| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sagar Shelake, Don Eslin, Robert M Sutphin, Umesh T Sankpal, Anmol Wadwani, Laura E Kenyon, Leslie Tabor-Simecka, W Paul Bowman, Jamboor K Vishwanatha, Riyaz Bash. Combination of 13 cis-retinoic acid and tolfenamic acid induces apoptosis and effectively inhibits high-risk neuroblastoma cell proliferation. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 46. 2016-06-20. PMID:26287661. |
la1-55n and sh-sy5y cells were treated with ta (30μm) or ra (20μm) or both (optimized doses, derived from dose curves) for 48h and tested the effect on cell viability, apoptosis and selected molecular markers (sp1, survivin, akt and erk1/2). |
2016-06-20 |
2023-08-13 |
Not clear |
| Lirui Zhang, Xiaofeng Yang, Xu Li, Chen Li, Le Zhao, Yuanyuan Zhou, Huilian Ho. Butein sensitizes HeLa cells to cisplatin through the AKT and ERK/p38 MAPK pathways by targeting FoxO3a. International journal of molecular medicine. vol 36. issue 4. 2016-06-20. PMID:26310353. |
the use of the akt inhibitor, ly294002, in combination with cisplatin, induced an increase in apoptosis compared to treatment with cisplatin alone, although this effect was not as prominent as that exerted by butein in combination with cisplatin. |
2016-06-20 |
2023-08-13 |
mouse |
| Huiyao Hao, Di Zhang, Junli Shi, Yan Wang, Lei Chen, Yongze Guo, Junji Ma, Xiaoyu Jiang, Huiqing Jian. Sorafenib induces autophagic cell death and apoptosis in hepatic stellate cell through the JNK and Akt signaling pathways. Anti-cancer drugs. vol 27. issue 3. 2016-06-20. PMID:26629768. |
sorafenib induces autophagic cell death and apoptosis in hepatic stellate cell through the jnk and akt signaling pathways. |
2016-06-20 |
2023-08-13 |
rat |
| Yanwei Liu, Sen Chen, Rui Xue, Juan Zhao, Maojun D. Mefloquine effectively targets gastric cancer cells through phosphatase-dependent inhibition of PI3K/Akt/mTOR signaling pathway. Biochemical and biophysical research communications. vol 470. issue 2. 2016-06-14. PMID:26780727. |
overexpression of constitutively active akt significantly restored mefloquine-mediated inhibition of mtor phosphorylation and growth, and induction of apoptosis, suggesting that mefloquine acts on gastric cancer cells via suppressing pi3k/akt/mtor pathway. |
2016-06-14 |
2023-08-13 |
mouse |
| Chong Xu, Hai Zhang, Chunxiao Liu, Yu Zhu, Xiaoxue Wang, Wei Gao, Shile Huang, Long Che. Rapamycin inhibits Erk1/2-mediated neuronal apoptosis caused by cadmium. Oncotarget. vol 6. issue 25. 2016-06-10. PMID:26046303. |
inhibition of pp2a with okadaic acid or ectopic expression of dominant negative pp2a attenuated rapamycin's inhibition of cd-induced phospho-erk1/2 and apoptosis, whereas over-expression of wild-type pp2a enhanced rapamycin's effects; over-expression of wild-type pten or dominant negative akt, or inhibition of akt with akt inhibitor x strengthened rapamycin's inhibition of cd-induced phospho-erk1/2 and cell death. |
2016-06-10 |
2023-08-13 |
Not clear |
| Anja Heinemann, Carleen Cullinane, Ricardo De Paoli-Iseppi, James S Wilmott, Dilini Gunatilake, Jason Madore, Dario Strbenac, Jean Y Yang, Kavitha Gowrishankar, Jessamy C Tiffen, Rab K Prinjha, Nicholas Smithers, Grant A McArthur, Peter Hersey, Stuart J Gallaghe. Combining BET and HDAC inhibitors synergistically induces apoptosis of melanoma and suppresses AKT and YAP signaling. Oncotarget. vol 6. issue 25. 2016-06-10. PMID:26087189. |
combining bet and hdac inhibitors synergistically induces apoptosis of melanoma and suppresses akt and yap signaling. |
2016-06-10 |
2023-08-13 |
Not clear |
| Ying Piao, Ying Li, Qian Xu, Jing-wei Liu, Cheng-zhong Xing, Xiao-dong Xie, Yuan Yua. Association of MTOR and AKT Gene Polymorphisms with Susceptibility and Survival of Gastric Cancer. PloS one. vol 10. issue 8. 2016-06-09. PMID:26317520. |
the phosphoinositide 3-kinase (pi3k)/protein kinase b (pkb, akt)/mammalian target of rapamycin (mtor) signaling pathway plays a critical role in angiogenesis and cell growth, proliferation, metabolism, migration, differentiation, and apoptosis. |
2016-06-09 |
2023-08-13 |
Not clear |
| Alessia Bertamino, Simona Musella, Veronica Di Sarno, Carmine Ostacolo, Michele Manfra, Daniela Vanacore, Paola Stiuso, Ettore Novellino, Pietro Campiglia, Isabel M Gomez-Monterre. Dihydrithieno[2,3-b]naphto-4,9-dione analogues as anticancer agents: Synthesis and in cell pharmacological studies. European journal of medicinal chemistry. vol 102. 2016-06-08. PMID:26253231. |
moreover, compound 14 reduced both cellular glucose uptake and serine/threonine kinase akt expression, and triggered cell apoptosis. |
2016-06-08 |
2023-08-13 |
human |
| Simona Dinicola, Maria Grazia Masiello, Sara Proietti, Pierpaolo Coluccia, Gianmarco Fabrizi, Alessandro Palombo, Federico Micciulla, Silvia Bistarelli, Giulia Ricci, Angela Catizone, Giorgio De Toma, Mariano Bizzarri, Stefano Bellucci, Alessandra Cucin. Multiwalled carbon nanotube buckypaper induces cell cycle arrest and apoptosis in human leukemia cell lines through modulation of AKT and MAPK signaling pathways. Toxicology in vitro : an international journal published in association with BIBRA. vol 29. issue 7. 2016-06-07. PMID:25998161. |
multiwalled carbon nanotube buckypaper induces cell cycle arrest and apoptosis in human leukemia cell lines through modulation of akt and mapk signaling pathways. |
2016-06-07 |
2023-08-13 |
human |
| Shu-Hung Huang, Sheng-Hua Wu, Su-Shin Lee, Kao-Ping Chang, Chee-Yin Chai, Jwu-Lai Yeh, Sin-Daw Lin, Aij-Lie Kwan, Hui-Min David Wang, Chung-Sheng La. Fat Grafting in Burn Scar Alleviates Neuropathic Pain via Anti-Inflammation Effect in Scar and Spinal Cord. PloS one. vol 10. issue 9. 2016-06-07. PMID:26368011. |
double immunofluorescent staining images for measuring p-iκb, p-nfκb, p-jnk, and tunel as well as western blots of akt, bax/bcl-2 for the inflammatory process, and apoptosis were analyzed. |
2016-06-07 |
2023-08-13 |
Not clear |
| Mingchang Li, Bin Feng, Lang Wang, Sen Guo, Peng Zhang, Jun Gong, Yan Zhang, Ankang Zheng, Hongliang L. Tollip is a critical mediator of cerebral ischaemia-reperfusion injury. The Journal of pathology. vol 237. issue 2. 2016-06-06. PMID:26011492. |
mechanistically, the detrimental effects of tollip on neuronal apoptosis and inflammation following i/r injury were largely mediated by the suppression of akt signalling. |
2016-06-06 |
2023-08-13 |
mouse |
| Mingchang Li, Bin Feng, Lang Wang, Sen Guo, Peng Zhang, Jun Gong, Yan Zhang, Ankang Zheng, Hongliang L. Tollip is a critical mediator of cerebral ischaemia-reperfusion injury. The Journal of pathology. vol 237. issue 2. 2016-06-06. PMID:26011492. |
the tollip-deficient rats were also protected from i/r injury, based on dramatic decreases in neuronal apoptosis and ischaemic inflammation through akt activation. |
2016-06-06 |
2023-08-13 |
mouse |
| Mingchang Li, Bin Feng, Lang Wang, Sen Guo, Peng Zhang, Jun Gong, Yan Zhang, Ankang Zheng, Hongliang L. Tollip is a critical mediator of cerebral ischaemia-reperfusion injury. The Journal of pathology. vol 237. issue 2. 2016-06-06. PMID:26011492. |
taken together, our findings demonstrate that tollip acts as a novel modulator of i/r injury by promoting neuronal apoptosis and ischaemic inflammation, which are largely mediated by suppression of akt signalling. |
2016-06-06 |
2023-08-13 |
mouse |
| Jie Gong, Hong Liu, Jing Wu, Hong Qi, Zhou-Yang Wu, Hua-Qing Shu, Hong-Bin Li, Lin Chen, Ya-Xin Wang, Bo Li, Min Tang, Yu-Dong Ji, Shi-Ying Yuan, Shang-Long Yao, You Shan. MARESIN 1 PREVENTS LIPOPOLYSACCHARIDE-INDUCED NEUTROPHIL SURVIVAL AND ACCELERATES RESOLUTION OF ACUTE LUNG INJURY. Shock (Augusta, Ga.). vol 44. issue 4. 2016-06-06. PMID:26196844. |
we found that culture of isolated human neutrophils with lps dramatically delayed neutrophil apoptosis through the phosphorylation of akt, erk, and p38 to upregulate the expression of the antiapoptotic proteins mcl-1 and bcl-2, which was blocked by pretreatment with mar1 in vitro. |
2016-06-06 |
2023-08-13 |
mouse |
| Michaela Angelika Ihle, Marcel Trautmann, Helen Kuenstlinger, Sebastian Huss, Carina Heydt, Jana Fassunke, Eva Wardelmann, Sebastian Bauer, Hans-Ulrich Schildhaus, Reinhard Buettner, Sabine Merkelbach-Brus. miRNA-221 and miRNA-222 induce apoptosis via the KIT/AKT signalling pathway in gastrointestinal stromal tumours. Molecular oncology. vol 9. issue 7. 2016-06-03. PMID:25898773. |
our results demonstrate that mir-221 and mir-222 which are downregulated in wildtype and mutated gists, induce apoptosis in vitro by a signalling cascade involving kit, akt and bcl2. |
2016-06-03 |
2023-08-13 |
Not clear |
| Umut Fahrioğlu, Yavuz Dodurga, Levent Elmas, Mücahit Seçm. Ferulic acid decreases cell viability and colony formation while inhibiting migration of MIA PaCa-2 human pancreatic cancer cells in vitro. Gene. vol 576. issue 1 Pt 3. 2016-06-03. PMID:26516023. |
expression profiles of certain cell cycle and apoptosis genes such as ccnd1 (cyclin d1),cdk4, cdk6, rb, p21, p16, p53, caspase-3, caspase-9, caspase-8, caspase-10, bcl-2, bcl-xl,bid, dr4,dr5,fadd,tradd,parp, apaf, bax, akt, pten, puma, noxa, mmp2, mmp9, timp1 and timp2 were determined by real-time pcr. |
2016-06-03 |
2023-08-13 |
human |
| Jing-Ping Wang, Ya-Chu Yu, Shih-Ping Chen, Huan-Chang Liang, Chia-Wei Lin, Kang Fan. The collective nuclear migration of p53 and phosphorylated S473 of Akt during ellipticine-mediated apoptosis in human lung epithelial cancer cells. Molecular and cellular biochemistry. vol 407. issue 1-2. 2016-05-31. PMID:26014912. |
the collective nuclear migration of p53 and phosphorylated s473 of akt during ellipticine-mediated apoptosis in human lung epithelial cancer cells. |
2016-05-31 |
2023-08-13 |
human |
| Mohamed H Mahmoud, Gamal Badr, Badr Mohamed Badr, Ahmad Usama Kassem, Mahmoud Shaaban Mohame. Elevated IFN-alpha/beta levels in a streptozotocin-induced type I diabetic mouse model promote oxidative stress and mediate depletion of spleen-homing CD8+ T cells by apoptosis through impaired CCL21/CCR7 axis and IL-7/CD127 signaling. Cellular signalling. vol 27. issue 10. 2016-05-31. PMID:26192098. |
this decrease in spleen-homing cd8+ t cells resulted from a marked reduction in the ccl21-mediated entry of cd8+ t cells into the spleen and from increased apoptosis due to a marked reduction in il-7-mediated stat5 and akt phosphorylation. |
2016-05-31 |
2023-08-13 |
mouse |
| Jialing Wu, Chong Chen, Xi Hu, Xianbin Cai, Yinghong Guan, Hui Hu, Qinjia Wang, Xiaofeng Chen, Bozhi Cai, Xubin Jin. Suppressing cyclooxygenase-2 prevents nonalcoholic and inhibits apoptosis of hepatocytes that are involved in the Akt/p53 signal pathway. Biochemical and biophysical research communications. vol 469. issue 4. 2016-05-27. PMID:26723251. |
after that, liver histology, serum alanine aminotransferase (alt) levels, hepatic triglyceride (tg) levels, hepatocyte apoptosis, phosphorylated akt (ser473, pakt) and p53 protein levels in mice livers were assessed. |
2016-05-27 |
2023-08-13 |
mouse |
| Yixiang Han, Aifang Ye, Yan Zhang, Zhimin Cai, Wei Wang, Lan Sun, Songfu Jiang, Jianbo Wu, Kang Yu, Shenghui Zhan. Musashi-2 Silencing Exerts Potent Activity against Acute Myeloid Leukemia and Enhances Chemosensitivity to Daunorubicin. PloS one. vol 10. issue 8. 2016-05-26. PMID:26308531. |
suppression of akt, erk1/2 and p38 phosphorylation also contributed to apoptosis mediated by msi2 silencing. |
2016-05-26 |
2023-08-13 |
Not clear |