| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bo Zhu, Yi-Qun Huan. [Effects of Silencing AKT Gene by shRNA on Proliferation, Apoptosis and Notch1 Signal Pathway in Jeko-1 Cells]. Zhongguo shi yan xue ye xue za zhi. vol 23. issue 3. 2015-11-24. PMID:26117016. |
to investigate the effects of silencing akt gene by rna interference on the proliferation, apoptosis and the expression of notch1 signal pathway-related proteins in mantle cell lymphoma jeko-1 cell line. |
2015-11-24 |
2023-08-13 |
Not clear |
| Taiji Hamada, Masakazu Souda, Takuya Yoshimura, Shoko Sasaguri, Kazuhito Hatanaka, Takashi Tasaki, Takako Yoshioka, Yasuyo Ohi, Sohsuke Yamada, Masato Tsutsui, Yoshihisa Umekita, Akihide Tanimot. Anti-apoptotic effects of PCP4/PEP19 in human breast cancer cell lines: a novel oncotarget. Oncotarget. vol 5. issue 15. 2015-11-20. PMID:25153723. |
in both cell lines, pcp4/pep19 knockdown induced apoptosis and slightly decreased akt phosphorylation. |
2015-11-20 |
2023-08-13 |
human |
| Izabella T Silva, Annelise Carvalho, Karen L Lang, Sabine E Dudek, Dörthe Masemann, Fernando J Durán, Miguel S B Caro, Ulf R Rapp, Viktor Wixler, Eloir P Schenkel, Cláudia M O Simões, Stephan Ludwi. In vitro and in vivo antitumor activity of a novel semisynthetic derivative of cucurbitacin B. PloS one. vol 10. issue 2. 2015-11-20. PMID:25674792. |
dace arrested the cell cycle of lung epithelial cells at the g2/m phase and induced cell apoptosis by interfering with egfr activation and its downstream signaling, including akt, erk, and stat3. |
2015-11-20 |
2023-08-13 |
mouse |
| Sattar Gorgani-Firuzjaee, Khosrow Adeli, Reza Meshkan. Inhibition of SH2-domain-containing inositol 5-phosphatase (SHIP2) ameliorates palmitate induced-apoptosis through regulating Akt/FOXO1 pathway and ROS production in HepG2 cells. Biochemical and biophysical research communications. vol 464. issue 2. 2015-11-17. PMID:26123392. |
the serine-threonine kinase akt regulates proliferation and survival by phosphorylating a network of protein substrates; however, the role of a negative regulator of the akt pathway, the sh2-domain-containing inositol 5-phosphatase (ship2) in apoptosis of the hepatocytes, remains unknown. |
2015-11-17 |
2023-08-13 |
Not clear |
| Yingwei Chang, Qianqian Wu, Ting Tian, Li Li, Xuyan Guo, Zhuoying Feng, Junchen Zhou, Luping Zhang, Shuai Zhou, Guoying Feng, Fengchan Han, Jun Yang, Fei Huan. The influence of SRPK1 on glioma apoptosis, metastasis, and angiogenesis through the PI3K/Akt signaling pathway under normoxia. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 8. 2015-11-16. PMID:25833691. |
we show here that a strong link exists among srpk1, akt, eif4e, hif-1, and vegf activity that is functionally involved in apoptosis, metastasis, and angiogenesis of gliomas under normoxic conditions. |
2015-11-16 |
2023-08-13 |
Not clear |
| Shaobo Tian, Weilong Chang, Hansong Du, Jie Bai, Zhenhai Sun, Qing Zhang, Hui Wang, Guangsheng Zhu, Kaixiong Tao, Yueping Lon. The interplay between GRP78 expression and Akt activation in human colon cancer cells under celecoxib treatment. Anti-cancer drugs. vol 26. issue 9. 2015-11-16. PMID:26225471. |
besides, silencing the grp78 expression regulated akt activation in a time-dependent manner and increased the induction of the c/ebp homologous protein (chop) as well as considerably promoted celecoxib-induced apoptosis. |
2015-11-16 |
2023-08-13 |
human |
| Anna Maria Wróbel, Ewa Łucja Gregoraszczu. Action of methyl-, propyl- and butylparaben on GPR30 gene and protein expression, cAMP levels and activation of ERK1/2 and PI3K/Akt signaling pathways in MCF-7 breast cancer cells and MCF-10A non-transformed breast epithelial cells. Toxicology letters. vol 238. issue 2. 2015-11-16. PMID:26253279. |
moreover, among investigated parabens, propylparaben appears to inhibit apoptosis in cancer cells through activation of akt kinases, confirming conclusions suggested by our previously published data. |
2015-11-16 |
2023-08-13 |
Not clear |
| Eriko Tanaka, Katsuhiko Asanuma, Eunhee Kim, Yu Sasaki, Juan Alejandro Oliva Trejo, Takuto Seki, Kanae Nonaka, Rin Asao, Yoshiko Nagai-Hosoe, Miyuki Akiba-Takagi, Teruo Hidaka, Masatoshi Takagi, Akemi Koyanagi, Shuki Mizutani, Hideo Yagita, Yasuhiko Tomin. Notch2 activation ameliorates nephrosis. Nature communications. vol 5. 2015-11-12. PMID:24526233. |
in vitro, the specific knockdown of notch2 increases apoptosis in damaged podocytes, while notch2 agonistic antibodies enhance activation of akt and protect damaged podocytes from apoptosis. |
2015-11-12 |
2023-08-12 |
mouse |
| Jianli Li, Honghai Wu, Gai Xue, Pei Wang, Yanning Ho. 17β-Oestradiol Protects Primary-Cultured Rat Cortical Neurons from Ketamine-Induced Apoptosis by Activating PI3K/Akt/Bcl-2 Signalling. Basic & clinical pharmacology & toxicology. vol 113. issue 6. 2015-11-09. PMID:23981522. |
furthermore, we found that 17β-oestradiol not only induced phosphorylation of the pi3k substrate akt, but also increased the expression of bcl-2, which down-regulated ketamine-induced caspase-3 activity and inhibited neuronal apoptosis. |
2015-11-09 |
2023-08-12 |
rat |
| Shaiban Jubair, Jianping Li, Heather M Dehlin, Edward J Manteufel, Paul H Goldspink, Scott P Levick, Joseph S Janick. Substance P induces cardioprotection in ischemia-reperfusion via activation of AKT. American journal of physiology. Heart and circulatory physiology. vol 309. issue 4. 2015-11-06. PMID:26071541. |
the results indicate that substance p reduced the ischemia-related release of lactate dehydrogenase in both preparations and the degree of apoptosis and necrosis in the hypoxic left ventricular slices, indicating its ability to attenuate cell damage; and induced akt phosphorylation, with both the akt inhibitor and nk-1 receptor antagonist preventing the increased phosphorylation of akt and the ability of substance p to attenuate hypoxic cellular damage. |
2015-11-06 |
2023-08-13 |
rat |
| J Schrader, P Niebel, A Rossi, E Archontidou-Aprin, D Hörsc. Differential signaling by regulatory subunits of phosphoinositide-3-kinase influences cell survival in INS-1E insulinoma cells. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 123. issue 2. 2015-11-05. PMID:25393342. |
selective overexpression of p50α prevented cytokine induced apoptosis in ins-1e cells.in conclusion, signalling of p50α, p55α and p85α is similar at the level of akt, but differentially influence downstream gsk-3 activation and cell cycle entry. |
2015-11-05 |
2023-08-13 |
Not clear |
| Lin E Guo, Jun Feng Zhang, Xin Yi Liu, Li Mei Zhang, Hong Li Zhang, Jian Hua Chen, Xiao Guang Xie, Ying Zhou, Kaijun Luo, Juyoung Yoo. Phosphate ion targeted colorimetric and fluorescent probe and its use to monitor endogeneous phosphate ion in a hemichannel-closed cell. Analytical chemistry. vol 87. issue 2. 2015-11-05. PMID:25511872. |
moreover, probe 1 was utilized to show that apoptosis of hemichannel-closed sf9 cells is caused by inx3 promoted dephosphorylation of akt (rac serine/threonine-protein kinase), leading to an elevation of the concentration of pi. |
2015-11-05 |
2023-08-13 |
caenorhabditis_elegans |
| Florian Ewald, Dominik Nörz, Astrid Grottke, Johanna Bach, Christiane Herzberger, Bianca T Hofmann, Björn Nashan, Manfred Jücke. Vertical Targeting of AKT and mTOR as Well as Dual Targeting of AKT and MEK Signaling Is Synergistic in Hepatocellular Carcinoma. Journal of Cancer. vol 6. issue 12. 2015-11-04. PMID:26535060. |
since the pi3k/akt/mtor and raf/mek/erk signaling pathways are frequently upregulated in hcc, we have analyzed the effects of akt inhibitor mk-2206, mek inhibitor azd6244 (arry 142886) and mtor kinase inhibitor azd8055, given as single drugs or in combination, on proliferation and apoptosis of three hcc cell lines in vitro. |
2015-11-04 |
2023-08-13 |
Not clear |
| Huiyan Niu, Yifei Zhang, Baogang Wu, Yi Zhang, Hongfang Jiang, Ping H. Matrine induces the apoptosis of lung cancer cells through downregulation of inhibitor of apoptosis proteins and the Akt signaling pathway. Oncology reports. vol 32. issue 3. 2015-11-03. PMID:24969052. |
matrine induces the apoptosis of lung cancer cells through downregulation of inhibitor of apoptosis proteins and the akt signaling pathway. |
2015-11-03 |
2023-08-13 |
Not clear |
| Yao Yu, Yu Yang, Jing Wan. Anti-apoptotic and apoptotic pathway analysis of arsenic trioxide‑induced apoptosis in human gastric cancer SGC-7901 cells. Oncology reports. vol 32. issue 3. 2015-11-03. PMID:24969414. |
the protein expression patterns of the apoptosis factors, bax, fas and caspase-8, and anti-apoptosis factors, akt, p-akt, mtor and p-mtor, were evaluated by western blot analysis following treatment of the cells with different as2o3 concentrations in the cell growth media for 48 h. |
2015-11-03 |
2023-08-13 |
human |
| Henry Aceros, Georges Farah, Nicolas Noiseux, Suhayla Mukaddam-Dahe. Moxonidine modulates cytokine signalling and effects on cardiac cell viability. European journal of pharmacology. vol 740. 2015-11-03. PMID:25036265. |
studies were performed on neonatal rat cardiomyocytes and fibroblasts incubated with interleukin (il)-1β (5 ng/ml), tumor necrosis factor (tnf)-α (10 ng/ml), and moxonidine (10(-7) and 10(-5) m), separately and in combination, for 15 min, and 24 and 48 h for the measurement of mapks (erk1/2, jnk, and p38) and akt activation and inducible nos (inos) expression, by western blotting, and cardiac cell viability/proliferation and apoptosis by flow cytometry, mtt assay, and live/dead assay. |
2015-11-03 |
2023-08-13 |
rat |
| Tongxin Liu, Quanquan Sun, Qi Li, Hua Yang, Yuqin Zhang, Rong Wang, Xiaoshan Lin, Dong Xiao, Yawei Yuan, Longhua Chen, Wei Wan. Dual PI3K/mTOR inhibitors, GSK2126458 and PKI-587, suppress tumor progression and increase radiosensitivity in nasopharyngeal carcinoma. Molecular cancer therapeutics. vol 14. issue 2. 2015-11-03. PMID:25504751. |
antitumor effect was correlated with induction of apoptosis and suppression of the phosphorylation of mtor, akt, and 4ebp1. |
2015-11-03 |
2023-08-13 |
Not clear |
| Ji-Hong Moon, Jae-Kyo Jeong, Sang-Youel Par. Deferoxamine inhibits TRAIL-mediated apoptosis via regulation of autophagy in human colon cancer cells. Oncology reports. vol 33. issue 3. 2015-11-03. PMID:25524470. |
the experimental results showed that dfo treatment inhibited trail-mediated cancer cell apoptosis by increasing akt activation and decreasing caspase activation in human colon cancer cells. |
2015-11-03 |
2023-08-13 |
human |
| Miao Deng, Jianguang Wang, Yanbin Chen, Like Zhang, Dechun Li. Combination of SF1126 and gefitinib induces apoptosis of triple-negative breast cancer cells through the PI3K/AKT-mTOR pathway. Anti-cancer drugs. vol 26. issue 4. 2015-11-03. PMID:25588160. |
moreover, phosphorylated akt (p-akt) and 70 kda ribosomal protein s6-kinase (p-p70s6k) were also inhibited by the gefitinib and sf1126 combination, which may be responsible for the apoptosis. |
2015-11-03 |
2023-08-13 |
Not clear |
| Jianping Chen, Lin Li, Jianyu Su, Bing Li, Tianfeng Chen, Yum-Shing Won. Synergistic apoptosis-inducing effects on A375 human melanoma cells of natural borneol and curcumin. PloS one. vol 9. issue 6. 2015-10-28. PMID:24971451. |
further mechanistic studies by western blotting showed that after treatment of the cells with nb/cur, up-regulation of the expression level of phosphorylated jnk and down-regulation of the expression level of phosphorylated erk and akt contributed to a375 cells apoptosis. |
2015-10-28 |
2023-08-13 |
human |