| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Annalisa Bonifacio, Gerda M Sanvee, Jamal Bouitbir, Stephan Krähenbüh. The AKT/mTOR signaling pathway plays a key role in statin-induced myotoxicity. Biochimica et biophysica acta. vol 1853. issue 8. 2015-09-09. PMID:25913013. |
furthermore, impaired akt phosphorylation was associated with activation of caspases and parp, reflecting induction of apoptosis. |
2015-09-09 |
2023-08-13 |
mouse |
| Qi Zhang, Jing Pan, Ronald A Lubet, Yian Wang, Ming Yo. Targeting the insulin-like growth factor-1 receptor by picropodophyllin for lung cancer chemoprevention. Molecular carcinogenesis. vol 54 Suppl 1. 2015-09-08. PMID:25163779. |
in human lung cancer cell lines, ppp inhibited cell proliferation, and also inhibited phosphorylation of igf-1r downstream targets, akt and mapk, ultimately resulting in increased apoptosis. |
2015-09-08 |
2023-08-13 |
mouse |
| Meng-Liang Lin, Shih-Shun Chen, Ren-Yu Huang, Yao-Cheng Lu, Yu-Ren Liao, Mopuru Vijaya Bhaskar Reddy, Chuan-Chun Lee, Tian-Shung W. Suppression of PI3K/Akt signaling by synthetic bichalcone analog TSWU-CD4 induces ER stress- and Bax/Bak-mediated apoptosis of cancer cells. Apoptosis : an international journal on programmed cell death. vol 19. issue 11. 2015-09-04. PMID:25183449. |
inhibition of lipid raft-associated phosphatidylinositol 3-kinase (pi3k)/protein kinase b (akt) signaling by tswu-cd4 induced er stress- and oligomeric bax/bak-mediated apoptosis, which were substantially reversed by overexpression of the wt pi3k p85α subunit. |
2015-09-04 |
2023-08-13 |
human |
| Julie K Mason, Minghua Fu, Jianmin Chen, Lilian U Thompso. Flaxseed oil enhances the effectiveness of trastuzumab in reducing the growth of HER2-overexpressing human breast tumors (BT-474). The Journal of nutritional biochemistry. vol 26. issue 1. 2015-09-04. PMID:25441844. |
fso×tras interactive effect may be modulated by their combined reductions of her2 signaling through the akt and mapk pathways leading to reduced cell proliferation and increased apoptosis. |
2015-09-04 |
2023-08-13 |
mouse |
| Zhitu Zhu, Hongzhi Sun, Guangyou Ma, Zhenghua Wang, Enze Li, Yangyang Liu, Yunpeng Li. Bufalin induces lung cancer cell apoptosis via the inhibition of PI3K/Akt pathway. International journal of molecular sciences. vol 13. issue 2. 2015-09-01. PMID:22408435. |
moreover, bufalin synergized with akt inhibitor to induce the apoptosis of a549 cells and this was associated with the upregulation of bax expression, the downregulation of bcl-2 and livin expression, and the activation of caspase-3. |
2015-09-01 |
2023-08-12 |
human |
| Ying-Ka Ingar Lau, Xing Du, Vinayak Rayannavar, Benjamin Hopkins, Jacquelyn Shaw, Eliana Bessler, Tiffany Thomas, Maira M Pires, Megan Keniry, Ramon E Parsons, Serge Cremers, Matthias Szabolcs, Matthew A Maure. Metformin and erlotinib synergize to inhibit basal breast cancer. Oncotarget. vol 5. issue 21. 2015-08-31. PMID:25361177. |
combined metformin and erlotinib led to partial regression of pten-null and egfr-amplified xenografted mda-mb-468 bbc tumors with evidence of significant apoptosis, reduction of egfr and akt signaling, and lack of altered plasma insulin levels. |
2015-08-31 |
2023-08-13 |
mouse |
| Lei Xu, Shijun Wang, Bingyu Li, Aijun Sun, Yunzeng Zou, Junbo G. A protective role of ciglitazone in ox-LDL-induced rat microvascular endothelial cells via modulating PPARγ-dependent AMPK/eNOS pathway. Journal of cellular and molecular medicine. vol 19. issue 1. 2015-08-31. PMID:25388834. |
the impact of ciglitazone on cell apoptosis and angiogenesis, enos expression and phosphorylation, nitric oxide synthesis and related ampk, akt and vegf signalling pathway were observed. |
2015-08-31 |
2023-08-13 |
rat |
| Lei Xu, Shijun Wang, Bingyu Li, Aijun Sun, Yunzeng Zou, Junbo G. A protective role of ciglitazone in ox-LDL-induced rat microvascular endothelial cells via modulating PPARγ-dependent AMPK/eNOS pathway. Journal of cellular and molecular medicine. vol 19. issue 1. 2015-08-31. PMID:25388834. |
our data showed that both enos and akt phosphorylation, vegf expression and nitric oxide production were significantly decreased, rmvecs ageing and apoptosis increased after ox-ldl induction for 24 hrs, all of which were effectively reversed by ciglitazone pre-treatment. |
2015-08-31 |
2023-08-13 |
rat |
| Jie Yu Ye, En Yu Liang, Yuan Shan Cheng, Godfrey C F Chan, Yue Ding, Fanyi Meng, Margaret H L Ng, Beng H Chong, Qizhou Lian, Mo Yan. Serotonin enhances megakaryopoiesis and proplatelet formation via p-Erk1/2 and F-actin reorganization. Stem cells (Dayton, Ohio). vol 32. issue 11. 2015-08-28. PMID:24980849. |
5-ht also promoted the megakaryocytes (mks) proliferation and reduced the cell apoptosis via the activation of 5-ht(2b)r and akt pathway. |
2015-08-28 |
2023-08-13 |
mouse |
| Xiaojun Yu, Bo'an Zheng, Rui Cha. Lentivirus-mediated knockdown of eukaryotic translation initiation factor 3 subunit D inhibits proliferation of HCT116 colon cancer cells. Bioscience reports. vol 34. issue 6. 2015-08-24. PMID:25370813. |
signalling pathways responsible for cell growth and apoptosis have also been found altered after eif3d silencing, such as ampkα (amp-activated protein kinase alpha), bad, pras40 [proline-rich akt (pkb) substrate of 40 kda], sapk (stress-activated protein kinase)/jnk (c-jun n-terminal kinase), gsk3β and parp [poly(adp-ribose) polymerase]. |
2015-08-24 |
2023-08-13 |
human |
| Lizhi Zhang, Ke Wen, Xinxin Han, Rong Liu, Quanxin Q. Adiponectin mediates antiproliferative and apoptotic responses in endometrial carcinoma by the AdipoRs/AMPK pathway. Gynecologic oncology. vol 137. issue 2. 2015-08-24. PMID:25703675. |
we assessed the functions of adipor1 and adipor2 in endometrial cancer cells to determine whether the ampk/erk and akt pathways mediate the effects of adiponectin-induced apoptosis and anti-proliferation. |
2015-08-24 |
2023-08-13 |
Not clear |
| Clifford J Cookman, Scott M Belche. Estrogen Receptor-β Up-Regulates IGF1R Expression and Activity to Inhibit Apoptosis and Increase Growth of Medulloblastoma. Endocrinology. vol 156. issue 7. 2015-08-24. PMID:25885794. |
the absence of esr2 resulted in increased apoptosis, decreased b-cell lymphoma 2 (bcl2), and igf-1 receptor (igf1r) expression, and decreased levels of active mapks (erk1/2) and protein kinase b (akt). |
2015-08-24 |
2023-08-13 |
mouse |
| Dong Hoon Kwak, Ji-Hye Park, Hak-Seung Lee, Ji-Sook Moon, Seoul Le. Aristolochic Acid I induces ovarian toxicity by inhibition of akt phosphorylation. Chemical research in toxicology. vol 27. issue 12. 2015-08-21. PMID:25406029. |
these results suggest that aai strongly induces toxic damage during ovarian maturation by inhibiting akt phosphorylation-mediated suppression of apoptosis. |
2015-08-21 |
2023-08-13 |
mouse |
| Xiaoyun Dai, Jingwen Zhang, Frank Arfuso, Arunachalam Chinnathambi, M E Zayed, Sulaiman Ali Alharbi, Alan Prem Kumar, Kwang Seok Ahn, Gautam Seth. Targeting TNF-related apoptosis-inducing ligand (TRAIL) receptor by natural products as a potential therapeutic approach for cancer therapy. Experimental biology and medicine (Maywood, N.J.). vol 240. issue 6. 2015-08-21. PMID:25854879. |
however, besides activating caspase-dependent apoptosis in several cancer cells, trail may also activate nonapoptotic signal transduction pathways such as nuclear factor-kappa b, mitogen-activated protein kinases, akt, and signal transducers and activators of transcription 3, which may contribute to trail resistance that is being now frequently encountered in various cancers. |
2015-08-21 |
2023-08-13 |
Not clear |
| Goutam Dey, Rashmi Bharti, Ramkrishna Sen, Mahitosh Manda. Microbial amphiphiles: a class of promising new-generation anticancer agents. Drug discovery today. vol 20. issue 1. 2015-08-18. PMID:25241656. |
they exhibit anticancer activities by retarding cell cycle progression, inhibiting crucial signaling pathways such as akt, extracellular signal-regulated kinase/c-jun n-terminal kinase (erk/jnk) and janus kinase/signal transducer and activator of transcription (jak/stat), reducing angiogenesis, activating natural killer t (nkt) cells and inducing apoptosis through death receptors in cancer cells. |
2015-08-18 |
2023-08-13 |
Not clear |
| Syed Umesalma, Ponnuraj Nagendraprabhu, Ganapasam Sudhandira. Ellagic acid inhibits proliferation and induced apoptosis via the Akt signaling pathway in HCT-15 colon adenocarcinoma cells. Molecular and cellular biochemistry. vol 399. issue 1-2. 2015-08-17. PMID:25355159. |
ellagic acid inhibits proliferation and induced apoptosis via the akt signaling pathway in hct-15 colon adenocarcinoma cells. |
2015-08-17 |
2023-08-13 |
human |
| Zhong Yun, Peter M Glaze. Tumor suppressor p53 stole the AKT in hypoxia. The Journal of clinical investigation. vol 125. issue 6. 2015-08-13. PMID:25961449. |
induction of p53-dependent apoptosis under hypoxia was mediated by akt inhibition, and treatment with the combination of an akt inhibitor and ionizing radiation decreased tumor size in a p53-deficient xenograft model more substantially than either single-agent treatment. |
2015-08-13 |
2023-08-13 |
Not clear |
| Zhong Yun, Peter M Glaze. Tumor suppressor p53 stole the AKT in hypoxia. The Journal of clinical investigation. vol 125. issue 6. 2015-08-13. PMID:25961449. |
the results of this study provide important insight into p53-mediated apoptosis under hypoxia and suggest that akt inhibition has therapeutic potential for inducing apoptosis in hypoxic, p53-deficient cancers. |
2015-08-13 |
2023-08-13 |
Not clear |
| Katerina Kapodistria, Effie-Photini Tsilibary, Panagiotis Politis, Petros Moustardas, Aristidis Charonis, Paraskevi Kitsio. Nephrin, a transmembrane protein, is involved in pancreatic beta-cell survival signaling. Molecular and cellular endocrinology. vol 400. 2015-08-12. PMID:25448064. |
nephrin silencing abolished akt activation and increased susceptibility of cells to apoptosis. |
2015-08-12 |
2023-08-13 |
mouse |
| Katrin E Wiese, Heidi M Haikala, Björn von Eyss, Elmar Wolf, Cyril Esnault, Andreas Rosenwald, Richard Treisman, Juha Klefström, Martin Eiler. Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells. The EMBO journal. vol 34. issue 11. 2015-08-12. PMID:25896507. |
restoring srf activity antagonizes myc repression of srf target genes, attenuates myc-induced apoptosis, and reverts a myc-dependent decrease in akt phosphorylation and activity, a well-characterized suppressor of myc-induced apoptosis. |
2015-08-12 |
2023-08-13 |
Not clear |