| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Zhang, Dali Zhao, Zhongwei Xie, Yali Q. Down-regulation of AKT combined with radiation-induced autophagy and apoptosis roles in MCF-7 cells. Bio-medical materials and engineering. vol 26 Suppl 1. 2016-07-22. PMID:26406007. |
down-regulation of akt combined with radiation-induced autophagy and apoptosis roles in mcf-7 cells. |
2016-07-22 |
2023-08-13 |
Not clear |
| Jing Zhang, Dali Zhao, Zhongwei Xie, Yali Q. Down-regulation of AKT combined with radiation-induced autophagy and apoptosis roles in MCF-7 cells. Bio-medical materials and engineering. vol 26 Suppl 1. 2016-07-22. PMID:26406007. |
in addition, akt is a molecule that down-regulates autophagy and apoptosis; blocking akt can enhance autophagy and apoptosis induced by radiation in mcf-7 cells. |
2016-07-22 |
2023-08-13 |
Not clear |
| Hongrui Guo, Hengmin Cui, Xi Peng, Jing Fang, Zhicai Zuo, Junliang Deng, Xun Wang, Bangyuan Wu, Kejie Chen, Jie Den. Modulation of the PI3K/Akt Pathway and Bcl-2 Family Proteins Involved in Chicken's Tubular Apoptosis Induced by Nickel Chloride (NiCl₂). International journal of molecular sciences. vol 16. issue 9. 2016-07-21. PMID:26404262. |
we evaluated the alterations of apoptosis, mitochondrial membrane potential (mmp), phosphoinositide-3-kinase (pi3k)/serine-threonine kinase (akt) pathway, and bcl-2 family proteins induced by nickel chloride (nicl₂) in the kidneys of broiler chickens, using flow cytometry, terminal deoxynucleotidyl transferase 2'-deoxyuridine 5'-triphosphate dutp nick end-labeling (tunel), immunohistochemstry and quantitative real-time polymerase chain reaction (qrt-pcr). |
2016-07-21 |
2023-08-13 |
chicken |
| Lingling Yang, Wenjie Sui, Yunqiu Li, Xia Qi, Yao Wang, Qingjun Zhou, Hua Ga. Substance P Inhibits Hyperosmotic Stress-Induced Apoptosis in Corneal Epithelial Cells through the Mechanism of Akt Activation and Reactive Oxygen Species Scavenging via the Neurokinin-1 Receptor. PloS one. vol 11. issue 2. 2016-07-20. PMID:26901348. |
substance p inhibits hyperosmotic stress-induced apoptosis in corneal epithelial cells through the mechanism of akt activation and reactive oxygen species scavenging via the neurokinin-1 receptor. |
2016-07-20 |
2023-08-13 |
mouse |
| Lingling Yang, Wenjie Sui, Yunqiu Li, Xia Qi, Yao Wang, Qingjun Zhou, Hua Ga. Substance P Inhibits Hyperosmotic Stress-Induced Apoptosis in Corneal Epithelial Cells through the Mechanism of Akt Activation and Reactive Oxygen Species Scavenging via the Neurokinin-1 Receptor. PloS one. vol 11. issue 2. 2016-07-20. PMID:26901348. |
in conclusion, sp protects corneal epithelial cells from hyperosmotic stress-induced apoptosis through the mechanism of akt activation and ros scavenging via the nk-1 receptor. |
2016-07-20 |
2023-08-13 |
mouse |
| Liping Wang, Zhufang Tian, Qi Yang, Heng Li, Haixia Guan, Bingyin Shi, Peng Hou, Meiju J. Sulforaphane inhibits thyroid cancer cell growth and invasiveness through the reactive oxygen species-dependent pathway. Oncotarget. vol 6. issue 28. 2016-07-19. PMID:26312762. |
mechanically, sfn inhibited thyroid cancer cell growth and invasiveness through repressing phosphorylation of akt, enhancing p21 expression by the activation of erk and p38 signaling cascades, and promoting mitochondrial-mediated apoptosis via reactive oxygen species (ros)-dependent pathway. |
2016-07-19 |
2023-08-13 |
mouse |
| Chung-Weng Phang, Saiful Anuar Karsani, Gautam Sethi, Sri Nurestri Abd Male. Flavokawain C Inhibits Cell Cycle and Promotes Apoptosis, Associated with Endoplasmic Reticulum Stress and Regulation of MAPKs and Akt Signaling Pathways in HCT 116 Human Colon Carcinoma Cells. PloS one. vol 11. issue 2. 2016-07-19. PMID:26859847. |
flavokawain c inhibits cell cycle and promotes apoptosis, associated with endoplasmic reticulum stress and regulation of mapks and akt signaling pathways in hct 116 human colon carcinoma cells. |
2016-07-19 |
2023-08-13 |
human |
| Hyun Sook Lim, Yong Jung Kang, Bokyung Sung, Seon Hee Kim, Min Jeong Kim, Hye Rim Kim, Seong Jin Kim, Yung Hyun Choi, Hyung Ryong Moon, Hae Young Chung, Nam Deuk Ki. Novel dihydrobenzofuro[4,5-b][1,8]naphthyridin-6-one derivative, MHY-449, induces cell cycle arrest and apoptosis via the downregulation of Akt in human lung cancer cells. Oncology reports. vol 34. issue 5. 2016-07-18. PMID:26324335. |
novel dihydrobenzofuro[4,5-b][1,8]naphthyridin-6-one derivative, mhy-449, induces cell cycle arrest and apoptosis via the downregulation of akt in human lung cancer cells. |
2016-07-18 |
2023-08-13 |
human |
| Hyun Sook Lim, Yong Jung Kang, Bokyung Sung, Seon Hee Kim, Min Jeong Kim, Hye Rim Kim, Seong Jin Kim, Yung Hyun Choi, Hyung Ryong Moon, Hae Young Chung, Nam Deuk Ki. Novel dihydrobenzofuro[4,5-b][1,8]naphthyridin-6-one derivative, MHY-449, induces cell cycle arrest and apoptosis via the downregulation of Akt in human lung cancer cells. Oncology reports. vol 34. issue 5. 2016-07-18. PMID:26324335. |
moreover, mhy-449 downregulated the phosphorylation of akt, and the phosphatidylinositol-3 kinase/akt inhibitor ly294002 was found to enhance its induction of apoptosis. |
2016-07-18 |
2023-08-13 |
human |
| Hyun Sook Lim, Yong Jung Kang, Bokyung Sung, Seon Hee Kim, Min Jeong Kim, Hye Rim Kim, Seong Jin Kim, Yung Hyun Choi, Hyung Ryong Moon, Hae Young Chung, Nam Deuk Ki. Novel dihydrobenzofuro[4,5-b][1,8]naphthyridin-6-one derivative, MHY-449, induces cell cycle arrest and apoptosis via the downregulation of Akt in human lung cancer cells. Oncology reports. vol 34. issue 5. 2016-07-18. PMID:26324335. |
taken together, the results suggested that mhy-449 exerts anticancer effects by promoting cell cycle arrest and apoptosis via the downregulation of akt. |
2016-07-18 |
2023-08-13 |
human |
| Kislay Roy, Rupinder K Kanwar, Jagat R Kanwa. LNA aptamer based multi-modal, Fe3O4-saturated lactoferrin (Fe3O4-bLf) nanocarriers for triple positive (EpCAM, CD133, CD44) colon tumor targeting and NIR, MRI and CT imaging. Biomaterials. vol 71. 2016-07-12. PMID:26318819. |
from tumor tissue analyses of 35 apoptotic markers, 55 angiogenesis markers, 40 cytokines, 15 stem cell markers and gene expression studies of important signaling molecules, it was revealed that the anti-cancer mechanism of fe3o4-blf was intervened through trail, fas, fas-associated protein with death domain (fadd) mediated phosphorylation of p53, to induce activation of second mitochondria-derived activator of caspases (smac)/diablo (inhibiting survivin) and mitochondrial depolarization leading to release of cytochrome c. induction of apoptosis was observed by inhibition of the akt pathway and activation of cytokines released from monocytes/macrophages and dendritic cells (interleukin (il) 27, keratinocyte chemoattractant (kc)). |
2016-07-12 |
2023-08-13 |
mouse |
| Anna Kawiak, Ewa Lojkowsk. Ramentaceone, a Naphthoquinone Derived from Drosera sp., Induces Apoptosis by Suppressing PI3K/Akt Signaling in Breast Cancer Cells. PloS one. vol 11. issue 2. 2016-07-12. PMID:26840401. |
moreover, inhibition of pi3k and silencing of akt expression increased the sensitivity of cells to ramentaceone-induced apoptosis. |
2016-07-12 |
2023-08-13 |
Not clear |
| Victor A Neel, Kristina Todorova, Jun Wang, Eunjeong Kwon, Minjeong Kang, Qingsong Liu, Nathanael Gray, Sam W Lee, Anna Mandinov. Sustained Akt Activity Is Required to Maintain Cell Viability in Seborrheic Keratosis, a Benign Epithelial Tumor. The Journal of investigative dermatology. vol 136. issue 3. 2016-07-11. PMID:26739095. |
akt inhibition suppressed phosphorylation of downstream targets of akt kinase that are critical for cell survival, including mdm2 and foxo3a, and induced apoptosis. |
2016-07-11 |
2023-08-13 |
Not clear |
| Geun-Young Kim, Soon Yong Park, Ara Jo, Mira Kim, Sun-Hee Leem, Woo-Jin Jun, Sang In Shim, Sang Chul Lee, Jin Woong Chun. Gecko proteins induce the apoptosis of bladder cancer 5637 cells by inhibiting Akt and activating the intrinsic caspase cascade. BMB reports. vol 48. issue 9. 2016-07-07. PMID:26246284. |
gecko proteins induce the apoptosis of bladder cancer 5637 cells by inhibiting akt and activating the intrinsic caspase cascade. |
2016-07-07 |
2023-08-13 |
human |
| Geun-Young Kim, Soon Yong Park, Ara Jo, Mira Kim, Sun-Hee Leem, Woo-Jin Jun, Sang In Shim, Sang Chul Lee, Jin Woong Chun. Gecko proteins induce the apoptosis of bladder cancer 5637 cells by inhibiting Akt and activating the intrinsic caspase cascade. BMB reports. vol 48. issue 9. 2016-07-07. PMID:26246284. |
taken together, our data demonstrated that gecko proteins suppressed the akt pathway and activated the intrinsic caspase pathway, leading to the apoptosis of bladder cancer cells. |
2016-07-07 |
2023-08-13 |
human |
| Ayesha Bhatia, Kathryn O'Brien, Mei Chen, Alex Wong, Warren Garner, David T Woodley, Wei L. Dual therapeutic functions of F-5 fragment in burn wounds: preventing wound progression and promoting wound healing in pigs. Molecular therapy. Methods & clinical development. vol 3. 2016-07-06. PMID:27382602. |
first, f-5 prevents burn wound progression by protecting the surrounding cells from undergoing heat-induced caspase 3 activation and apoptosis with increased akt activation. |
2016-07-06 |
2023-08-13 |
Not clear |
| Kellie R Machlus, Kelly E Johnson, Rajesh Kulenthirarajan, Jodi A Forward, Mason D Tippy, Thomas S Soussou, Saleh H El-Husayni, Stephen K Wu, Suming Wang, Randolph S Watnick, Joseph E Italiano, Elisabeth M Battinell. CCL5 derived from platelets increases megakaryocyte proplatelet formation. Blood. vol 127. issue 7. 2016-07-01. PMID:26647394. |
interrogation of the akt signaling pathway suggested that ccl5/ccr5 may influence proplatelet production by suppressing apoptosis. |
2016-07-01 |
2023-08-13 |
Not clear |
| Zhiming Zhao, Chenggang Li, Hao Xi, Yuanxing Gao, Dabin X. Curcumin induces apoptosis in pancreatic cancer cells through the induction of forkhead box O1 and inhibition of the PI3K/Akt pathway. Molecular medicine reports. vol 12. issue 4. 2016-06-27. PMID:26166196. |
using sirna against foxo1, and akt inhibitor and activator, the present study confirmed that curcumin induced the expression of foxo1 by inhibition of phosphoinositide 3‑kinase/akt signaling, leading to cell cycle arrest and apoptosis. |
2016-06-27 |
2023-08-13 |
Not clear |
| Zhen Huang, Ye Xu, Wei Pen. Colchicine induces apoptosis in HT‑29 human colon cancer cells via the AKT and c-Jun N-terminal kinase signaling pathways. Molecular medicine reports. vol 12. issue 4. 2016-06-27. PMID:26299305. |
colchicine induces apoptosis in ht‑29 human colon cancer cells via the akt and c-jun n-terminal kinase signaling pathways. |
2016-06-27 |
2023-08-13 |
human |
| Timothy M LeJeune, Hei Yin Tsui, Laura B Parsons, Gerald E Miller, Crystal Whitted, Kayla E Lynch, Robert E Ramsauer, Jasmine U Patel, Jarrett E Wyatt, Doris S Street, Carolyn B Adams, Brian McPherson, Hei Man Tsui, Julie A Evans, Christopher Livesay, Ruben D Torrenegra, Victoria E Pala. Mechanism of Action of Two Flavone Isomers Targeting Cancer Cells with Varying Cell Differentiation Status. PloS one. vol 10. issue 11. 2016-06-27. PMID:26606169. |
these changes in protein levels ultimately lead to activation of apoptosis, without the involvement of akt. |
2016-06-27 |
2023-08-13 |
Not clear |