| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jianhua Shi, Jin-hua Gu, Chun-ling Dai, Jianlan Gu, Xiaoxia Jin, Jianming Sun, Khalid Iqbal, Fei Liu, Cheng-Xin Gon. O-GlcNAcylation regulates ischemia-induced neuronal apoptosis through AKT signaling. Scientific reports. vol 5. 2016-08-19. PMID:26412745. |
these findings provide a novel mechanism through which o-glcnacylation regulates ischemia-induced neuronal apoptosis through akt signaling. |
2016-08-19 |
2023-08-13 |
mouse |
| Paul Toren, Soojin Kim, Fraser Johnson, Amina Zoubeid. Combined AKT and MEK Pathway Blockade in Pre-Clinical Models of Enzalutamide-Resistant Prostate Cancer. PloS one. vol 11. issue 4. 2016-08-19. PMID:27046225. |
our data reveal that akt inhibition induces apoptosis and inhibits cell growth in pten null cell lines independently of their sensitivity to hormone therapy; however, akt inhibition had no effect on the pten positive 22rv1 cell line. |
2016-08-19 |
2023-08-13 |
Not clear |
| Suman Mukhopadhyay, Amrita Chatterjee, Diane Kogan, Deven Patel, David A Foste. 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR) enhances the efficacy of rapamycin in human cancer cells. Cell cycle (Georgetown, Tex.). vol 14. issue 20. 2016-08-18. PMID:26323019. |
the reduced level of pa sensitizes mtorc2 to rapamycin at tolerable nano-molar doses leading reduced akt phosphorylation and apoptosis. |
2016-08-18 |
2023-08-13 |
human |
| Ji-Ae Shin, Mi Heon Ryu, Ki-Han Kwon, BuYoung Choi, Sung-Dae Ch. Down-regulation of Akt by methanol extracts of Impatiens balsamina L. promotes apoptosis in human oral squamous cell carcinoma cell lines. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. vol 44. issue 6. 2016-08-15. PMID:25212570. |
down-regulation of akt by methanol extracts of impatiens balsamina l. promotes apoptosis in human oral squamous cell carcinoma cell lines. |
2016-08-15 |
2023-08-13 |
human |
| Peng Lin, Xing-Han Tian, Yong-Shang Yi, Wen-Shi Jiang, Ying-Jie Zhou, Wen-Jing Chen. Luteolin-induced protection of H₂O₂-induced apoptosis in PC12 cells and the associated pathway. Molecular medicine reports. vol 12. issue 5. 2016-08-15. PMID:26459830. |
the aim of the current study was to investigate the effect of luteolin on h2o2‑induced cell apoptosis in cultured rat pheochromocytoma cells (pc12 cells) and to investigate the role of the phosphatidylinositol‑3‑kinase (pi3k)/protein kinase b (akt) pathway on h2o2‑induced apoptosis. |
2016-08-15 |
2023-08-13 |
rat |
| Ipsita Pal, Sheetal Parida, B N Prashanth Kumar, Payel Banik, Kaushik Kumar Dey, Sandipan Chakraborty, Sujit K Bhutia, Mahitosh Manda. Blockade of autophagy enhances proapoptotic potential of BI-69A11, a novel Akt inhibitor, in colon carcinoma. European journal of pharmacology. vol 765. 2016-08-12. PMID:26306675. |
bi-69a11, novel akt inhibitor, is currently drawing much attention due to its intriguing effect in inducing apoptosis in melanoma, breast, prostate and colon cancer. |
2016-08-12 |
2023-08-13 |
Not clear |
| Ipsita Pal, Sheetal Parida, B N Prashanth Kumar, Payel Banik, Kaushik Kumar Dey, Sandipan Chakraborty, Sujit K Bhutia, Mahitosh Manda. Blockade of autophagy enhances proapoptotic potential of BI-69A11, a novel Akt inhibitor, in colon carcinoma. European journal of pharmacology. vol 765. 2016-08-12. PMID:26306675. |
it was also suggested that bi-69a11 mediated interaction between akt, hsp-90 and beclin-1 maintained the fine balance between autophagy and apoptosis. |
2016-08-12 |
2023-08-13 |
Not clear |
| Jiayi Wang, Lifang Ma, Xun Tang, Xiao Zhang, Yongxia Qiao, Yuling Shi, Yanfeng Xu, Zhongyong Wang, Yongchun Yu, Fenyong Su. Doxorubicin induces apoptosis by targeting Madcam1 and AKT and inhibiting protein translation initiation in hepatocellular carcinoma cells. Oncotarget. vol 6. issue 27. 2016-08-10. PMID:26124182. |
doxorubicin induces apoptosis by targeting madcam1 and akt and inhibiting protein translation initiation in hepatocellular carcinoma cells. |
2016-08-10 |
2023-08-13 |
Not clear |
| Jiayi Wang, Lifang Ma, Xun Tang, Xiao Zhang, Yongxia Qiao, Yuling Shi, Yanfeng Xu, Zhongyong Wang, Yongchun Yu, Fenyong Su. Doxorubicin induces apoptosis by targeting Madcam1 and AKT and inhibiting protein translation initiation in hepatocellular carcinoma cells. Oncotarget. vol 6. issue 27. 2016-08-10. PMID:26124182. |
taken together, we uncovered a potential mechanism for doxo-induced apoptosis in hcc treatment through targeting madcam1 and akt and blocking protein translation initiation. |
2016-08-10 |
2023-08-13 |
Not clear |
| Gao-feng Zeng, Shao-hui Zong, Zhi-yong Zhang, Song-wen Fu, Ke-ke Li, Ye Fang, Li Lu, De-Qiang Xia. The Role of 6-Gingerol on Inhibiting Amyloid β Protein-Induced Apoptosis in PC12 Cells. Rejuvenation research. vol 18. issue 5. 2016-08-09. PMID:25811848. |
overall, these results indicate that 6-gingerol exhibited protective effects on apoptosis induced by aβ1-42 in cultured pc12 cells by reducing oxidative stress and inflammatory responses, suppressing the activation of gsk-3β and enhancing the activation of akt, thereby exerting neuroprotective effects. |
2016-08-09 |
2023-08-13 |
rat |
| Marc E Healy, Ronan Bergin, Bernard P Mahon, Karen Englis. Mesenchymal stromal cells protect against caspase 3-mediated apoptosis of CD19(+) peripheral B cells through contact-dependent upregulation of VEGF. Stem cells and development. vol 24. issue 20. 2016-08-09. PMID:26076727. |
however, cell contact between msc and b cells resulted in increased production of vascular endothelial growth factor (vegf) by msc facilitating akt phosphorylation within the b cell and inhibiting caspase 3-mediated apoptosis. |
2016-08-09 |
2023-08-13 |
human |
| Lilit Simonyan, Thibaud T Renault, Maria João da Costa Novais, Maria João Sousa, Manuela Côrte-Real, Nadine Camougrand, Cécile Gonzalez, Stéphen Mano. Regulation of Bax/mitochondria interaction by AKT. FEBS letters. vol 590. issue 1. 2016-08-08. PMID:26763134. |
bax-dependent mitochondrial permeabilization during apoptosis is controlled by multiple factors, including the phosphorylation by the protein kinase akt. |
2016-08-08 |
2023-08-13 |
human |
| Piaopiao Jin, Chi Chun Wong, Sibin Mei, Xingkang He, Yun Qian, Leimin Su. MK-2206 co-treatment with 5-fluorouracil or doxorubicin enhances chemosensitivity and apoptosis in gastric cancer by attenuation of Akt phosphorylation. OncoTargets and therapy. vol 9. 2016-08-08. PMID:27499633. |
mk-2206 co-treatment with 5-fluorouracil or doxorubicin enhances chemosensitivity and apoptosis in gastric cancer by attenuation of akt phosphorylation. |
2016-08-08 |
2023-08-13 |
Not clear |
| Piaopiao Jin, Chi Chun Wong, Sibin Mei, Xingkang He, Yun Qian, Leimin Su. MK-2206 co-treatment with 5-fluorouracil or doxorubicin enhances chemosensitivity and apoptosis in gastric cancer by attenuation of Akt phosphorylation. OncoTargets and therapy. vol 9. 2016-08-08. PMID:27499633. |
therefore, mk-2206 effectively inhibits gastric cancer cell growth by attenuation of akt phosphorylation and synergistically enhances the antitumor effect of doxorubicin and 5-fu via caspase-dependent apoptosis. |
2016-08-08 |
2023-08-13 |
Not clear |
| Tetsuo Sato, Kazuko Kita, Chihomi Sato, Atsushi Kaned. Hochu‑ekki‑to (Bu‑zhong‑yi‑qi‑tang), a herbal medicine, enhances cisplatin‑induced apoptosis in HeLa cells. Molecular medicine reports. vol 12. issue 4. 2016-08-02. PMID:26239548. |
proteins associated with cell viability and apoptosis, including phosphorylated (p‑)akt, p53, b‑cell lymphoma 2 (bcl‑2), bcl‑2‑associated x protein (bax) and active caspase‑3 were analyzed by immunoblotting. |
2016-08-02 |
2023-08-13 |
Not clear |
| Harish Chandra Pal, Ronald D Baxter, Katherine M Hunt, Jyoti Agarwal, Craig A Elmets, Mohammad Athar, Farrukh Afa. Fisetin, a phytochemical, potentiates sorafenib-induced apoptosis and abrogates tumor growth in athymic nude mice implanted with BRAF-mutated melanoma cells. Oncotarget. vol 6. issue 29. 2016-08-02. PMID:26299806. |
in addition, combination treatment resulted in enhanced (i) apoptosis, (ii) cleavage of caspase-3 and parp, (iii) expression of bax and bak, (iv) inhibition of bcl2 and mcl-1, and (v) inhibition of expression of pi3k, phosphorylation of mek1/2, erk1/2, akt and mtor. |
2016-08-02 |
2023-08-13 |
mouse |
| Yongtao Zhang, Fang Fang Liu, Xiaolei Bi, Shuangxi Wang, Xiao Wu, Fan Jian. The antioxidant compound tert-butylhydroquinone activates Akt in myocardium, suppresses apoptosis and ameliorates pressure overload-induced cardiac dysfunction. Scientific reports. vol 5. 2016-08-01. PMID:26260024. |
the antioxidant compound tert-butylhydroquinone activates akt in myocardium, suppresses apoptosis and ameliorates pressure overload-induced cardiac dysfunction. |
2016-08-01 |
2023-08-13 |
mouse |
| Yongtao Zhang, Fang Fang Liu, Xiaolei Bi, Shuangxi Wang, Xiao Wu, Fan Jian. The antioxidant compound tert-butylhydroquinone activates Akt in myocardium, suppresses apoptosis and ameliorates pressure overload-induced cardiac dysfunction. Scientific reports. vol 5. 2016-08-01. PMID:26260024. |
mechanistically, we showed that in cultured h9c2 cells and primary cardiac myocytes, tbhq stimulated akt phosphorylation and suppressed oxidant-induced apoptosis; this effect was abolished by wortmannin or an akt inhibitor. |
2016-08-01 |
2023-08-13 |
mouse |
| María Isabel Cerezo-Guisado, Rafal Zur, María Jesús Lorenzo, Ana Risco, Miguel A Martín-Serrano, Alberto Alvarez-Barrientos, Ana Cuenda, Francisco Centen. Implication of Akt, ERK1/2 and alternative p38MAPK signalling pathways in human colon cancer cell apoptosis induced by green tea EGCG. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 84. 2016-08-01. PMID:26303273. |
implication of akt, erk1/2 and alternative p38mapk signalling pathways in human colon cancer cell apoptosis induced by green tea egcg. |
2016-08-01 |
2023-08-13 |
human |
| Ling Li, Tongda Xu, Yinping Du, Defeng Pan, Wanling Wu, Hong Zhu, Yanbin Zhang, Dongye L. Salvianolic Acid A Attenuates Cell Apoptosis, Oxidative Stress, Akt and NF-κB Activation in Angiotensin-II Induced Murine Peritoneal Macrophages. Current pharmaceutical biotechnology. vol 17. issue 3. 2016-08-01. PMID:26873077. |
salvianolic acid a attenuates cell apoptosis, oxidative stress, akt and nf-κb activation in angiotensin-ii induced murine peritoneal macrophages. |
2016-08-01 |
2023-08-13 |
mouse |