| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anja K Bosserhoff, Lisa Ellmann, Annika S Quast, Juergen Eberle, Glen M Boyle, Silke Kupha. Loss of T-cadherin (CDH-13) regulates AKT signaling and desensitizes cells to apoptosis in melanoma. Molecular carcinogenesis. vol 53. issue 8. 2014-09-11. PMID:23625515. |
loss of t-cadherin (cdh-13) regulates akt signaling and desensitizes cells to apoptosis in melanoma. |
2014-09-11 |
2023-08-12 |
mouse |
| Yanxia Zhao, Dandan Yu, Hongge Wu, Hongli Liu, Hongxia Zhou, Runxia Gu, Ruiguang Zhang, Sheng Zhang, Gang W. Anticancer activity of SAHA, a potent histone deacetylase inhibitor, in NCI-H460 human large-cell lung carcinoma cells in vitro and in vivo. International journal of oncology. vol 44. issue 2. 2014-09-11. PMID:24297449. |
here, we report that saha was able to inhibit the proliferation of the lcc cell line nci-h460 in a dose- and time-dependent manner, induced cell apoptosis and g2/m cell cycle arrest, decreased akt and erk phosphorylation, inhibited the expression of pro-angiogenic factors (vegf, hif-1α) in vitro, and suppressed tumor progression in an nci-h460 cell nude mouse xenograft model in vivo. |
2014-09-11 |
2023-08-12 |
mouse |
| Qingling Yang, Changjie Chen, Zhifeng Yang, Yangjun Gao, Jie Tan. Suppression of breast cancer proliferation and induction of apoptosis via AKT and ERK1/2 signal transduction pathways by synthetic polypeptide derived from viral macrophage inflammatory protein II. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 31. issue 4. 2014-09-09. PMID:21823011. |
suppression of breast cancer proliferation and induction of apoptosis via akt and erk1/2 signal transduction pathways by synthetic polypeptide derived from viral macrophage inflammatory protein ii. |
2014-09-09 |
2023-08-12 |
human |
| Xingang Wang, Anne L Robertson, Jingyu Li, Ruth Jinfen Chai, Wang Haishan, Pranvera Sadiku, Nikolay V Ogryzko, Martin Everett, Kanagasundaram Yoganathan, Hongbo Robert Luo, Stephen A Renshaw, Philip W Ingha. Inhibitors of neutrophil recruitment identified using transgenic zebrafish to screen a natural product library. Disease models & mechanisms. vol 7. issue 1. 2014-09-08. PMID:24291762. |
in human neutrophils, pf1052 neither induced apoptosis nor blocked akt phosphorylation. |
2014-09-08 |
2023-08-12 |
human |
| Hwan Hee Lee, Shuai Ye, Xiu Juan Li, Kwang Bok Lee, Man Hee Park, Soo Mi Ki. Combination treatment with paclitaxel and doxorubicin inhibits growth of human esophageal squamous cancer cells by inactivation of Akt. Oncology reports. vol 31. issue 1. 2014-09-05. PMID:24247637. |
these results suggest that combination treatment with paclitaxel and doxorubicin induced g2/m cell cycle arrest and apoptosis in human escc cells by suppressing akt activity. |
2014-09-05 |
2023-08-12 |
human |
| Gaetano Calì, Luigi Insabato, Domenico Conza, Giuseppe Bifulco, Luca Parrillo, Paola Mirra, Francesca Fiory, Claudia Miele, Gregory Alexander Raciti, Bruno Di Jeso, Giuseppe Terrazzano, Francesco Beguinot, Luca Ulianic. GRP78 mediates cell growth and invasiveness in endometrial cancer. Journal of cellular physiology. vol 229. issue 10. 2014-09-05. PMID:24526410. |
induction of apoptosis in an3ca cells was not mediated by the p53 pathway activation but was rather associated to reduced akt phosphorylation. |
2014-09-05 |
2023-08-12 |
Not clear |
| Jing Lu, Bo Sun, Rong Huo, Yu-Chun Wang, Di Yang, Yue Xing, Xiao-Lin Xiao, Xin Xie, De-Li Don. Bone morphogenetic protein-2 antagonizes bone morphogenetic protein-4 induced cardiomyocyte hypertrophy and apoptosis. Journal of cellular physiology. vol 229. issue 10. 2014-09-05. PMID:24648278. |
bmp2 stimulated akt in cardiomyocytes and akt inhibitor prevented the antagonism of bmp2 on bmp4-induced cardiomyocyte apoptosis. |
2014-09-05 |
2023-08-12 |
mouse |
| Jing Lu, Bo Sun, Rong Huo, Yu-Chun Wang, Di Yang, Yue Xing, Xiao-Lin Xiao, Xin Xie, De-Li Don. Bone morphogenetic protein-2 antagonizes bone morphogenetic protein-4 induced cardiomyocyte hypertrophy and apoptosis. Journal of cellular physiology. vol 229. issue 10. 2014-09-05. PMID:24648278. |
the anti-apoptotic effects of bmp2 on bmp4-induced cardiomyocyte apoptosis might be through activating akt and inhibiting jnk activation. |
2014-09-05 |
2023-08-12 |
mouse |
| Ryoko Taguchi, Shinya Tanaka, Ga-Hyun Joe, Hideaki Maseda, Nobuhiko Nomura, Junji Ohnishi, Satoshi Ishizuka, Hidehisa Shimizu, Hitoshi Miyazak. Mucin 3 is involved in intestinal epithelial cell apoptosis via N-(3-oxododecanoyl)-L-homoserine lactone-induced suppression of Akt phosphorylation. American journal of physiology. Cell physiology. vol 307. issue 2. 2014-09-05. PMID:24848113. |
mucin 3 is involved in intestinal epithelial cell apoptosis via n-(3-oxododecanoyl)-l-homoserine lactone-induced suppression of akt phosphorylation. |
2014-09-05 |
2023-08-13 |
Not clear |
| Ryoko Taguchi, Shinya Tanaka, Ga-Hyun Joe, Hideaki Maseda, Nobuhiko Nomura, Junji Ohnishi, Satoshi Ishizuka, Hidehisa Shimizu, Hitoshi Miyazak. Mucin 3 is involved in intestinal epithelial cell apoptosis via N-(3-oxododecanoyl)-L-homoserine lactone-induced suppression of Akt phosphorylation. American journal of physiology. Cell physiology. vol 307. issue 2. 2014-09-05. PMID:24848113. |
a low concentration of 3-oxo-c12-hsl (30 μm) is sufficient to reduce viability accompanied by apoptosis via the suppression of phosphorylation by akt in undifferentiated caco-2 cells. |
2014-09-05 |
2023-08-13 |
Not clear |
| Xiaoyun Shen, Yong Zhang, Yan Feng, Litu Zhang, Jilin Li, Yu-An Xie, Xiaoling Lu. Epigallocatechin-3-gallate inhibits cell growth, induces apoptosis and causes S phase arrest in hepatocellular carcinoma by suppressing the AKT pathway. International journal of oncology. vol 44. issue 3. 2014-09-04. PMID:24402647. |
epigallocatechin-3-gallate inhibits cell growth, induces apoptosis and causes s phase arrest in hepatocellular carcinoma by suppressing the akt pathway. |
2014-09-04 |
2023-08-12 |
Not clear |
| Takashi Ui, Kazue Morishima, Shin Saito, Yuji Sakuma, Hirofumi Fujii, Yoshinori Hosoya, Shumpei Ishikawa, Hiroyuki Aburatani, Masashi Fukayama, Toshiro Niki, Yoshikazu Yasud. The HSP90 inhibitor 17-N-allylamino-17-demethoxy geldanamycin (17-AAG) synergizes with cisplatin and induces apoptosis in cisplatin-resistant esophageal squamous cell carcinoma cell lines via the Akt/XIAP pathway. Oncology reports. vol 31. issue 2. 2014-09-03. PMID:24317439. |
time-course experiments showed that reduction in x-linked inhibitor of apoptosis protein (xiap) and phosphorylated akt were concomitant with apoptosis. |
2014-09-03 |
2023-08-12 |
human |
| Imge Kunter, Esra Erdal, Deniz Nart, Funda Yilmaz, Sedat Karademir, Ozgul Sagol, Nese Atabe. Active form of AKT controls cell proliferation and response to apoptosis in hepatocellular carcinoma. Oncology reports. vol 31. issue 2. 2014-09-03. PMID:24337632. |
active form of akt controls cell proliferation and response to apoptosis in hepatocellular carcinoma. |
2014-09-03 |
2023-08-12 |
Not clear |
| Imge Kunter, Esra Erdal, Deniz Nart, Funda Yilmaz, Sedat Karademir, Ozgul Sagol, Nese Atabe. Active form of AKT controls cell proliferation and response to apoptosis in hepatocellular carcinoma. Oncology reports. vol 31. issue 2. 2014-09-03. PMID:24337632. |
however, the effect of akt activation on the proliferation and apoptosis in hcc is not clear. |
2014-09-03 |
2023-08-12 |
Not clear |
| Imge Kunter, Esra Erdal, Deniz Nart, Funda Yilmaz, Sedat Karademir, Ozgul Sagol, Nese Atabe. Active form of AKT controls cell proliferation and response to apoptosis in hepatocellular carcinoma. Oncology reports. vol 31. issue 2. 2014-09-03. PMID:24337632. |
thus, akt signaling controls growth and chemical-induced apoptosis in hcc and p-akt may be a potential target for therapeutic interventions in hcc patients. |
2014-09-03 |
2023-08-12 |
Not clear |
| Ju-Yoon Yoon, Ganchimeg Ishdorj, Bonnie A Graham, James B Johnston, Spencer B Gibso. Valproic acid enhances fludarabine-induced apoptosis mediated by ROS and involving decreased AKT and ATM activation in B-cell-lymphoid neoplastic cells. Apoptosis : an international journal on programmed cell death. vol 19. issue 1. 2014-09-02. PMID:24057147. |
valproic acid enhances fludarabine-induced apoptosis mediated by ros and involving decreased akt and atm activation in b-cell-lymphoid neoplastic cells. |
2014-09-02 |
2023-08-12 |
Not clear |
| Ju-Yoon Yoon, Ganchimeg Ishdorj, Bonnie A Graham, James B Johnston, Spencer B Gibso. Valproic acid enhances fludarabine-induced apoptosis mediated by ROS and involving decreased AKT and ATM activation in B-cell-lymphoid neoplastic cells. Apoptosis : an international journal on programmed cell death. vol 19. issue 1. 2014-09-02. PMID:24057147. |
chemical inhibition of akt or atm was sufficient to enhance fludarabine-induced apoptosis. |
2014-09-02 |
2023-08-12 |
Not clear |
| Kyoung-Jae Won, Bo Kyung Kim, Gyoonhee Han, Kyeong Lee, Young-Jin Jung, Hwan-Mook Kim, Kyung Bin Song, Kyung-Sook Chung, Misun Wo. NSC126188 induces apoptosis of prostate cancer PC-3 cells through inhibition of Akt membrane translocation, FoxO3a activation, and RhoB transcription. Apoptosis : an international journal on programmed cell death. vol 19. issue 1. 2014-09-02. PMID:24085402. |
nsc126188 induces apoptosis of prostate cancer pc-3 cells through inhibition of akt membrane translocation, foxo3a activation, and rhob transcription. |
2014-09-02 |
2023-08-12 |
Not clear |
| Kyoung-Jae Won, Bo Kyung Kim, Gyoonhee Han, Kyeong Lee, Young-Jin Jung, Hwan-Mook Kim, Kyung Bin Song, Kyung-Sook Chung, Misun Wo. NSC126188 induces apoptosis of prostate cancer PC-3 cells through inhibition of Akt membrane translocation, FoxO3a activation, and RhoB transcription. Apoptosis : an international journal on programmed cell death. vol 19. issue 1. 2014-09-02. PMID:24085402. |
the apoptosis and akt dephosphorylation caused by nsc126188 was not substantially relieved by overexpressing wild-type akt but was relieved by overexpressing constitutively active akt (ca-akt) or myristoylated akt (myr-akt). |
2014-09-02 |
2023-08-12 |
Not clear |
| Kyoung-Jae Won, Bo Kyung Kim, Gyoonhee Han, Kyeong Lee, Young-Jin Jung, Hwan-Mook Kim, Kyung Bin Song, Kyung-Sook Chung, Misun Wo. NSC126188 induces apoptosis of prostate cancer PC-3 cells through inhibition of Akt membrane translocation, FoxO3a activation, and RhoB transcription. Apoptosis : an international journal on programmed cell death. vol 19. issue 1. 2014-09-02. PMID:24085402. |
taken together, nsc126188 induces apoptosis of pc-3 cells by interfering with membrane recruitment of akt, resulting in akt dephosphorylation and foxo3a activation, which leads to transcription of rhob. |
2014-09-02 |
2023-08-12 |
Not clear |