| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Byoungduck Park, Young-Tae Je, Kwang-Hoon Chu. Akt is translocated to the mitochondria during etoposide-induced apoptosis of HeLa cells. Molecular medicine reports. vol 12. issue 5. 2016-08-29. PMID:26458825. |
it was found that akt activity was increased and sustained during apoptosis triggered by etoposide in hela cells. |
2016-08-29 |
2023-08-13 |
Not clear |
| Byoungduck Park, Young-Tae Je, Kwang-Hoon Chu. Akt is translocated to the mitochondria during etoposide-induced apoptosis of HeLa cells. Molecular medicine reports. vol 12. issue 5. 2016-08-29. PMID:26458825. |
during apoptosis, akt was translocated from the cytoplasm into the mitochondria in a phosphoinositide 3‑kinase-dependent manner at the early and late stages of apoptosis. |
2016-08-29 |
2023-08-13 |
Not clear |
| Byoungduck Park, Young-Tae Je, Kwang-Hoon Chu. Akt is translocated to the mitochondria during etoposide-induced apoptosis of HeLa cells. Molecular medicine reports. vol 12. issue 5. 2016-08-29. PMID:26458825. |
the results suggest that etoposide‑stimulated akt is translocated into the mitochondria, thereby possibly enhancing its interaction with smac and promoting apoptosis in hela cells. |
2016-08-29 |
2023-08-13 |
Not clear |
| Xiaocen Chang, Yuyan Zhao, Shujing Ju, Lei Gu. Orexin-A regulates cell apoptosis in human H295R adrenocortical cells via orexin receptor type 1 through the AKT signaling pathway. Molecular medicine reports. vol 12. issue 5. 2016-08-29. PMID:26459696. |
orexin-a regulates cell apoptosis in human h295r adrenocortical cells via orexin receptor type 1 through the akt signaling pathway. |
2016-08-29 |
2023-08-13 |
human |
| b' Gabriela Vallejo-Flores, Javier Torres, Claudia Sandoval-Montes, Haruki Ar\\xc3\\xa9valo-Romero, Isaura Meza, Margarita Camorlinga-Ponce, Juli\\xc3\\xa1n Torres-Morales, Adriana Karina Ch\\xc3\\xa1vez-Rueda, Mar\\xc3\\xada Victoria Legorreta-Haquet, Ezequiel M Fuentes-Panan\\xc3\\xa. Helicobacter pylori CagA Suppresses Apoptosis through Activation of AKT in a Nontransformed Epithelial Cell Model of Glandular Acini Formation. BioMed research international. vol 2015. 2016-08-29. PMID:26557697.' |
helicobacter pylori caga suppresses apoptosis through activation of akt in a nontransformed epithelial cell model of glandular acini formation. |
2016-08-29 |
2023-08-13 |
mouse |
| b' Gabriela Vallejo-Flores, Javier Torres, Claudia Sandoval-Montes, Haruki Ar\\xc3\\xa9valo-Romero, Isaura Meza, Margarita Camorlinga-Ponce, Juli\\xc3\\xa1n Torres-Morales, Adriana Karina Ch\\xc3\\xa1vez-Rueda, Mar\\xc3\\xada Victoria Legorreta-Haquet, Ezequiel M Fuentes-Panan\\xc3\\xa. Helicobacter pylori CagA Suppresses Apoptosis through Activation of AKT in a Nontransformed Epithelial Cell Model of Glandular Acini Formation. BioMed research international. vol 2015. 2016-08-29. PMID:26557697.' |
anoikis is a specific type of apoptosis characterized by akt and bim activation and it is the mechanism responsible for lumen formation of mcf-10a acini in vitro and mammary glands in vivo. |
2016-08-29 |
2023-08-13 |
mouse |
| Gang Wang, JunJie Wang, Li Du, Fei L. Effect and Mechanism of Total Flavonoids Extracted from Cotinus coggygria against Glioblastoma Cancer In Vitro and In Vivo. BioMed research international. vol 2015. 2016-08-29. PMID:26557705. |
the current investigation also revealed that ccf induced apoptosis in highly malignant glioblastoma cells, a process that apparently involved the inhibition of akt coupled with erk protein expression. |
2016-08-29 |
2023-08-13 |
Not clear |
| Shan Hu, Liming Huang, Liwei Meng, He Sun, Wei Zhang, Yingchun X. Isorhamnetin inhibits cell proliferation and induces apoptosis in breast cancer via Akt and mitogen‑activated protein kinase kinase signaling pathways. Molecular medicine reports. vol 12. issue 5. 2016-08-26. PMID:26502751. |
isorhamnetin inhibits cell proliferation and induces apoptosis in breast cancer via akt and mitogen‑activated protein kinase kinase signaling pathways. |
2016-08-26 |
2023-08-13 |
Not clear |
| Shangfeng Sun, Shuguang Cheng, Yunxiao Zhu, Peng Zhang, Ning Liu, Tong Xu, Chao Sun, Yanfeng L. Identification of PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide) as an essential gene for colorectal cancer (CRCs) cells. Gene. vol 584. issue 1. 2016-08-26. PMID:26992638. |
prkdc down-regulation induced apoptosis partially through inhibiting akt activation, and sensitized hct116 cells to chemotherapeutic agents interfering with dna replication. |
2016-08-26 |
2023-08-13 |
mouse |
| Dale Carpenter, Chinhui Hsiang, Xianzhi Jiang, Nelson Osorio, Lbachir BenMohamed, Clinton Jones, Steven L Wechsle. The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) protects cells against cold-shock-induced apoptosis by maintaining phosphorylation of protein kinase B (AKT). Journal of neurovirology. vol 21. issue 5. 2016-08-24. PMID:26071090. |
the herpes simplex virus type 1 (hsv-1) latency-associated transcript (lat) protects cells against cold-shock-induced apoptosis by maintaining phosphorylation of protein kinase b (akt). |
2016-08-24 |
2023-08-13 |
mouse |
| Dale Carpenter, Chinhui Hsiang, Xianzhi Jiang, Nelson Osorio, Lbachir BenMohamed, Clinton Jones, Steven L Wechsle. The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) protects cells against cold-shock-induced apoptosis by maintaining phosphorylation of protein kinase B (AKT). Journal of neurovirology. vol 21. issue 5. 2016-08-24. PMID:26071090. |
we previously showed that serum starvation (removal of serum from tissue culture media), which takes several days to induce apoptosis, results in decreased levels of both akt (protein kinase b) and phosphorylated akt (pakt) in cells not expressing lat. |
2016-08-24 |
2023-08-13 |
mouse |
| S Kaur, M P Bansa. Protective role of dietary-supplemented selenium and vitamin E in heat-induced apoptosis and oxidative stress in mice testes. Andrologia. vol 47. issue 10. 2016-08-23. PMID:25521483. |
apoptosis was evaluated by tunel assay and further by mrna expression of bcl-2, caspase 3, 8, 9, bid and akt. |
2016-08-23 |
2023-08-13 |
mouse |
| Fang-Yuan Shao, Zhi-Yun Du, Dong-Lei Ma, Wen-Bo Chen, Wu-Yu Fu, Bi-Bo Ruan, Wen Rui, Jia-Xuan Zhang, Sheng Wang, Nai Sum Wong, Hao Xiao, Man-Mei Li, Xiao Liu, Qiu-Ying Liu, Xiao-Dong Zhou, Hai-Zhao Yan, Yi-Fei Wang, Chang-Yan Chen, Zhong Liu, Hong-Yuan Che. B5, a thioredoxin reductase inhibitor, induces apoptosis in human cervical cancer cells by suppressing the thioredoxin system, disrupting mitochondrion-dependent pathways and triggering autophagy. Oncotarget. vol 6. issue 31. 2016-08-23. PMID:26439985. |
unlike b5-induced apoptosis, autophagy induced by b5 is not ros-mediated but a role for the akt and ampk signaling pathways is implied. |
2016-08-23 |
2023-08-13 |
human |
| M-L Gao, W-L Deng, N Huang, Y-Y Wang, X-L Lei, Z-Q Xu, D-N Hu, J-Q Cai, F Lu, Z-B Ji. Upregulation of GADD45α in light-damaged retinal pigment epithelial cells. Cell death discovery. vol 2. 2016-08-23. PMID:27551507. |
treatment also exacerbated rpe cellular apoptosis after light exposure, confirming that inhibition of akt phosphorylation increases gadd45α expression. |
2016-08-23 |
2023-08-13 |
human |
| Victor Ho, Tong Seng Lim, Justin Lee, Jeffrey Steinberg, Radoslaw Szmyd, Muly Tham, Jadegoud Yaligar, Philipp Kaldis, Jean-Pierre Abastado, Valerie Che. TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression. Oncotarget. vol 6. issue 29. 2016-08-22. PMID:26287667. |
combinatorial therapy with poly-iclc and sorafenib increased apoptosis and reduced proliferation of hcc cell lines in vitro, in association with impaired phosphorylation of akt, mek and erk. |
2016-08-22 |
2023-08-13 |
mouse |
| Ying Ying, Huazhang Zhu, Zhen Liang, Xiaosong Ma, Shiwei L. GLP1 protects cardiomyocytes from palmitate-induced apoptosis via Akt/GSK3b/b-catenin pathway. Journal of molecular endocrinology. vol 55. issue 3. 2016-08-19. PMID:26386043. |
in contrast, inhibition of akt with an akt-specific inhibitor mk2206 or blockade of glp1 receptor (glp1r) with a competitive antagonist exendin-(9-39) significantly abrogated the glp1-mediated activation of gsk3b/b-catenin signalling, leading to increased apoptosis in palmitate-stressed cardiomyocytes. |
2016-08-19 |
2023-08-13 |
rat |
| Jianhua Shi, Jin-hua Gu, Chun-ling Dai, Jianlan Gu, Xiaoxia Jin, Jianming Sun, Khalid Iqbal, Fei Liu, Cheng-Xin Gon. O-GlcNAcylation regulates ischemia-induced neuronal apoptosis through AKT signaling. Scientific reports. vol 5. 2016-08-19. PMID:26412745. |
o-glcnacylation regulates ischemia-induced neuronal apoptosis through akt signaling. |
2016-08-19 |
2023-08-13 |
mouse |
| Jianhua Shi, Jin-hua Gu, Chun-ling Dai, Jianlan Gu, Xiaoxia Jin, Jianming Sun, Khalid Iqbal, Fei Liu, Cheng-Xin Gon. O-GlcNAcylation regulates ischemia-induced neuronal apoptosis through AKT signaling. Scientific reports. vol 5. 2016-08-19. PMID:26412745. |
in this study, we found that o-glcnacylation, a unique protein posttranslational modification with o-linked β-n-acetylglucosamine (glcnac), promoted apoptosis through attenuating phosphorylation/activation of akt and bad. |
2016-08-19 |
2023-08-13 |
mouse |
| Jianhua Shi, Jin-hua Gu, Chun-ling Dai, Jianlan Gu, Xiaoxia Jin, Jianming Sun, Khalid Iqbal, Fei Liu, Cheng-Xin Gon. O-GlcNAcylation regulates ischemia-induced neuronal apoptosis through AKT signaling. Scientific reports. vol 5. 2016-08-19. PMID:26412745. |
o-glcnacylation-induced apoptosis was attenuated by over-expression of akt. |
2016-08-19 |
2023-08-13 |
mouse |
| Jianhua Shi, Jin-hua Gu, Chun-ling Dai, Jianlan Gu, Xiaoxia Jin, Jianming Sun, Khalid Iqbal, Fei Liu, Cheng-Xin Gon. O-GlcNAcylation regulates ischemia-induced neuronal apoptosis through AKT signaling. Scientific reports. vol 5. 2016-08-19. PMID:26412745. |
these results indicate that cerebral ischemia induces a rapid increase of o-glcnacylation that promotes apoptosis through down-regulation of akt activity. |
2016-08-19 |
2023-08-13 |
mouse |