| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nirut Suwanna, Wipawan Thangnipon, Shalini Kumar, Jean de Velli. Neuroprotection by diarylpropionitrile in mice with spinal cord injury. EXCLI journal. vol 13. 2015-09-29. PMID:26417324. |
dpn acted through activation of pi3k/ akt pathway, known to be involved in down-regulation of apoptosis and up-regulation of cell survival in injured tissues. |
2015-09-29 |
2023-08-13 |
mouse |
| Hong-Chao Pan, Qiong Jiang, Yang Yu, Jin-Ping Mei, Yu-Kun Cui, Wei-Jiang Zha. Quercetin promotes cell apoptosis and inhibits the expression of MMP-9 and fibronectin via the AKT and ERK signalling pathways in human glioma cells. Neurochemistry international. vol 80. 2015-09-28. PMID:25481090. |
quercetin promotes cell apoptosis and inhibits the expression of mmp-9 and fibronectin via the akt and erk signalling pathways in human glioma cells. |
2015-09-28 |
2023-08-13 |
human |
| Xuhe Gong, Guangpu Fan, Wei Wang, Guogan Wan. Trimetazidine protects umbilical cord mesenchymal stem cells against hypoxia and serum deprivation induced apoptosis by activation of Akt. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 34. issue 6. 2015-09-28. PMID:25562170. |
trimetazidine protects umbilical cord mesenchymal stem cells against hypoxia and serum deprivation induced apoptosis by activation of akt. |
2015-09-28 |
2023-08-13 |
human |
| Hyun-Woo Lee, Seok-Jun Kim, Il Ju Choi, Jaewhan Song, Kyung-Hee Chu. Targeting Notch signaling by γ-secretase inhibitor I enhances the cytotoxic effect of 5-FU in gastric cancer. Clinical & experimental metastasis. vol 32. issue 6. 2015-09-28. PMID:26134677. |
the levels of phosphorylated akt were significantly decreased upon gsi i treatment, and constitutively activated myristoylated akt completely blocked gsi i-induced apoptosis and cell survival, suggesting that inhibition of akt signaling is critical for gsi i-mediated effects in gastric cancer cells. |
2015-09-28 |
2023-08-13 |
mouse |
| Fen Ai, Manhua Chen, Wei Li, Yang Yang, Guizhong Xu, Feng Gui, Zhenxing Liu, Xiangyan Bai, Zhen Che. Protective role of Klotho on cardiomyocytes upon hypoxia/reoxygenation via downregulation of Akt and FOXO1 phosphorylation. Molecular medicine reports. vol 11. issue 3. 2015-09-23. PMID:25377663. |
the mechanism of this effect may be associated with suppressed apoptosis of cardiomyocytes, inhibition of phosphorylation of foxo1 and akt as well as suppression of cytoplasm transfer of foxo1. |
2015-09-23 |
2023-08-13 |
human |
| Wei Wang, Ping Chen, Min Tang, Junli Li, Yanfang Pei, Shan Cai, Xiao Zhou, Senlin Che. Tumstatin 185-191 increases the sensitivity of non-small cell lung carcinoma cells to cisplatin by blocking proliferation, promoting apoptosis and inhibiting Akt activation. American journal of translational research. vol 7. issue 8. 2015-09-23. PMID:26396665. |
tumstatin 185-191 increases the sensitivity of non-small cell lung carcinoma cells to cisplatin by blocking proliferation, promoting apoptosis and inhibiting akt activation. |
2015-09-23 |
2023-08-13 |
Not clear |
| Guanmin Meng, Wei Wang, Kequn Chai, Suwen Yang, Fangqiong Li, Kai Jian. Combination treatment with triptolide and hydroxycamptothecin synergistically enhances apoptosis in A549 lung adenocarcinoma cells through PP2A-regulated ERK, p38 MAPKs and Akt signaling pathways. International journal of oncology. vol 46. issue 3. 2015-09-22. PMID:25573072. |
combination treatment with triptolide and hydroxycamptothecin synergistically enhances apoptosis in a549 lung adenocarcinoma cells through pp2a-regulated erk, p38 mapks and akt signaling pathways. |
2015-09-22 |
2023-08-13 |
Not clear |
| Guanmin Meng, Wei Wang, Kequn Chai, Suwen Yang, Fangqiong Li, Kai Jian. Combination treatment with triptolide and hydroxycamptothecin synergistically enhances apoptosis in A549 lung adenocarcinoma cells through PP2A-regulated ERK, p38 MAPKs and Akt signaling pathways. International journal of oncology. vol 46. issue 3. 2015-09-22. PMID:25573072. |
finally, pharmacological inhibitors oa, sb203580, sp600125 and pd98059 confirm the role of pp2a and its substrates erk, p38 mapk and akt in mediating tp/hcpt-induced apoptosis. |
2015-09-22 |
2023-08-13 |
Not clear |
| Anya Alayev, Sara Malka Berger, Melissa Y Kramer, Naomi S Schwartz, Marina K Hol. The combination of rapamycin and resveratrol blocks autophagy and induces apoptosis in breast cancer cells. Journal of cellular biochemistry. vol 116. issue 3. 2015-09-17. PMID:25336146. |
however, patients often develop drug resistance in part due to activation of the oncogenic akt signaling and upregulation of autophagy, which protects cancer cells from apoptosis. |
2015-09-17 |
2023-08-13 |
Not clear |
| Anya Alayev, Sara Malka Berger, Melissa Y Kramer, Naomi S Schwartz, Marina K Hol. The combination of rapamycin and resveratrol blocks autophagy and induces apoptosis in breast cancer cells. Journal of cellular biochemistry. vol 116. issue 3. 2015-09-17. PMID:25336146. |
our results show that combination of these drugs maintains inhibition of mtorc1 signaling, while preventing upregulation of akt activation and autophagy, causing apoptosis. |
2015-09-17 |
2023-08-13 |
Not clear |
| Lei Duan, Ricardo E Perez, Michael Hansen, Steven Gitelis, Carl G Mak. Increasing cisplatin sensitivity by schedule-dependent inhibition of AKT and Chk1. Cancer biology & therapy. vol 15. issue 12. 2015-09-16. PMID:25482935. |
cp induced apoptosis to varying extents and activated akt and chk1 in multiple p53 wild-type and p53-null os cell lines. |
2015-09-16 |
2023-08-13 |
Not clear |
| Lei Duan, Ricardo E Perez, Michael Hansen, Steven Gitelis, Carl G Mak. Increasing cisplatin sensitivity by schedule-dependent inhibition of AKT and Chk1. Cancer biology & therapy. vol 15. issue 12. 2015-09-16. PMID:25482935. |
in contrast, an akt inhibitor increased cp-induced apoptosis only in p53 wild-type os cells, but not p53 nulll cells. |
2015-09-16 |
2023-08-13 |
Not clear |
| Rujun Li, Junyang Li, Dongping Sang, Qing La. Phosphorylation of AKT induced by phosphorylated Hsp27 confers the apoptosis-resistance in t-AUCB-treated glioblastoma cells in vitro. Journal of neuro-oncology. vol 121. issue 1. 2015-09-14. PMID:25200832. |
inhibition of akt phosphorylation by akt inhibitor iv sensitizes glioblastoma cells to t-aucb, strengthens t-aucb suppressing cell growth and inducing cell apoptosis. |
2015-09-14 |
2023-08-13 |
Not clear |
| Mingchang Li, Sen Guo, Peng Zhang, Jun Gong, Ankang Zheng, Yan Zhang, Hongliang L. Vinexin-β deficiency protects against cerebral ischaemia/reperfusion injury by inhibiting neuronal apoptosis. Journal of neurochemistry. vol 134. issue 2. 2015-09-14. PMID:25824575. |
taken together, our results demonstrate that the deletion of vinexin-β potently protects against ischaemic injury by inhibiting neuronal apoptosis, and this effect may occur via the up-regulation of akt signalling. |
2015-09-14 |
2023-08-13 |
mouse |
| P Picone, D Nuzzo, L Caruana, E Messina, V Scafidi, M Di Carl. Curcumin induces apoptosis in human neuroblastoma cells via inhibition of AKT and Foxo3a nuclear translocation. Free radical research. vol 48. issue 12. 2015-09-11. PMID:25179440. |
curcumin induces apoptosis in human neuroblastoma cells via inhibition of akt and foxo3a nuclear translocation. |
2015-09-11 |
2023-08-13 |
human |
| Y Tatsumi, R Takano, M S Islam, T Yokochi, M Itami, Y Nakamura, A Nakagawar. BMCC1, which is an interacting partner of BCL2, attenuates AKT activity, accompanied by apoptosis. Cell death & disease. vol 6. 2015-09-11. PMID:25611382. |
bmcc1, which is an interacting partner of bcl2, attenuates akt activity, accompanied by apoptosis. |
2015-09-11 |
2023-08-13 |
human |
| Y Tatsumi, R Takano, M S Islam, T Yokochi, M Itami, Y Nakamura, A Nakagawar. BMCC1, which is an interacting partner of BCL2, attenuates AKT activity, accompanied by apoptosis. Cell death & disease. vol 6. 2015-09-11. PMID:25611382. |
bmcc1 upregulation was correlated with the activation of forkhead box-o3a (foxo3a) (a downstream inducer of apoptosis, which is suppressed by akt) and induction of bcl2 inhibitor bim, suggesting that bmcc1 negatively regulates phosphorylation pathway of akt, resulted in apoptosis. |
2015-09-11 |
2023-08-13 |
human |
| Xiaosheng Lu, Jinmin Zhao, Tingyang Li, Meijing Huang, Jian Liang, Wen We. 5,7-Dihydroxy-4'-methoxyisoflavone induces apoptosis by inhibiting the ERK and Akt pathways in human osteosarcoma cells. Connective tissue research. vol 56. issue 1. 2015-09-10. PMID:25363142. |
5,7-dihydroxy-4'-methoxyisoflavone induces apoptosis by inhibiting the erk and akt pathways in human osteosarcoma cells. |
2015-09-10 |
2023-08-13 |
human |
| Xiaosheng Lu, Jinmin Zhao, Tingyang Li, Meijing Huang, Jian Liang, Wen We. 5,7-Dihydroxy-4'-methoxyisoflavone induces apoptosis by inhibiting the ERK and Akt pathways in human osteosarcoma cells. Connective tissue research. vol 56. issue 1. 2015-09-10. PMID:25363142. |
together, we suggest that 5,7-dihydroxy-4'-methoxyisoflavone promotes cell death of human os cells u2os by induction of apoptosis, which is associated with the inhibition of erk and akt signaling. |
2015-09-10 |
2023-08-13 |
human |
| Ying Jiang, Longling Li, Xiaodan Tan, Bin Liu, Yanhong Zhang, Changqing L. miR-210 mediates vagus nerve stimulation-induced antioxidant stress and anti-apoptosis reactions following cerebral ischemia/reperfusion injury in rats. Journal of neurochemistry. vol 134. issue 1. 2015-09-09. PMID:25783636. |
vns acts to activate neuronal and astrocytes a7nachr , inhibits the apoptosis and oxidant stress responses possibly associated with increased akt phosphorylation and mir210 expression. |
2015-09-09 |
2023-08-13 |
rat |