| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zengjun Li, Haipeng Wang, Zhongfa Xu, Yanlai Sun, Jianjun Ha. Expression and mechanism of microRNA-181A on incidence and survival in late liver metastases of colorectal cancer. Oncology reports. vol 35. issue 3. 2016-10-28. PMID:26750720. |
upregulation of mir-181a promoted cell viability and inhibited apoptosis of sw620 cells, suppressed pten expression and activated phosphorylation of akt (p-akt) in sw620 cells. |
2016-10-28 |
2023-08-13 |
Not clear |
| Qi Ren, Sheng You Y. CD2-associated protein participates in podocyte apoptosis via PI3K/Akt signaling pathway. Journal of receptor and signal transduction research. vol 36. issue 3. 2016-10-24. PMID:26584949. |
pan reduces akt phosphorylation levels of gsk3β, ly294002 can promote podocyte apoptosis induced by pan. |
2016-10-24 |
2023-08-13 |
Not clear |
| Yang Zhang, Zhen Fu, Zibiao Zhong, Ren Wang, Long Hu, Yan Xiong, Yanfeng Wang, Qifa Y. Hypothermic Machine Perfusion Decreases Renal Cell Apoptosis During Ischemia/Reperfusion Injury via the Ezrin/AKT Pathway. Artificial organs. vol 40. issue 2. 2016-10-21. PMID:26263023. |
tunel staining was performed on paraffin sections to detect apoptosis, and the expressions of cleaved caspase-3, ezrin, akt, and p-akt in frozen kidney tissues were detected by western blotting. |
2016-10-21 |
2023-08-13 |
Not clear |
| Yu Li, Yu-bing Dai, Jie-yun Sun, Yue Xiang, Jun Yang, Song-yang Dai, Xiong Zhan. Neuroglobin Attenuates Beta Amyloid-Induced Apoptosis Through Inhibiting Caspases Activity by Activating PI3K/Akt Signaling Pathway. Journal of molecular neuroscience : MN. vol 58. issue 1. 2016-10-20. PMID:26346601. |
in pappswe transfected sh-sy5y cells, ngb not only decreased the generation of aβ42, but also attenuated mitochondrial dysfunction and apoptosis through suppressing the activation of caspase-3, caspase-9 by akt activating phosphorylation, which were restrained by phosphatidylinositol 3-kinase inhibitor (ly294002). |
2016-10-20 |
2023-08-13 |
mouse |
| Peri S Aytaç, Irem Durmaz, Douglas R Houston, Rengül Çetin-Atalay, Birsen Tozkopara. Novel triazolothiadiazines act as potent anticancer agents in liver cancer cells through Akt and ASK-1 proteins. Bioorganic & medicinal chemistry. vol 24. issue 4. 2016-10-20. PMID:26810835. |
these molecules triggered oxidative stress induced apoptosis through ask-1 protein activation and akt protein inhibition as demonstrated by downstream targets such as gsk3β, β-catenin and cyclin d1. |
2016-10-20 |
2023-08-13 |
Not clear |
| Alessandra Pistilli, Mario Rende, Lucia Crispoltoni, Claudia Montagnoli, Anna Maria Stabil. LY294002 induces in vitro apoptosis and overexpression of p75NTR in human uterine leiomyosarcoma HTB 114 cells. Growth factors (Chur, Switzerland). vol 33. issue 5-6. 2016-10-19. PMID:26653825. |
in the present study, htb114 cells were exposed to the phosphoinositide 3-kinase (pi3k) inhibitor ly294002 with and without β-ngf: apoptosis, cell cycle, activation of caspase-3 and protein kinase b (akt) and trka/p75ntr phenotypic expression were evaluated. |
2016-10-19 |
2023-08-13 |
human |
| Chuping Zheng, Yanan Liu, Ying Liu, Xiuying Qin, Yanhui Zhou, Jie Li. Dinuclear ruthenium complexes display loop isomer selectivity to c-MYC DNA G-quadriplex and exhibit anti-tumour activity. Journal of inorganic biochemistry. vol 156. 2016-10-19. PMID:26775282. |
the mechanism studies revealed that complexes can induce apoptosis in hepg2 cells by generating ros metabolites, triggering mitochondrial membrane potential loss and down-regulation of p-akt (akt also known as protein kinase b), p-p44/42 map kinase protein (p-p44/42), and c-myc. |
2016-10-19 |
2023-08-13 |
Not clear |
| Abu Syed Md Anisuzzaman, Abedul Haque, Mohammad Aminur Rahman, Dongsheng Wang, James R Fuchs, Selwyn Hurwitz, Yuan Liu, Gabriel Sica, Fadlo R Khuri, Zhuo Georgia Chen, Dong M Shin, A R M Ruhul Ami. Preclinical In Vitro, In Vivo, and Pharmacokinetic Evaluations of FLLL12 for the Prevention and Treatment of Head and Neck Cancers. Cancer prevention research (Philadelphia, Pa.). vol 9. issue 1. 2016-10-18. PMID:26511491. |
overexpression of constitutively active akt or bcl-2 or ablation of bim or bid significantly inhibited flll12-induced apoptosis. |
2016-10-18 |
2023-08-13 |
Not clear |
| Abu Syed Md Anisuzzaman, Abedul Haque, Mohammad Aminur Rahman, Dongsheng Wang, James R Fuchs, Selwyn Hurwitz, Yuan Liu, Gabriel Sica, Fadlo R Khuri, Zhuo Georgia Chen, Dong M Shin, A R M Ruhul Ami. Preclinical In Vitro, In Vivo, and Pharmacokinetic Evaluations of FLLL12 for the Prevention and Treatment of Head and Neck Cancers. Cancer prevention research (Philadelphia, Pa.). vol 9. issue 1. 2016-10-18. PMID:26511491. |
taken together, our results strongly suggest that flll12 is a potent curcumin analogue with more favorable pharmacokinetic properties that induces apoptosis of head and neck cancer cell lines by inhibition of survival proteins including egfr, akt, and bcl-2 and increasing of the proapoptotic protein bim. |
2016-10-18 |
2023-08-13 |
Not clear |
| Gao-Xiang Zhao, Li-Hui Xu, Hao Pan, Qiu-Ru Lin, Mei-Yun Huang, Ji-Ye Cai, Dong-Yun Ouyang, Xian-Hui H. The BH3-mimetic gossypol and noncytotoxic doses of valproic acid induce apoptosis by suppressing cyclin-A2/Akt/FOXO3a signaling. Oncotarget. vol 6. issue 36. 2016-10-18. PMID:26517515. |
furthermore, blocking proteasome activity by mg132 prevented the downregulation of cyclin a2, dephosphorylation of akt and foxo3a, and induction of apoptosis in cells co-treated with gos and vpa. |
2016-10-18 |
2023-08-13 |
mouse |
| Chang-Chi Lai, Po-Hsung Huang, An-Han Yang, Shu-Chiung Chiang, Chia-Yu Tang, Kuo-Wei Tseng, Cheng-Hsiung Huan. Baicalein, a Component of Scutellaria baicalensis, Attenuates Kidney Injury Induced by Myocardial Ischemia and Reperfusion. Planta medica. vol 82. issue 3. 2016-10-18. PMID:26550790. |
the underlying mechanisms might be related to the inhibition of apoptosis, possibly through the reduction of tumor necrosis factor-α production, the modulation of bcl-2 and bax, and the activation of akt and extracellular signal-regulated kinases 1 and 2. |
2016-10-18 |
2023-08-13 |
rat |
| Shaun Rosebeck, Mattina M Alonge, Malathi Kandarpa, Anoop Mayampurath, Samuel L Volchenboum, Jagoda Jasielec, Dominik Dytfeld, Sean P Maxwell, Stephanie J Kraftson, Dilara McCauley, Sharon Shacham, Michael Kauffman, Andrzej J Jakubowia. Synergistic Myeloma Cell Death via Novel Intracellular Activation of Caspase-10-Dependent Apoptosis by Carfilzomib and Selinexor. Molecular cancer therapeutics. vol 15. issue 1. 2016-10-18. PMID:26637366. |
investigating the details of sine/pi-induced cell death revealed (i) reduced bcl-2 expression and cleavage and inactivation of akt, two prosurvival regulators of apoptosis and autophagy; (ii) intracellular membrane-associated aggregation of active caspases, which depended on caspase-10 protease activity; and (iii) novel association of caspase-10 and autophagy-associated proteins p62 and lc3 ii, which may prime activation of the caspase cascade. |
2016-10-18 |
2023-08-13 |
mouse |
| Shishir Shishodia, Nkem Azu, Jason A Rosenzweig, Desiree A Jackso. Guggulsterone for Chemoprevention of Cancer. Current pharmaceutical design. vol 22. issue 3. 2016-10-14. PMID:26561056. |
guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (iap1, xiap, bfl-1/a1, bcl-2, cflip, and survivin), modulation of cell cycle proteins (cyclin d1 and c-myc), activation of caspases, inhibition of akt, and activation of jnk. |
2016-10-14 |
2023-08-13 |
Not clear |
| Yuchang Lin, Dezhi Xu, Xiaohong Li, Chun Liu, Xia Liu, Shen Huang, Yuwei Huang, Xiaojuan Li. Upregulation of Interferon Regulatory Factor 6 Promotes Neuronal Apoptosis After Traumatic Brain Injury in Adult Rats. Cellular and molecular neurobiology. vol 36. issue 1. 2016-10-07. PMID:26077898. |
we conclude that irf6 might promote neuronal apoptosis by inhibiting akt phosphorylation after tbi. |
2016-10-07 |
2023-08-13 |
rat |
| Alexandra Vétillard, Barbara Jonchère, Marie Moreau, Bertrand Toutain, Cécile Henry, Simon Fontanel, Anne-Charlotte Bernard, Mario Campone, Catherine Guette, Olivier Coquere. Akt inhibition improves irinotecan treatment and prevents cell emergence by switching the senescence response to apoptosis. Oncotarget. vol 6. issue 41. 2016-10-06. PMID:26485768. |
akt inhibition improves irinotecan treatment and prevents cell emergence by switching the senescence response to apoptosis. |
2016-10-06 |
2023-08-13 |
Not clear |
| Qing Yang, Ren-Wen Zhang, Peng-Cheng Sui, Hai-Tao He, Lei Din. Dysregulation of non-coding RNAs in gastric cancer. World journal of gastroenterology. vol 21. issue 39. 2016-10-05. PMID:26494954. |
we summarize instances of aberrant expression of the ncrnas in gc and their effect on survival-related events, including cell cycle regulation, akt signaling, apoptosis and drug resistance. |
2016-10-05 |
2023-08-13 |
Not clear |
| Hun Seok Lee, Juthika Kundu, Ryong Nam Kim, Young Kee Shi. Transducer of ERBB2.1 (TOB1) as a Tumor Suppressor: A Mechanistic Perspective. International journal of molecular sciences. vol 16. issue 12. 2016-10-05. PMID:26694352. |
tob1 antagonizes the v-akt murine thymoma viral oncogene (akt) signaling and induces cancer cell apoptosis by activating bcl2-associated x (bax) protein and inhibiting the bcl-2 and bcl-xl expressions. |
2016-10-05 |
2023-08-13 |
mouse |
| Ki-Jong Rhee, Jong In Lee, Young Woo Eo. Mesenchymal Stem Cell-Mediated Effects of Tumor Support or Suppression. International journal of molecular sciences. vol 16. issue 12. 2016-10-05. PMID:26694366. |
in contrast to the tumor-promoting properties, mscs inhibit tumor growth by increasing inflammatory infiltration, inhibiting angiogenesis, suppressing wnt signaling and akt signaling, and inducing cell cycle arrest and apoptosis. |
2016-10-05 |
2023-08-13 |
Not clear |
| Y-C Zhang, W-Q Du, R-Y Zhang, J-N Zheng, D-S Pe. Jade-1: its structure, regulation and functions in the renal cancer. Current molecular medicine. vol 16. issue 1. 2016-10-05. PMID:26695694. |
numerous downstream effectors, including β-catenin, akt, p21, and bcl-2, are well modulated by jade-1, which mainly regulates cell proliferation and apoptosis. |
2016-10-05 |
2023-08-13 |
Not clear |
| Chao-Huei Yang, Chiung-Fang Tsao, Wang-Sheng Ko, Ya-Ling Chio. The Oligo Fucoidan Inhibits Platelet-Derived Growth Factor-Stimulated Proliferation of Airway Smooth Muscle Cells. Marine drugs. vol 14. issue 1. 2016-10-05. PMID:26761017. |
platelet-derived growth factor (pdgf)-treated primary asmcs were cultured with or without oligo-fucoidan (100, 500, or 1000 µg/ml) to evaluate its effects on cell proliferation, cell cycle, apoptosis, and akt, erk1/2 signaling pathway. |
2016-10-05 |
2023-08-13 |
human |