| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shweta Shrivastava, Prasad Kulkarni, Dinesh Thummuri, Manish Kumar Jeengar, V G M Naidu, Mallika Alvala, G Bhanuprakash Redddy, Sistla Ramakrishn. Piperlongumine, an alkaloid causes inhibition of PI3 K/Akt/mTOR signaling axis to induce caspase-dependent apoptosis in human triple-negative breast cancer cells. Apoptosis : an international journal on programmed cell death. vol 19. issue 7. 2015-04-22. PMID:24729100. |
the objective of this study was to investigate the effect of piperlongumine (pplgm), a natural alkaloid on pi3 k/akt/mtor signaling, akt mediated regulation of nf-kb and apoptosis evasion in human breast cancer cells. |
2015-04-22 |
2023-08-13 |
human |
| Wei-Lin Liu, Ming Gao, Kai-Yuan Tzen, Chiao-Ling Tsai, Feng-Ming Hsu, Ann-Lii Cheng, Jason Chia-Hsien Chen. Targeting Phosphatidylinositide3-Kinase/Akt pathway by BKM120 for radiosensitization in hepatocellular carcinoma. Oncotarget. vol 5. issue 11. 2015-04-22. PMID:25004403. |
bkm120 pretreatment inhibited radiation-induced akt phosphorylation and enhanced the tumor-suppressive effect and radiation-induced tumor cell apoptosis in ectopic xenografts. |
2015-04-22 |
2023-08-13 |
mouse |
| Wei-Lin Liu, Ming Gao, Kai-Yuan Tzen, Chiao-Ling Tsai, Feng-Ming Hsu, Ann-Lii Cheng, Jason Chia-Hsien Chen. Targeting Phosphatidylinositide3-Kinase/Akt pathway by BKM120 for radiosensitization in hepatocellular carcinoma. Oncotarget. vol 5. issue 11. 2015-04-22. PMID:25004403. |
the synergism between bkm120 and irradiation likely inhibits the activation of akt by radiation, leading to increased cell apoptosis and suppression of dna-double-strand breaks repair in hepatocellular carcinoma cells. |
2015-04-22 |
2023-08-13 |
mouse |
| Yi-Qun Huang, Xiao-Lu Huang, Xu-Dong M. [Effect of silencing NOTCH1 gene by shRNA interference on AKT/mTOR pathway in mantle cell lymphoma]. Zhongguo shi yan xue ye xue za zhi. vol 22. issue 6. 2015-04-22. PMID:25543484. |
the study was purposed to investigate the effect of silencing notch1 gene by shrna interference on the proliferation, apoptosis and the expression of akt signaling pathway-related proteins in mantle cell lymphoma jeko-1 cell line. |
2015-04-22 |
2023-08-13 |
Not clear |
| Honghui Wang, Taro Misaki, Vanessa Taupin, Akiko Eguchi, Pradipta Ghosh, Marilyn G Farquha. GIV/girdin links vascular endothelial growth factor signaling to Akt survival signaling in podocytes independent of nephrin. Journal of the American Society of Nephrology : JASN. vol 26. issue 2. 2015-04-21. PMID:25012178. |
in giv-depleted podocytes, vegf-induced akt activation was abolished, apoptosis was triggered, and cell migration was impaired. |
2015-04-21 |
2023-08-13 |
Not clear |
| Xu Li, Feng Zhu, Jianxin Jiang, Chengyi Sun, Xin Wang, Ming Shen, Rui Tian, Chengjian Shi, Meng Xu, Feng Peng, Xingjun Guo, Min Wang, Renyi Qi. Synergistic antitumor activity of withaferin A combined with oxaliplatin triggers reactive oxygen species-mediated inactivation of the PI3K/AKT pathway in human pancreatic cancer cells. Cancer letters. vol 357. issue 1. 2015-04-21. PMID:25444914. |
pretreatment of cells with the ros scavenger n-acetylcysteine completely blocked the apoptosis induced by combination treatment, and recovered expression of akt inactivation, which revealed the important role of ros in apoptosis and akt regulation. |
2015-04-21 |
2023-08-13 |
human |
| Anna L Greenshields, Carolyn D Doucette, Kimberly M Sutton, Laurence Madera, Henry Annan, Paul B Yaffe, Allison F Knickle, Zhongmin Dong, David W Hoski. Piperine inhibits the growth and motility of triple-negative breast cancer cells. Cancer letters. vol 357. issue 1. 2015-04-21. PMID:25444919. |
piperine also inhibited survival-promoting akt activation in tnbc cells and caused caspase-dependent apoptosis via the mitochondrial pathway. |
2015-04-21 |
2023-08-13 |
mouse |
| D A Cunha, E N Gurzov, N Naamane, F Ortis, A K Cardozo, M Bugliani, P Marchetti, D L Eizirik, M Cno. JunB protects β-cells from lipotoxicity via the XBP1-AKT pathway. Cell death and differentiation. vol 21. issue 8. 2015-04-19. PMID:24786832. |
glp-1 agonists induced camp-dependent akt phosphorylation leading to β-cell protection against palmitate-induced apoptosis. |
2015-04-19 |
2023-08-13 |
Not clear |
| D A Cunha, E N Gurzov, N Naamane, F Ortis, A K Cardozo, M Bugliani, P Marchetti, D L Eizirik, M Cno. JunB protects β-cells from lipotoxicity via the XBP1-AKT pathway. Cell death and differentiation. vol 21. issue 8. 2015-04-19. PMID:24786832. |
junb and xbp1 knockdown or ire1 inhibition decreased akt activation by camp, leading to β-cell apoptosis. |
2015-04-19 |
2023-08-13 |
Not clear |
| Maria Grazia Masiello, Alessandra Cucina, Sara Proietti, Alessandro Palombo, Pierpaolo Coluccia, Fabrizio D'Anselmi, Simona Dinicola, Alessia Pasqualato, Veronica Morini, Mariano Bizzarr. Phenotypic switch induced by simulated microgravity on MDA-MB-231 breast cancer cells. BioMed research international. vol 2014. 2015-04-17. PMID:25215287. |
these morphological differences are mirrored by the concomitant dramatic functional changes in cell processes (proliferation and apoptosis) and signaling pathways (erk, akt, and survivin). |
2015-04-17 |
2023-08-13 |
Not clear |
| Weiwei Yu, Tao Shen, Baoyi Liu, Shu Wang, Jian Li, Dapeng Dai, Jianping Cai, Qing H. Cardiac shock wave therapy attenuates H9c2 myoblast apoptosis by activating the AKT signal pathway. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 33. issue 5. 2015-04-14. PMID:24802592. |
cardiac shock wave therapy attenuates h9c2 myoblast apoptosis by activating the akt signal pathway. |
2015-04-14 |
2023-08-13 |
Not clear |
| Yun Li, Hongwei Shen, Jingming Shi, Luosheng Tan. The effects of alpha lipoic acid in preventing oxidative stress-induced retinal pigment epithelial cell injury. Canadian journal of physiology and pharmacology. vol 92. issue 9. 2015-04-14. PMID:25179747. |
h2o2 (12.5 μmol/l) induced early stage apoptosis, significantly decreased akt phosphorylation, and increased bax protein level 4 h after stimulation. |
2015-04-14 |
2023-08-13 |
human |
| Jennifer L Larson-Casey, Shubha Murthy, Alan J Ryan, A Brent Carte. Modulation of the mevalonate pathway by akt regulates macrophage survival and development of pulmonary fibrosis. The Journal of biological chemistry. vol 289. issue 52. 2015-04-14. PMID:25378391. |
akt, a serine/threonine kinase, is known to increase cell survival by regulation of the intrinsic pathway for apoptosis. |
2015-04-14 |
2023-08-13 |
mouse |
| Atsushi Kasamatsu, Katsuhiro Uzawa, Yasuyuki Minakawa, Shunsaku Ishige, Hiroki Kasama, Yosuke Endo-Sakamoto, Katsunori Ogawara, Masashi Shiiba, Yuichi Takiguchi, Hideki Tanzaw. Decorin in human oral cancer: a promising predictive biomarker of S-1 neoadjuvant chemosensitivity. Biochemical and biophysical research communications. vol 457. issue 1. 2015-04-14. PMID:25550184. |
in addition to the in vitro data, dcn knockdown zenografting tumors in nude mice demonstrate decreasing cell proliferation and increasing apoptosis with dephosphorylation of akt after s-1 chemotherapy. |
2015-04-14 |
2023-08-13 |
mouse |
| Jisha Joshua, Hema Kalyanaraman, Nisha Marathe, Renate B Pil. Nitric oxide as a mediator of estrogen effects in osteocytes. Vitamins and hormones. vol 96. 2015-04-13. PMID:25189390. |
moreover, we found that 17β-estradiol protects osteocytes against apoptosis via the no/cgmp signaling pathway: type ii pkg mediates estradiol-induced activation of the prosurvival kinases erk and akt, whereas type i pkg contributes to prosurvival signaling by directly phosphorylating and inactivating the cell death protein bad. |
2015-04-13 |
2023-08-13 |
Not clear |
| Siddhartha Rawat, Michael J Bouchar. The hepatitis B virus (HBV) HBx protein activates AKT to simultaneously regulate HBV replication and hepatocyte survival. Journal of virology. vol 89. issue 2. 2015-04-13. PMID:25355887. |
while this may seem counterintuitive, we show that an important effect of hbx activation of akt is inhibition of apoptosis. |
2015-04-13 |
2023-08-13 |
Not clear |
| Xiaoxian Zhao, Juraj Bodo, Danyu Sun, Lisa Durkin, Jeffrey Lin, Mitchell R Smith, Eric D Hs. Combination of ibrutinib with ABT-199: synergistic effects on proliferation inhibition and apoptosis in mantle cell lymphoma cells through perturbation of BTK, AKT and BCL2 pathways. British journal of haematology. vol 168. issue 5. 2015-04-10. PMID:25284608. |
combination of ibrutinib with abt-199: synergistic effects on proliferation inhibition and apoptosis in mantle cell lymphoma cells through perturbation of btk, akt and bcl2 pathways. |
2015-04-10 |
2023-08-13 |
Not clear |
| Liqun Chen, Zhi-Gang Wang, Alexander E Aleshin, Fan Chen, Jiebo Chen, Fuquan Jiang, Gulimiran Alitongbieke, Zhiping Zeng, Yue Ma, Mingfeng Huang, Hu Zhou, Gregory Cadwell, Jian-Feng Zheng, Pei-Qiang Huang, Robert C Liddington, Xiao-kun Zhang, Ying S. Sulindac-derived RXRα modulators inhibit cancer cell growth by binding to a novel site. Chemistry & biology. vol 21. issue 5. 2015-04-06. PMID:24704507. |
the analogs inhibit the interaction of the n-terminally truncated rxrα (trxrα) with the p85α subunit of pi3k, leading to suppression of akt activation and induction of apoptosis. |
2015-04-06 |
2023-08-13 |
Not clear |
| Olympia Vasou, Lazaros Skagias, Margariti Anastasia, Athanasiadou Paulina, Efstratios Patsouris, Ekaterini Polit. Detection of pAkt protein in imprint cytology of invasive breast cancer: Correlation with HER2/neu, hormone receptors, and other clinicopathological variables. CytoJournal. vol 12. 2015-04-03. PMID:25838835. |
akt is a serine/threonine protein kinase and has emerged as a crucial regulator of widely divergent cellular processes, including apoptosis, proliferation, differentiation, and metabolism. |
2015-04-03 |
2023-08-13 |
human |
| Premranjan Kumar, G Nageswar Rao, Bibhuti Bhusan Pal, Arttatrana Pa. Hyperglycemia-induced oxidative stress induces apoptosis by inhibiting PI3-kinase/Akt and ERK1/2 MAPK mediated signaling pathway causing downregulation of 8-oxoG-DNA glycosylase levels in glial cells. The international journal of biochemistry & cell biology. vol 53. 2015-03-31. PMID:24907397. |
our results demonstrate that high glucose induces apoptosis and inhibits proliferation of glial cells, which may be mediated by the phosphorylation of tuberin, down regulation of 8-oxog-dna glycosylase and 8-hydroxydeoxyguanosine accumulation via activation of akt and erk1/2mapk pathways. |
2015-03-31 |
2023-08-13 |
Not clear |