| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Saurus, S Kuusela, E Lehtonen, M E Hyvönen, M Ristola, C L Fogarty, J Tienari, M I Lassenius, C Forsblom, M Lehto, M A Saleem, P-H Groop, H Holthöfer, S Lehtone. Podocyte apoptosis is prevented by blocking the Toll-like receptor pathway. Cell death & disease. vol 6. 2016-02-23. PMID:25950482. |
knockdown of pdk1 in cultured human podocytes inhibited antiapoptotic akt pathway, stimulated proapoptotic p38 mapk pathway, and increased apoptosis demonstrating an antiapoptotic role for pdk1 in podocytes. |
2016-02-23 |
2023-08-13 |
mouse |
| Antonio Calles, Nicholas Kwiatkowski, Bernard K Cammarata, Dalia Ercan, Nathanael S Gray, Pasi A Jänn. Tivantinib (ARQ 197) efficacy is independent of MET inhibition in non-small-cell lung cancer cell lines. Molecular oncology. vol 9. issue 1. 2016-02-17. PMID:25226813. |
the pattern of activity was related to met inhibition and downstream signaling inhibition of akt and erk1/2, resulting in g0/g1 cycle arrest and apoptosis. |
2016-02-17 |
2023-08-13 |
Not clear |
| Zuzana Berkova, Shu Wang, Lalit Sehgal, Keyur Pravinchandra Patel, Om Prakash, Felipe Samanieg. Lymphoid hyperplasia and lymphoma in KSHV K1 transgenic mice. Histology and histopathology. vol 30. issue 5. 2016-02-16. PMID:25301266. |
k1 protein was previously shown to contain a constitutively active itam domain, involved in activation of akt and pro-survival signaling, and to inhibit fas-mediated apoptosis by interfering with binding of fasl. |
2016-02-16 |
2023-08-13 |
mouse |
| Priyajit Chatterjee, Soma Seal, Sandip Mukherjee, Rakesh Kundu, Mantu Bhuyan, Nabin C Barua, Pranab K Baruah, Santi Prasad Sinha Babu, Samir Bhattachary. A carbazole alkaloid deactivates mTOR through the suppression of rictor and that induces apoptosis in lung cancer cells. Molecular and cellular biochemistry. vol 405. issue 1-2. 2016-02-16. PMID:25893736. |
disruption of mtor and akt activation caused drastic mortality of nsclc cancer cells through apoptosis. |
2016-02-16 |
2023-08-13 |
Not clear |
| Z-H Song, Y-L Ke, K Xiao, L-F Jiao, Q-H Hong, C-H H. Diosmectite-zinc oxide composite improves intestinal barrier restoration and modulates TGF-β1, ERK1/2, and Akt in piglets after acetic acid challenge. Journal of animal science. vol 93. issue 4. 2016-02-12. PMID:26020182. |
these results suggest that ds-zno attenuates the acetic acid-induced colitis by improving mucosa barrier restoration, inhibiting apoptosis, and improving intestinal epithelial cells proliferation and modulation of tgf-β1 and erk1/2 and akt signaling pathway. |
2016-02-12 |
2023-08-13 |
Not clear |
| Hyojin Park, Sungwoon Lee, Pravesh Shrestha, Jihye Kim, Jeong Ae Park, Yeongrim Ko, Young Ho Ban, Dae-Young Park, Sang-Jun Ha, Gou Young Koh, Victor Sukbong Hong, Naoki Mochizuki, Young-Myeong Kim, Weontae Lee, Young-Guen Kwo. AMIGO2, a novel membrane anchor of PDK1, controls cell survival and angiogenesis via Akt activation. The Journal of cell biology. vol 211. issue 3. 2016-02-12. PMID:26553931. |
loss of amigo2 in endothelial cells (ecs) led to apoptosis and inhibition of angiogenesis with akt inactivation. |
2016-02-12 |
2023-08-13 |
Not clear |
| Yunus Akkoç, Özge Berrak, Elif Damla Arısan, Pınar Obakan, Ajda Çoker-Gürkan, Narçin Palavan-Ünsa. Inhibition of PI3K signaling triggered apoptotic potential of curcumin which is hindered by Bcl-2 through activation of autophagy in MCF-7 cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 71. 2016-02-10. PMID:25960232. |
phosphoinositol-3-kinase (pi3k) and akt, key molecular players in the survival mechanism, have been shown to be associated with the bcl-2 signaling cascade; therefore, evaluating the therapeutic efficiency of drugs that target both survival and the apoptosis mechanism has gained importance in cancer therapy. |
2016-02-10 |
2023-08-13 |
Not clear |
| H Li, Y Xu, R Guan, M Matheu, H Lei, W Tian, Z Gao, G Lin, Y Guo, Z Xin, W Son. Icariside II prevents high-glucose-induced injury on human cavernous endothelial cells through Akt-eNOS signaling pathway. Andrology. vol 3. issue 2. 2016-02-09. PMID:25641754. |
the cell apoptosis and proliferation, expression of ki67 and erk1/2, antioxidant capacity, and expression of akt and enos were examined. |
2016-02-09 |
2023-08-13 |
human |
| Belén Blanco, M Carmen Herrero-Sánchez, Concepción Rodríguez-Serrano, Mercedes Sánchez-Barba, M Consuelo Del Cañiz. Profound blockade of T cell activation requires concomitant inhibition of different class I PI3K isoforms. Immunologic research. vol 62. issue 2. 2016-02-09. PMID:25869396. |
in particular, we have analyzed proliferation, expression of activation and differentiation markers, apoptosis induction, cytokine secretion and akt phosphorylation in t cells stimulated in vitro with anti-cd3 and anti-cd28 monoclonal antibodies and cultured with either one of these compounds: p110β-specific inhibitor tgx-221, p110δ-specific inhibitor ic-87114, p110γ inhibitor as-242525 or pan-class i pi3k inhibitor bkm120. |
2016-02-09 |
2023-08-13 |
human |
| Mahmoud Alhosin, Antonio J León-González, Israa Dandache, Agnès Lelay, Sherzad K Rashid, Claire Kevers, Joël Pincemail, Luc-Matthieu Fornecker, Laurent Mauvieux, Raoul Herbrecht, Valérie B Schini-Kert. Bilberry extract (Antho 50) selectively induces redox-sensitive caspase 3-related apoptosis in chronic lymphocytic leukemia cells by targeting the Bcl-2/Bad pathway. Scientific reports. vol 5. 2016-02-08. PMID:25757575. |
antho 50-induced apoptosis is associated with activation of caspase 3, down-regulation of uhrf1, a rapid dephosphorylation of akt and bad, and down-regulation of bcl-2. |
2016-02-08 |
2023-08-13 |
human |
| R Vázquez-López, J Argueta-Donohué, A Wilkins-Rodríguez, A Escalona-Montaño, M Aguirre-García, L Gutiérrez-Kobe. Leishmania mexicana amastigotes inhibit p38 and JNK and activate PI3K/AKT: role in the inhibition of apoptosis of dendritic cells. Parasite immunology. vol 37. issue 11. 2016-02-05. PMID:26352010. |
our results indicate that l. mexicana amastigotes have the capacity to diminish map kinases activation and activate pi3k and akt, which is probably one of the strategies employed by l. mexicana amastigotes to inhibit apoptosis in the infected modc. |
2016-02-05 |
2023-08-13 |
Not clear |
| Hwang-Bo Hyun, Won Sup Lee, Se-Il Go, Arulkumar Nagappan, Cheol Park, Min Ho Han, Su Hyun Hong, Gonsup Kim, Gi Young Kim, Jaehun Cheong, Chung Ho Ryu, Sung Chul Shin, Yung Hyun Cho. The flavonoid morin from Moraceae induces apoptosis by modulation of Bcl-2 family members and Fas receptor in HCT 116 cells. International journal of oncology. vol 46. issue 6. 2016-02-02. PMID:25892545. |
as an upstream signaling pathway, suppressed akt activity by morin was associated to apoptosis. |
2016-02-02 |
2023-08-13 |
human |
| Hwang-Bo Hyun, Won Sup Lee, Se-Il Go, Arulkumar Nagappan, Cheol Park, Min Ho Han, Su Hyun Hong, Gonsup Kim, Gi Young Kim, Jaehun Cheong, Chung Ho Ryu, Sung Chul Shin, Yung Hyun Cho. The flavonoid morin from Moraceae induces apoptosis by modulation of Bcl-2 family members and Fas receptor in HCT 116 cells. International journal of oncology. vol 46. issue 6. 2016-02-02. PMID:25892545. |
this study suggests that morin induces caspase-dependent apoptosis through extrinsic pathway by upregulating fas receptor as well as through the intrinsic pathway by modulating bcl-2 and iap family members, and ros generation, and that akt is the critical upstream signaling that regulates the apoptotic effect of morin in human colon cancer hct-116 cells. |
2016-02-02 |
2023-08-13 |
human |
| Y G Lin, J Shen, E Yoo, R Liu, H-Y Yen, A Mehta, A Rajaei, W Yang, P Mhawech-Fauceglia, F J DeMayo, J Lydon, P Gill, A S Le. Targeting the glucose-regulated protein-78 abrogates Pten-null driven AKT activation and endometrioid tumorigenesis. Oncogene. vol 34. issue 43. 2016-01-28. PMID:25684138. |
consistent with previous findings that cell surface grp78 is an upstream regulator of pi3k/akt signaling, we show here that in vivo short-term systemic treatment with a highly specific monoclonal antibody against grp78 suppressed akt activation and increased apoptosis in the cpten(f/f) tumors. |
2016-01-28 |
2023-08-13 |
mouse |
| Xiaozhen Liu, Shaoping Nie, Danfei Huang, Mingyong Xi. Mitogen-activated protein kinase and Akt pathways are involved in 4-n-nonyphenol induced apoptosis in mouse Sertoli TM4 cells. Environmental toxicology and pharmacology. vol 39. issue 2. 2016-01-25. PMID:25748095. |
mitogen-activated protein kinase and akt pathways are involved in 4-n-nonyphenol induced apoptosis in mouse sertoli tm4 cells. |
2016-01-25 |
2023-08-13 |
mouse |
| Xiaozhen Liu, Shaoping Nie, Danfei Huang, Mingyong Xi. Mitogen-activated protein kinase and Akt pathways are involved in 4-n-nonyphenol induced apoptosis in mouse Sertoli TM4 cells. Environmental toxicology and pharmacology. vol 39. issue 2. 2016-01-25. PMID:25748095. |
taken together, it was concluded that np induced cytotoxicity and apoptosis in tm4 cells, and the apoptosis may be mediated via mapks and akt pathways in addition to ca(2+) release and ros generation. |
2016-01-25 |
2023-08-13 |
mouse |
| Mu Jin, Yan-Wei Yang, Wei-Ping Cheng, Jia-Kai Lu, Si-Yu Hou, Xiu-Hua Dong, Shi-Yao Li. Serine-threonine protein kinase activation may be an effective target for reducing neuronal apoptosis after spinal cord injury. Neural regeneration research. vol 10. issue 11. 2016-01-25. PMID:26807120. |
these findings suggest that activation of akt may be a key contributing factor in the delay of neuronal apoptosis after spinal cord ischemia, particularly at the stage of reperfusion, and thus may be a target for neuronal protection and reduction of neuronal apoptosis after spinal cord injury. |
2016-01-25 |
2023-08-13 |
rat |
| Roberta Marino, Dana C Baiu, Saswati Bhattacharya, Benjamin Titz, Ellen Hebron, Bryan D Menapace, Sorabh Singhal, Jens C Eickhoff, Fotis Asimakopoulos, Jamey P Weichert, Mario Ott. Tumor-selective anti-cancer effects of the synthetic alkyl phosphocholine analog CLR1404 in neuroblastoma. American journal of cancer research. vol 5. issue 11. 2016-01-25. PMID:26807322. |
using flow cytometry, mtt assay, western blotting and caspase 3/7 assay, we confirm that in vitro treatment with clr1404 leads to robust apoptosis and cell death in multiple nb cell lines and is associated with akt inhibition, while sparing normal cells. |
2016-01-25 |
2023-08-13 |
mouse |
| Alisa B Lee-Sherick, Weihe Zhang, Kelly K Menachof, Amanda A Hill, Sean Rinella, Gregory Kirkpatrick, Lauren S Page, Michael A Stashko, Craig T Jordan, Qi Wei, Jing Liu, Dehui Zhang, Deborah DeRyckere, Xiaodong Wang, Stephen Frye, H Shelton Earp, Douglas K Graha. Efficacy of a Mer and Flt3 tyrosine kinase small molecule inhibitor, UNC1666, in acute myeloid leukemia. Oncotarget. vol 6. issue 9. 2016-01-19. PMID:25762638. |
treatment with unc1666 mediated biochemical and functional effects in aml cell lines expressing mer or flt3 internal tandem duplication (itd), including decreased phosphorylation of mer, flt3 and downstream effectors stat, akt and erk, induction of apoptosis in up to 98% of cells, and reduction of colony formation by greater than 90%, compared to treatment with vehicle. |
2016-01-19 |
2023-08-13 |
Not clear |
| Alice Cani, Carolina Simioni, Alberto M Martelli, Giorgio Zauli, Giovanna Tabellini, Simona Ultimo, James A McCubrey, Silvano Capitani, Luca M Ner. Triple Akt inhibition as a new therapeutic strategy in T-cell acute lymphoblastic leukemia. Oncotarget. vol 6. issue 9. 2016-01-19. PMID:25788264. |
furthermore the triple treatment had greater efficacy in inducing cell cycle arrest in g0/g1 phase and both apoptosis and autophagy.targeting akt as a key protein of pi3k/akt/mtor pathway with multiple drugs might represent a new and promising pharmacological strategy for treatment of t-all patients. |
2016-01-19 |
2023-08-13 |
Not clear |