| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amy N Shore, Chi-Hsuan Chang, Oh-Joon Kwon, Matthew C Weston, Mei Zhang, Li Xin, Jeffrey M Rose. PTEN is required to maintain luminal epithelial homeostasis and integrity in the adult mammary gland. Developmental biology. vol 409. issue 1. 2016-05-25. PMID:26526198. |
despite their elevated levels of activated akt, pten-null intraluminal cells showed increased levels of apoptosis. |
2016-05-25 |
2023-08-13 |
Not clear |
| Samira M Sadowski, Myriem Boufraqech, Lisa Zhang, Amit Mehta, Payal Kapur, Yaqin Zhang, Zhuyin Li, Min Shen, Electron Kebebe. Torin2 targets dysregulated pathways in anaplastic thyroid cancer and inhibits tumor growth and metastasis. Oncotarget. vol 6. issue 20. 2016-05-24. PMID:25945839. |
torin2 inhibited cellular migration and inhibited the phosphorylation of key effectors of the mtor-pathway (akt, 4e-bp1 and 70s6k), as well as claspin and survivin expression, regulators of cell cycle and apoptosis. |
2016-05-24 |
2023-08-13 |
mouse |
| Kimberly A Foster, Esther P Jane, Daniel R Premkumar, Alejandro Morales, Ian F Pollac. NVP-BKM120 potentiates apoptosis in tumor necrosis factor-related apoptosis-inducing ligand-resistant glioma cell lines via upregulation of Noxa and death receptor 5. International journal of oncology. vol 47. issue 2. 2016-05-24. PMID:26044191. |
based on our observation that trail-resistant glioma cell lines typically exhibited high levels of akt activation, we hypothesized that inhibition of akt signaling using the pi3 kinase inhibitor nvp-bkm120 could promote trail-induced apoptosis in gliomas. |
2016-05-24 |
2023-08-13 |
human |
| Fan Chen, Jiebo Chen, Jiacheng Lin, Anton V Cheltsov, Lin Xu, Ya Chen, Zhiping Zeng, Liqun Chen, Mingfeng Huang, Mengjie Hu, Xiaohong Ye, Yuqi Zhou, Guanghui Wang, Ying Su, Long Zhang, Fangfang Zhou, Xiao-Kun Zhang, Hu Zho. NSC-640358 acts as RXRα ligand to promote TNFα-mediated apoptosis of cancer cell. Protein & cell. vol 6. issue 9. 2016-05-24. PMID:26156677. |
for its physiological activities, we show that n-6 strongly inhibits tumor necrosis factor α (tnfα)-induced akt activation and stimulates tnfα-mediated apoptosis in cancer cells in an rxrα/trxrα dependent manner. |
2016-05-24 |
2023-08-13 |
Not clear |
| Fan Chen, Jiebo Chen, Jiacheng Lin, Anton V Cheltsov, Lin Xu, Ya Chen, Zhiping Zeng, Liqun Chen, Mingfeng Huang, Mengjie Hu, Xiaohong Ye, Yuqi Zhou, Guanghui Wang, Ying Su, Long Zhang, Fangfang Zhou, Xiao-Kun Zhang, Hu Zho. NSC-640358 acts as RXRα ligand to promote TNFα-mediated apoptosis of cancer cell. Protein & cell. vol 6. issue 9. 2016-05-24. PMID:26156677. |
the inhibition of tnfα-induced trxrα/p85α complex formation by n-6 implies that n-6 targets trxrα to inhibit tnfα-induced akt activation and to induce cancer cell apoptosis. |
2016-05-24 |
2023-08-13 |
Not clear |
| Kwon Pyo Hong, Mi Hyang Shin, SangSoon Yoon, Gil Yong Ji, Yoo Ri Moon, Ok-Jun Lee, Song-Yi Choi, Yong-Moon Lee, Ji Hae Koo, Ho-Chang Lee, Geon Kook Lee, Seung Ryul Kim, Ki Hyeong Lee, Hye-Suk Han, Kang Hyeon Choe, Ki Man Lee, Jong-Myeon Hong, Si-Wook Kim, Jae Hyuk Yi, Hyeong-Jin Ji, Yun-Bae Kim, Hyung Geun Son. Therapeutic effect of anti CEACAM6 monoclonal antibody against lung adenocarcinoma by enhancing anoikis sensitivity. Biomaterials. vol 67. 2016-05-23. PMID:26204223. |
8f5 also decreased cellular status of akt phosphorylation and increased apoptosis via caspase activation. |
2016-05-23 |
2023-08-13 |
mouse |
| Cristina Valacca, Evelyne Tassone, Paolo Mignatt. TIMP-2 Interaction with MT1-MMP Activates the AKT Pathway and Protects Tumor Cells from Apoptosis. PloS one. vol 10. issue 9. 2016-05-23. PMID:26331622. |
timp-2 interaction with mt1-mmp activates the akt pathway and protects tumor cells from apoptosis. |
2016-05-23 |
2023-08-13 |
Not clear |
| Cristina Valacca, Evelyne Tassone, Paolo Mignatt. TIMP-2 Interaction with MT1-MMP Activates the AKT Pathway and Protects Tumor Cells from Apoptosis. PloS one. vol 10. issue 9. 2016-05-23. PMID:26331622. |
erk1/2 and akt activation by timp-2 binding to mt1-mmp protects tumor cells from apoptosis induced by serum starvation. |
2016-05-23 |
2023-08-13 |
Not clear |
| Yajuan Gao, Yan Zeng, Jian Tian, Mohammad Shyful Islam, Guoqin Jiang, Dong Xia. Retracted: Guggulsterone inhibits prostate cancer growth via inactivation of Akt regulated by ATP citrate lyase signaling. Oncotarget. 2016-05-19. PMID:24980815. |
the gug-induced apoptosis was associated with remarkably down-regulation of akt and acly in both cancer cells and xenografts tumor tissue of gug-treated group. |
2016-05-19 |
2023-08-13 |
mouse |
| Yajuan Gao, Yan Zeng, Jian Tian, Mohammad Shyful Islam, Guoqin Jiang, Dong Xia. Retracted: Guggulsterone inhibits prostate cancer growth via inactivation of Akt regulated by ATP citrate lyase signaling. Oncotarget. 2016-05-19. PMID:24980815. |
moreover, the gug-induced apoptosis, and akt and acly inactivation in pc-3 and lncap cells was intensified by sirna-based knockdown of acly protein level and by pharmacological inhibition of acly, or was protected by the ectopic expression of acly. |
2016-05-19 |
2023-08-13 |
mouse |
| Shuji Wakatsuki, Toshiyuki Arak. NADPH oxidases promote apoptosis by activating ZNRF1 ubiquitin ligase in neurons treated with an exogenously applied oxidant. Communicative & integrative biology. vol 9. issue 2. 2016-05-19. PMID:27195063. |
we recently reported that ros serve as a signal to activate neuronal apoptosis and axonal degeneration by activating znrf1 (zinc- and ring-finger 1), a ubiquitin ligase that targets akt for proteasomal degradation in neurons. |
2016-05-19 |
2023-08-13 |
Not clear |
| Fangfang Shi, Yamei Len, Yuping Gong, Rui Shi, Xi Yang, Duolan Naren, Tianyou Ya. Ribavirin Inhibits the Activity of mTOR/eIF4E, ERK/Mnk1/eIF4E Signaling Pathway and Synergizes with Tyrosine Kinase Inhibitor Imatinib to Impair Bcr-Abl Mediated Proliferation and Apoptosis in Ph+ Leukemia. PloS one. vol 10. issue 8. 2016-05-18. PMID:26317515. |
our results showed that ribavirin had anti-proliferation effect; it down-regulated the phosphorylation levels of akt, mtor, 4ebp1, and eif4e proteins in the mtor/eif4e signaling pathway, and mek, erk, mnk1 and eif4e proteins in erk/mnk1/eif4e signaling pathway; reduced the expression of mcl-1 (a translation substrates of eif4f translation initiation complex) at protein synthesis level not mrna transcriptional level; and induced cell apoptosis in both sup-b15 and k562. |
2016-05-18 |
2023-08-13 |
Not clear |
| Deling Yin, Xiaohua Yang, Hui Li, Huimin Fan, Xiaoli Zhang, Yimin Feng, Charles Stuart, Dan Hu, Yi Caudle, Nanchang Xie, Zhongmin Liu, Gene LeSag. β-Arrestin 2 Promotes Hepatocyte Apoptosis by Inhibiting Akt Protein. The Journal of biological chemistry. vol 291. issue 2. 2016-05-18. PMID:26582201. |
β-arrestin 2 promotes hepatocyte apoptosis by inhibiting akt protein. |
2016-05-18 |
2023-08-13 |
mouse |
| Dan Lv, Jinye Liu, Lianying Guo, Dawei Wu, Ken Matsumoto, Lin Huan. PRAS40 deregulates apoptosis in Ewing sarcoma family tumors by enhancing the insulin receptor/Akt and mTOR signaling pathways. American journal of cancer research. vol 6. issue 2. 2016-05-17. PMID:27186418. |
activation of akt only partially reversed the apoptosis induced by pras40 knockdown, and downregulation of s6 phosphorylation by pras40 silencing could not be sufficiently restored via akt activation. |
2016-05-17 |
2023-08-13 |
Not clear |
| Dan Lv, Jinye Liu, Lianying Guo, Dawei Wu, Ken Matsumoto, Lin Huan. PRAS40 deregulates apoptosis in Ewing sarcoma family tumors by enhancing the insulin receptor/Akt and mTOR signaling pathways. American journal of cancer research. vol 6. issue 2. 2016-05-17. PMID:27186418. |
therefore, pras40 may enhance ir phosphorylation to facilitate akt and mtor signaling leading to the apoptosis deregulation in esfts. |
2016-05-17 |
2023-08-13 |
Not clear |
| Kelly Brooks, Max Ranall, Loredana Spoerri, Alex Stevenson, Gency Gunasingh, Sandra Pavey, Fred Meunier, Thomas J Gonda, Brian Gabriell. Decatenation checkpoint-defective melanomas are dependent on PI3K for survival. Pigment cell & melanoma research. vol 27. issue 5. 2016-05-16. PMID:24890688. |
the pi3k inhibitor pf-05212384 promoted apoptosis in the checkpoint-defective lines, and the increased sensitivity to pi3k inhibition correlated with increased levels of activated akt. |
2016-05-16 |
2023-08-13 |
Not clear |
| Peng Zhang, Zhiyong Guo, Ying Wu, Ronglin Hu, Jun Du, Xiaoshun He, Xingyuan Jiao, Xiaofeng Zh. Histone Deacetylase Inhibitors Inhibit the Proliferation of Gallbladder Carcinoma Cells by Suppressing AKT/mTOR Signaling. PloS one. vol 10. issue 8. 2016-05-16. PMID:26287365. |
tsa and saha promoted apoptosis of sgc-996 cells, down-regulated the expression of cyclin d1, c-myc and bmi1, and decreased the phosphorylation of akt, mtor p70s6k1, s6 and 4e-bp1. |
2016-05-16 |
2023-08-13 |
Not clear |
| Yiming Sun, Zhe Liu, Xue Zou, Yadong Lan, Xiaojin Sun, Xiu Wang, Surong Zhao, Chenchen Jiang, Hao Li. Mechanisms underlying 3-bromopyruvate-induced cell death in colon cancer. Journal of bioenergetics and biomembranes. vol 47. issue 4. 2016-05-14. PMID:26054380. |
our previous research showed that 3bp can induce apoptosis via akt /protein kinase b signaling in breast cancer cells. |
2016-05-14 |
2023-08-13 |
mouse |
| Huanan Wang, Lingling Zhang, Xu Yang, Yipeng Jin, Shimin Pei, Di Zhang, Hong Zhang, Bin Zhou, Yingjie Zhang, Degui Li. PUMA mediates the combinational therapy of 5-FU and NVP-BEZ235 in colon cancer. Oncotarget. vol 6. issue 16. 2016-05-12. PMID:25965911. |
our results show 5-fu induced cell apoptosis through p53/puma pathway, with aberrant akt activation, which may well explain the mechanism of 5-fu resistance. |
2016-05-12 |
2023-08-13 |
Not clear |
| Shang-Min Chou, Wan-Jung Lai, Tzuwen Hong, Sheng-Hong Tsai, Yen-Hsun Chen, Cheng-Hsiang Kao, Richard Chu, Tang-Long Shen, Tsai-Kun L. Involvement of p38 MAPK in the Anticancer Activity of Cultivated Cordyceps militaris. The American journal of Chinese medicine. vol 43. issue 5. 2016-05-12. PMID:26205966. |
moreover, two signaling molecules, akt and p38 mapk, were activated during the course of apoptosis induction. |
2016-05-12 |
2023-08-13 |
human |