| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bing Zhao, Xiaomeng L. Altholactone induces reactive oxygen species-mediated apoptosis in bladder cancer T24 cells through mitochondrial dysfunction, MAPK-p38 activation and Akt suppression. Oncology reports. vol 31. issue 6. 2014-12-17. PMID:24700345. |
altholactone induces reactive oxygen species-mediated apoptosis in bladder cancer t24 cells through mitochondrial dysfunction, mapk-p38 activation and akt suppression. |
2014-12-17 |
2023-08-13 |
human |
| Bing Zhao, Xiaomeng L. Altholactone induces reactive oxygen species-mediated apoptosis in bladder cancer T24 cells through mitochondrial dysfunction, MAPK-p38 activation and Akt suppression. Oncology reports. vol 31. issue 6. 2014-12-17. PMID:24700345. |
furthermore, our results revealed that altholactone-induced apoptosis was associated with decreased expression of akt phosphorylation and activation of mapk‑p38. |
2014-12-17 |
2023-08-13 |
human |
| Bing Zhao, Xiaomeng L. Altholactone induces reactive oxygen species-mediated apoptosis in bladder cancer T24 cells through mitochondrial dysfunction, MAPK-p38 activation and Akt suppression. Oncology reports. vol 31. issue 6. 2014-12-17. PMID:24700345. |
taken together, our data demonstrate that altholactone induces ros-dependent apoptosis in t24 cells via a novel mechanism involving inhibition of akt and provide the rationale for further in vivo and preclinical investigation of altholactone against bladder cancer. |
2014-12-17 |
2023-08-13 |
human |
| Yan-Hong Wang, Xiang-Jiu Xu, Ling-Fang Zhang, Hong-Ling L. Mimic of manganese superoxide dismutase induces apoptosis in human acute myeloid leukemia cells. Leukemia & lymphoma. vol 55. issue 5. 2014-12-16. PMID:23879200. |
mnsodm inhibition of akt phosphorylation may contribute to mnsodm-mediated acute myeloid leukemia cell growth inhibition and apoptosis induction. |
2014-12-16 |
2023-08-12 |
mouse |
| JinYan Chen, MengRu Sun, XingHua Wang, Jing Lu, Yan Wei, Yan Tan, Ying Liu, Jürgen Götz, RongQiao He, Qian Hu. The herbal compound geniposide rescues formaldehyde-induced apoptosis in N2a neuroblastoma cells. Science China. Life sciences. vol 57. issue 4. 2014-12-16. PMID:24658849. |
fa-exposed murine n2a neuroblastoma cells were incubated with tljn, its main ingredient gp, as well as pns, to measure cell viability and morphology, the rate of apoptosis and expression of genes encoding akt, foxo3, bcl2 and p53. |
2014-12-16 |
2023-08-12 |
mouse |
| Wei Zhang, Shengqing Lv, Jun Liu, Zhenle Zang, Junyi Yin, Ning An, Hui Yang, Yechun Son. PCI-24781 down-regulates EZH2 expression and then promotes glioma apoptosis by suppressing the PIK3K/Akt/mTOR pathway. Genetics and molecular biology. vol 37. issue 4. 2014-12-16. PMID:25505847. |
in addition, pci-24781 or ezh2 sirna accelerated cell apoptosis by down-regulating the expression of akt, mtor, p70 ribosomal protein s6 kinase (p70s6k), glycogen synthase kinase 3a and b (gsk3a/b) and eukaryotic initiation factor 4e binding protein 1 (4e-bp1). |
2014-12-16 |
2023-08-13 |
Not clear |
| Mei Feng, Juan Li, Jun Wang, Chunyan Ma, Yulian Jiao, Yan Wang, Jie Zhang, Qiuying Sun, Ying Ju, Ling Gao, Yueran Zha. High glucose increases LPS-induced DC apoptosis through modulation of ERK1/2, AKT and Bax/Bcl-2. BMC gastroenterology. vol 14. 2014-12-15. PMID:24885625. |
high glucose increases lps-induced dc apoptosis through modulation of erk1/2, akt and bax/bcl-2. |
2014-12-15 |
2023-08-13 |
mouse |
| Masakiyo Sakaguchi, Hitoshi Murata, Yumi Aoyama, Toshihiko Hibino, Endy Widya Putranto, I Made Winarsa Ruma, Yusuke Inoue, Yoshihiko Sakaguchi, Ken-Ichi Yamamoto, Rie Kinoshita, Junichiro Futami, Ken Kataoka, Keiji Iwatsuki, Nam-Ho Hu. DNAX-activating protein 10 (DAP10) membrane adaptor associates with receptor for advanced glycation end products (RAGE) and modulates the RAGE-triggered signaling pathway in human keratinocytes. The Journal of biological chemistry. vol 289. issue 34. 2014-12-15. PMID:25002577. |
functional blocking of dap10 in the cell lines abrogated the akt phosphorylation from s100a8/a9-activated rage, eventually leading to an increase in apoptosis. |
2014-12-15 |
2023-08-13 |
human |
| Xiaoming Hou, Xing Chen, Ping Zhang, Youfei Fan, Aihua Ma, Tingting Pang, Zhao Song, Youpeng Jin, Wei Hao, Fengqin Liu, Wei Wang, Yulin Wan. Inhibition of hedgehog signaling by GANT58 induces apoptosis and shows synergistic antitumor activity with AKT inhibitor in acute T cell leukemia cells. Biochimie. vol 101. 2014-12-09. PMID:24394624. |
inhibition of hedgehog signaling by gant58 induces apoptosis and shows synergistic antitumor activity with akt inhibitor in acute t cell leukemia cells. |
2014-12-09 |
2023-08-12 |
Not clear |
| Ion Cristóbal, Rebeca Manso, Raúl Rincón, Cristina Caramés, Clara Senin, Aurea Borrero, Javier Martínez-Useros, María Rodriguez, Sandra Zazo, Oscar Aguilera, Juan Madoz-Gúrpide, Federico Rojo, Jesús García-Foncilla. PP2A inhibition is a common event in colorectal cancer and its restoration using FTY720 shows promising therapeutic potential. Molecular cancer therapeutics. vol 13. issue 4. 2014-12-09. PMID:24448818. |
moreover, we observed that its restoration using fty720 impairs proliferation and clonogenic potential of colorectal cancer cells, induces caspase-dependent apoptosis, and affects akt and extracellular signal-regulated kinase-1/2 activation status. |
2014-12-09 |
2023-08-12 |
Not clear |
| Lijuan Wang, Suxia Han, Guihua Jin, Xia Zhou, Meng Li, Xia Ying, Le Wang, Huili Wu, Qing Zh. Linc00963: a novel, long non-coding RNA involved in the transition of prostate cancer from androgen-dependence to androgen-independence. International journal of oncology. vol 44. issue 6. 2014-12-09. PMID:24691949. |
knockdown of linc00963 attenuated c4-2 cell proliferation, motility, invasion ability, the expression of egfr and phosphorylation levels of akt, and promoted cell apoptosis. |
2014-12-09 |
2023-08-13 |
Not clear |
| Ahmed Jashari, Faik Imeri, Lulzime Ballazhi, Agim Shabani, Bozhana Mikhova, Gerald Dräger, Emil Popovski, Andrea Huwile. Synthesis and cellular characterization of novel isoxazolo- and thiazolohydrazinylidene-chroman-2,4-diones on cancer and non-cancer cell growth and death. Bioorganic & medicinal chemistry. vol 22. issue 9. 2014-12-09. PMID:24721833. |
reduced cell viability was accompanied by increased apoptosis as shown by parp-1 cleavage and reduced activity of the survival protein kinase akt. |
2014-12-09 |
2023-08-13 |
Not clear |
| Adam Hafeez, Omar Elmadhoun, Changya Peng, Jamie Y Ding, Xiaokun Geng, Murali Guthikonda, Yuchuan Din. Reduced Apoptosis by Ethanol and Its Association with PKC-δ and Akt Signaling in Ischemic Stroke. Aging and disease. vol 5. issue 6. 2014-12-09. PMID:25489491. |
reduced apoptosis by ethanol and its association with pkc-δ and akt signaling in ischemic stroke. |
2014-12-09 |
2023-08-13 |
rat |
| Adam Hafeez, Omar Elmadhoun, Changya Peng, Jamie Y Ding, Xiaokun Geng, Murali Guthikonda, Yuchuan Din. Reduced Apoptosis by Ethanol and Its Association with PKC-δ and Akt Signaling in Ischemic Stroke. Aging and disease. vol 5. issue 6. 2014-12-09. PMID:25489491. |
in order to investigate this further, we assessed the hypothesis that ethanol's neuroprotective effect is through reduction of apoptosis and the modulation of the important apoptotic pkc-δ and akt signaling pathway. |
2014-12-09 |
2023-08-13 |
rat |
| Tadashi Watanabe, Shigeo Nakamura, Toshiya Ono, Sadaharu Ui, Syota Yagi, Hiroki Kagawa, Hisami Watanabe, Tomoyuki Ohe, Tadahiko Mashino, Masahiro Fujimur. Pyrrolidinium fullerene induces apoptosis by activation of procaspase-9 via suppression of Akt in primary effusion lymphoma. Biochemical and biophysical research communications. vol 451. issue 1. 2014-12-08. PMID:25063029. |
pyrrolidinium fullerene induces apoptosis by activation of procaspase-9 via suppression of akt in primary effusion lymphoma. |
2014-12-08 |
2023-08-13 |
Not clear |
| Tadashi Watanabe, Shigeo Nakamura, Toshiya Ono, Sadaharu Ui, Syota Yagi, Hiroki Kagawa, Hisami Watanabe, Tomoyuki Ohe, Tadahiko Mashino, Masahiro Fujimur. Pyrrolidinium fullerene induces apoptosis by activation of procaspase-9 via suppression of Akt in primary effusion lymphoma. Biochemical and biophysical research communications. vol 451. issue 1. 2014-12-08. PMID:25063029. |
our data therefore suggest that akt activation is essential for cell survival in pel and a pyrrolidinium fullerene derivative induced apoptosis by activating caspase-9 via suppression of akt in pel cells. |
2014-12-08 |
2023-08-13 |
Not clear |
| Susi Zara, Marianna De Colli, Monica Rapino, Valentina Di Valerio, Guya Diletta Marconi, Amelia Cataldi, Veronica Macchi, Raffaele De Caro, Andrea Porzionat. NF-κB involvement in hyperoxia-induced myocardial damage in newborn rat hearts. Histochemistry and cell biology. vol 140. issue 5. 2014-12-05. PMID:23568329. |
in conclusion, our findings suggest the involvement of the nf-κb pathway and akt signaling in the mechanisms of myocardial hyperoxic damage in the newborns, with particular reference to the induction of oxidative stress-related apoptosis. |
2014-12-05 |
2023-08-12 |
rat |
| Ioanna Andreadou, Emmanuel Mikros, Konstantinos Ioannidis, Fragiska Sigala, Katerina Naka, Sarantos Kostidis, Dimitrios Farmakis, Roxane Tenta, Nikolaos Kavantzas, Sofia-Iris Bibli, Evangelos Gikas, Leandros Skaltsounis, Dimitrios Th Kremastinos, Efstathios K Iliodromiti. Oleuropein prevents doxorubicin-induced cardiomyopathy interfering with signaling molecules and cardiomyocyte metabolism. Journal of molecular and cellular cardiology. vol 69. 2014-12-04. PMID:24486195. |
in the present study, we investigated the role of oleuropein in dxr-cm by addressing cardiac geometry and function (transthoracic echocardiography), cardiac histopathology, nitro-oxidative stress (mda, pcs, nt), inflammatory cytokines (il-6, big et-1), no homeostasis (inos and enos expressions), kinases involved in apoptosis and metabolism (akt, ampk) and myocardial metabonomics. |
2014-12-04 |
2023-08-12 |
rat |
| Ling-Qing Luo, Xiao Cheng, Yan Chen, Zhao-Lei Cui, Dong-Hong Li. [Effect of SU11248 on leukemia cell line K562 and its molecular mechanisms]. Zhongguo shi yan xue ye xue za zhi. vol 22. issue 4. 2014-12-04. PMID:25130811. |
it is concluded that su11248 can inhibit the growth of k562 cells efficiently through inducing apoptosis, its mechanism may be closely relate with the expression down-regulation of c-myc, htert, bcr-abl and the inhibition of akt phosphorylation. |
2014-12-04 |
2023-08-13 |
Not clear |
| Telmo A Mejía-García, Camila C Portugal, Thaísa G Encarnação, Marco Antônio M Prado, Roberto Paes-de-Carvalh. Nitric oxide regulates AKT phosphorylation and nuclear translocation in cultured retinal cells. Cellular signalling. vol 25. issue 12. 2014-12-03. PMID:23958999. |
previous studies have shown that nitric oxide (no) inhibits apoptosis of retinal neurons in culture through the canonical cyclic gmp/protein kinase g (pkg)-dependent pathway, but also involving multiple kinase pathways, such as phosphatidylinositol 3' kinase (pi3k) and akt. |
2014-12-03 |
2023-08-12 |
chicken |