, Jhi Biau Foo, Agustono Wibowo, Norsharina Ismail, Yoke Kqueen Cheah, Rasedee Abdullah, Maznah Ismail, Intan Safinar Ismail, Swee Keong Yea. Induction of Apoptosis in MCF-7 Cells via Oxidative Stress Generation, Mitochondria-Dependent and Caspase-Independent Pathway by Ethyl Acetate Extract of Dillenia suffruticosa and Its Chemical Profile. PloS one. vol 10. issue 6. 2016-03-04. PMID:26047480. |
the data indicate that induction of oxidative-stress related apoptosis by eads was mediated by inhibition of akt and erk, and activation of jnk. |
2016-03-04 |
2023-08-13 |
Not clear |
| Dmitry L Aminin, Ekaterina S Menchinskaya, Evgeny A Pisliagin, Alexandra S Silchenko, Sergey A Avilov, Vladimir I Kalini. Anticancer activity of sea cucumber triterpene glycosides. Marine drugs. vol 13. issue 3. 2016-03-03. PMID:25756523. |
the anticancer molecular mechanisms include the induction of tumor cell apoptosis through the activation of intracellular caspase cell death pathways, arrest of the cell cycle at s or g2/m phases, influence on nuclear factors, nf-κb, and up-down regulation of certain cellular receptors and enzymes participating in cancerogenesis, such as egfr (epidermal growth factor receptor), akt (protein kinase b), erk (extracellular signal-regulated kinases), fak (focal adhesion kinase), mmp-9 (matrix metalloproteinase-9) and others. |
2016-03-03 |
2023-08-13 |
human |
| Xin Wang, Ting Tan, Zhi-Gang Mao, Ni Lei, Zong-Ming Wang, Bin Hu, Zhi-Yong Chen, Zhi-Gang She, Yong-Hong Zhu, Hai-Jun Wan. The marine metabolite SZ-685C induces apoptosis in primary human nonfunctioning pituitary adenoma cells by inhibition of the Akt pathway in vitro. Marine drugs. vol 13. issue 3. 2016-03-03. PMID:25806467. |
the marine metabolite sz-685c induces apoptosis in primary human nonfunctioning pituitary adenoma cells by inhibition of the akt pathway in vitro. |
2016-03-03 |
2023-08-13 |
human |
| Xin Wang, Ting Tan, Zhi-Gang Mao, Ni Lei, Zong-Ming Wang, Bin Hu, Zhi-Yong Chen, Zhi-Gang She, Yong-Hong Zhu, Hai-Jun Wan. The marine metabolite SZ-685C induces apoptosis in primary human nonfunctioning pituitary adenoma cells by inhibition of the Akt pathway in vitro. Marine drugs. vol 13. issue 3. 2016-03-03. PMID:25806467. |
here, we show that sz-685c induces apoptosis of human nfpa cells through inhibition of the akt pathway in vitro. |
2016-03-03 |
2023-08-13 |
human |
| Mingqun Li, Li Hon. Pseudolaric acid B exerts antitumor activity via suppression of the Akt signaling pathway in HeLa cervical cancer cells. Molecular medicine reports. vol 12. issue 2. 2016-03-03. PMID:25891953. |
these results suggested that pab inhibited cell proliferation and induced apoptosis in hela cells, and that the anti-tumor effects of pab were associated with inhibition of the akt pathway. |
2016-03-03 |
2023-08-13 |
human |
| Zhongmian Zhang, Ping Liu, Jian Wang, Tianxiao Gong, Fang Zhang, Jun Ma, Na Ha. Ubiquitin-conjugating enzyme E2C regulates apoptosis-dependent tumor progression of non-small cell lung cancer via ERK pathway. Medical oncology (Northwood, London, England). vol 32. issue 5. 2016-03-02. PMID:25832867. |
furthermore, ube2c could regulate phospho-erk1/2 level but not stat3, yap, or akt pathway, which was accompanied with the classic function of erk pathway in cell growth and apoptosis. |
2016-03-02 |
2023-08-13 |
human |
| Geun-Young Kim, Soon Yong Park, Ara Jo, Mira Kim, Sun-Hee Leem, Woo-Jin Jun, Sang In Shim, Sang Chul Lee, Jin Woong Chun. Erratum to: Gecko proteins induce the apoptosis of bladder cancer 5637 cells by inhibiting Akt and activating the intrinsic caspase cascade. BMB reports. vol 48. issue 11. 2016-03-02. PMID:26612629. |
erratum to: gecko proteins induce the apoptosis of bladder cancer 5637 cells by inhibiting akt and activating the intrinsic caspase cascade. |
2016-03-02 |
2023-08-13 |
Not clear |
| Geun-Young Kim, Soon Yong Park, Ara Jo, Mira Kim, Sun-Hee Leem, Woo-Jin Jun, Sang In Shim, Sang Chul Lee, Jin Woong Chun. Erratum to: Gecko proteins induce the apoptosis of bladder cancer 5637 cells by inhibiting Akt and activating the intrinsic caspase cascade. BMB reports. vol 48. issue 11. 2016-03-02. PMID:26612629. |
the bmb reports would like to correct in the reference of bmb rep. 48(9), 531-536 titled "gecko proteins induce the apoptosis of bladder cancer 5637 cells by inhibiting akt and activating the intrinsic caspase cascade". |
2016-03-02 |
2023-08-13 |
Not clear |
| Han-Li Huang, Chieh-Yu Peng, Mei-Jung Lai, Chun-Han Chen, Hsueh-Yun Lee, Jing-Chi Wang, Jing-Ping Liou, Shiow-Lin Pan, Che-Ming Ten. Novel oral histone deacetylase inhibitor, MPT0E028, displays potent growth-inhibitory activity against human B-cell lymphoma in vitro and in vivo. Oncotarget. vol 6. issue 7. 2016-03-01. PMID:25669976. |
transient transfection assay revealed that both targeting hdacs and akt contribute to the apoptosis induced by mpt0e028, with both mechanisms functioning independently. |
2016-03-01 |
2023-08-13 |
mouse |
| Jian Zhou, Toshifumi Fujiwara, Shiqiao Ye, Xiaolin Li, Haibo Zha. Ubiquitin E3 Ligase LNX2 is Critical for Osteoclastogenesis In Vitro by Regulating M-CSF/RANKL Signaling and Notch2. Calcified tissue international. vol 96. issue 5. 2016-03-01. PMID:25712254. |
decreased lnx2 expression attenuated macrophage colony-stimulating factor (m-csf)-induced erk and akt activation and rankl-stimulated activation of nf-κb and jnk pathways; therefore, accelerated osteoclast apoptosis. |
2016-03-01 |
2023-08-13 |
Not clear |
| Dan Xiong, Yunlin Ye, Yujie Fu, Jinglong Wang, Bohua Kuang, Hongbo Wang, Xiumin Wang, Lidong Zu, Gang Xiao, Mingang Hao, Jianhua Wan. Bmi-1 expression modulates non-small cell lung cancer progression. Cancer biology & therapy. vol 16. issue 5. 2016-03-01. PMID:25880371. |
we find that bmi-1 does not affect cell cycle and apoptosis in lung cancer cell lines as it does not affect the expression of p16/p19, pten, akt and p-akt. |
2016-03-01 |
2023-08-13 |
Not clear |
| Yang Chen, Guo-Fang Peng, Xiang-Zhen Han, Wei Wang, Guo-Qiang Zhang, Xiao L. Apoptosis prediction via inhibition of AKT signaling pathway by neogrifolin. International journal of clinical and experimental pathology. vol 8. issue 2. 2016-03-01. PMID:25973001. |
apoptosis prediction via inhibition of akt signaling pathway by neogrifolin. |
2016-03-01 |
2023-08-13 |
human |
| Yuh Baba, Masato Fujii, Toyonobu Maeda, Atsuko Suzuki, Satoshi Yuzawa, Yasumasa Kat. Deguelin induces apoptosis by targeting both EGFR-Akt and IGF1R-Akt pathways in head and neck squamous cell cancer cell lines. BioMed research international. vol 2015. 2016-03-01. PMID:26075254. |
the deguelin-induced apoptosis was accompanied by the reduction of constitutive phosphorylated levels of igf1r, akt, and extracellular signal-regulated kinase1/2 (erk1/2). |
2016-03-01 |
2023-08-13 |
Not clear |
| b' Erwann Salaun, Arlette Gratas-Delamarche, Fr\\xc3\\xa9d\\xc3\\xa9ric Derbr\\xc3\\xa. De novo ceramides synthesis is not involved in skeletal muscle atrophy induced by short-term mechanical unloading. Free radical biology & medicine. vol 75 Suppl 1. 2016-03-01. PMID:26461326.' |
decrease in akt activation, increase in murf1 and polyubiquinated proteins content) and apoptosis activations (i.e. |
2016-03-01 |
2023-08-13 |
rat |
| Weipeng Xiong, Aaron J Knox, Mei Xu, Katja Kiseljak-Vassiliades, Sean P Colgan, Kelley S Brodsky, Bette K Kleinschmidt-Demasters, Kevin O Lillehei, Margaret E Wierma. Mammalian Ste20-like kinase 4 promotes pituitary cell proliferation and survival under hypoxia. Molecular endocrinology (Baltimore, Md.). vol 29. issue 3. 2016-02-29. PMID:25650755. |
under short-term severe hypoxic stress, mst4 decreased the rates of apoptosis via p38 mapk, akt, hypoxia-inducible factor-1, and its cell-specific downstream targets. |
2016-02-29 |
2023-08-13 |
human |
| Aude Salomon, Michelle Keramidas, Cécile Maisin, Michaël Thoma. Loss of β-catenin in adrenocortical cancer cells causes growth inhibition and reversal of epithelial-to-mesenchymal transition. Oncotarget. vol 6. issue 13. 2016-02-29. PMID:25823656. |
in addition, the knockdown of β-catenin decreased phosphorylated akt and increased apoptosis. |
2016-02-29 |
2023-08-13 |
mouse |
| Ayako Nogami, Gaku Oshikawa, Keigo Okada, Shusaku Fukutake, Yoshihiro Umezawa, Toshikage Nagao, Tetsuya Kurosu, Osamu Miur. FLT3-ITD confers resistance to the PI3K/Akt pathway inhibitors by protecting the mTOR/4EBP1/Mcl-1 pathway through STAT5 activation in acute myeloid leukemia. Oncotarget. vol 6. issue 11. 2016-02-29. PMID:25826077. |
here, we show that the pi3k inhibitor gdc-0941 or the akt inhibitor mk-2206 induced apoptosis through the mitochondria-mediated intrinsic pathway more efficiently in hematopoietic 32d cells driven by flt3-tkd (32d/tkd) than flt3-itd (32d/itd), which robustly activated stat5. |
2016-02-29 |
2023-08-13 |
human |
| Yan-Hong Wang, Zu-Bang Zhou, Chang-An Guo, Jing Zhai, Fa-Mei Qi, Hong-Ling L. Role of mimic of manganese superoxide dismutase in proliferation and apoptosis of gastric carcinoma BGC-823 cells in vitro and in vivo. International immunopharmacology. vol 26. issue 2. 2016-02-29. PMID:25889634. |
the main mechanisms on mnsodm-induced apoptosis were related to the inhibition of pi3k expression, which inactivated the phosphorylation of akt involving the prevention of nf-κb phosphorylation and nuclear translocation. |
2016-02-29 |
2023-08-13 |
mouse |
| Jie Tang, Lili Ji, Yuchan Wang, Yuejiao Huang, Haibing Yin, Yunhua He, Jing Liu, Xiaobing Miao, Yaxun Wu, Xiaohong Xu, Song He, Chun Chen. Cell adhesion down-regulates the expression of vacuolar protein sorting 4B (VPS4B) and contributes to drug resistance in multiple myeloma cells. International journal of hematology. vol 102. issue 1. 2016-02-24. PMID:25804841. |
this induced cam-dr phenotype manifested through down-regulation of cell apoptosis and requires phosphorylation of akt and erk. |
2016-02-24 |
2023-08-13 |
human |
| P Saurus, S Kuusela, E Lehtonen, M E Hyvönen, M Ristola, C L Fogarty, J Tienari, M I Lassenius, C Forsblom, M Lehto, M A Saleem, P-H Groop, H Holthöfer, S Lehtone. Podocyte apoptosis is prevented by blocking the Toll-like receptor pathway. Cell death & disease. vol 6. 2016-02-23. PMID:25950482. |
we observed that treatment of cultured human podocytes with sera from normoalbuminuric t1d patients with high lps activity downregulated 3-phosphoinositide-dependent kinase-1 (pdk1), an activator of the akt cell survival pathway, and induced apoptosis. |
2016-02-23 |
2023-08-13 |
mouse |