| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Risa Shiragami, Soichiro Murata, Chihiro Kosugi, Tohru Tezuka, Masato Yamazaki, Atsushi Hirano, Yukino Yoshimura, Masato Suzuki, Kiyohiko Shuto, Keiji Kod. Enhanced antitumor activity of cerulenin combined with oxaliplatin in human colon cancer cells. International journal of oncology. vol 43. issue 2. 2014-03-20. PMID:23754252. |
cerulenin treatment was associated with reduced levels of phosphorylated akt, activation of p38 and induced caspase-3 cleavage and finally caused apoptosis. |
2014-03-20 |
2023-08-12 |
mouse |
| Mohamed K Al-Sadoon, Danny M Rabah, Gamal Bad. Enhanced anticancer efficacy of snake venom combined with silica nanoparticles in a murine model of human multiple myeloma: molecular targets for cell cycle arrest and apoptosis induction. Cellular immunology. vol 284. issue 1-2. 2014-03-20. PMID:23973876. |
in addition, the results of treatment with wev+np or wev alone revealed that the combination of wev with np robustly decreased the expression of cyclin d1, bcl-2 and the phosphorylation of akt; increased the expression of cyclin b1; altered the mitochondrial membrane potential; increased the activity of caspase-3, -8 and -9; and sensitized mm cells to growth arrest and apoptosis. |
2014-03-20 |
2023-08-12 |
mouse |
| David N Douda, Lily Yip, Meraj A Khan, Hartmut Grasemann, Nades Palaniya. Akt is essential to induce NADPH-dependent NETosis and to switch the neutrophil death to apoptosis. Blood. vol 123. issue 4. 2014-03-19. PMID:24458280. |
akt is essential to induce nadph-dependent netosis and to switch the neutrophil death to apoptosis. |
2014-03-19 |
2023-08-12 |
Not clear |
| Yu Huang, Qingsong Xi, Yu Chen, Jing Wang, Ping Peng, Shu Xia, Shiying Y. A dual mTORC1 and mTORC2 inhibitor shows antitumor activity in esophageal squamous cell carcinoma cells and sensitizes them to cisplatin. Anti-cancer drugs. vol 24. issue 9. 2014-03-18. PMID:23838676. |
furthermore, pp242 promoted cisplatin-induced apoptosis and enhanced the antitumor efficacy of cisplatin in escc cells, which was likely to be associated with inhibition of akt activity. |
2014-03-18 |
2023-08-12 |
Not clear |
| Grazia Pula, Alessandra Pistilli, Claudia Montagnoli, Anna M Stabile, Maria G Rambotti, Mario Rend. The tricyclic antidepressant amitriptyline is cytotoxic to HTB114 human leiomyosarcoma and induces p75(NTR)-dependent apoptosis. Anti-cancer drugs. vol 24. issue 9. 2014-03-18. PMID:23872911. |
this converted the trka⁺-proliferating cells into trka⁺/p75(ntr⁺), leading to downregulation of trka-prosurvival signaling (akt) and activation of p75(ntr)-dependent apoptosis (through caspase-3). |
2014-03-18 |
2023-08-12 |
human |
| Lulu Fan, Guoping Sun, Tai Ma, Fei Zhong, Wei We. Melatonin overcomes apoptosis resistance in human hepatocellular carcinoma by targeting survivin and XIAP. Journal of pineal research. vol 55. issue 2. 2014-03-17. PMID:23679681. |
inhibition of cox-2 activity with the selective inhibitor, ns398, and inhibition of akt activation using the pi3k inhibitor, ly294002, in tumor cells confirmed that melatonin-induced apoptosis was cox-2/pi3k/akt-dependent, suggesting that the cox-2/pi3k/akt pathway plays a role in melatonin inhibition of iaps. |
2014-03-17 |
2023-08-12 |
human |
| Lulu Fan, Guoping Sun, Tai Ma, Fei Zhong, Yu Lei, Xiaoqiu Li, Wei We. Melatonin reverses tunicamycin-induced endoplasmic reticulum stress in human hepatocellular carcinoma cells and improves cytotoxic response to doxorubicin by increasing CHOP and decreasing survivin. Journal of pineal research. vol 55. issue 2. 2014-03-17. PMID:23711089. |
furthermore, consistent with inhibition of akt activation by using the pi3k inhibitor ly294002, melatonin elevated the levels of chop (c/ebp-homologous protein) and reduced the levels of survivin (a member of the inhibitor of apoptosis protein family)suggesting that inhibition of the pi3k/akt pathway by melatonin-reversed er stress-induced resistance to doxorubicin in human hepatocellular carcinoma cells. |
2014-03-17 |
2023-08-12 |
human |
| Lin Yang, Xiao-Hou Wu, Dan Wang, Chun-Li Luo, Li-Xue Che. Bladder cancer cell-derived exosomes inhibit tumor cell apoptosis and induce cell proliferation in vitro. Molecular medicine reports. vol 8. issue 4. 2014-03-17. PMID:23969721. |
in conclusion, this study demonstrated that bladder cancer cell‑derived exosomes inhibited tumor cell apoptosis, which was associated with the activation of akt and erk pathway genes, suggesting that tumor‑derived exosomes are involved in bladder cancer progression. |
2014-03-17 |
2023-08-12 |
human |
| Lee Farrand, Ji Young Kim, Sanguine Byun, Akechai Im-aram, Jihoon Lee, Jeong-Yong Suh, Ki-Won Lee, Hyong Joo Lee, Benjamin K Tsan. The diarylheptanoid hirsutenone sensitizes chemoresistant ovarian cancer cells to cisplatin via modulation of apoptosis-inducing factor and X-linked inhibitor of apoptosis. The Journal of biological chemistry. vol 289. issue 3. 2014-03-17. PMID:24247248. |
this was found to be, at least in part, under the influence of upstream akt activity, linking hirsutenone-dependent pi3k inhibition with downstream effects on apoptosis-inducing factor, x-linked inhibitor of apoptosis, and apoptosis. |
2014-03-17 |
2023-08-12 |
Not clear |
| Yurong Tao, Yan Guo, Wenchao Liu, Jian Zhang, Xia Li, Lan Shen, Yi Ru, Yan Xue, Jin Zheng, Xinping Liu, Jing Zhang, Libo Ya. AKT inhibitor suppresses hyperthermia-induced Ndrg2 phosphorylation in gastric cancer cells. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 46. issue 4. 2014-03-14. PMID:23558861. |
accordingly, the apoptosis rate rose significantly in mkn28 cells (16.4%) treated with a combination of akt inhibitor viii and hyperthermia compared to that (6.8%) of cells treated with hyperthermia alone (p < 0.05). |
2014-03-14 |
2023-08-12 |
Not clear |
| Yurong Tao, Yan Guo, Wenchao Liu, Jian Zhang, Xia Li, Lan Shen, Yi Ru, Yan Xue, Jin Zheng, Xinping Liu, Jing Zhang, Libo Ya. AKT inhibitor suppresses hyperthermia-induced Ndrg2 phosphorylation in gastric cancer cells. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 46. issue 4. 2014-03-14. PMID:23558861. |
furthermore, akt inhibitor viii suppressed ndrg2 phosphorylation and rendered gastric cancer cells susceptible to apoptosis induced by hyperthermia. |
2014-03-14 |
2023-08-12 |
Not clear |
| X Li, Z Li, W Zhou, X Xing, L Huang, L Tian, J Chen, C Chen, X Ma, Z Yan. Overexpression of 4EBP1, p70S6K, Akt1 or Akt2 differentially promotes Coxsackievirus B3-induced apoptosis in HeLa cells. Cell death & disease. vol 4. 2014-03-12. PMID:24030155. |
as 4ebp1, p70s6k and akt are the important substrates of pi3k and mammalian target of rapamycin (mtor), we further illustrated the role of pi3k/akt/mtor signaling pathway in the process of cvb3-induced apoptosis. |
2014-03-12 |
2023-08-12 |
Not clear |
| J Chen, H Bi, J Hou, X Zhang, C Zhang, L Yue, X Wen, D Liu, H Shi, J Yuan, J Liu, B Li. Atorvastatin overcomes gefitinib resistance in KRAS mutant human non-small cell lung carcinoma cells. Cell death & disease. vol 4. 2014-03-12. PMID:24071646. |
atorvastatin (1 μm) plus gefitinib treatment inhibited proliferation, promoted cell apoptosis, and reduced the akt activity in kras mutant nsclc cells compared with gefitinib alone. |
2014-03-12 |
2023-08-12 |
human |
| Sujata Lalitkumar, Nageswara R Boggavarapu, Judith Menezes, Evdokia Dimitriadis, Jian-Guo Zhang, Nicos A Nicola, Kristina Gemzell-Danielsson, Luther P G Lalitkuma. Polyethylene glycated leukemia inhibitory factor antagonist inhibits human blastocyst implantation and triggers apoptosis by down-regulating embryonic AKT. Fertility and sterility. vol 100. issue 4. 2014-03-11. PMID:23876532. |
polyethylene glycated leukemia inhibitory factor antagonist inhibits human blastocyst implantation and triggers apoptosis by down-regulating embryonic akt. |
2014-03-11 |
2023-08-12 |
human |
| De-Xiang Zhuo, Xiao-Wei Zhang, Bo Jin, Zheng Zhang, Bu-Shan Xie, Cheng-Lin Wu, Kan Gong, Ze-Bin Ma. CSTP1, a novel protein phosphatase, blocks cell cycle, promotes cell apoptosis, and suppresses tumor growth of bladder cancer by directly dephosphorylating Akt at Ser473 site. PloS one. vol 8. issue 6. 2014-03-05. PMID:23799035. |
cstp1, a novel protein phosphatase, blocks cell cycle, promotes cell apoptosis, and suppresses tumor growth of bladder cancer by directly dephosphorylating akt at ser473 site. |
2014-03-05 |
2023-08-12 |
mouse |
| De-Xiang Zhuo, Xiao-Wei Zhang, Bo Jin, Zheng Zhang, Bu-Shan Xie, Cheng-Lin Wu, Kan Gong, Ze-Bin Ma. CSTP1, a novel protein phosphatase, blocks cell cycle, promotes cell apoptosis, and suppresses tumor growth of bladder cancer by directly dephosphorylating Akt at Ser473 site. PloS one. vol 8. issue 6. 2014-03-05. PMID:23799035. |
in this study, we identified a novel protein phosphatase cstp1(complete s transactivated protein 1), which interacts and dephosphorylates akt specifically at ser473 site in vivo and in vitro, blocks cell cycle progression and promotes cell apoptosis. |
2014-03-05 |
2023-08-12 |
mouse |
| Hiromichi Ebi, Carlotta Costa, Anthony C Faber, Madhuri Nishtala, Hiroshi Kotani, Dejan Juric, Patricia Della Pelle, Youngchul Song, Seiji Yano, Mari Mino-Kenudson, Cyril H Benes, Jeffrey A Engelma. PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 52. 2014-02-27. PMID:24327733. |
in contrast, protein kinase akt inhibitors failed to block mek/erk signaling, did not up-regulate bim, and failed to induce apoptosis. |
2014-02-27 |
2023-08-12 |
Not clear |
| So-Jung Kim, Hyeong-Jin Kim, Hye-Ri Kim, Seung-Ho Lee, Sung-Dae Cho, Chang-Sun Choi, Jeong-Seok Nam, Ji-Youn Jun. Antitumor actions of baicalein and wogonin in HT-29 human colorectal cancer cells. Molecular medicine reports. vol 6. issue 6. 2014-02-26. PMID:22992837. |
the results indicated that baicalein induced apoptosis via akt activation in a p53-dependent manner in the ht-29 colon cancer cells and that it may serve as a chemopreventive or therapeutic agent for ht-29 colon cancer. |
2014-02-26 |
2023-08-12 |
mouse |
| Xi-Lan Tang, Jian-Xun Liu, Peng Li, Wei Dong, Lei Li, Yong-Qiu Zheng, Jin-Cai Ho. [Protective effect of succinic acid on primary cardiomyocyte hypoxia/reoxygenation injury]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 38. issue 21. 2014-02-25. PMID:24494565. |
therefore, this study demonstrated that succinic acid could inhibit necrosis and apoptosis caused by cardiomyocyte hypoxia/reoxygenation by activating akt phosphorylation. |
2014-02-25 |
2023-08-12 |
rat |
| Hasaya Dokduang, Sirinun Juntana, Anchalee Techasen, Nisana Namwat, Puangrat Yongvanit, Narong Khuntikeo, Gregory J Riggins, Watcharin Loilom. Survey of activated kinase proteins reveals potential targets for cholangiocarcinoma treatment. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 34. issue 6. 2014-02-21. PMID:23812726. |
the inhibition of kinase activation using multi-targeted kinase inhibitors, sorafenib and sunitinib led to significant cell growth inhibition and apoptosis induction via suppression of erk1/2 and akt activation, whereas drugs with specificity to a single kinase showed less potency. |
2014-02-21 |
2023-08-12 |
human |