| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kyoung-Youn Han, Jee Won Hwang, Gyu-Un Bae, Su-Nam Kim, Yong Kee Ki. Akt regulation of Aven contributes to the sensitivity of cancer cells to chemotherapeutic agents. Molecular medicine reports. vol 11. issue 5. 2016-03-24. PMID:25573060. |
in the present study, it was demonstrated that the protein level of the apoptosis inhibitor aven is regulated by the akt signaling pathway, evidenced by the observation that aven levels were significantly increased in mcf7 constitutively active (ca)‑akt cells and significantly inhibited following treatment with ly294002. |
2016-03-24 |
2023-08-13 |
Not clear |
| Mun-Wai Cheong, Li-Hua Kuo, Yi-Ning Cheng, Pei-Jane Tsai, Li-Chun Ho, Haw-Chih Tai, Wen-Tai Chiu, Shun-Hua Chen, Pei-Jung Lu, Yan-Shen Shan, Lee-Ming Chuang, Yau-Sheng Tsa. Loss of Egr-1 sensitizes pancreatic β-cells to palmitate-induced ER stress and apoptosis. Journal of molecular medicine (Berlin, Germany). vol 93. issue 7. 2016-03-24. PMID:25737480. |
akt replenishment and insulin supplementation rescued pa-induced apoptosis in egr-1 knockdown cells. |
2016-03-24 |
2023-08-13 |
mouse |
| Goutam Dey, Rashmi Bharti, Gunaseelan Dhanarajan, Subhasis Das, Kaushik Kumar Dey, B N Prashanth Kumar, Ramkrishna Sen, Mahitosh Manda. Marine lipopeptide Iturin A inhibits Akt mediated GSK3β and FoxO3a signaling and triggers apoptosis in breast cancer. Scientific reports. vol 5. 2016-03-24. PMID:25974307. |
marine lipopeptide iturin a inhibits akt mediated gsk3β and foxo3a signaling and triggers apoptosis in breast cancer. |
2016-03-24 |
2023-08-13 |
human |
| Goutam Dey, Rashmi Bharti, Gunaseelan Dhanarajan, Subhasis Das, Kaushik Kumar Dey, B N Prashanth Kumar, Ramkrishna Sen, Mahitosh Manda. Marine lipopeptide Iturin A inhibits Akt mediated GSK3β and FoxO3a signaling and triggers apoptosis in breast cancer. Scientific reports. vol 5. 2016-03-24. PMID:25974307. |
gene silencing of akt in mda-mb-231 and mcf-7 cells reduced the sensitivity of cancer cells to iturin a. interestingly, overexpression of akt with akt plasmid in cancer cells caused highly susceptible to induce apoptosis by iturin a treatment. |
2016-03-24 |
2023-08-13 |
human |
| Qiong Yang, Kan Yang, An-Ying L. Trimetazidine protects against hypoxia-reperfusion-induced cardiomyocyte apoptosis by increasing microRNA-21 expression. International journal of clinical and experimental pathology. vol 8. issue 4. 2016-03-24. PMID:26097555. |
the increased activity of akt signaling decreased the ratio of bax/bcl-2 and the expression of caspase-3 and inhibited h/r induced apoptosis. |
2016-03-24 |
2023-08-13 |
Not clear |
| Hidehisa Shimizu, Nanako Baba, Takuma Nose, Ryoko Taguchi, Shinya Tanaka, Ga-Hyun Joe, Hideaki Maseda, Nobuhiko Nomura, Masahito Hagio, Ja-Young Lee, Satoru Fukiya, Atsushi Yokota, Satoshi Ishizuka, Hitoshi Miyazak. Activity of ERK regulates mucin 3 expression and is involved in undifferentiated Caco-2 cell death induced by 3-oxo-C12-homoserine lactone. Bioscience, biotechnology, and biochemistry. vol 79. issue 6. 2016-03-21. PMID:25774422. |
although most studies have examined the effects of high 3-oxo-c12-hsl concentrations (>200 μm) on mammalian cellular functions because ~600 μm 3-oxo-c12-hsl can be secreted in biofilms of pseudomonas aeruginosa grown in vitro, we previously showed that a low 3-oxo-c12-hsl concentration (30 μm) induces the apoptosis of undifferentiated caco-2 cells through suppressing akt activity. |
2016-03-21 |
2023-08-13 |
Not clear |
| Li-Tao Pan, Yip Sheung, Wen-Peng Guo, Zhi-Bin Rong, Zhi-Ming Ca. Hedyotis diffusa plus Scutellaria barbata Induce Bladder Cancer Cell Apoptosis by Inhibiting Akt Signaling Pathway through Downregulating miR-155 Expression. Evidence-based complementary and alternative medicine : eCAM. vol 2016. 2016-03-18. PMID:26989427. |
hedyotis diffusa plus scutellaria barbata induce bladder cancer cell apoptosis by inhibiting akt signaling pathway through downregulating mir-155 expression. |
2016-03-18 |
2023-08-13 |
Not clear |
| Li-Tao Pan, Yip Sheung, Wen-Peng Guo, Zhi-Bin Rong, Zhi-Ming Ca. Hedyotis diffusa plus Scutellaria barbata Induce Bladder Cancer Cell Apoptosis by Inhibiting Akt Signaling Pathway through Downregulating miR-155 Expression. Evidence-based complementary and alternative medicine : eCAM. vol 2016. 2016-03-18. PMID:26989427. |
it also induced cell apoptosis through decreasing akt activation and reducing the expression of antiapoptotic proteins bcl-2 and mcl-1. |
2016-03-18 |
2023-08-13 |
Not clear |
| Li-Tao Pan, Yip Sheung, Wen-Peng Guo, Zhi-Bin Rong, Zhi-Ming Ca. Hedyotis diffusa plus Scutellaria barbata Induce Bladder Cancer Cell Apoptosis by Inhibiting Akt Signaling Pathway through Downregulating miR-155 Expression. Evidence-based complementary and alternative medicine : eCAM. vol 2016. 2016-03-18. PMID:26989427. |
further experiments showed that mir-155 was reduced by the herb-pair and mirna-155 inhibitor induced cell apoptosis and suppressed akt activation. |
2016-03-18 |
2023-08-13 |
Not clear |
| Li-Tao Pan, Yip Sheung, Wen-Peng Guo, Zhi-Bin Rong, Zhi-Ming Ca. Hedyotis diffusa plus Scutellaria barbata Induce Bladder Cancer Cell Apoptosis by Inhibiting Akt Signaling Pathway through Downregulating miR-155 Expression. Evidence-based complementary and alternative medicine : eCAM. vol 2016. 2016-03-18. PMID:26989427. |
overexpression of mir-155 reversed herb-pair induced cell apoptosis through activating akt pathway in both bladder cancer cell lines. |
2016-03-18 |
2023-08-13 |
Not clear |
| Li-Tao Pan, Yip Sheung, Wen-Peng Guo, Zhi-Bin Rong, Zhi-Ming Ca. Hedyotis diffusa plus Scutellaria barbata Induce Bladder Cancer Cell Apoptosis by Inhibiting Akt Signaling Pathway through Downregulating miR-155 Expression. Evidence-based complementary and alternative medicine : eCAM. vol 2016. 2016-03-18. PMID:26989427. |
the findings reveal that hedyotis diffusa plus scutellaria barbata reduce akt activation through reducing mir-155 expression, resulting in cell apoptosis. |
2016-03-18 |
2023-08-13 |
Not clear |
| Annalisa Lonetti, Alessandra Cappellini, Antonino Maria Spartà, Francesca Chiarini, Francesca Buontempo, Camilla Evangelisti, Cecilia Evangelisti, Ester Orsini, James A McCubrey, Alberto Maria Martell. PI3K pan-inhibition impairs more efficiently proliferation and survival of T-cell acute lymphoblastic leukemia cell lines when compared to isoform-selective PI3K inhibitors. Oncotarget. vol 6. issue 12. 2016-03-15. PMID:25871383. |
pi3k pan-inhibition suppressed akt activation and induced caspase-independent apoptosis. |
2016-03-15 |
2023-08-13 |
Not clear |
| Guohua Ren, Lijun Sheng, Haibo Liu, Yahong Sun, Yuji An, Yan L. The crucial role of SRPK1 in TGF-β-induced proliferation and apoptosis in the esophageal squamous cell carcinomas. Medical oncology (Northwood, London, England). vol 32. issue 7. 2016-03-15. PMID:26099172. |
in conclusion, srpk1 mediates tgf-β-induced proliferation and apoptosis by regulating akt and jnk in escc, which indicates tgf-β-srpk1 pathway may be suggested as a useful target to affect the progression of escc. |
2016-03-15 |
2023-08-13 |
mouse |
| Yi Lin, Zhongjie Su. Antiaging Gene Klotho Attenuates Pancreatic β-Cell Apoptosis in Type 1 Diabetes. Diabetes. vol 64. issue 12. 2016-03-15. PMID:26340932. |
mkl abolished stz- and tnfα-induced inhibition of fak and akt phosphorylation, caspase 3 cleavage, and β-cell apoptosis. |
2016-03-15 |
2023-08-13 |
mouse |
| Shahid Ali Shah, Gwang Ho Yoon, Myeong Ok Ki. Protection of the developing brain with anthocyanins against ethanol-induced oxidative stress and neurodegeneration. Molecular neurobiology. vol 51. issue 3. 2016-03-10. PMID:24997566. |
the results suggest that anthocyanins significantly reversed the ethanol-induced inhibition of glutamatergic neurotransmission, synaptic dysfunction, gabab1r activation, and neuronal apoptosis by stimulating the phosphatidylinositol-4,5-bisphosphate 3-kinase (pi3k)/v-akt murine thymoma viral oncogene (akt)/glycogen synthase kinase 3 beta (gsk3β) pathway in the hippocampus of postnatal rat brain. |
2016-03-10 |
2023-08-13 |
rat |
| Shi-mei Qi, Jun Lv, Yu Meng, Zhi-lin Qi, Lie-feng Lin. [Effect of sodium aescinate in inducing human breast cancer MCF-7 cells apoptosis by inhibiting AKT, ERK and upstream signal SRC activity]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 40. issue 16. 2016-03-10. PMID:26790305. |
[effect of sodium aescinate in inducing human breast cancer mcf-7 cells apoptosis by inhibiting akt, erk and upstream signal src activity]. |
2016-03-10 |
2023-08-13 |
human |
| Shi-mei Qi, Jun Lv, Yu Meng, Zhi-lin Qi, Lie-feng Lin. [Effect of sodium aescinate in inducing human breast cancer MCF-7 cells apoptosis by inhibiting AKT, ERK and upstream signal SRC activity]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 40. issue 16. 2016-03-10. PMID:26790305. |
the findings indicated that sodium aescinate can block signals transiting to downstream molecules akt, erk, inhibit the proliferation of breast cancer cell mcf-7 cell apoptosis and induced cell apoptosis by suppressing the activation of src. |
2016-03-10 |
2023-08-13 |
human |
| Gautier Chene, Veronique Ouellet, Kurosh Rahimi, Veronique Barres, Diane Provencher, Anne Marie Mes-Masso. The ARID1A pathway in ovarian clear cell and endometrioid carcinoma, contiguous endometriosis, and benign endometriosis. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. vol 130. issue 1. 2016-03-08. PMID:25912412. |
to assess arid1a-encoded protein (baf250a) and phosphorylated akt (pakt) expression, apoptosis, and the dna damage response pathway in endometrioid and clear cell ovarian cancers (endometriosis-associated ovarian cancers [eaocs]), and benign endometriotic ovarian cysts. |
2016-03-08 |
2023-08-13 |
Not clear |
| Jing Wen, Yuyan Zhao, Yang Shen, Lei Gu. Effect of orexin A on apoptosis in BGC-823 gastric cancer cells via OX1R through the AKT signaling pathway. Molecular medicine reports. vol 11. issue 5. 2016-03-04. PMID:25586545. |
effect of orexin a on apoptosis in bgc-823 gastric cancer cells via ox1r through the akt signaling pathway. |
2016-03-04 |
2023-08-13 |
Not clear |
| Jing Wen, Yuyan Zhao, Yang Shen, Lei Gu. Effect of orexin A on apoptosis in BGC-823 gastric cancer cells via OX1R through the AKT signaling pathway. Molecular medicine reports. vol 11. issue 5. 2016-03-04. PMID:25586545. |
in conclusion, the results of the present study demonstrated that orexin a inhibited gastric cancer cell apoptosis via ox1r through the akt signaling pathway. |
2016-03-04 |
2023-08-13 |
Not clear |