| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kyoung-Jae Won, Bo Kyung Kim, Gyoonhee Han, Kyeong Lee, Young-Jin Jung, Hwan-Mook Kim, Kyung Bin Song, Kyung-Sook Chung, Misun Wo. NSC126188 induces apoptosis of prostate cancer PC-3 cells through inhibition of Akt membrane translocation, FoxO3a activation, and RhoB transcription. Apoptosis : an international journal on programmed cell death. vol 19. issue 1. 2014-09-02. PMID:24085402. |
the apoptosis and akt dephosphorylation caused by nsc126188 was not substantially relieved by overexpressing wild-type akt but was relieved by overexpressing constitutively active akt (ca-akt) or myristoylated akt (myr-akt). |
2014-09-02 |
2023-08-12 |
Not clear |
| Kyoung-Jae Won, Bo Kyung Kim, Gyoonhee Han, Kyeong Lee, Young-Jin Jung, Hwan-Mook Kim, Kyung Bin Song, Kyung-Sook Chung, Misun Wo. NSC126188 induces apoptosis of prostate cancer PC-3 cells through inhibition of Akt membrane translocation, FoxO3a activation, and RhoB transcription. Apoptosis : an international journal on programmed cell death. vol 19. issue 1. 2014-09-02. PMID:24085402. |
taken together, nsc126188 induces apoptosis of pc-3 cells by interfering with membrane recruitment of akt, resulting in akt dephosphorylation and foxo3a activation, which leads to transcription of rhob. |
2014-09-02 |
2023-08-12 |
Not clear |
| G Li, L Liu, C Shan, Q Cheng, A Budhraja, T Zhou, H Cui, N Ga. RhoA/ROCK/PTEN signaling is involved in AT-101-mediated apoptosis in human leukemia cells in vitro and in vivo. Cell death & disease. vol 5. 2014-09-02. PMID:24434521. |
inhibiting rhoa and rock1 activation by c3 exoenzyme (c3) and y27632, respectively, attenuated the rock1 cleavage/activation, pten activity, akt inactivation, mcl-1 downregulation, bad dephosphorylation, and apoptosis mediated by at-101. |
2014-09-02 |
2023-08-12 |
mouse |
| G Li, L Liu, C Shan, Q Cheng, A Budhraja, T Zhou, H Cui, N Ga. RhoA/ROCK/PTEN signaling is involved in AT-101-mediated apoptosis in human leukemia cells in vitro and in vivo. Cell death & disease. vol 5. 2014-09-02. PMID:24434521. |
constitutively active akt prevented the at-101-induced mcl-1 downregulation, bad dephosphorylation, and apoptosis. |
2014-09-02 |
2023-08-12 |
mouse |
| G Li, L Liu, C Shan, Q Cheng, A Budhraja, T Zhou, H Cui, N Ga. RhoA/ROCK/PTEN signaling is involved in AT-101-mediated apoptosis in human leukemia cells in vitro and in vivo. Cell death & disease. vol 5. 2014-09-02. PMID:24434521. |
collectively, these findings suggest that at-101 may preferentially induce apoptosis in leukemia cells by interrupting the rhoa/rock1/pten pathway, leading to akt inactivation, mcl-1 downregulation, bad dephosphorylation, and bax translocation, which culminate in mitochondrial injury and apoptosis. |
2014-09-02 |
2023-08-12 |
mouse |
| Esther P Jane, Daniel R Premkumar, Alejandro Morales, Kimberly A Foster, Ian F Pollac. Inhibition of phosphatidylinositol 3-kinase/AKT signaling by NVP-BKM120 promotes ABT-737-induced toxicity in a caspase-dependent manner through mitochondrial dysfunction and DNA damage response in established and primary cultured glioblastoma cells. The Journal of pharmacology and experimental therapeutics. vol 350. issue 1. 2014-08-26. PMID:24741074. |
our recent study suggested that akt is a crucial mediator of apoptosis sensitivity in response to abt-737 in glioma cell lines. |
2014-08-26 |
2023-08-13 |
Not clear |
| Kyoung Ah Kang, Zhi Hong Wang, Rui Zhang, Mei Jing Piao, Ki Cheon Kim, Sam Sik Kang, Young Woo Kim, Jongsung Lee, Deokhoon Park, Jin Won Hyu. Myricetin protects cells against oxidative stress-induced apoptosis via regulation of PI3K/Akt and MAPK signaling pathways. International journal of molecular sciences. vol 11. issue 11. 2014-08-19. PMID:21151442. |
myricetin-induced survival correlated with akt activity, and the rescue of cells by myricetin treatment against h(2)o(2)-induced apoptosis was inhibited by the specific pi3k (phosphoinositol-3-kinase) inhibitor. |
2014-08-19 |
2023-08-12 |
Not clear |
| Thangaiyan Rabi, Andrea Huwiler, Uwe Zangemeister-Wittk. AMR-Me inhibits PI3K/Akt signaling in hormone-dependent MCF-7 breast cancer cells and inactivates NF-κB in hormone-independent MDA-MB-231 cells. Molecular carcinogenesis. vol 53. issue 7. 2014-08-19. PMID:23475563. |
the pi3k inhibitor ly294002 suppressed akt activation similar to amr-me and potentiated amr-me induced apoptosis in mcf-7 cells. |
2014-08-19 |
2023-08-12 |
human |
| Zhimin Gao, Fenghua Liu, Peng Yin, Changrong Wan, Shasha He, Xiaoxi Liu, Hong Zhao, Tao Liu, Jianqin Xu, Shining Gu. Inhibition of heat-induced apoptosis in rat small intestine and IEC-6 cells through the AKT signaling pathway. BMC veterinary research. vol 9. 2014-08-13. PMID:24295139. |
inhibition of heat-induced apoptosis in rat small intestine and iec-6 cells through the akt signaling pathway. |
2014-08-13 |
2023-08-12 |
rat |
| Pengda Liu, Michael Begley, Wojciech Michowski, Hiroyuki Inuzuka, Miriam Ginzberg, Daming Gao, Peiling Tsou, Wenjian Gan, Antonella Papa, Byeong Mo Kim, Lixin Wan, Amrik Singh, Bo Zhai, Min Yuan, Zhiwei Wang, Steven P Gygi, Tae Ho Lee, Kun-Ping Lu, Alex Toker, Pier Paolo Pandolfi, John M Asara, Marc W Kirschner, Piotr Sicinski, Lewis Cantley, Wenyi We. Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. Nature. vol 508. issue 7497. 2014-08-13. PMID:24670654. |
notably, cyclin a2-deletion-induced cellular apoptosis in mouse embryonic stem cells is partly rescued by s477d/t479e-akt1, supporting a physiological role for cyclin a2 in governing akt activation. |
2014-08-13 |
2023-08-12 |
mouse |
| Zheng Fu, Li Ren, Huiting Wei, Junqiang Lv, Xuchun Che, Zhifeng Zhu, Jing Jia, Li Wang, Gang Lin, Rong Lu, Zhi Ya. Effects of Tyroserleutide on phosphatidylinositol 3'-kinase/AKT pathway in human hepatocellular carcinoma cell. Journal of drug targeting. vol 22. issue 2. 2014-08-12. PMID:24147456. |
(3) inactivation of akt removed its inhibition effect on phosphorylation of bad, which might decrease protein level of apoptosis inhibitor bcl-2 and bcl-xl, damaging mitochondria of tumor cells and inducing apoptosis. |
2014-08-12 |
2023-08-12 |
human |
| Jun Luo, Matthew S Weaver, Baohong Cao, James E Dennis, Benjamin Van Biber, Michael A Laflamme, Margaret D Alle. Cobalt protoporphyrin pretreatment protects human embryonic stem cell-derived cardiomyocytes from hypoxia/reoxygenation injury in vitro and increases graft size and vascularization in vivo. Stem cells translational medicine. vol 3. issue 6. 2014-08-11. PMID:24736402. |
compared with pbs-pretreated cells, copp-pretreated hesc-cm preparations exhibited higher levels of ho-1 expression, akt phosphorylation, and vascular endothelial growth factor production, with reduced apoptosis, and a 30% decrease in intracellular reactive oxygen species. |
2014-08-11 |
2023-08-13 |
human |
| JongYeob Choi, MinWha Jo, EunYoung Lee, DooSeok Cho. AKT is involved in granulosa cell autophagy regulation via mTOR signaling during rat follicular development and atresia. Reproduction (Cambridge, England). vol 147. issue 1. 2014-07-31. PMID:24131573. |
furthermore, co-treatment with fsh and akt inhibitor increased the levels of apoptosis and cell death of granulosa cells compared with the single treatment with fsh. |
2014-07-31 |
2023-08-12 |
rat |
| Ketao Wang, Changlong Lin, Chengqin Wang, Qianqian Shao, Wenjuan Gao, Bingfeng Song, Lei Wang, Xiaobin Song, Xun Qu, Fengcai We. Silencing Kif2a induces apoptosis in squamous cell carcinoma of the oral tongue through inhibition of the PI3K/Akt signaling pathway. Molecular medicine reports. vol 9. issue 1. 2014-07-29. PMID:24248467. |
the results revealed that silencing kif2a induces apoptosis and decreases the mrna and protein level of pi3k, akt and b‑cell lymphoma 2 (bcl‑2) in tca8113 cells. |
2014-07-29 |
2023-08-12 |
human |
| Ketao Wang, Changlong Lin, Chengqin Wang, Qianqian Shao, Wenjuan Gao, Bingfeng Song, Lei Wang, Xiaobin Song, Xun Qu, Fengcai We. Silencing Kif2a induces apoptosis in squamous cell carcinoma of the oral tongue through inhibition of the PI3K/Akt signaling pathway. Molecular medicine reports. vol 9. issue 1. 2014-07-29. PMID:24248467. |
the pi3k-specific agonist insulin‑like growth factor 1 (igf‑1) eliminated the upregulation of apoptosis of tca8113‑kif2a cells by phosphorylation of akt. |
2014-07-29 |
2023-08-12 |
human |
| A Lonetti, I L Antunes, F Chiarini, E Orsini, F Buontempo, F Ricci, P L Tazzari, P Pagliaro, F Melchionda, A Pession, A Bertaina, F Locatelli, J A McCubrey, J T Barata, A M Martell. Activity of the pan-class I phosphoinositide 3-kinase inhibitor NVP-BKM120 in T-cell acute lymphoblastic leukemia. Leukemia. vol 28. issue 6. 2014-07-29. PMID:24310736. |
bkm120 treatment resulted in g2/m phase cell cycle arrest and apoptosis, being cytotoxic to a panel of t-all cell lines and patient t lymphoblasts, and promoting a dose- and time-dependent dephosphorylation of akt and s6rp. |
2014-07-29 |
2023-08-12 |
human |
| Anna Caretti, Paola Bianciardi, Marina Marini, Provvidenza M Abruzzo, Alessandra Bolotta, Carlo Terruzzi, Franco Lucchina, Michele Samaj. Supplementation of creatine and ribose prevents apoptosis and right ventricle hypertrophy in hypoxic hearts. Current pharmaceutical design. vol 19. issue 39. 2014-07-22. PMID:23590158. |
the simultaneous supplementation of creatine and d-ribose has been shown to reduce apoptosis in vitro in non-irreversibly injured cultured ischemic cardiomyocytes through down-regulation of the signaling mechanisms governing adenosine monophosphate-activated protein kinase (ampk) and protein kinase b (akt). |
2014-07-22 |
2023-08-12 |
Not clear |
| Jie Li, Biyin Cao, Shunye Zhou, Jingyu Zhu, Zubin Zhang, Tingjun Hou, Xinliang Ma. Cyproheptadine-induced myeloma cell apoptosis is associated with inhibition of the PI3K/AKT signaling. European journal of haematology. vol 91. issue 6. 2014-07-18. PMID:24033664. |
more importantly, cyproheptadine-induced apoptosis was accompanied by suppressing akt activation in myeloma cells. |
2014-07-18 |
2023-08-12 |
Not clear |
| Hui Ren, Junghui Koo, Baoxiang Guan, Ping Yue, Xingming Deng, Mingwei Chen, Fadlo R Khuri, Shi-Yong Su. The E3 ubiquitin ligases β-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1, resulting in apoptosis. Molecular cancer. vol 12. 2014-07-17. PMID:24261825. |
the e3 ubiquitin ligases β-trcp and fbxw7 cooperatively mediates gsk3-dependent mcl-1 degradation induced by the akt inhibitor api-1, resulting in apoptosis. |
2014-07-17 |
2023-08-12 |
Not clear |
| Hui Ren, Junghui Koo, Baoxiang Guan, Ping Yue, Xingming Deng, Mingwei Chen, Fadlo R Khuri, Shi-Yong Su. The E3 ubiquitin ligases β-TrCP and FBXW7 cooperatively mediates GSK3-dependent Mcl-1 degradation induced by the Akt inhibitor API-1, resulting in apoptosis. Molecular cancer. vol 12. 2014-07-17. PMID:24261825. |
the novel akt inhibitor, api-1, induces apoptosis through undefined mechanisms. |
2014-07-17 |
2023-08-12 |
Not clear |