| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bao-Zhu Yuan, Joshua Chapman, Min Ding, Junzhi Wang, Binghua Jiang, Yon Rojanasakul, Steven H Reynold. TRAIL and proteasome inhibitors combination induces a robust apoptosis in human malignant pleural mesothelioma cells through Mcl-1 and Akt protein cleavages. BMC cancer. vol 13. 2015-01-27. PMID:23517112. |
trail and proteasome inhibitors combination induces a robust apoptosis in human malignant pleural mesothelioma cells through mcl-1 and akt protein cleavages. |
2015-01-27 |
2023-08-12 |
human |
| Yunmin Lu, Meiying Zhu, Wei Chen, Li Yin, Jinshui Zhu, Niwei Chen, Weixiong Che. Oleanolic acid induces apoptosis of MKN28 cells via AKT and JNK signaling pathways. Pharmaceutical biology. vol 52. issue 6. 2015-01-26. PMID:24824325. |
oleanolic acid induces apoptosis of mkn28 cells via akt and jnk signaling pathways. |
2015-01-26 |
2023-08-13 |
Not clear |
| Xiping Liang, Qin Hu, Bo Li, Devin McBride, Hetao Bian, Pierre Spagnoli, Di Chen, Jiping Tang, John H Zhan. Follistatin-like 1 attenuates apoptosis via disco-interacting protein 2 homolog A/Akt pathway after middle cerebral artery occlusion in rats. Stroke. vol 45. issue 10. 2015-01-26. PMID:25139876. |
we hypothesized that recombinant fstl1 attenuates neuronal apoptosis through its receptor disco-interacting protein 2 homolog a (dip2a) and the akt pathway after middle cerebral artery occlusion (mcao) in rats. |
2015-01-26 |
2023-08-13 |
rat |
| Jingru Li, Yicheng Chen, Jiali Wan, Xin Liu, Chunrong Yu, Wenhua L. ABT-263 enhances sorafenib-induced apoptosis associated with Akt activity and the expression of Bax and p21((CIP1/WAF1)) in human cancer cells. British journal of pharmacology. vol 171. issue 13. 2015-01-20. PMID:24571452. |
abt-263 enhances sorafenib-induced apoptosis associated with akt activity and the expression of bax and p21((cip1/waf1)) in human cancer cells. |
2015-01-20 |
2023-08-12 |
human |
| Birgit Bölck, Marwa Ibrahim, Dirk Steinritz, Christian Morguet, Sandra Dühr, Frank Suhr, Juxian Lu-Hesselmann, Wilhelm Bloc. Detection of key enzymes, free radical reaction products and activated signaling molecules as biomarkers of cell damage induced by benzo[a]pyrene in human keratinocytes. Toxicology in vitro : an international journal published in association with BIBRA. vol 28. issue 5. 2015-01-20. PMID:24685774. |
apoptosis, akt, mapk, nos, nitrotyrosine and 8-isoprostane formation), detection of nitrosative stress using diaminofluorescein (daf-fm) and oxidative stress using 3' -(p-aminophenyl)fluorescein (apf). |
2015-01-20 |
2023-08-12 |
human |
| Kumar Nikhil, Shruti Sharan, Ajanta Chakraborty, Partha Ro. Pterostilbene-isothiocyanate conjugate suppresses growth of prostate cancer cells irrespective of androgen receptor status. PloS one. vol 9. issue 4. 2015-01-20. PMID:24699278. |
while the inhibitor of akt (a6730) or akt-specific small interference rna (sirna) greatly sensitized pc-3 cells to conjugate-induced apoptosis, on the contrary, apoptosis was accelerated by inhibition of erk (by pd98059 or erk sirna) in case of lncap cells, both ultimately culminating in the expression of cleaved caspase-3 protein. |
2015-01-20 |
2023-08-13 |
Not clear |
| Kumar Nikhil, Shruti Sharan, Ajanta Chakraborty, Partha Ro. Pterostilbene-isothiocyanate conjugate suppresses growth of prostate cancer cells irrespective of androgen receptor status. PloS one. vol 9. issue 4. 2015-01-20. PMID:24699278. |
all these data suggests that conjugate-induced inhibition of cell proliferation and induction of apoptosis are partly mediated by the down regulation of ar, akt, and erk signaling. |
2015-01-20 |
2023-08-13 |
Not clear |
| Honey Modi, Marion Cornu, Bernard Thoren. Glutamine stimulates biosynthesis and secretion of insulin-like growth factor 2 (IGF2), an autocrine regulator of beta cell mass and function. The Journal of biological chemistry. vol 289. issue 46. 2015-01-20. PMID:25271169. |
finally, exposure of insulinomas or beta cells to glutamine induced akt phosphorylation, an effect that was dependent on igf2 secretion, and reduced cytokine-induced apoptosis. |
2015-01-20 |
2023-08-13 |
Not clear |
| Zhihao Liu, Huiling Liu, Jie Jiang, Siwei Tan, Yidong Yang, Yashi Zhan, Bin W. PDGF-BB and bFGF ameliorate radiation-induced intestinal progenitor/stem cell apoptosis via Akt/p53 signaling in mice. American journal of physiology. Gastrointestinal and liver physiology. vol 307. issue 11. 2015-01-20. PMID:25301184. |
treatment with platelet-derived growth factor (pdgf-bb) or bfgf activated akt phosphorylation in the intestinal crypt, lessened intestinal crypt p53 expression, decreased radiation-induced apoptosis in mouse intestinal progenitor/stem cell marker leucine-rich repeat-containing g protein-coupled receptor 5 (lgr5)-positive cells by an average of 50%, and increased the survival rate of mice with abdominal radiation by 3 days in average. |
2015-01-20 |
2023-08-13 |
mouse |
| Zhihao Liu, Huiling Liu, Jie Jiang, Siwei Tan, Yidong Yang, Yashi Zhan, Bin W. PDGF-BB and bFGF ameliorate radiation-induced intestinal progenitor/stem cell apoptosis via Akt/p53 signaling in mice. American journal of physiology. Gastrointestinal and liver physiology. vol 307. issue 11. 2015-01-20. PMID:25301184. |
consistently, pdgf-bb and bfgf both upregulated akt activation, suppressed radiation-induced p53 expression, and abrogated radiation-induced apoptosis in iec-6 cells, although p53 overexpression in iec-6 cells partially counteracted the radioprotection of pdgf-bb and bfgf. |
2015-01-20 |
2023-08-13 |
mouse |
| William Beau Mitchell, Mariana P Pinheiro, Nayla Boulad, David Kaplan, Michele N Edison, Bethan Psaila, Marissa Karpoff, Michael J White, Emma C Josefsson, Benjamin T Kile, James B Busse. Effect of thrombopoietin receptor agonists on the apoptotic profile of platelets in patients with chronic immune thrombocytopenia. American journal of hematology. vol 89. issue 12. 2015-01-16. PMID:25132654. |
platelet survival depends upon mediators of apoptosis e.g., bcl-xl, bax, and bak, which are regulated by thrombopoietin (tpo)-mediated akt signaling. |
2015-01-16 |
2023-08-13 |
Not clear |
| William Beau Mitchell, Mariana P Pinheiro, Nayla Boulad, David Kaplan, Michele N Edison, Bethan Psaila, Marissa Karpoff, Michael J White, Emma C Josefsson, Benjamin T Kile, James B Busse. Effect of thrombopoietin receptor agonists on the apoptotic profile of platelets in patients with chronic immune thrombocytopenia. American journal of hematology. vol 89. issue 12. 2015-01-16. PMID:25132654. |
platelet survival may be enhanced by tpo-r-agonists as a transient decrease in platelet sensitivity to apoptosis was accompanied by transient activation of akt. |
2015-01-16 |
2023-08-13 |
Not clear |
| Madhumita Chatterjee, Oliver Borst, Britta Walker, Anna Fotinos, Sebastian Vogel, Peter Seizer, Andreas Mack, Setareh Alampour-Rajabi, Dominik Rath, Tobias Geisler, Florian Lang, Harald F Langer, Jürgen Bernhagen, Meinrad Gawa. Macrophage migration inhibitory factor limits activation-induced apoptosis of platelets via CXCR7-dependent Akt signaling. Circulation research. vol 115. issue 11. 2015-01-16. PMID:25266363. |
macrophage migration inhibitory factor limits activation-induced apoptosis of platelets via cxcr7-dependent akt signaling. |
2015-01-16 |
2023-08-13 |
Not clear |
| Kun-Chieh Chen, Tsung-Ying Yang, Chun-Chi Wu, Chi-Chih Cheng, Shih-Lan Hsu, Hsiao-Wen Hung, Jian-Wei Chen, Gee-Chen Chan. Pemetrexed induces S-phase arrest and apoptosis via a deregulated activation of Akt signaling pathway. PloS one. vol 9. issue 5. 2015-01-15. PMID:24847863. |
pemetrexed induces s-phase arrest and apoptosis via a deregulated activation of akt signaling pathway. |
2015-01-15 |
2023-08-13 |
Not clear |
| Kun-Chieh Chen, Tsung-Ying Yang, Chun-Chi Wu, Chi-Chih Cheng, Shih-Lan Hsu, Hsiao-Wen Hung, Jian-Wei Chen, Gee-Chen Chan. Pemetrexed induces S-phase arrest and apoptosis via a deregulated activation of Akt signaling pathway. PloS one. vol 9. issue 5. 2015-01-15. PMID:24847863. |
this study showed that stimulation with pemetrexed induced s-phase arrest and cell apoptosis and a parallel increase in sustained akt phosphorylation and nuclear accumulation in the nsclc a549 cell line. |
2015-01-15 |
2023-08-13 |
Not clear |
| Kun-Chieh Chen, Tsung-Ying Yang, Chun-Chi Wu, Chi-Chih Cheng, Shih-Lan Hsu, Hsiao-Wen Hung, Jian-Wei Chen, Gee-Chen Chan. Pemetrexed induces S-phase arrest and apoptosis via a deregulated activation of Akt signaling pathway. PloS one. vol 9. issue 5. 2015-01-15. PMID:24847863. |
inhibition of akt expression by akt specific sirna blocked s-phase arrest and protected cells from apoptosis, indicating an unexpected proapoptotic role of akt in the pemetrexed-mediated toxicity. |
2015-01-15 |
2023-08-13 |
Not clear |
| Kun-Chieh Chen, Tsung-Ying Yang, Chun-Chi Wu, Chi-Chih Cheng, Shih-Lan Hsu, Hsiao-Wen Hung, Jian-Wei Chen, Gee-Chen Chan. Pemetrexed induces S-phase arrest and apoptosis via a deregulated activation of Akt signaling pathway. PloS one. vol 9. issue 5. 2015-01-15. PMID:24847863. |
treatment of a549 cells with pharmacological inhibitors of phosphatidylinositol 3-kinase (pi3k), wortmannin and ly294002, similarly inhibited pemetrexed-induced s-phase arrest and apoptosis and akt phosphorylation, indicating that pi3k is an upstream mediator of akt and is involved in pemetrexed-mediated cell death. |
2015-01-15 |
2023-08-13 |
Not clear |
| Geping Qu, Changting Liu, Baojun Sun, Changxi Zhou, Zhijian Zhang, Peng Wan. Combination of BIBW2992 and ARQ 197 is effective against erlotinib-resistant human lung cancer cells with the EGFR T790M mutation. Oncology reports. vol 32. issue 1. 2015-01-14. PMID:24842595. |
the bibw2992/arq 197 combination significantly inhibited growth, induced cell cycle arrest and apoptosis, and altered the phosphorylation of egfr, met, akt and erk1/2 in the h1975 cells. |
2015-01-14 |
2023-08-13 |
human |
| Kaijie Wu, Zhongyun Ning, Jiancheng Zhou, Bin Wang, Jinhai Fan, Jianning Zhu, Yang Gao, Xinyang Wang, Jer-Tsong Hsieh, Dalin H. 2'-hydroxyflavanone inhibits prostate tumor growth through inactivation of AKT/STAT3 signaling and induction of cell apoptosis. Oncology reports. vol 32. issue 1. 2015-01-14. PMID:24859932. |
mechanistically, besides its known inhibitory effects on aldo‑keto reductase activity and de novo androgen synthesis, 2hf also markedly suppressed akt phosphorylation, signal transducer and activator of transcription-3 (stat3) phosphorylation and transactivation subsequently regulating the expression of members of the bcl-2 family (i.e., mcl-1, bcl-2 and bax) and modulating caspase-mediated cell apoptosis. |
2015-01-14 |
2023-08-13 |
Not clear |
| Asli Ozmen, Gozde Unek, Dijle Kipmen-Korgun, Emin Turkay Korgu. The PI3K/Akt and MAPK-ERK1/2 pathways are altered in STZ induced diabetic rat placentas. Histology and histopathology. vol 29. issue 6. 2015-01-13. PMID:24346807. |
moreover, it is still not determined how akt and erk1/2 proteins related proliferation and apoptosis mechanisms are influenced by streptozotocin (stz) induced diabetic rat placental development. |
2015-01-13 |
2023-08-12 |
rat |