| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A R M Ruhul Amin, Abedul Haque, Mohammad Aminur Rahman, Zhuo Georgia Chen, Fadlo Raja Khuri, Dong Moon Shi. Curcumin induces apoptosis of upper aerodigestive tract cancer cells by targeting multiple pathways. PloS one. vol 10. issue 4. 2016-01-19. PMID:25910231. |
curcumin treatment also strongly inhibited p-akt and bcl-2 and overexpression of constitutively active akt or bcl-2 significantly inhibited curcumin-induced apoptosis. |
2016-01-19 |
2023-08-13 |
Not clear |
| Hui Wang, Peng Zhang, Chunhua Lin, Qingxia Yu, Jitao Wu, Lin Wang, Yupeng Cui, Ke Wang, Zhenli Gao, Hong L. Relevance and therapeutic possibility of PTEN-long in renal cell carcinoma. PloS one. vol 10. issue 2. 2016-01-18. PMID:25714556. |
when purified pten-long was added into cultured 786-0 cells, it entered cells, blocked akt activation, and induced apoptosis involving caspase 3 cleavage. |
2016-01-18 |
2023-08-13 |
mouse |
| Lucía Barbier-Torres, Teresa C Delgado, Juan L García-Rodríguez, Imanol Zubiete-Franco, David Fernández-Ramos, Xabier Buqué, Ainara Cano, Virginia Gutiérrez-de Juan, Itziar Fernández-Domínguez, Fernando Lopitz-Otsoa, Pablo Fernández-Tussy, Loreto Boix, Jordi Bruix, Erica Villa, Azucena Castro, Shelly C Lu, Patricia Aspichueta, Dimitris Xirodimas, Marta Varela-Rey, José M Mato, Naiara Beraza, María L Martínez-Chanta. Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer. Oncotarget. vol 6. issue 4. 2016-01-15. PMID:25650664. |
importantly, we show that neddylation-induced metabolic reprogramming and apoptosis were dependent on lkb1 and akt stabilization. |
2016-01-15 |
2023-08-13 |
mouse |
| Liwei Zhao, Peng Liu, Guangqin Guo, Li Wan. Combination of cytokinin and auxin induces apoptosis, cell cycle progression arrest and blockage of the Akt pathway in HeLa cells. Molecular medicine reports. vol 12. issue 1. 2016-01-15. PMID:25738331. |
combination of cytokinin and auxin induces apoptosis, cell cycle progression arrest and blockage of the akt pathway in hela cells. |
2016-01-15 |
2023-08-13 |
Not clear |
| Yanhui Yang, Qian Deng, Xiaoshan Feng, Junjun Su. Use of the disulfiram/copper complex for breast cancer chemoprevention in MMTV-erbB2 transgenic mice. Molecular medicine reports. vol 12. issue 1. 2016-01-15. PMID:25738885. |
furthermore, the present study observed that ds/cu may inhibit proliferation via inhibition of akt and cyclin d1 signaling and promote apoptosis via c-jun n-terminal kinase activation and suppression of nuclear factor κb signaling. |
2016-01-15 |
2023-08-13 |
mouse |
| Weiwei Wang, Jing Cheng, Aili Sun, Shasha Lv, Haiying Liu, Xiangchun Liu, Guangju Guan, Gang Li. TRB3 mediates renal tubular cell apoptosis associated with proteinuria. Clinical and experimental medicine. vol 15. issue 2. 2016-01-13. PMID:24925634. |
in addition, we found that albumin-induced apoptosis was related to inhibition of akt phosphorylation, which was, however, partially reversed by trb3 silencing, indicating that trb3 worked through akt pathway in this apoptotic signaling cascade. |
2016-01-13 |
2023-08-13 |
rat |
| Hai-Yan Sun, Bei-Bei Liu, Jian-Yang Hu, Li-Jia Xu, Shun-Wan Chan, Chi-On Chan, Daniel K W Mok, Dong-Mei Zhang, Wen-Cai Ye, Si-Bao Che. Novel cycloartane triterpenoid from Cimicifuga foetida (Sheng ma) induces mitochondrial apoptosis via inhibiting Raf/MEK/ERK pathway and Akt phosphorylation in human breast carcinoma MCF-7 cells. Chinese medicine. vol 11. 2016-01-13. PMID:26759603. |
novel cycloartane triterpenoid from cimicifuga foetida (sheng ma) induces mitochondrial apoptosis via inhibiting raf/mek/erk pathway and akt phosphorylation in human breast carcinoma mcf-7 cells. |
2016-01-13 |
2023-08-13 |
human |
| Marjan Popovic, Zeljka Stanojevic, Jelena Tosic, Aleksandra Isakovic, Verica Paunovic, Sasa Petricevic, Tamara Martinovic, Darko Ciric, Tamara Kravic-Stevovic, Vukic Soskic, Sladjana Kostic-Rajacic, Kaveh Shakib, Vladimir Bumbasirevic, Vladimir Trajkovi. Neuroprotective arylpiperazine dopaminergic/serotonergic ligands suppress experimental autoimmune encephalomyelitis in rats. Journal of neurochemistry. vol 135. issue 1. 2016-01-08. PMID:26083644. |
arylpiperazine treatment reduced apoptosis and increased the activation of anti-apoptotic mediators akt and p70s6 kinase in the cns of eae animals. |
2016-01-08 |
2023-08-13 |
rat |
| Dandan Liang, Peng Zhong, Jie Hu, Feng Lin, Yuanyuan Qian, Zheng Xu, Jingying Wang, Chunlai Zeng, Xiaokun Li, Guang Lian. EGFR inhibition protects cardiac damage and remodeling through attenuating oxidative stress in STZ-induced diabetic mouse model. Journal of molecular and cellular cardiology. vol 82. 2016-01-06. PMID:25758431. |
it was observed that diabetes induced phospohorylation of egfr and akt, increased cardiac ros levels, and ultimately led to cardiac remodeling including cardiac hypertrophy, disorganization, apoptosis, and fibrosis, while all these molecular and pathological alterations were attenuated by the treatment with egfr inhibitors. |
2016-01-06 |
2023-08-13 |
mouse |
| Yunhui You, Shiqing Liu, Lijuan Peng, Mei Long, Hongxiang Deng, Hongjun Zha. Arg972 insulin receptor substrate-1 enhances tumor necrosis factor-α-induced apoptosis in osteoblasts. Molecular medicine reports. vol 12. issue 1. 2016-01-05. PMID:25760103. |
following stimulation with 10 nm insulin for 30 min, the stable overexpression of arg972 irs-1 and knock down of irs-1 significantly decreased irs-1-associated pi3k activity and akt activation/phosphorylation at serine 473 (ser473) and enhanced tnf-α-induced apoptosis in normal and in ra osteoblasts. |
2016-01-05 |
2023-08-13 |
human |
| Yunhui You, Shiqing Liu, Lijuan Peng, Mei Long, Hongxiang Deng, Hongjun Zha. Arg972 insulin receptor substrate-1 enhances tumor necrosis factor-α-induced apoptosis in osteoblasts. Molecular medicine reports. vol 12. issue 1. 2016-01-05. PMID:25760103. |
by contrast, the stable overexpression of irs-1 significantly increased the levels of irs-1-associated pi3k activity and akt phosphorylation (ser473) and inhibited tnf-α-induced apoptosis, which was eliminated by pretreatment with 50 µn bjm120, a selective pi3k inhibitor, for 30 min. |
2016-01-05 |
2023-08-13 |
human |
| Abedul Haque, Mohammad Aminur Rahman, Zhuo Georgia Chen, Nabil F Saba, Fadlo R Khuri, Dong M Shin, A R M Ruhul Ami. Combination of erlotinib and EGCG induces apoptosis of head and neck cancers through posttranscriptional regulation of Bim and Bcl-2. Apoptosis : an international journal on programmed cell death. vol 20. issue 7. 2016-01-04. PMID:25860284. |
on the other hand, overexpression of bcl-2 markedly protected cells from apoptosis (p = 0.003), whereas overexpression of constitutively active akt only minimally protected cells from apoptosis induced by the combination of the two compounds. |
2016-01-04 |
2023-08-13 |
Not clear |
| Dingqi Sun, Atsuro Sawada, Masakazu Nakashima, Takashi Kobayashi, Osamu Ogawa, Yoshiyuki Matsu. MK2206 potentiates cisplatin-induced cytotoxicity and apoptosis through an interaction of inactivated Akt signaling pathway. Urologic oncology. vol 33. issue 3. 2015-12-30. PMID:25499922. |
mk2206 potentiates cisplatin-induced cytotoxicity and apoptosis through an interaction of inactivated akt signaling pathway. |
2015-12-30 |
2023-08-13 |
Not clear |
| Dingqi Sun, Atsuro Sawada, Masakazu Nakashima, Takashi Kobayashi, Osamu Ogawa, Yoshiyuki Matsu. MK2206 potentiates cisplatin-induced cytotoxicity and apoptosis through an interaction of inactivated Akt signaling pathway. Urologic oncology. vol 33. issue 3. 2015-12-30. PMID:25499922. |
in this study, we investigated how mk2206, an allosteric akt inhibitor, enhances the cisplatin (cddp)-induced cytotoxicity and apoptosis in urothelial cancer cells. |
2015-12-30 |
2023-08-13 |
Not clear |
| Miyong Yun, Duckgue Lee, Moon-Nyeo Park, Eun-Ok Kim, Eun Jung Sohn, Byung-Mog Kwon, Sung-Hoon Ki. Cinnamaldehyde derivative (CB-PIC) sensitizes chemo-resistant cancer cells to drug-induced apoptosis via suppression of MDR1 and its upstream STAT3 and AKT signalling. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 35. issue 5. 2015-12-28. PMID:25833196. |
cinnamaldehyde derivative (cb-pic) sensitizes chemo-resistant cancer cells to drug-induced apoptosis via suppression of mdr1 and its upstream stat3 and akt signalling. |
2015-12-28 |
2023-08-13 |
Not clear |
| Y Qi, J Liu, S Saadat, X Tian, Y Han, G-H Fong, P P Pandolfi, L Y Lee, S L. PTEN induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation. Cell death and differentiation. vol 22. issue 5. 2015-12-24. PMID:25394489. |
genetic ablation of pten causes akt overactivation, apoptosis resistance and cavitation blockade. |
2015-12-24 |
2023-08-13 |
mouse |
| Tingting Yi, Luhua Zhuang, Gang Song, Bing Zhang, Guideng Li, Tianhui H. Akt signaling is associated with the berberine-induced apoptosis of human gastric cancer cells. Nutrition and cancer. vol 67. issue 3. 2015-12-24. PMID:25837881. |
akt signaling is associated with the berberine-induced apoptosis of human gastric cancer cells. |
2015-12-24 |
2023-08-13 |
mouse |
| Tingting Yi, Luhua Zhuang, Gang Song, Bing Zhang, Guideng Li, Tianhui H. Akt signaling is associated with the berberine-induced apoptosis of human gastric cancer cells. Nutrition and cancer. vol 67. issue 3. 2015-12-24. PMID:25837881. |
thus, our findings reveal that the underlying mechanism that akt signaling may contribute to berberine-induced cell apoptosis in gastric cancer cells and might represent an important molecular basis for berberine to act as an anticancer agent. |
2015-12-24 |
2023-08-13 |
mouse |
| Jing-Ping Wang, Ya-Chu Yu, Shih-Ping Chen, Huan-Chang Liang, Chia-Wei Lin, Kang Fan. Erratum to: The collective nuclear migration of p53 and phosphorylated S473 of Akt during ellipticine-mediated apoptosis in human lung epithelial cancer cells. Molecular and cellular biochemistry. vol 409. issue 1-2. 2015-12-24. PMID:26377961. |
erratum to: the collective nuclear migration of p53 and phosphorylated s473 of akt during ellipticine-mediated apoptosis in human lung epithelial cancer cells. |
2015-12-24 |
2023-08-13 |
human |
| Nives Hörmann, Inês Brandão, Sven Jäckel, Nelli Ens, Maren Lillich, Ulrich Walter, Christoph Reinhard. Gut microbial colonization orchestrates TLR2 expression, signaling and epithelial proliferation in the small intestinal mucosa. PloS one. vol 9. issue 11. 2015-12-21. PMID:25396415. |
tlr2 downstream signaling via the mitogen-activated protein kinase (erk1/2) and protein-kinase b (akt) induced by bacterial tlr2 agonists resulted in increased proliferation of the small intestinal epithelial cell line mode-k. mice that were colonized from birth with a normal gut microbiota (conventionally-raised; conv-r) showed signs of increased small intestinal renewal and apoptosis compared with gf controls as indicated by elevated mrna levels of the proliferation markers ki67 and cyclin d1, elevated transcripts of the apoptosis marker caspase-3 and increased numbers of tunel-positive cells per intestinal villus structure. |
2015-12-21 |
2023-08-13 |
mouse |