| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| X Y Chen, G M Li, Q Dong, H Pen. MiR-577 inhibits pancreatic β-cell function and survival by targeting fibroblast growth factor 21 (FGF-21) in pediatric diabetes. Genetics and molecular research : GMR. vol 14. issue 4. 2016-09-19. PMID:26634512. |
we demonstrated that, although fgf-21 does not acutely stimulate insulin secretion in isolated islets from normal rats, it increases insulin secretion and insulin content in diabetic islets and protects β-cells from apoptosis via the activation of extracellular signal-regulated kinase 1/2 and akt signaling pathways. |
2016-09-19 |
2023-08-13 |
rat |
| Kimio Yonesaka, Keita Kudo, Satomi Nishida, Takayuki Takahama, Tsutomu Iwasa, Takeshi Yoshida, Kaoru Tanaka, Masayuki Takeda, Hiroyasu Kaneda, Isamu Okamoto, Kazuto Nishio, Kazuhiko Nakagaw. The pan-HER family tyrosine kinase inhibitor afatinib overcomes HER3 ligand heregulin-mediated resistance to EGFR inhibitors in non-small cell lung cancer. Oncotarget. vol 6. issue 32. 2016-09-16. PMID:26418897. |
afatinib, unlike erlotinib, inhibited akt activation, resulting in elevated apoptosis in pc9hrg cells. |
2016-09-16 |
2023-08-13 |
mouse |
| Yu-Lu Dai, Su-Ling Huang, Ying Len. AICAR and Metformin Exert AMPK-dependent Effects on INS-1E Pancreatic β-cell Apoptosis via Differential Downstream Mechanisms. International journal of biological sciences. vol 11. issue 11. 2016-09-16. PMID:26435693. |
both aicar and metformin protected ins-1e cells from palmitate-induced apoptosis, as reflected by decreases in both cleaved caspase 3 protein expression and caspase 3/7 activity, and these protective effects were abrogated by ampk inhibitor compound c. the protective action of aicar was probably mediated by the suppression of triacylglycerol accumulation, increase in akt phosphorylation and decrease in p38 mapk phosphorylation, while metformin might exert its protective effect on ins-1e cells by decreases in both jnk and p38 mapk phosphorylation. |
2016-09-16 |
2023-08-13 |
rat |
| Canan Eroğlu, Mücahit Seçme, Pelin Atmaca, Oğuzhan Kaygusuz, Kutret Gezer, Gülseren Bağcı, Yavuz Dodurg. Extract of Calvatia gigantea inhibits proliferation of A549 human lung cancer cells. Cytotechnology. vol 68. issue 5. 2016-09-16. PMID:26820971. |
c. gigantea extract induced cell cycle arrest and apoptosis by decreasing the ccnd1, ccnd2, cdk4, akt and bcl-2 expression and by increasing bax, p53, caspase-3 and caspase-9 expression in a549 cells. |
2016-09-16 |
2023-08-13 |
human |
| Jie Jian, Feifei Xuan, Feizhang Qin, Renbin Huan. Bauhinia championii flavone inhibits apoptosis and autophagy via the PI3K/Akt pathway in myocardial ischemia/reperfusion injury in rats. Drug design, development and therapy. vol 9. 2016-09-15. PMID:26604691. |
furthermore, bcf inhibited apoptosis, downregulated caspase-3, beclin1, and microtubule-associated protein 1 light chain 3-ii, upregulated pi3k, and increased the protein levels of phosphorylated akt and endothelial nitric oxide synthase. |
2016-09-15 |
2023-08-13 |
rat |
| Sonia Aroui, Lucie Dardevet, Wafa Ben Ajmia, Madryssa de Boisvilliers, Florian Perrin, Amel Laajimi, Ahcène Boumendjel, Abderraouf Kenani, Jean Marc Muller, Michel De Waar. A Novel Platinum-Maurocalcine Conjugate Induces Apoptosis of Human Glioblastoma Cells by Acting through the ROS-ERK/AKT-p53 Pathway. Molecular pharmaceutics. vol 12. issue 12. 2016-09-14. PMID:26465677. |
decreased phosphorylated akt and erk levels were associated with the apoptosis induced by the novel synthesized cisplatin analogue. |
2016-09-14 |
2023-08-13 |
human |
| Yu Zhang, Suning Huang, Yuhua Leng, Xin Chen, Tiantian Liu, Hanlin Wang, Fanglin Wei, Dianzhong Luo, Gang Chen, Zhuxin We. Effect of DcR3-specific siRNA on cell growth suppression and apoptosis induction in glioma cells via affecting ERK and AKT. OncoTargets and therapy. vol 9. 2016-09-13. PMID:27621648. |
effect of dcr3-specific sirna on cell growth suppression and apoptosis induction in glioma cells via affecting erk and akt. |
2016-09-13 |
2023-08-13 |
Not clear |
| Eric Haines, Sabrina Schlienger, Audrey Clain. The small GTPase ADP-Ribosylation Factor 1 mediates the sensitivity of triple negative breast cancer cells to EGFR tyrosine kinase inhibitors. Cancer biology & therapy. vol 16. issue 10. 2016-09-12. PMID:26176330. |
this may be explained by the observation that the depletion of arf1 suppressed gefitinib-mediated activation of key mediators of survival such as erk1/2, akt and src, while enhancing cascades leading to apoptosis such as the p38mapk and jnk pathways, modifying the bax/bcl2 ratio and cytochrome c release. |
2016-09-12 |
2023-08-13 |
Not clear |
| Satoru Morishita, Keiko Tomita, Tomoji Ono, Michiaki Murakoshi, Kenji Saito, Keikichi Sugiyama, Hoyoku Nishino, Hisanori Kat. Lactoferrin attenuates fatty acid-induced lipotoxicity via Akt signaling in hepatocarcinoma cells. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 93. issue 6. 2016-09-12. PMID:26335364. |
we also found that lf added to fam-treated cells induced akt phosphorylation, which contributed to inhibition of jnk signaling pathway-dependent apoptosis. |
2016-09-12 |
2023-08-13 |
human |
| Monika Paul-Samojedny, Adam Pudełko, Małgorzata Kowalczyk, Anna Fila-Daniłow, Renata Suchanek-Raif, Paulina Borkowska, Jan Kowalsk. Knockdown of AKT3 and PI3KCA by RNA interference changes the expression of the genes that are related to apoptosis and autophagy in T98G glioblastoma multiforme cells. Pharmacological reports : PR. vol 67. issue 6. 2016-09-12. PMID:26481529. |
akt is involved in various aspects of cancer cell biology such as cell survival, in addition to both apoptosis and autophagy. |
2016-09-12 |
2023-08-13 |
human |
| Neha Rai, Munna Sarkar, Sanghamitra Rah. Piroxicam, a traditional non-steroidal anti-inflammatory drug (NSAID) causes apoptosis by ROS mediated Akt activation. Pharmacological reports : PR. vol 67. issue 6. 2016-09-12. PMID:26481545. |
piroxicam, a traditional non-steroidal anti-inflammatory drug (nsaid) causes apoptosis by ros mediated akt activation. |
2016-09-12 |
2023-08-13 |
Not clear |
| Ya-Qin Hou, Yao Yao, Yong-Li Bao, Zhen-Bo Song, Cheng Yang, Xiu-Li Gao, Wen-Jing Zhang, Lu-Guo Sun, Chun-Lei Yu, Yan-Xin Huang, Guan-Nan Wang, Yu-Xin L. Juglanthraquinone C Induces Intracellular ROS Increase and Apoptosis by Activating the Akt/Foxo Signal Pathway in HCC Cells. Oxidative medicine and cellular longevity. vol 2016. 2016-09-08. PMID:26682007. |
consistent with the previous results, the data indicated that jc could induce apoptosis and hyperactivated akt. |
2016-09-08 |
2023-08-13 |
Not clear |
| Ya-Qin Hou, Yao Yao, Yong-Li Bao, Zhen-Bo Song, Cheng Yang, Xiu-Li Gao, Wen-Jing Zhang, Lu-Guo Sun, Chun-Lei Yu, Yan-Xin Huang, Guan-Nan Wang, Yu-Xin L. Juglanthraquinone C Induces Intracellular ROS Increase and Apoptosis by Activating the Akt/Foxo Signal Pathway in HCC Cells. Oxidative medicine and cellular longevity. vol 2016. 2016-09-08. PMID:26682007. |
furthermore, an obvious inhibitory effect on jc-induced apoptosis was observed when the akt levels were decreased, while the overexpression of constitutively active mutant akt greatly accelerated jc-induced apoptosis. |
2016-09-08 |
2023-08-13 |
Not clear |
| Ignazio Barbagallo, Rosalba Parenti, Agata Zappalà, Luca Vanella, Daniele Tibullo, Francesco Pepe, Toniangelo Onni, Giovanni Li Volt. Combined inhibition of Hsp90 and heme oxygenase-1 induces apoptosis and endoplasmic reticulum stress in melanoma. Acta histochemica. vol 117. issue 8. 2016-09-07. PMID:26493719. |
the inhibitors combination exhibited higher er stress, apoptosis as evidenced by bifunctional apoptosis regulator (bfar) mrna expression and lower phosphorylation of akt when compared to nms e973 alone. |
2016-09-07 |
2023-08-13 |
Not clear |
| Bin Xia, Heyu Liu, Juanke Xie, Rui Wu, Yali L. Akt enhances nerve growth factor-induced axon growth via activating the Nrf2/ARE pathway. International journal of molecular medicine. vol 36. issue 5. 2016-09-06. PMID:26324295. |
the results showed that akt overexpression significantly increased cell proliferation and decreased cell apoptosis. |
2016-09-06 |
2023-08-13 |
Not clear |
| Wanjing Zou, Shu Yang, Tie Zhang, Haimei Sun, Yuying Wang, Hong Xue, Deshan Zho. Hypoxia enhances glucocorticoid-induced apoptosis and cell cycle arrest via the PI3K/Akt signaling pathway in osteoblastic cells. Journal of bone and mineral metabolism. vol 33. issue 6. 2016-09-05. PMID:25230819. |
moreover, overexpression of akt abrogated the mpsl activation of p53, p21, and cleaved caspase 3 and the attenuation of cyclin d1 expression and rescued osteoblasts from mpsl-induced cell cycle arrest and apoptosis, indicating that phosphatidylinositol 3-kinase (pi3k)/akt signaling might play an essential role in mpsl-induced inhibition of osteoblasts. |
2016-09-05 |
2023-08-13 |
Not clear |
| Gabriela Hollmann, Rafael Linden, Angela Giangrande, Silvana Allod. Increased p53 and decreased p21 accompany apoptosis induced by ultraviolet radiation in the nervous system of a crustacean. Aquatic toxicology (Amsterdam, Netherlands). vol 173. 2016-09-02. PMID:26807499. |
after the fifth day of exposure, uvb radiation and sim increased the protein content of p53, increasing the content of akt and, somehow, blocking p21, increasing the content of activated caspase-3, which led the cells to apoptosis. |
2016-09-02 |
2023-08-13 |
Not clear |
| Byoungduck Park, Young-Tae Je, Kwang-Hoon Chu. Akt is translocated to the mitochondria during etoposide-induced apoptosis of HeLa cells. Molecular medicine reports. vol 12. issue 5. 2016-08-29. PMID:26458825. |
akt is translocated to the mitochondria during etoposide-induced apoptosis of hela cells. |
2016-08-29 |
2023-08-13 |
Not clear |
| Byoungduck Park, Young-Tae Je, Kwang-Hoon Chu. Akt is translocated to the mitochondria during etoposide-induced apoptosis of HeLa cells. Molecular medicine reports. vol 12. issue 5. 2016-08-29. PMID:26458825. |
during etoposide‑induced apoptosis of hela cells, akt enhances the interaction of second mitochondria‑derived activator of caspases/direct iap binding protein with low pi (smac/diablo) and x‑linked inhibitor of apoptosis protein by phosphorylating smac at serine 67, and thus promotes apoptosis. |
2016-08-29 |
2023-08-13 |
Not clear |
| Byoungduck Park, Young-Tae Je, Kwang-Hoon Chu. Akt is translocated to the mitochondria during etoposide-induced apoptosis of HeLa cells. Molecular medicine reports. vol 12. issue 5. 2016-08-29. PMID:26458825. |
however, the detailed mechanisms underlying akt regulation in etoposide‑mediated apoptosis remain to be determined. |
2016-08-29 |
2023-08-13 |
Not clear |