| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhuopeng Jia, Arui Dong, Hongmin Che, Yu Zhan. 17-DMAG Protects Against Hypoxia-/Reoxygenation-Induced Cell Injury in HT22 Cells Through Akt/Nrf2/HO-1 Pathway. DNA and cell biology. vol 36. issue 2. 2017-01-31. PMID:27982695. |
however, the akt inhibitor, ly294002, partially hampered the effects of 17-dmag on the expression of p-akt, nuclear nrf2, and ho-1 and cell viability, as well as cell apoptosis induced by h/r in ht22 cells. |
2017-01-31 |
2023-08-13 |
Not clear |
| Jongsung Lee, See-Hyoung Par. Tumor-suppressive activity of 1,25-dihydroxyvitamin D3 against kidney cancer cells via up-regulation of FOXO3. Bioscience, biotechnology, and biochemistry. vol 80. issue 10. 2017-01-30. PMID:27181027. |
moreover, 1,25-dihydroxyvitamin d3 down-regulated the phosphorylated akt and erk which might lead to apoptosis through activation of foxo3 in achn cells. |
2017-01-30 |
2023-08-13 |
human |
| Shaopeng Wang, Xiance Sun, Liping Jiang, Xiaofang Liu, Min Chen, Xiaofeng Yao, Qinghua Sun, Guang Yan. 6-Gingerol induces autophagy to protect HUVECs survival from apoptosis. Chemico-biological interactions. vol 256. 2017-01-30. PMID:27451028. |
to further elucidate the crosstalk between apoptosis and autophagy, we tested the expression of autophagy related proteins, lc3b, bcl-2, beclin1, akt, p-akt, mechanistic target of rapamycin (mtor), and p-mtor. |
2017-01-30 |
2023-08-13 |
human |
| Si Hyoung Kim, Jun Goo Kang, Chul Sik Kim, Sung-Hee Ihm, Moon Gi Choi, Hyung Joon Yoo, Seong Jin Le. Synergistic cytotoxicity of BIIB021 with triptolide through suppression of PI3K/Akt/mTOR and NF-κB signal pathways in thyroid carcinoma cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 83. 2017-01-30. PMID:27470546. |
in treatment of both biib021 and triptolide, compared with treatment of biib021 alone, the protein levels of total and phospho-p53, and cleaved caspase-3 were elevated, while those of total akt, phospho-mtor, phospho-4ebp1, phospho-s6k, phospho-nf-κb, survivin, x-linked inhibitor of apoptosis protein (xiap), cellular inhibitor of apoptosis protein (ciap) and acetyl. |
2017-01-30 |
2023-08-13 |
Not clear |
| Monica Benvenuto, Laura Masuelli, Enrico De Smaele, Massimo Fantini, Rosanna Mattera, Danilo Cucchi, Elena Bonanno, Enrica Di Stefano, Giovanni Vanni Frajese, Augusto Orlandi, Isabella Screpanti, Alberto Gulino, Andrea Modesti, Roberto Be. In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors. Oncotarget. vol 7. issue 8. 2017-01-06. PMID:26843616. |
gdc-0449 and gant-61 exhibited the following effects: a) inhibited breast cancer cell survival; b) induced apoptosis; c) inhibited hh pathway activity by decreasing the mrna expression levels of gli1 and ptch and inhibiting the nuclear translocation of gli1; d) increased/decreased egfr and erbb2 protein expression, reduced p21-ras and erk1/erk2 mapk activities and inhibited akt activation; and e) decreased the nuclear translocation of nf-κb. |
2017-01-06 |
2023-08-13 |
mouse |
| Xiaoshan Zhang, Xiaoyan Lu, Shamima Akhter, Maria-Magdalena Georgescu, Randy J Legersk. FANCI is a negative regulator of Akt activation. Cell cycle (Georgetown, Tex.). vol 15. issue 8. 2017-01-06. PMID:27097374. |
furthermore, depletion of fanci results in reduced apoptosis after dna damage in accord with its role as a negative regular of akt. |
2017-01-06 |
2023-08-13 |
Not clear |
| Yoon Hee Chung, Daejin Ki. Enhanced TLR4 Expression on Colon Cancer Cells After Chemotherapy Promotes Cell Survival and Epithelial-Mesenchymal Transition Through Phosphorylation of GSK3β. Anticancer research. vol 36. issue 7. 2017-01-06. PMID:27354597. |
phosphorylation of glycogen synthase kinase 3β (gsk3β) by phosphatidyl-inositide 3-kinase (pi3k)/protein kinase b (akt) or inhibition of gsk3β with small-molecule inhibitor attenuates cell survival and proliferation and increases apoptosis in most cancer cell lines. |
2017-01-06 |
2023-08-13 |
Not clear |
| Gensheng Zhang, Qiaoling Wang, Qin Zhou, Renjun Wang, Minze Xu, Huiping Wang, Lei Wang, Christopher S Wilcox, Ruisheng Liu, En Yin La. Protective Effect of Tempol on Acute Kidney Injury Through PI3K/Akt/Nrf2 Signaling Pathway. Kidney & blood pressure research. vol 41. issue 2. 2017-01-04. PMID:26894882. |
another factor, tubular epithelial apoptosis, is mediated by activation of phosphoinositide 3-kinase (pi3k)/protein kinase b (pkb, akt) signaling pathway during renal ischemic injury. |
2017-01-04 |
2023-08-13 |
Not clear |
| Miao-Miao Ma, Xiao-Li Zhu, Li Wang, Xiao-Fang Hu, Zhong Wang, Jin Zhao, Yi-Tong Ma, Yi-Ning Yang, Bang-Dang Chen, Fen Li. β3-adrenoceptor impacts apoptosis in cultured cardiomyocytes via activation of PI3K/Akt and p38MAPK. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 36. issue 1. 2016-12-30. PMID:26838732. |
furthermore, we investigated the ne-induced expression of the apoptosis marker genes akt and p38mapk, their phosphorylated counterparts p-akt and p-p38mapk, caspase-3, bcl-2, and bax. |
2016-12-30 |
2023-08-13 |
human |
| Miao-Miao Ma, Xiao-Li Zhu, Li Wang, Xiao-Fang Hu, Zhong Wang, Jin Zhao, Yi-Tong Ma, Yi-Ning Yang, Bang-Dang Chen, Fen Li. β3-adrenoceptor impacts apoptosis in cultured cardiomyocytes via activation of PI3K/Akt and p38MAPK. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 36. issue 1. 2016-12-30. PMID:26838732. |
in contrast, the β3-blocker reduced apoptosis of cms and the associated elevated akt expression. |
2016-12-30 |
2023-08-13 |
human |
| Liang Lin, Fan Yan, Dandan Zhao, Meng Lv, Xiaodong Liang, Hui Dai, Xiaodan Qin, Yan Zhang, Jie Hao, Xiuyuan Sun, Yanhui Yin, Xiaojun Huang, Jun Zhang, Jin Lu, Qing G. Reelin promotes the adhesion and drug resistance of multiple myeloma cells via integrin β1 signaling and STAT3. Oncotarget. vol 7. issue 9. 2016-12-30. PMID:26848618. |
the resulting phosphorylation of focal adhesion kinase (fak) led to the activation of src/syk/stat3 and akt, crucial signaling molecules involved in enhancing cell adhesion and protecting cells from drug-induced cell apoptosis. |
2016-12-30 |
2023-08-13 |
Not clear |
| Miao-Qian Shi, Fei-Fei Su, Xuan Xu, Xiong-Tao Liu, Hong-Tao Wang, Wei Zhang, Xue Li, Cheng Lian, Qiang-Sun Zheng, Zhi-Chun Fen. Cilostazol suppresses angiotensin II-induced apoptosis in endothelial cells. Molecular medicine reports. vol 13. issue 3. 2016-12-30. PMID:26862035. |
endothelial cell apoptosis and function, nitric oxide and superoxide production, phosphorylation (p) of akt, and caspase‑3 protein expression levels were investigated. |
2016-12-30 |
2023-08-13 |
human |
| Huiling Jing, Wenyan Sun, Jinghua Fan, Yanmin Zhang, Jiao Yang, Jinjing Jia, Jichang Li, Jiaqi Guo, Suju Luo, Yan Zhen. Shikonin induces apoptosis of HaCaT cells via the mitochondrial, Erk and Akt pathways. Molecular medicine reports. vol 13. issue 4. 2016-12-30. PMID:26935874. |
shikonin induces apoptosis of hacat cells via the mitochondrial, erk and akt pathways. |
2016-12-30 |
2023-08-13 |
Not clear |
| Huiling Jing, Wenyan Sun, Jinghua Fan, Yanmin Zhang, Jiao Yang, Jinjing Jia, Jichang Li, Jiaqi Guo, Suju Luo, Yan Zhen. Shikonin induces apoptosis of HaCaT cells via the mitochondrial, Erk and Akt pathways. Molecular medicine reports. vol 13. issue 4. 2016-12-30. PMID:26935874. |
these results indicated that shikonin may exert its anti‑proliferative effects by inducing apoptosis via activation of the mitochondrial signaling pathway and inactivation of the akt and erk pathways in hacat cells. |
2016-12-30 |
2023-08-13 |
Not clear |
| Dexiu Chen, Junshan Liu, Lu Lu, Yanfeng Huang, Yanjing Wang, Mingqing Wang, Yangyang Liu, Dandan Xie, Jiebing Chen, Jianxin Diao, Lianbo Wei, Ming Wan. Emodin attenuates TNF-α-induced apoptosis and autophagy in mouse C2C12 myoblasts though the phosphorylation of Akt. International immunopharmacology. vol 34. 2016-12-30. PMID:26943728. |
emodin attenuates tnf-α-induced apoptosis and autophagy in mouse c2c12 myoblasts though the phosphorylation of akt. |
2016-12-30 |
2023-08-13 |
mouse |
| Dexiu Chen, Junshan Liu, Lu Lu, Yanfeng Huang, Yanjing Wang, Mingqing Wang, Yangyang Liu, Dandan Xie, Jiebing Chen, Jianxin Diao, Lianbo Wei, Ming Wan. Emodin attenuates TNF-α-induced apoptosis and autophagy in mouse C2C12 myoblasts though the phosphorylation of Akt. International immunopharmacology. vol 34. 2016-12-30. PMID:26943728. |
taken together, these results suggest that emodin inhibited apoptosis and autophagy in tnf-α-induced c2c12 myoblasts, possibly through the activation of phosphorylated akt. |
2016-12-30 |
2023-08-13 |
mouse |
| Xian Yu, Tingting Li, Yifan Xia, Jun Lei, Yan Wang, Lijuan Zhan. Herpes simplex virus type 1 VP22-mediated intercellular delivery of PTEN increases the antitumor activity of PTEN in esophageal squamous cell carcinoma cells in vitro and in vivo. Oncology reports. vol 35. issue 5. 2016-12-27. PMID:27004535. |
vp22 alone did not exert antiproliferative effects or induce cell cycle arrest, induction of apoptosis, blockage of the akt and focal adhesion kinase (fak) pathways, tumor growth inhibition, or antiangiogenic effects in eca109 cells. |
2016-12-27 |
2023-08-13 |
Not clear |
| Peng Zhou, Liang Ma, Jun Zhou, Min Jiang, Enyu Rao, Yong Zhao, Feng Gu. miR-17-92 plays an oncogenic role and conveys chemo-resistance to cisplatin in human prostate cancer cells. International journal of oncology. vol 48. issue 4. 2016-12-26. PMID:26891588. |
we demonstrated that the mir-17-92 cluster suppressed the expression of inhibitor of the akt signaling pathway and activated the akt pathway subsequently, which played a central role in regulating cellular proliferation, apoptosis and chemo-resistance. |
2016-12-26 |
2023-08-13 |
human |
| Ji Hye Park, Chung Kwon Kim, Sang Bae Lee, Kyung-Hoon Lee, Sung-Woo Cho, Jee-Yin Ah. Akt attenuates apoptotic death through phosphorylation of H2A under hydrogen peroxide-induced oxidative stress in PC12 cells and hippocampal neurons. Scientific reports. vol 6. 2016-12-26. PMID:26899247. |
we demonstrated that akt attenuated neuronal apoptosis through direct association with histone 2a (h2a) and phosphorylation of h2a at threonine 17. |
2016-12-26 |
2023-08-13 |
Not clear |
| Ji Hye Park, Chung Kwon Kim, Sang Bae Lee, Kyung-Hoon Lee, Sung-Woo Cho, Jee-Yin Ah. Akt attenuates apoptotic death through phosphorylation of H2A under hydrogen peroxide-induced oxidative stress in PC12 cells and hippocampal neurons. Scientific reports. vol 6. 2016-12-26. PMID:26899247. |
ectopically expressed t17a-substituted h2a minimally interacted with akt and failed to prevent apoptosis under oxidative stress. |
2016-12-26 |
2023-08-13 |
Not clear |