| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gong-Ping Xu, Wei Zhao, Jin-Peng Zhuang, Jia-Ning Zu, Duan-Yang Wang, Fei Han, Zhi-Peng Zhang, Jing-Long Ya. Matrine inhibits the growth and induces apoptosis of osteosarcoma cells in vitro by inactivating the Akt pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 3. 2015-06-15. PMID:25371071. |
matrine inhibits the growth and induces apoptosis of osteosarcoma cells in vitro by inactivating the akt pathway. |
2015-06-15 |
2023-08-13 |
human |
| Gong-Ping Xu, Wei Zhao, Jin-Peng Zhuang, Jia-Ning Zu, Duan-Yang Wang, Fei Han, Zhi-Peng Zhang, Jing-Long Ya. Matrine inhibits the growth and induces apoptosis of osteosarcoma cells in vitro by inactivating the Akt pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 3. 2015-06-15. PMID:25371071. |
we therefore assessed the role of the serine/threonine kinase akt in the regulation of matrine-mediated cell growth inhibition and apoptosis induction in human os cell lines. |
2015-06-15 |
2023-08-13 |
human |
| Gong-Ping Xu, Wei Zhao, Jin-Peng Zhuang, Jia-Ning Zu, Duan-Yang Wang, Fei Han, Zhi-Peng Zhang, Jing-Long Ya. Matrine inhibits the growth and induces apoptosis of osteosarcoma cells in vitro by inactivating the Akt pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 3. 2015-06-15. PMID:25371071. |
overall, our findings suggest that matrine may be an effective anti-osteosarcoma drug due to its ability to inhibit proliferation and induce apoptosis in os cells, possibly through the involvement of akt signaling. |
2015-06-15 |
2023-08-13 |
human |
| Jinming Huang, Jiaoyuan Jia, Qiang Tong, Jun Liu, Jun Qiu, Rong Sun, Lixin Yao, Chun Yan. Knockdown of cancerous inhibitor of protein phosphatase 2A may sensitize metastatic castration-resistant prostate cancer cells to cabazitaxel chemotherapy. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 3. 2015-06-15. PMID:25377160. |
cip2a silencing led to decreased proliferation and enhanced chemosensitivity and apoptosis to cabazitaxel in human pca cells, as well as reduced akt phosphorylation. |
2015-06-15 |
2023-08-13 |
human |
| Yong Ai, Fenghua Kang, Zhangjian Huang, Xiaowen Xue, Yisheng Lai, Sixun Peng, Jide Tian, Yihua Zhan. Synthesis of CDDO-amino acid-nitric oxide donor trihybrids as potential antitumor agents against both drug-sensitive and drug-resistant colon cancer. Journal of medicinal chemistry. vol 58. issue 5. 2015-06-15. PMID:25675144. |
furthermore, 4c triggered hct-8 and hct-8/5-fu cell apoptosis more strongly than cddo-me, inhibited the hif-1α, stat3, akt, and erk signaling, and induced the nitration of p-gp, mrp1, and bcrp proteins in hct-8/5-fu cells. |
2015-06-15 |
2023-08-13 |
mouse |
| Magdalena Jurzak, Katarzyna Adamczyk, Paweł Antończak, Agnieszka Garncarczyk, Dariusz Kuśmierz, Małgorzata Latoch. Evaluation of genistein ability to modulate CTGF mRNA/protein expression, genes expression of TGFβ isoforms and expression of selected genes regulating cell cycle in keloid fibroblasts in vitro. Acta poloniae pharmaceutica. vol 71. issue 6. 2015-06-08. PMID:25745770. |
akt and ap-l signaling pathways, that are important for cytokines expression and cell proliferation, differentiation, survival and apoptosis. |
2015-06-08 |
2023-08-13 |
human |
| Liu Cao, Wangsheng Duanmu, Yi Yin, Zhihang Zhou, Hongfei Ge, Tunan Chen, Liang Tan, Anyong Yu, Rong Hu, Li Fei, Hua Fen. Dihydroartemisinin exhibits anti-glioma stem cell activity through inhibiting p-AKT and activating caspase-3. Die Pharmazie. vol 69. issue 10. 2015-06-08. PMID:25985565. |
these data indicate that dha selectively inhibits proliferation and induces apoptosis of gscs through the down-regulation of akt phosphorylation, which is followed by caspase-3 activation, and these findings offer a new approach for treating gliomas. |
2015-06-08 |
2023-08-13 |
Not clear |
| Takaomi Kurioka, Takeshi Matsunobu, Katsuki Niwa, Atsushi Tamura, Yasushi Satoh, Akihiro Shiotan. Activated protein C rescues the cochlea from noise-induced hearing loss. Brain research. vol 1583. 2015-06-05. PMID:25108045. |
we examined the potential of apc to protect against noise-induced hearing loss (nihl) and investigated phosphorylation of serine-threonine kinase (akt) and inhibition of apoptosis as possible cytoprotective mechanisms. |
2015-06-05 |
2023-08-13 |
rat |
| Yikai Zhang, Shanyuan Zheng, Sai-Ming Ngai, Wenjie Zheng, Jinying Li, Tianfeng Chen, Xueyun Zhon. A novel selenadiazole derivative induces apoptosis in human glioma cells by dephosphorylation of AKT. Chemical & pharmaceutical bulletin. vol 62. issue 10. 2015-06-05. PMID:25273058. |
a novel selenadiazole derivative induces apoptosis in human glioma cells by dephosphorylation of akt. |
2015-06-05 |
2023-08-13 |
human |
| Yikai Zhang, Shanyuan Zheng, Sai-Ming Ngai, Wenjie Zheng, Jinying Li, Tianfeng Chen, Xueyun Zhon. A novel selenadiazole derivative induces apoptosis in human glioma cells by dephosphorylation of AKT. Chemical & pharmaceutical bulletin. vol 62. issue 10. 2015-06-05. PMID:25273058. |
further mechanistic investigation showed that bsbd treatment induced dephosphorylation of akt and dna damage-mediated activation of p53, leading to extensive apoptosis through the mitochondrial pathway. |
2015-06-05 |
2023-08-13 |
human |
| Sherry Shuyi Wang, Jun Re. Aging as an essential modifier for the efficacy in mesenchymal stem cell therapy through an inositol phosphate 6 kinase-inositol pyrophosphate 7-dependent mechanism. Stem cell research & therapy. vol 5. issue 2. 2015-05-28. PMID:25157976. |
inhibition of inositol hexakis phosphate kinases (ip6ks) activates akt signaling, decreases apoptosis, and modulates paracrine profiles in aged mscs, and this greatly enhances the therapeutic efficacy of aged mscs in the face of hypoxic injury. |
2015-05-28 |
2023-08-13 |
Not clear |
| Kimberly M Sutton, Anna L Greenshields, David W Hoski. Thymoquinone, a bioactive component of black caraway seeds, causes G1 phase cell cycle arrest and apoptosis in triple-negative breast cancer cells with mutant p53. Nutrition and cancer. vol 66. issue 3. 2015-05-26. PMID:24579801. |
poly(adp-ribose) polymerase cleavage and increased γh2ax, as well as reduced akt phosphorylation and decreased expression of x-linked inhibitor of apoptosis, were evident in tq-treated cells. |
2015-05-26 |
2023-08-12 |
Not clear |
| Xiao-shu Chai, Xiao-xuan Zhang, Wan-yin W. Xiaoji Decoction inhibited cell proliferation and induced apoptosis through Akt signaling pathway in human lung cancer A549 cells. Chinese journal of integrative medicine. vol 20. issue 9. 2015-05-26. PMID:24938444. |
xiaoji decoction inhibited cell proliferation and induced apoptosis through akt signaling pathway in human lung cancer a549 cells. |
2015-05-26 |
2023-08-13 |
human |
| Jun Soo Park, Wan Tae Kim, Shin Kim, Taeg Kyu Kwon, Byeong-Churl Jang, Eung-Seok Lee, Jong Wook Par. FPDHP, a novel anticancer agent, induces cell detachment and caspase-dependent apoptosis in Caki cells. International journal of molecular medicine. vol 34. issue 4. 2015-05-26. PMID:25092524. |
in particular, fpdhp also induced caspase-dependent apoptosis and the downregulation of the protein expression levels of cellular flice-like inhibitory protein (cflip) and the phosphorylation of akt in caki cells. |
2015-05-26 |
2023-08-13 |
Not clear |
| Jun Soo Park, Wan Tae Kim, Shin Kim, Taeg Kyu Kwon, Byeong-Churl Jang, Eung-Seok Lee, Jong Wook Par. FPDHP, a novel anticancer agent, induces cell detachment and caspase-dependent apoptosis in Caki cells. International journal of molecular medicine. vol 34. issue 4. 2015-05-26. PMID:25092524. |
notably, the overexpression of cflip, but not that of akt, in part, blocked the fpdhp-mediated apoptosis in caki cells. |
2015-05-26 |
2023-08-13 |
Not clear |
| Hiroshi Ohkawara, Toshiyuki Ishibashi, Koichi Sugimoto, Kazuhiko Ikeda, Kazuei Ogawa, Yasuchika Takeish. Membrane type 1-matrix metalloproteinase/Akt signaling axis modulates TNF-α-induced procoagulant activity and apoptosis in endothelial cells. PloS one. vol 9. issue 8. 2015-05-26. PMID:25162582. |
our hypothesis was that mt1-mmp cooperates with protein kinase b (akt) in tumor necrosis factor (tnf)-α-induced signaling pathways of vascular responses, including tissue factor (tf) procoagulant activity and endothelial apoptosis, in cultured human aortic endothelial cells (ecs). |
2015-05-26 |
2023-08-13 |
human |
| Tong Li, Ze-Lin Sun, Qi Ying Xi. Protective effect of microRNA-30b on hypoxia/reoxygenation-induced apoptosis in H9C2 cardiomyocytes. Gene. vol 561. issue 2. 2015-05-26. PMID:25701595. |
h/r induced apoptosis was detected by flow cytometry and the pathways involved in mir-30b-mediated protection were examined by analyzing the expression of mir-30b, bcl-2, bax, caspase-3, kras, p-akt and total akt in h9c2 cells. |
2015-05-26 |
2023-08-13 |
rat |
| Ashley L Hein, Michel M Ouellette, Ying Ya. Radiation-induced signaling pathways that promote cancer cell survival (review). International journal of oncology. vol 45. issue 5. 2015-05-25. PMID:25174607. |
however, radiation can also simultaneously induce multiple pro-survival signaling pathways, such as those mediated by akt, erk and atm/atr, which can lead to suppression of apoptosis, induction of cell cycle arrest and/or initiation of dna repair. |
2015-05-25 |
2023-08-13 |
Not clear |
| Ke Zhang, Xian Wang, Hongyan Wan. Effect and mechanism of Src tyrosine kinase inhibitor sunitinib on the drug-resistance reversal of human A549/DDP cisplatin-resistant lung cancer cell line. Molecular medicine reports. vol 10. issue 4. 2015-05-22. PMID:25109654. |
it was observed that sunitinib was able to improve the sensitivity of a549/ddp lung cancer cells to cisplatin, enhance tumor apoptosis, arrest the cell cycle in g0/g1 phase, upregulate intracellular rh-123 content, downregulate the expression of p-glycoprotein, multidrug resistance protein 1, multidrug resistance-associated protein 1, lung resistance protein, glutathione-s-transferase, ercc1, survivin and bcl-2 in tumor cells, phosphorylation of akt and extracellular signal-regulated kinase (erk), glutathione activity, and transcriptional activity of nuclear factor-κb, twist, snail and ap-1. |
2015-05-22 |
2023-08-13 |
human |
| You-Chuan Xiao, Zhi-Bin Yang, Xian-Shuo Cheng, Xing-Bao Fang, Tao Shen, Cui-Feng Xia, Ping Liu, Hai-Hua Qian, Bin Sun, Zheng-Feng Yin, Yun-Feng L. CXCL8, overexpressed in colorectal cancer, enhances the resistance of colorectal cancer cells to anoikis. Cancer letters. vol 361. issue 1. 2015-05-21. PMID:25687885. |
cxcl8 treatment enhanced the resistance of crc cells to apoptosis, which was accompanied by the increase of topk, and the activation of akt and erk. |
2015-05-21 |
2023-08-13 |
Not clear |