| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Manoranjan Santra, Michael Chopp, Sutapa Santra, Ankita Nallani, Shivam Vyas, Zheng Gang Zhang, Daniel C Morri. Thymosin beta 4 up-regulates miR-200a expression and induces differentiation and survival of rat brain progenitor cells. Journal of neurochemistry. vol 136. issue 1. 2016-04-25. PMID:26466330. |
the up-regulation of mir-200a down-regulated the expression of the following targets in vitro and in vivo models: (i) growth factor receptor-bound protein 2 (grb2), an adaptor protein involved in epidermal growth factor receptor (egfr)/grb2/ras/mek/erk1/c-jun signaling pathway, which negatively regulates the expression of myelin basic protein (mbp), a marker of mature oligodendrocyte; (ii) errfi-1/mig-6, an endogenous potent kinase inhibitor of egfr, which resulted in activation/phosphorylation of egfr; (iii) friend of gata 2, and phosphatase and tensin homolog deleted in chromosome 10 (pten), which are potent inhibitors of the phosphatidylinositol-3-kinase (pi3k)/akt signaling pathway, and resulted in marked activation of akt; and (iv) transcription factor, p53, which induces pro-apoptotic genes, and possibly reduced apoptosis of the progenitor cells subjected to oxygen glucose deprivation (ogd). |
2016-04-25 |
2023-08-13 |
rat |
| Manoranjan Santra, Michael Chopp, Sutapa Santra, Ankita Nallani, Shivam Vyas, Zheng Gang Zhang, Daniel C Morri. Thymosin beta 4 up-regulates miR-200a expression and induces differentiation and survival of rat brain progenitor cells. Journal of neurochemistry. vol 136. issue 1. 2016-04-25. PMID:26466330. |
tβ4-induced micro-rna-200a (mir-200a) regulates egfr signaling pathways for mbp synthesis and apoptosis: up-regulation of mir-200a after tβ4 treatment, increases mbp synthesis after targeting grb2 and thereby inactivating c-jun from inhibition of mbp synthesis; and also inhibits ogd-mediated apoptosis after targeting egfr inhibitor (mig-6), pi3k inhibitors (fog2 and pten) and an inducer (p53) of pro-apoptotic genes, for akt activation and down-regulation of p53. |
2016-04-25 |
2023-08-13 |
rat |
| Bozena Popławska, Anna Bielawska, Arkadiusz Surazyński, Robert Czarnomysy, Krzysztof Bielawsk. Novel dinuclear platinum(II) complexes targets NFkappaB signaling pathway to induce apoptosis and inhibit metabolism of MCF-7 breast cancer cells. Folia histochemica et cytobiologica. vol 47. issue 5. 2016-04-22. PMID:20067886. |
four novel dinuclear platinum(ii) complexes of formula [pt2l4(berenil)2]cl4 (pt1-pt4) where l is piperazine (pt1), 4-picoline (pt2), 3-picoline (pt3) or isopropylamine (pt4) were compared to cisplatin in respect to collagen biosynthesis, beta1- integrin receptor, igf-i receptor, phosphorylated map-kinases (erk1/erk2 and p38), phosphorylated akt kinase expression and appearance of apoptosis in mcf-7 breast cancer cells. |
2016-04-22 |
2023-08-12 |
Not clear |
| Feiya Yang, Liming Song, Huiping Wang, Jun Wang, Zhiqing Xu, Nianzeng Xin. Combination of Quercetin and 2-Methoxyestradiol Enhances Inhibition of Human Prostate Cancer LNCaP and PC-3 Cells Xenograft Tumor Growth. PloS one. vol 10. issue 5. 2016-04-22. PMID:26011145. |
after therapeutic intervention for 4 weeks, combination treatment of quercetin and 2-me i) significantly inhibited prostate cancer xenograft tumor growth by 46.8% for lncap and 51.3% for pc-3 as compared to vehicle control group, more effective than quercetin (28.4% for lncap, 24.8% for pc3) or 2-me (32.1% for lncap, 28.9% for pc3) alone; ii) was well tolerated by balb/c mice and no obvious toxic reactions were observed; iii) led to higher bax/bcl-2 ratio, cleaved caspase-3 protein expression and apoptosis rate; and iv) resulted in lower phosphorylated akt (pakt) protein level, vascular endothelial growth factor protein and mrna expression, microvascular density and proliferation rate than single drug treatment. |
2016-04-22 |
2023-08-13 |
mouse |
| Mahesh Saqcena, Deven Patel, Deepak Menon, Suman Mukhopadhyay, David A Foste. Apoptotic effects of high-dose rapamycin occur in S-phase of the cell cycle. Cell cycle (Georgetown, Tex.). vol 14. issue 14. 2016-04-21. PMID:25945415. |
in calu-1 lung cancer cells, rapamycin induced a feedback increase in akt phosphorylation at ser473 in s-phase that mitigated rapamycin-induced apoptosis. |
2016-04-21 |
2023-08-13 |
human |
| Takanobu Nagata, Hideo Yasukawa, Sachiko Kyogoku, Toyoharu Oba, Jinya Takahashi, Shoichiro Nohara, Tomoko Minami, Kazutoshi Mawatari, Yusuke Sugi, Koutatsu Shimozono, Sylvain Pradervand, Masahiko Hoshijima, Hiroki Aoki, Yoshihiro Fukumoto, Tsutomu Imaizum. Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules. PloS one. vol 10. issue 5. 2016-04-21. PMID:26010537. |
in socs3-cko mice, stat3, akt, and erk1/2 phosphorylation was sustained, myocardial apoptosis was prevented, and the expression of anti-apoptotic bcl-2 family member myeloid cell leukemia-1 (mcl-1) was augmented. |
2016-04-21 |
2023-08-13 |
mouse |
| Qing-Qing Liu, Feng-Feng Zhang, Fang Wang, Jing-Hua Qiu, Chun-Hua Luo, Guo-Yong Zhu, Ying-Fu Li. TIPE2 Inhibits Lung Cancer Growth Attributing to Promotion of Apoptosis by Regulating Some Apoptotic Molecules Expression. PloS one. vol 10. issue 5. 2016-04-20. PMID:25946186. |
taken together, tipe2 promoted lung cancer cell apoptosis through affecting apoptosis-related molecules caspase-3, caspase-9, bcl-2 and bax, possibly via regulating p38 and akt pathways, indicating that tipe2 might be a novel marker for lung cancer diagnosis and therapy. |
2016-04-20 |
2023-08-13 |
mouse |
| Shu Zhang, Zhen Lu, Weiqun Mao, Ahmed A Ahmed, Hailing Yang, Jinhua Zhou, Nicholas Jennings, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Roberto Miranda, Wei Qiao, Veera Baladandayuthapani, Zongfang Li, Anil K Sood, Jinsong Liu, Xiao-Feng Le, Robert C Bas. CDK5 Regulates Paclitaxel Sensitivity in Ovarian Cancer Cells by Modulating AKT Activation, p21Cip1- and p27Kip1-Mediated G1 Cell Cycle Arrest and Apoptosis. PloS one. vol 10. issue 7. 2016-04-19. PMID:26146988. |
cdk5 regulates paclitaxel sensitivity in ovarian cancer cells by modulating akt activation, p21cip1- and p27kip1-mediated g1 cell cycle arrest and apoptosis. |
2016-04-19 |
2023-08-13 |
mouse |
| Shu Zhang, Zhen Lu, Weiqun Mao, Ahmed A Ahmed, Hailing Yang, Jinhua Zhou, Nicholas Jennings, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Roberto Miranda, Wei Qiao, Veera Baladandayuthapani, Zongfang Li, Anil K Sood, Jinsong Liu, Xiao-Feng Le, Robert C Bas. CDK5 Regulates Paclitaxel Sensitivity in Ovarian Cancer Cells by Modulating AKT Activation, p21Cip1- and p27Kip1-Mediated G1 Cell Cycle Arrest and Apoptosis. PloS one. vol 10. issue 7. 2016-04-19. PMID:26146988. |
cdk5 modulates paclitaxel sensitivity by regulating akt activation, the cell cycle and caspase-dependent apoptosis. |
2016-04-19 |
2023-08-13 |
mouse |
| Feng Hao, Jinsen Kang, Yajun Cao, Shengjun Fan, Haopeng Yang, Yu An, Yan Pan, Lu Tie, Xuejun L. Curcumin attenuates palmitate-induced apoptosis in MIN6 pancreatic β-cells through PI3K/Akt/FoxO1 and mitochondrial survival pathways. Apoptosis : an international journal on programmed cell death. vol 20. issue 11. 2016-04-19. PMID:26330141. |
these findings suggested that curcumin protected min6 pancreatic β-cells against apoptosis through activation of akt, inhibition of nuclear translocation of foxo1 and mitochondrial survival pathway. |
2016-04-19 |
2023-08-13 |
Not clear |
| Youzhong Ren, Hongguang Zhu, Chunyuan Chi, Fanghong Yang, Xin X. MiRNA-139 regulates oral cancer Tca8113 cells apoptosis through Akt signaling pathway. International journal of clinical and experimental pathology. vol 8. issue 5. 2016-04-18. PMID:26191149. |
mirna-139 regulates oral cancer tca8113 cells apoptosis through akt signaling pathway. |
2016-04-18 |
2023-08-13 |
Not clear |
| Youzhong Ren, Hongguang Zhu, Chunyuan Chi, Fanghong Yang, Xin X. MiRNA-139 regulates oral cancer Tca8113 cells apoptosis through Akt signaling pathway. International journal of clinical and experimental pathology. vol 8. issue 5. 2016-04-18. PMID:26191149. |
mir-139 could induce tca8113 cell apoptosis through akt signaling pathway. |
2016-04-18 |
2023-08-13 |
Not clear |
| Bing Zhu, Yinghua Li, Zhengfang Lin, Mingqi Zhao, Tiantian Xu, Changbing Wang, Ning Den. Silver Nanoparticles Induce HePG-2 Cells Apoptosis Through ROS-Mediated Signaling Pathways. Nanoscale research letters. vol 11. issue 1. 2016-04-14. PMID:27075340. |
furthermore, agnp-induced apoptosis was found dependent on the overproduction of reactive oxygen species (ros) and affecting of mapks and akt signaling and dna damage-mediated p53 phosphorylation to advance hepg-2 cells apoptosis. |
2016-04-14 |
2023-08-13 |
human |
| Bin Zhang, Mei Wang, Aihua Gong, Xu Zhang, Xiaodan Wu, Yanhua Zhu, Hui Shi, Lijun Wu, Wei Zhu, Hui Qian, Wenrong X. HucMSC-Exosome Mediated-Wnt4 Signaling Is Required for Cutaneous Wound Healing. Stem cells (Dayton, Ohio). vol 33. issue 7. 2016-04-13. PMID:24964196. |
in addition, the activation of akt pathway by hucmsc-ex was associated with the reduction of heat stress-induced apoptosis in rat skin burn model. |
2016-04-13 |
2023-08-13 |
human |
| Yang Zhang, G Talmon, J Wan. MicroRNA-587 antagonizes 5-FU-induced apoptosis and confers drug resistance by regulating PPP2R1B expression in colorectal cancer. Cell death & disease. vol 6. 2016-04-12. PMID:26247730. |
knockdown of ppp2r1b expression increases akt phosphorylation, which leads to elevated xiap expression and enhanced 5-fu resistance; whereas rescue of ppp2r1b expression in mir-587-expressing cells decreases akt phosphorylation/xiap expression, re-sensitizing colon cancer cells to 5-fu-induced apoptosis. |
2016-04-12 |
2023-08-13 |
mouse |
| L An, W W Li, G C Chen. Fyn arrests swainsonine-induced apoptosis in 293T cells via Akt and its phosphorylation. Genetics and molecular research : GMR. vol 14. issue 2. 2016-04-11. PMID:26125726. |
fyn arrests swainsonine-induced apoptosis in 293t cells via akt and its phosphorylation. |
2016-04-11 |
2023-08-13 |
Not clear |
| L An, W W Li, G C Chen. Fyn arrests swainsonine-induced apoptosis in 293T cells via Akt and its phosphorylation. Genetics and molecular research : GMR. vol 14. issue 2. 2016-04-11. PMID:26125726. |
our results establish that fyn can arrest sw-induced apoptosis via the activity of akt and its effective phosphorylation in 293t cells. |
2016-04-11 |
2023-08-13 |
Not clear |
| Ping Zeng, Bin Liu, Qun Wang, Qin Fan, Jian-Xin Diao, Jing Tang, Xiu-Qiong Fu, Xue-Gang Su. Apigenin Attenuates Atherogenesis through Inducing Macrophage Apoptosis via Inhibition of AKT Ser473 Phosphorylation and Downregulation of Plasminogen Activator Inhibitor-2. Oxidative medicine and cellular longevity. vol 2015. 2016-04-04. PMID:25960827. |
apigenin attenuates atherogenesis through inducing macrophage apoptosis via inhibition of akt ser473 phosphorylation and downregulation of plasminogen activator inhibitor-2. |
2016-04-04 |
2023-08-13 |
mouse |
| Dongdong Yu, Shuai Mu, Danyang Zhao, Guangbin Wang, Zhiguang Chen, Hongfei Ren, Qin F. Puerarin attenuates glucocorticoid-induced apoptosis of hFOB1.19 cells through the JNK- and Akt-mediated mitochondrial apoptotic pathways. International journal of molecular medicine. vol 36. issue 2. 2016-03-30. PMID:26101183. |
furthermore, the akt inhibitor, ly294002, partly eliminated the protective effect of puerarin on dex-induced apoptosis, and puerarin combined with the jnk inhibitor, sp600125, suppressed dex-induced apoptosis to a lesser extent than in the cells treated with sp600125 alone. |
2016-03-30 |
2023-08-13 |
Not clear |
| Kaouther Hadj Ayed Tka, Asma Mahfoudh Boussaid, Mohamed Amine Zaouali, Rym Kammoun, Mohamed Bejaoui, Sonia Ghoul Mazgar, Joan Rosello Catafau, Hassen Ben Abdenneb. Melatonin modulates endoplasmic reticulum stress and Akt/GSK3-beta signaling pathway in a rat model of renal warm ischemia reperfusion. Analytical cellular pathology (Amsterdam). vol 2015. 2016-03-25. PMID:26229743. |
in addition, western blot was performed to study er stress and its downstream apoptosis as well as phosphorylation of akt, gsk-3β, vdac, erk, and p38. |
2016-03-25 |
2023-08-13 |
rat |