| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hironobu Takano, Toru Nakamura, Takahiro Tsuchikawa, Toshihiro Kushibiki, Kouji Hontani, Kazuho Inoko, Mizuna Takahashi, Shoki Sato, Hirotake Abe, Shintaro Takeuchi, Nagato Sato, Kei Hiraoka, Hiroshi Nishihara, Toshiaki Shichinohe, Satoshi Hiran. Inhibition of Eph receptor A4 by 2,5-dimethylpyrrolyl benzoic acid suppresses human pancreatic cancer growing orthotopically in nude mice. Oncotarget. vol 6. issue 38. 2016-09-28. PMID:26516928. |
our study indicated that compound 1 suppressed both epha4 and akt phosphorylations, and induced apoptosis in pdac cells expressing epha4. |
2016-09-28 |
2023-08-13 |
mouse |
| Jiaming Liu, Jing Sun, Fangyan Wang, Xichong Yu, Zongxin Ling, Haixiao Li, Huiqing Zhang, Jiangtao Jin, Wenqian Chen, Mengqi Pang, Junjie Yu, Yiwen He, Jiru X. Neuroprotective Effects of Clostridium butyricum against Vascular Dementia in Mice via Metabolic Butyrate. BioMed research international. vol 2015. 2016-09-28. PMID:26523278. |
c. butyricum not only increased the levels of bdnf and bcl-2 and decreased level of bax but also induced akt phosphorylation (p-akt) and ultimately reduced neuronal apoptosis. |
2016-09-28 |
2023-08-13 |
mouse |
| Q Lu, S Yan, H Sun, W Wang, Y Li, X Yang, X Jiang, Y Che, Z X. Akt inhibition attenuates rasfonin-induced autophagy and apoptosis through the glycolytic pathway in renal cancer cells. Cell death & disease. vol 6. 2016-09-28. PMID:26633711. |
akt inhibition attenuates rasfonin-induced autophagy and apoptosis through the glycolytic pathway in renal cancer cells. |
2016-09-28 |
2023-08-13 |
Not clear |
| Q Lu, S Yan, H Sun, W Wang, Y Li, X Yang, X Jiang, Y Che, Z X. Akt inhibition attenuates rasfonin-induced autophagy and apoptosis through the glycolytic pathway in renal cancer cells. Cell death & disease. vol 6. 2016-09-28. PMID:26633711. |
the overexpression of myrakts (constant active form) promoted rasfonin-induced apoptosis and autophagy in a cell type- and akt isoform-specific manner. |
2016-09-28 |
2023-08-13 |
Not clear |
| Q Lu, S Yan, H Sun, W Wang, Y Li, X Yang, X Jiang, Y Che, Z X. Akt inhibition attenuates rasfonin-induced autophagy and apoptosis through the glycolytic pathway in renal cancer cells. Cell death & disease. vol 6. 2016-09-28. PMID:26633711. |
collectively, these results demonstrated that akt positively regulated rasfonin-enhanced autophagy and caspase-dependent apoptosis primarily through affecting the glycolytic pathway. |
2016-09-28 |
2023-08-13 |
Not clear |
| Matteo Sorge, Mara Brancacci. Melusin Promotes a Protective Signal Transduction Cascade in Stressed Hearts. Frontiers in molecular biosciences. vol 3. 2016-09-27. PMID:27672636. |
in particular melusin activates akt and erk1/2 signaling, protects cardiomyocytes from apoptosis and induces a compensatory hypertrophic response in several pathological conditions. |
2016-09-27 |
2023-08-13 |
human |
| Muneyoshi Okada, Hideyuki Yamawak. Levosimendan inhibits interleukin-1β-induced apoptosis through activation of Akt and inhibition of inducible nitric oxide synthase in rat cardiac fibroblasts. European journal of pharmacology. vol 769. 2016-09-26. PMID:26528797. |
levosimendan inhibits interleukin-1β-induced apoptosis through activation of akt and inhibition of inducible nitric oxide synthase in rat cardiac fibroblasts. |
2016-09-26 |
2023-08-13 |
rat |
| Fang Zeng, Hui-Qun Qin, Wei-Jia Xu, Ming-Dan Zheng, Hong-Tao Hu, Hua Shu. Mycophenolic acid inhibits the phosphorylation of nuclear factor‑κB and Akt in renal tubular epithelial cells. Molecular medicine reports. vol 13. issue 1. 2016-09-26. PMID:26548367. |
in addition, the akt signaling pathway has important roles in cell proliferation, differentiation, metabolism and apoptosis. |
2016-09-26 |
2023-08-13 |
rat |
| Xuhe Gong, Pengbo Wang, Qingqing Wu, Sijia Wang, Litian Yu, Guogan Wan. Human umbilical cord blood derived mesenchymal stem cells improve cardiac function in cTnT(R141W) transgenic mouse of dilated cardiomyopathy. European journal of cell biology. vol 95. issue 1. 2016-09-26. PMID:26655348. |
cultured ucb-mscs, which were identified by there morphology, differentiation and cell surface markers, were transplanted into ctnt(r141w) transgenic mice to examine apoptosis, fibrosis, vasculogenesis and the associated akt pathway. |
2016-09-26 |
2023-08-13 |
mouse |
| Xuhe Gong, Pengbo Wang, Qingqing Wu, Sijia Wang, Litian Yu, Guogan Wan. Human umbilical cord blood derived mesenchymal stem cells improve cardiac function in cTnT(R141W) transgenic mouse of dilated cardiomyopathy. European journal of cell biology. vol 95. issue 1. 2016-09-26. PMID:26655348. |
mscs transplanted hearts showed a significant decrease in cardiac apoptosis and its regulation by the akt pathway. |
2016-09-26 |
2023-08-13 |
mouse |
| Xuhe Gong, Pengbo Wang, Qingqing Wu, Sijia Wang, Litian Yu, Guogan Wan. Human umbilical cord blood derived mesenchymal stem cells improve cardiac function in cTnT(R141W) transgenic mouse of dilated cardiomyopathy. European journal of cell biology. vol 95. issue 1. 2016-09-26. PMID:26655348. |
in conclusion, ucb-mscs preserve cardiac function after intramyocardial transplantation in a dcm mouse, and this effect may be associated with reductions in cellular apoptosis, inflammation, hypertrophy and myocardial fibrosis; in addition to; up-regulation of akt, vegf and igf-1; and enhanced angiogenesis. |
2016-09-26 |
2023-08-13 |
mouse |
| Yuxiang Dai, Wen Zhang, Xiaoming Zhou, Jixin Sh. Activation of the Protein Kinase B (Akt) Reduces Nur77-induced Apoptosis During Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rat. Annals of clinical and laboratory science. vol 45. issue 6. 2016-09-26. PMID:26663789. |
activation of the protein kinase b (akt) reduces nur77-induced apoptosis during early brain injury after experimental subarachnoid hemorrhage in rat. |
2016-09-26 |
2023-08-13 |
rat |
| Yuxiang Dai, Wen Zhang, Xiaoming Zhou, Jixin Sh. Activation of the Protein Kinase B (Akt) Reduces Nur77-induced Apoptosis During Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rat. Annals of clinical and laboratory science. vol 45. issue 6. 2016-09-26. PMID:26663789. |
previous researches show that protein kinase b (akt) negatively regulates nur77 dna binding and apoptosis by phosphorylating nur77. |
2016-09-26 |
2023-08-13 |
rat |
| Yuxiang Dai, Wen Zhang, Xiaoming Zhou, Jixin Sh. Activation of the Protein Kinase B (Akt) Reduces Nur77-induced Apoptosis During Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rat. Annals of clinical and laboratory science. vol 45. issue 6. 2016-09-26. PMID:26663789. |
to determine whether activation of akt is directly associated with nur77 dependent apoptosis pathway, we hypothesized that insulin, an activator of akt, may effectively ameliorate ebi by inhibiting nur77 transcriptional activity. |
2016-09-26 |
2023-08-13 |
rat |
| Dunyun Shi, Yun Xu, Xin Du, Xuhong Chen, Xiaoli Zhang, Jin Lou, Ming Li, Jiacai Zhu. Co-treatment of THP-1 cells with naringenin and curcumin induces cell cycle arrest and apoptosis via numerous pathways. Molecular medicine reports. vol 12. issue 6. 2016-09-22. PMID:26496980. |
these results indicated that naringenin may enhance curcumin‑induced apoptosis through inhibiting the akt and erk pathways, and promoting the jnk and p53 pathways. |
2016-09-22 |
2023-08-13 |
Not clear |
| Jessica J Gierut, Levi B Wood, Ken S Lau, Yi-Jang Lin, Casie Genetti, Ahmed A Samatar, Douglas A Lauffenburger, Kevin M Haigi. Network-level effects of kinase inhibitors modulate TNF-α-induced apoptosis in the intestinal epithelium. Science signaling. vol 8. issue 407. 2016-09-21. PMID:26671150. |
computational modeling and experimental perturbation identified the kinase akt as the primary signaling node that enhanced apoptosis in the context of tnf-α signaling in the presence of ch5126766. |
2016-09-21 |
2023-08-13 |
mouse |
| Jian Qin, JiaAn Teng, Zhou Zhu, JiaXin Chen, Wen-Jun Huan. Genistein induces activation of the mitochondrial apoptosis pathway by inhibiting phosphorylation of Akt in colorectal cancer cells. Pharmaceutical biology. vol 54. issue 1. 2016-09-20. PMID:25880142. |
genistein induces activation of the mitochondrial apoptosis pathway by inhibiting phosphorylation of akt in colorectal cancer cells. |
2016-09-20 |
2023-08-13 |
Not clear |
| Liu Li, Hao Song, Liang Zhong, Rong Yang, Xiao-Qun Yang, Kai-Ling Jiang, Bei-Zhong Li. Lithium Chloride Promotes Apoptosis in Human Leukemia NB4 Cells by Inhibiting Glycogen Synthase Kinase-3 Beta. International journal of medical sciences. vol 12. issue 10. 2016-09-20. PMID:26516309. |
taken together, these findings demonstrated that licl promoted apoptosis in nb4 cells through the akt signaling pathway and that g2/m phase arrest was induced by increase of p-gsk-3β(s9). |
2016-09-20 |
2023-08-13 |
human |
| Magdalena Donejko, Andrzej Przylipiak, Edyta Rysiak, Wojciech Miltyk, Elżbieta Galicka, Jerzy Przylipiak, Ilona Zaręba, Arkadiusz Surazynsk. Hyaluronic acid abrogates ethanol-dependent inhibition of collagen biosynthesis in cultured human fibroblasts. Drug design, development and therapy. vol 9. 2016-09-20. PMID:26648698. |
regarding the mechanism of ethanol action on human skin fibroblasts we investigated: expression of β1 integrin and insulin-like growth factor 1 receptor (igf-ir), signaling pathway protein expression: mitogen-activated protein kinases (mapks), protein kinase b (akt), nuclear factor kappa b (nf-κb) transcription factor, cytotoxicity assay and apoptosis, metalloproteinase activity, as well as the influence of ha on these processes. |
2016-09-20 |
2023-08-13 |
human |
| Wei Wang, Wen Bin Liu, Da Bing Huang, Wei Jia, Chu Shu Ji, Bing H. Targeting PCDH20 gene by microRNA-122 confers 5-FU resistance in hepatic carcinoma. American journal of cancer research. vol 6. issue 8. 2016-09-20. PMID:27648358. |
knockdown of pcdh20 expression increases akt phosphorylation, which leads to elevated mtor activity and enhanced 5-fluorouracil resistance; whereas rescue of pcdh20 expression in mir-122-expressing cells decreases akt and mtor phosphorylation, re-sensitizing hepatocellular carcinoma cell to 5-fluorouracil induced apoptosis. |
2016-09-20 |
2023-08-13 |
mouse |