| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B S Tan, K H Tiong, H L Choo, F Fei-Lei Chung, L-W Hii, S H Tan, I K S Yap, S Pani, N T W Khor, S F Wong, R Rosli, S-K Cheong, C-O Leon. Mutant p53-R273H mediates cancer cell survival and anoikis resistance through AKT-dependent suppression of BCL2-modifying factor (BMF). Cell death & disease. vol 6. 2016-05-10. PMID:26181206. |
here, we showed that silencing of endogenous p53-r273h contact mutant, but not p53-r175h conformational mutant, reduced akt phosphorylation, induced bcl2-modifying factor (bmf) expression, sensitized bim dissociation from bcl-xl and induced mitochondria-dependent apoptosis in cancer cells. |
2016-05-10 |
2023-08-13 |
human |
| Kevin Brasseur, Pascal Auger, Eric Asselin, Sophie Parent, Jean-Charles Côté, Marc Siroi. Parasporin-2 from a New Bacillus thuringiensis 4R2 Strain Induces Caspases Activation and Apoptosis in Human Cancer Cells. PloS one. vol 10. issue 8. 2016-05-10. PMID:26263002. |
further analyses were performed to study survival pathways, including akt, xiap, erk1/2 and par-4, a known inducer of apoptosis. |
2016-05-10 |
2023-08-13 |
human |
| Zheng Huang, Yanke Huang, Hongtao He, Jiangdong N. Podocalyxin promotes cisplatin chemoresistance in osteosarcoma cells through phosphatidylinositide 3-kinase signaling. Molecular medicine reports. vol 12. issue 3. 2016-05-09. PMID:26017117. |
overexpression of pcx in the two cell lines significantly increased the half maximal inhibitory concentration (ic50) of cisplatin, cell colony formation, phosphatidylinositide 3‑kinase (pi3k) activity and akt phosphorylation at serine 473, and decreased cisplatin‑induced cell apoptosis. |
2016-05-09 |
2023-08-13 |
human |
| Zheng Huang, Yanke Huang, Hongtao He, Jiangdong N. Podocalyxin promotes cisplatin chemoresistance in osteosarcoma cells through phosphatidylinositide 3-kinase signaling. Molecular medicine reports. vol 12. issue 3. 2016-05-09. PMID:26017117. |
conversely, knockdown of pcx expression markedly decreased the ic50 of cisplatin, cell colony formation, pi3k activity and akt phosphorylation at serine 473, and increased cisplatin‑induced cell apoptosis. |
2016-05-09 |
2023-08-13 |
human |
| Nahee Park, Hyoung Seok Baek, Young-Jin Chu. Embelin-Induced Apoptosis of Human Prostate Cancer Cells Is Mediated through Modulation of Akt and β-Catenin Signaling. PloS one. vol 10. issue 8. 2016-05-09. PMID:26252009. |
embelin-induced apoptosis of human prostate cancer cells is mediated through modulation of akt and β-catenin signaling. |
2016-05-09 |
2023-08-13 |
human |
| Xin Yu, Zheng Li, Jianxiong She. BRD7: a novel tumor suppressor gene in different cancers. American journal of translational research. vol 8. issue 2. 2016-05-09. PMID:27158366. |
moreover, brd7 inhibited cancer cell growth and metastasis and promote apoptosis in vitro and in vivo via downregulating akt pathway. |
2016-05-09 |
2023-08-13 |
human |
| Zhiming Ma, Dacheng Wen, Xudong Wang, Longfei Yang, Tianzhou Liu, Jingjing Liu, Jiaming Zhu, Xuedong Fan. Growth inhibition of human gastric adenocarcinoma cells in vitro by STO-609 is independent of calcium/calmodulin-dependent protein kinase kinase-beta and adenosine monophosphate-activated protein kinase. American journal of translational research. vol 8. issue 2. 2016-05-09. PMID:27158402. |
in the present study, we found that sto-609 suppressed amp-activated protein kinase activity, reduced expression of akt and erk, and increased cell apoptosis in snu-1 and n87 cells but not normal gastric epithelial cells (ccl-241). |
2016-05-09 |
2023-08-13 |
human |
| Min Ho Han, Won Sup Lee, Ji Hyun Jung, Jae-Hun Jeong, Cheol Park, Hye Jung Kim, GonSup Kim, Jin-Myung Jung, Taeg Kyu Kwon, Gi-Young Kim, Chung Ho Ryu, Sung Chul Shin, Soon Chan Hong, Yung Hyun Cho. Polyphenols isolated from Allium cepa L. induces apoptosis by suppressing IAP-1 through inhibiting PI3K/Akt signaling pathways in human leukemic cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 62. 2016-05-06. PMID:24021570. |
in addition, peal suppressed akt activity and the peal-induced apoptosis was significantly attenuated in akt-overexpressing u937 cells. |
2016-05-06 |
2023-08-12 |
human |
| Benjawan Kaewseekhao, Vivek Naranbhai, Sittiruk Roytrakul, Wises Namwat, Atchara Paemanee, Viraphong Lulitanond, Angkana Chaiprasert, Kiatichai Faksr. Comparative Proteomics of Activated THP-1 Cells Infected with Mycobacterium tuberculosis Identifies Putative Clearance Biomarkers for Tuberculosis Treatment. PloS one. vol 10. issue 7. 2016-05-06. PMID:26214306. |
counteracting proteins (casp3 vs. akt and nf-κb vs. tp53) associated with apoptosis regulation and its networks were enriched among the early and sustained infection biomarkers, indicating host-pathogen competition. |
2016-05-06 |
2023-08-13 |
Not clear |
| María Cristina Estañ, Eva Calviño, Susana Calvo, Beatriz Guillén-Guío, María Del Carmen Boyano-Adánez, Elena de Blas, Eduardo Rial, Patricio Alle. Apoptotic efficacy of etomoxir in human acute myeloid leukemia cells. Cooperation with arsenic trioxide and glycolytic inhibitors, and regulation by oxidative stress and protein kinase activities. PloS one. vol 9. issue 12. 2016-05-05. PMID:25506699. |
apoptosis generation by etomoxir plus 2-deoxy-d-glucose was further increased by co-incubation with ato, which is apparently explained by the capacity of ato to attenuate akt and erk activation. |
2016-05-05 |
2023-08-13 |
human |
| Ni Wang, Yanxian Feng, Lilan Zeng, Zhennan Zhao, Tianfeng Che. Functionalized Multiwalled Carbon Nanotubes as Carriers of Ruthenium Complexes to Antagonize Cancer Multidrug Resistance and Radioresistance. ACS applied materials & interfaces. vol 7. issue 27. 2016-05-04. PMID:26107995. |
interestingly, rupop@mwcnts significantly enhanced the anticancer efficacy of clinically used x-ray against r-hepg2 cells through induction of apoptosis and g0/g1 cell cycle arrest, with the involvement of ros overproduction, which activated several downstream signaling pathways, including dna damage-mediated p53 phosphorylation, activation of p38, and inactivation of akt and erk. |
2016-05-04 |
2023-08-13 |
Not clear |
| Jiancheng Zhou, Guodong Zhu, Jun Huang, Lei Li, Yuefeng Du, Yang Gao, Dapeng Wu, Xinyang Wang, Jer-Tsong Hsieh, Dalin He, Kaijie W. Non-canonical GLI1/2 activation by PI3K/AKT signaling in renal cell carcinoma: A novel potential therapeutic target. Cancer letters. vol 370. issue 2. 2016-05-03. PMID:26577809. |
up-regulation of gli1 and gli2 promoted rcc proliferation and clonogenic ability, whereas, a combination of glis inhibitor gant61 and akt inhibitor perifosine synergistically suppressed rcc growth and induced apoptosis in vitro and in vivo. |
2016-05-03 |
2023-08-13 |
human |
| Jianzhong Li, Zhuo Xu, Lei Jiang, Junhua Mao, Zhifeng Zeng, Li Fang, Weichun He, Weiping Yuan, Junwei Yang, Chunsun Da. Rictor/mTORC2 protects against cisplatin-induced tubular cell death and acute kidney injury. Kidney international. vol 86. issue 1. 2016-05-02. PMID:24451322. |
as expected, tubular cell apoptosis, akt phosphorylation (ser473), and autophagy were induced in the kidneys from the control littermates by cisplatin treatment. |
2016-05-02 |
2023-08-12 |
mouse |
| Jianzhong Li, Zhuo Xu, Lei Jiang, Junhua Mao, Zhifeng Zeng, Li Fang, Weichun He, Weiping Yuan, Junwei Yang, Chunsun Da. Rictor/mTORC2 protects against cisplatin-induced tubular cell death and acute kidney injury. Kidney international. vol 86. issue 1. 2016-05-02. PMID:24451322. |
less cell autophagy or akt phosphorylation and more cell apoptosis in the kidneys of the knockout mice were identified compared with those in the control littermates. |
2016-05-02 |
2023-08-12 |
mouse |
| Philine Schneider, Margarete Schön, Nadin Pletz, Cornelia S Seitz, Ningshu Liu, Karl Ziegelbauer, Karolin Zachmann, Steffen Emmert, Michael P Schö. The novel PI3 kinase inhibitor, BAY 80-6946, impairs melanoma growth in vivo and in vitro. Experimental dermatology. vol 23. issue 8. 2016-04-29. PMID:24942196. |
we provide experimental evidence that specifically inhibiting the pi3k pathway and phosphorylation of akt by this novel compound results in antitumoral activities including inhibition of proliferation, induction of apoptosis and cell cycle arrest in vitro and in vivo. |
2016-04-29 |
2023-08-13 |
mouse |
| Weina Chen, Chang Han, Jinqiang Zhang, Kyoungsub Song, Ying Wang, Tong W. miR-150 Deficiency Protects against FAS-Induced Acute Liver Injury in Mice through Regulation of AKT. PloS one. vol 10. issue 7. 2016-04-28. PMID:26196694. |
these findings demonstrate that mir-150 deficiency prevents fas-induced hepatocyte apoptosis and liver injury through regulation of the akt pathway. |
2016-04-28 |
2023-08-13 |
mouse |
| Lu Gan, Zhenjiang Liu, Wei Jin, Zhongjie Zhou, Chao Su. Foxc2 enhances proliferation and inhibits apoptosis through activating Akt/mTORC1 signaling pathway in mouse preadipocytes. Journal of lipid research. vol 56. issue 8. 2016-04-26. PMID:26113535. |
moreover, the protein kinase b (akt)/mammalian target of rapamycin (mtor)c1 signaling pathway and the erk/mtorc1 signaling pathway were activated along with preadipocyte proliferation in response to foxc2 overexpression, whereas apoptosis marker genes were downregulated during this process. |
2016-04-26 |
2023-08-13 |
mouse |
| Changcun Fang, Yuwen Shen, Peng Qi, Zhengqin Liu, Min Zhang, Xinyan Pan. Astrocyte-elevated gene-1 mediates insulin-like growth factor 1-induced the progression of cardiac myxoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 12. 2016-04-26. PMID:26156800. |
in conclusion, aeg-1 regulates igf-1-induced proliferation and apoptosis via erk1/2 and akt signaling in cm development, which suggests igf-1-aeg-1 signaling could be recommended to be a useful target to exert anti-tumor effects on cm. |
2016-04-26 |
2023-08-13 |
Not clear |
| Min Li, Fei Lin, Yanliang Lin, Wen Pen. Extracellular polysaccharide from Bordetella species reduces high glucose-induced macrophage apoptosis via regulating interaction between caveolin-1 and TLR4. Biochemical and biophysical research communications. vol 466. issue 4. 2016-04-26. PMID:26424181. |
in the present investigation, high glucose treatment inhibited akt phosphorylation and activated caspase 3 in primary peritoneal macrophage, leading to cell apoptosis. |
2016-04-26 |
2023-08-13 |
Not clear |
| Zhaoxin Guo, Xiaolin Hu, Zhaoquan Xing, Rui Xing, Renguang Lv, Xiangyu Cheng, Jing Su, Zunlin Zhou, Zhonghua Xu, Sten Nilsson, Zhaoxu Li. Baicalein inhibits prostate cancer cell growth and metastasis via the caveolin-1/AKT/mTOR pathway. Molecular and cellular biochemistry. vol 406. issue 1-2. 2016-04-25. PMID:25957503. |
moreover, the inhibition of the activation of akt with ly294002 significantly promoted the apoptosis and metastasis induced by baicalein. |
2016-04-25 |
2023-08-13 |
Not clear |