| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jaejoon Lee, Hyemin Jeong, Eun-Jung Park, Ji Won Hwang, Bo Huang, Eun-Kyung Bae, Joong Kyong Ahn, Hoon-Suk Cha, Eun-Mi Ko. CIP2A facilitates apoptotic resistance of fibroblast-like synoviocytes in rheumatoid arthritis independent of c-Myc expression. Rheumatology international. vol 33. issue 9. 2014-06-13. PMID:23455633. |
to evaluate the signal transduction pathways engaged in apoptosis, caspase-3 activity, caspase-9 activity, parp, and phosphorylation of the akt kinase were analyzed by western blot. |
2014-06-13 |
2023-08-12 |
Not clear |
| B D Green, A M Jabbour, J J Sandow, C D Riffkin, D Masouras, C P Daunt, M Salmanidis, G Brumatti, B A Hemmings, M A Guthridge, R B Pearson, P G Eker. Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations. Cell death and differentiation. vol 20. issue 10. 2014-06-12. PMID:23787999. |
akt1 is the principal akt isoform regulating apoptosis in limiting cytokine concentrations. |
2014-06-12 |
2023-08-12 |
mouse |
| Jun-Dong Zhou, Fei Shen, Jian-Song Ji, Kai Zheng, Min Huang, Jin-Chang W. FAM9C plays an anti-apoptotic role through activation of the PI3K/Akt pathway in human hepatocellular carcinoma. Oncology reports. vol 30. issue 3. 2014-06-12. PMID:23836295. |
most importantly, fam9c regulated activation of akt and uv-induced apoptosis in hcc cells. |
2014-06-12 |
2023-08-12 |
human |
| M Castells, D Milhas, C Gandy, B Thibault, A Rafii, J-P Delord, B Couder. Microenvironment mesenchymal cells protect ovarian cancer cell lines from apoptosis by inhibiting XIAP inactivation. Cell death & disease. vol 4. 2014-06-12. PMID:24176845. |
ca-msc secretions promoted akt and x-linked inhibitor of apoptosis protein (xiap; caspase inhibitor from inhibitor of apoptosis protein (iap) family) phosphorylation. |
2014-06-12 |
2023-08-12 |
Not clear |
| Hua Jin, Paul R Sanberg, Robert J Hennin. Human umbilical cord blood mononuclear cell-conditioned media inhibits hypoxic-induced apoptosis in human coronary artery endothelial cells and cardiac myocytes by activation of the survival protein Akt. Cell transplantation. vol 22. issue 9. 2014-06-09. PMID:23336598. |
human umbilical cord blood mononuclear cell-conditioned media inhibits hypoxic-induced apoptosis in human coronary artery endothelial cells and cardiac myocytes by activation of the survival protein akt. |
2014-06-09 |
2023-08-12 |
human |
| Hua Jin, Paul R Sanberg, Robert J Hennin. Human umbilical cord blood mononuclear cell-conditioned media inhibits hypoxic-induced apoptosis in human coronary artery endothelial cells and cardiac myocytes by activation of the survival protein Akt. Cell transplantation. vol 22. issue 9. 2014-06-09. PMID:23336598. |
inhibition of akt activation in endothelial cells and myocytes by the sensitive and specific antagonist api-1 during 24 h of hypoxia nearly completely prevented the beneficial effects of hucm on inhibiting caspase-3 activity and apoptosis. |
2014-06-09 |
2023-08-12 |
human |
| Evelyn Lamy, Dewi Oey, Florian Eißmann, Corinna Herz, Karsten Münstedt, Hans-Rudolf Tinneberg, Volker Mersch-Sunderman. Erucin and benzyl isothiocyanate suppress growth of late stage primary human ovarian carcinoma cells and telomerase activity in vitro. Phytotherapy research : PTR. vol 27. issue 7. 2014-06-05. PMID:22949403. |
this concurred with an increase in internucleosomal dna fragmentation, mitochondrial membrane depolarization and downregulation of akt as indicator for apoptosis induction. |
2014-06-05 |
2023-08-12 |
human |
| Kai Zhang, Fang Tian, Yonggang Zhang, Qing Zhu, Na Xue, Huimin Zhu, Heng Wang, Xinjun Gu. MACC1 is involved in the regulation of proliferation, colony formation, invasion ability, cell cycle distribution, apoptosis and tumorigenicity by altering Akt signaling pathway in human osteosarcoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 3. 2014-06-03. PMID:24163085. |
macc1 is involved in the regulation of proliferation, colony formation, invasion ability, cell cycle distribution, apoptosis and tumorigenicity by altering akt signaling pathway in human osteosarcoma. |
2014-06-03 |
2023-08-12 |
human |
| Yue-mei Jin, Tian-min Xu, Yan-hui Zhao, Yi-chao Wang, Man-hua Cu. In vitro and in vivo anti-cancer activity of formononetin on human cervical cancer cell line HeLa. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 3. 2014-06-03. PMID:24272199. |
we showed that formononetin inhibited the phosphorylation of akt and induced the apoptosis of cc cell line hela in a dose-dependent manner. |
2014-06-03 |
2023-08-12 |
mouse |
| Xiaojuan Liu, Chun Cheng, Bai Shao, Xiaohong Wu, Yuhong Ji, Xiang Lu, Aiguo She. LPS-stimulating astrocyte-conditioned medium causes neuronal apoptosis via increasing CDK11(p58) expression in PC12 cells through downregulating AKT pathway. Cellular and molecular neurobiology. vol 33. issue 6. 2014-05-28. PMID:23703121. |
lps-stimulating astrocyte-conditioned medium causes neuronal apoptosis via increasing cdk11(p58) expression in pc12 cells through downregulating akt pathway. |
2014-05-28 |
2023-08-12 |
Not clear |
| Xiaojuan Liu, Chun Cheng, Bai Shao, Xiaohong Wu, Yuhong Ji, Xiang Lu, Aiguo She. LPS-stimulating astrocyte-conditioned medium causes neuronal apoptosis via increasing CDK11(p58) expression in PC12 cells through downregulating AKT pathway. Cellular and molecular neurobiology. vol 33. issue 6. 2014-05-28. PMID:23703121. |
akt signaling pathway is involved in cdk11(p58)-induced neuronal apoptosis process. |
2014-05-28 |
2023-08-12 |
Not clear |
| Xian Xiao, Weidong Cao, Xiaofan Jiang, Wei Zhang, Yongqiang Zhang, Bolin Liu, Jinxiang Cheng, Huiyong Huang, Junli Huo, Xiang Zhan. Glaucocalyxin A, a negative Akt regulator, specifically induces apoptosis in human brain glioblastoma U87MG cells. Acta biochimica et biophysica Sinica. vol 45. issue 11. 2014-05-27. PMID:24041957. |
glaucocalyxin a, a negative akt regulator, specifically induces apoptosis in human brain glioblastoma u87mg cells. |
2014-05-27 |
2023-08-12 |
human |
| Xian Xiao, Weidong Cao, Xiaofan Jiang, Wei Zhang, Yongqiang Zhang, Bolin Liu, Jinxiang Cheng, Huiyong Huang, Junli Huo, Xiang Zhan. Glaucocalyxin A, a negative Akt regulator, specifically induces apoptosis in human brain glioblastoma U87MG cells. Acta biochimica et biophysica Sinica. vol 45. issue 11. 2014-05-27. PMID:24041957. |
in human-derived malignant glioma u87mg cells, glaucocalyxin a inhibited akt phosphorylation, suppressed proliferation, and promoted apoptosis in a dose-dependent manner, but not in normal glial cells. |
2014-05-27 |
2023-08-12 |
human |
| Victor Jeannot, Benoît Busser, Elisabeth Brambilla, Marie Wislez, Blaise Robin, Jacques Cadranel, Jean-Luc Coll, Amandine Hurbi. The PI3K/AKT pathway promotes gefitinib resistance in mutant KRAS lung adenocarcinoma by a deacetylase-dependent mechanism. International journal of cancer. vol 134. issue 11. 2014-05-22. PMID:24374738. |
deacetylase inhibitors, which decreased the bax/ku70 interaction, inhibited akt signaling and induced gefitinib-dependent apoptosis. |
2014-05-22 |
2023-08-12 |
Not clear |
| DaWu Wang, ZhenMing Hu, Jie Hao, Bin He, Qiang Gan, XiaoMing Zhong, XiaoJun Zhang, JieLiang Shen, Ji Fang, Wei Jian. SIRT1 inhibits apoptosis of degenerative human disc nucleus pulposus cells through activation of Akt pathway. Age (Dordrecht, Netherlands). vol 35. issue 5. 2014-05-20. PMID:22990594. |
sirt1 inhibits apoptosis of degenerative human disc nucleus pulposus cells through activation of akt pathway. |
2014-05-20 |
2023-08-12 |
human |
| DaWu Wang, ZhenMing Hu, Jie Hao, Bin He, Qiang Gan, XiaoMing Zhong, XiaoJun Zhang, JieLiang Shen, Ji Fang, Wei Jian. SIRT1 inhibits apoptosis of degenerative human disc nucleus pulposus cells through activation of Akt pathway. Age (Dordrecht, Netherlands). vol 35. issue 5. 2014-05-20. PMID:22990594. |
treatment with ly294002 or akt sirna increased the rate of apoptosis. |
2014-05-20 |
2023-08-12 |
human |
| Nobuhisa Nakamura, Keiko Naruse, Yasuko Kobayashi, Takashi Matsuki, Yoji Hamada, Eitaro Nakashima, Hideki Kamiya, Masaki Hata, Toru Nishikawa, Atsushi Enomoto, Masahide Takahashi, Toyoaki Murohara, Tatsuaki Matsubara, Yutaka Oiso, Jiro Nakamur. High glucose impairs the proliferation and increases the apoptosis of endothelial progenitor cells by suppression of Akt. Journal of diabetes investigation. vol 2. issue 4. 2014-05-20. PMID:24843496. |
high glucose impairs the proliferation and increases the apoptosis of endothelial progenitor cells by suppression of akt. |
2014-05-20 |
2023-08-13 |
Not clear |
| Chae Won Kim, Jing Nan Lu, Se-Il Go, Ji Hyun Jung, Sang Mi Yi, Jae-Hoon Jeong, Young-Sool Hah, Myung Shin Han, Jeong Woo Park, Won Sup Lee, Young Joo Mi. p53 restoration can overcome cisplatin resistance through inhibition of Akt as well as induction of Bax. International journal of oncology. vol 43. issue 5. 2014-05-19. PMID:23970333. |
akt inhibition slightly enhanced cddp-induced apoptosis in snu-16 cells. |
2014-05-19 |
2023-08-12 |
Not clear |
| Chae Won Kim, Jing Nan Lu, Se-Il Go, Ji Hyun Jung, Sang Mi Yi, Jae-Hoon Jeong, Young-Sool Hah, Myung Shin Han, Jeong Woo Park, Won Sup Lee, Young Joo Mi. p53 restoration can overcome cisplatin resistance through inhibition of Akt as well as induction of Bax. International journal of oncology. vol 43. issue 5. 2014-05-19. PMID:23970333. |
the induction of wild-type p53 can enhance cddp-induced apoptosis not only by inducing bax protein but also by suppressing anti-apoptotic proteins through inhibition of akt. |
2014-05-19 |
2023-08-12 |
Not clear |
| Chae Won Kim, Jing Nan Lu, Se-Il Go, Ji Hyun Jung, Sang Mi Yi, Jae-Hoon Jeong, Young-Sool Hah, Myung Shin Han, Jeong Woo Park, Won Sup Lee, Young Joo Mi. p53 restoration can overcome cisplatin resistance through inhibition of Akt as well as induction of Bax. International journal of oncology. vol 43. issue 5. 2014-05-19. PMID:23970333. |
in conclusion, this study suggests that the primary contributor to resistance to cddp in snu-16 cells may well be a failure of induction of apoptosis due to a lack of induction of pro-apoptotic proteins rather than suppression of anti-apoptotic proteins, and that restoration of p53 function can overcome the resistance to cddp not only by augmenting the pro-apoptotic drive through p53-mediated transcriptional activation but also by inhibiting the anti-apoptotic drive through inhibition of akt activity. |
2014-05-19 |
2023-08-12 |
Not clear |