| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li-Juan Sun, Xiang-Hong Hou, Sen-Hai Xue, Feng Yan, Yu-Jie Dai, Chang-Hai Zhao, Feng Wang, Rui-Hua Yan. Fish oil modulates glycogen synthase kinase-3 signaling pathway in diabetes-induced hippocampal neurons apoptosis. Brain research. vol 1574. 2015-02-26. PMID:24924805. |
fish oil administration ameliorated cognitive deficit, reduced oxidative stress, increased akt phosphorylation, decreased gsk-3β phosphorylation, and decreased pro-apoptotic molecules expression, which protected the hippocampal neurons from apoptosis in diabetic rats. |
2015-02-26 |
2023-08-13 |
rat |
| Zuoren Yu, Zengguang Xu, Gabriele Disante, Jennifer Wright, Min Wang, Yuan Li, Qian Zhao, Tao Ren, Xiaoming Ju, Ellen Gutman, Guangxue Wang, Sankar Addya, Tieyan Li, Zhendong Xiang, Chenguang Wang, Xiongfei Yang, Xiaolai Yang, Richard Pestel. miR-17/20 sensitization of breast cancer cells to chemotherapy-induced apoptosis requires Akt1. Oncotarget. vol 5. issue 4. 2015-02-21. PMID:24658544. |
herein, disruption of the ubiquitously expressed member of the akt family of genes, akt1, in the mouse, demonstrates a requirement for akt1 in mirna-mediated cellular apoptosis. |
2015-02-21 |
2023-08-12 |
mouse |
| Zuoren Yu, Zengguang Xu, Gabriele Disante, Jennifer Wright, Min Wang, Yuan Li, Qian Zhao, Tao Ren, Xiaoming Ju, Ellen Gutman, Guangxue Wang, Sankar Addya, Tieyan Li, Zhendong Xiang, Chenguang Wang, Xiongfei Yang, Xiaolai Yang, Richard Pestel. miR-17/20 sensitization of breast cancer cells to chemotherapy-induced apoptosis requires Akt1. Oncotarget. vol 5. issue 4. 2015-02-21. PMID:24658544. |
mir-17/20 mediates apoptosis via increased p53 expression which promotes akt degradation. |
2015-02-21 |
2023-08-12 |
mouse |
| Zuoren Yu, Zengguang Xu, Gabriele Disante, Jennifer Wright, Min Wang, Yuan Li, Qian Zhao, Tao Ren, Xiaoming Ju, Ellen Gutman, Guangxue Wang, Sankar Addya, Tieyan Li, Zhendong Xiang, Chenguang Wang, Xiongfei Yang, Xiaolai Yang, Richard Pestel. miR-17/20 sensitization of breast cancer cells to chemotherapy-induced apoptosis requires Akt1. Oncotarget. vol 5. issue 4. 2015-02-21. PMID:24658544. |
these results demonstrated a novel pathway through which mir17/20 regulate p53 and akt controlling breast cancer cell apoptosis. |
2015-02-21 |
2023-08-12 |
mouse |
| b' Nevena Grdovi\\xc4\\x87, Svetlana Dini\\xc4\\x87, Mirjana Mihailovi\\xc4\\x87, Aleksandra Uskokovi\\xc4\\x87, Jelena Aramba\\xc5\\xa1i\\xc4\\x87 Jovanovi\\xc4\\x87, Goran Poznanovi\\xc4\\x87, Ludwig Wagner, Melita Vidakovi\\xc4\\x8. CXC chemokine ligand 12 protects pancreatic \\xce\\xb2-cells from necrosis through Akt kinase-mediated modulation of poly(ADP-ribose) polymerase-1 activity. PloS one. vol 9. issue 7. 2015-02-21. PMID:24988468.' |
cxcl12 downstream signalling through akt kinase was responsible for the reduction of parp-1 activity which switched cell death from necrosis to apoptosis, providing increased protection to cells from oxidative stress. |
2015-02-21 |
2023-08-13 |
rat |
| Juan M Gallardo Bolaños, Carolina M Balao da Silva, Patricia Martín Muñoz, Antolín Morillo Rodríguez, María Plaza Dávila, Heriberto Rodríguez-Martínez, Inés M Aparicio, José A Tapia, Cristina Ortega Ferrusola, Fernando J Peñ. Phosphorylated AKT preserves stallion sperm viability and motility by inhibiting caspases 3 and 7. Reproduction (Cambridge, England). vol 148. issue 2. 2015-02-19. PMID:24850868. |
akt, also referred to as protein kinase b (pkb or rac), plays a critical role in controlling cell survival and apoptosis. |
2015-02-19 |
2023-08-13 |
Not clear |
| Juan M Gallardo Bolaños, Carolina M Balao da Silva, Patricia Martín Muñoz, Antolín Morillo Rodríguez, María Plaza Dávila, Heriberto Rodríguez-Martínez, Inés M Aparicio, José A Tapia, Cristina Ortega Ferrusola, Fernando J Peñ. Phosphorylated AKT preserves stallion sperm viability and motility by inhibiting caspases 3 and 7. Reproduction (Cambridge, England). vol 148. issue 2. 2015-02-19. PMID:24850868. |
it is concluded that akt maintains the membrane integrity of ejaculated stallion spermatozoa, presumably by inhibiting caspases 3 and 7, which prevents the progression of spermatozoa to an incomplete form of apoptosis. |
2015-02-19 |
2023-08-13 |
Not clear |
| Elizabeth Jaworski, Aarthi Narayanan, Rachel Van Duyne, Shabana Shabbeer-Meyering, Sergey Iordanskiy, Mohammed Saifuddin, Ravi Das, Philippe V Afonso, Gavin C Sampey, Myung Chung, Anastas Popratiloff, Bindesh Shrestha, Mohit Sehgal, Pooja Jain, Akos Vertes, Renaud Mahieux, Fatah Kashanch. Human T-lymphotropic virus type 1-infected cells secrete exosomes that contain Tax protein. The Journal of biological chemistry. vol 289. issue 32. 2015-02-19. PMID:24939845. |
finally, il-2-dependent ctll-2 cells that received tax-containing exosomes were protected from apoptosis through activation of akt. |
2015-02-19 |
2023-08-13 |
human |
| To Sing Fung, Ying Liao, Ding Xiang Li. The endoplasmic reticulum stress sensor IRE1α protects cells from apoptosis induced by the coronavirus infectious bronchitis virus. Journal of virology. vol 88. issue 21. 2015-02-19. PMID:25142592. |
moreover, ire1α antagonized ibv-induced apoptosis by modulating the phosphorylation status of the proapoptotic c-jun n-terminal kinase (jnk) and the prosurvival rac-alpha serine/threonine-protein kinase (akt). |
2015-02-19 |
2023-08-13 |
Not clear |
| Akihisa Nakagawa, Kelly D Sullivan, Ding Xu. Caspase-activated phosphoinositide binding by CNT-1 promotes apoptosis by inhibiting the AKT pathway. Nature structural & molecular biology. vol 21. issue 12. 2015-02-18. PMID:25383666. |
caspase-activated phosphoinositide binding by cnt-1 promotes apoptosis by inhibiting the akt pathway. |
2015-02-18 |
2023-08-13 |
caenorhabditis_elegans |
| Akihisa Nakagawa, Kelly D Sullivan, Ding Xu. Caspase-activated phosphoinositide binding by CNT-1 promotes apoptosis by inhibiting the AKT pathway. Nature structural & molecular biology. vol 21. issue 12. 2015-02-18. PMID:25383666. |
our findings reveal a new mechanism that negatively regulates akt cell signaling to promote apoptosis and that may restrict cell growth and proliferation in normal cells. |
2015-02-18 |
2023-08-13 |
caenorhabditis_elegans |
| Maryam Moosavi, Amir Hossein Zarifkar, Yaghoub Farbood, Mahin Dianat, Alireza Sarkaki, Rasoul Ghasem. Agmatine protects against intracerebroventricular streptozotocin-induced water maze memory deficit, hippocampal apoptosis and Akt/GSK3β signaling disruption. European journal of pharmacology. vol 736. 2015-02-13. PMID:24769303. |
after complement of behavioral studies the hippocampi was isolated and the amounts of hippocampal cleaved caspase-3 (the landmark of apoptosis), bax/bcl-2 ratio, total and phosphorylated forms of gsk-3β and akt were analyzed by western blot. |
2015-02-13 |
2023-08-13 |
rat |
| Simon Taylor, Matthew Lam, Chathyan Pararasa, James Ep Brown, Amtul R Carmichael, Helen R Griffith. Evaluating the evidence for targeting FOXO3a in breast cancer: a systematic review. Cancer cell international. vol 15. issue 1. 2015-02-13. PMID:25678856. |
downstream of growth factor receptors, signal transduction proceeds via phosphatidylinositol 3-kinase (pi3k), akt and foxo3a inhibition, the latter being partly responsible for coordinated increases in glycolysis and apoptosis resistance. |
2015-02-13 |
2023-08-13 |
Not clear |
| Jacob M Wilson, Selvi Kunnimalaiyaan, Muthusamy Kunnimalaiyaan, T Clark Gambli. Inhibition of the AKT pathway in cholangiocarcinoma by MK2206 reduces cellular viability via induction of apoptosis. Cancer cell international. vol 15. issue 1. 2015-02-12. PMID:25674039. |
inhibition of the akt pathway in cholangiocarcinoma by mk2206 reduces cellular viability via induction of apoptosis. |
2015-02-12 |
2023-08-13 |
Not clear |
| Tianfu Wu, Yujin Ye, So-Youn Min, Jiankun Zhu, Elhaum Khobahy, Jason Zhou, Mei Yan, Sriram Hemachandran, Simanta Pathak, Xin J Zhou, Michael Andreeff, Chandra Moha. Prevention of murine lupus nephritis by targeting multiple signaling axes and oxidative stress using a synthetic triterpenoid. Arthritis & rheumatology (Hoboken, N.J.). vol 66. issue 11. 2015-02-10. PMID:25047252. |
since the synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate (cddo-me) has been shown to inhibit akt, mek-1/2, and nf-κb, and to induce caspase-mediated apoptosis, we tested the therapeutic potential of this agent in murine lupus nephritis. |
2015-02-10 |
2023-08-13 |
mouse |
| Yoshiaki Chinen, Junya Kuroda, Yuji Shimura, Hisao Nagoshi, Miki Kiyota, Mio Yamamoto-Sugitani, Shinsuke Mizutani, Natsumi Sakamoto, Masaki Ri, Eri Kawata, Tsutomu Kobayashi, Yosuke Matsumoto, Shigeo Horiike, Shinsuke Iida, Masafumi Taniwak. Phosphoinositide protein kinase PDPK1 is a crucial cell signaling mediator in multiple myeloma. Cancer research. vol 74. issue 24. 2015-02-10. PMID:25269480. |
our results revealed that pdpk1 is a pivotal regulator of molecules that are essential for myelomagenesis, such as rsk2, akt, c-myc, irf4, or cyclin ds, and that pdpk1 inhibition caused the growth inhibition and the induction of apoptosis with the activation of bim and bad, and augmented the in vitro cytotoxic effects of antimyeloma agents in myeloma cells. |
2015-02-10 |
2023-08-13 |
Not clear |
| Xiuli Zhang, Yue Zhao, Qingqing Chu, Zhan-You Wang, Hongjuan Li, Zhi-Hong Ch. Zinc modulates high glucose-induced apoptosis by suppressing oxidative stress in renal tubular epithelial cells. Biological trace element research. vol 158. issue 2. 2015-02-09. PMID:24591003. |
taken together, these findings suggest that zn antiapoptosis capacity through the activation of akt and erk signal pathways leads to nrf2 activation and, subsequently, nrf2 target gene induction, thereby protecting the nrk-52e cells from hg-induced apoptosis. |
2015-02-09 |
2023-08-12 |
Not clear |
| Aurelia Busca, Mansi Saxena, Salma Iqbal, Jonathan Angel, Ashok Kuma. PI3K/Akt regulates survival during differentiation of human macrophages by maintaining NF-κB-dependent expression of antiapoptotic Bcl-xL. Journal of leukocyte biology. vol 96. issue 6. 2015-01-30. PMID:25225677. |
with the use of pharmacological inhibitors and sirna for akt and bcl-xl, we show that in the absence of akt-dependent bcl-xl expression during differentiation, cells undergo caspase-mediated apoptosis. |
2015-01-30 |
2023-08-13 |
human |
| Guoyou Zhang, Ming Li, Xiaodong Zhu, Yushu Bai, Changwei Yan. Knockdown of Akt sensitizes osteosarcoma cells to apoptosis induced by cisplatin treatment. International journal of molecular sciences. vol 12. issue 5. 2015-01-29. PMID:21686164. |
knockdown of akt sensitizes osteosarcoma cells to apoptosis induced by cisplatin treatment. |
2015-01-29 |
2023-08-12 |
Not clear |
| Guoyou Zhang, Ming Li, Xiaodong Zhu, Yushu Bai, Changwei Yan. Knockdown of Akt sensitizes osteosarcoma cells to apoptosis induced by cisplatin treatment. International journal of molecular sciences. vol 12. issue 5. 2015-01-29. PMID:21686164. |
akt plays an important role in the inhibition of apoptosis induced by chemotherapy and other stimuli. |
2015-01-29 |
2023-08-12 |
Not clear |