| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Denis Lane, Isabelle Matte, Claude Laplante, Perrine Garde-Granger, Claudine Rancourt, Alain Pich\\xc3\\xa. Osteoprotegerin (OPG) activates integrin, focal adhesion kinase (FAK), and Akt signaling in ovarian cancer cells to attenuate TRAIL-induced apoptosis. Journal of ovarian research. vol 6. issue 1. 2014-01-17. PMID:24267510.' |
osteoprotegerin (opg) activates integrin, focal adhesion kinase (fak), and akt signaling in ovarian cancer cells to attenuate trail-induced apoptosis. |
2014-01-17 |
2023-08-12 |
Not clear |
| Shashi Rajput, B N Prashanth Kumar, Kaushik Kumar Dey, Ipsita Pal, Aditya Parekh, Mahitosh Manda. Molecular targeting of Akt by thymoquinone promotes G(1) arrest through translation inhibition of cyclin D1 and induces apoptosis in breast cancer cells. Life sciences. vol 93. issue 21. 2014-01-14. PMID:24044882. |
molecular targeting of akt by thymoquinone promotes g(1) arrest through translation inhibition of cyclin d1 and induces apoptosis in breast cancer cells. |
2014-01-14 |
2023-08-12 |
Not clear |
| I-Ling Lin, Han-Lin Chou, Jin-Ching Lee, Feng-Wei Chen, Yao Fong, Wei-Chiao Chang, Hurng Wern Huang, Chang-Yi Wu, Wen-Tsan Chang, Hui-Min David Wang, Chien-Chih Chi. The antiproliferative effect of C2-ceramide on lung cancer cells through apoptosis by inhibiting Akt and NFκB. Cancer cell international. vol 14. issue 1. 2014-01-14. PMID:24393431. |
the antiproliferative effect of c2-ceramide on lung cancer cells through apoptosis by inhibiting akt and nfκb. |
2014-01-14 |
2023-08-12 |
Not clear |
| Shu-Yu Liu, Chia-Ling Chen, Tsan-Tzu Yang, Wei-Ching Huang, Chia-Yuan Hsieh, Wan-Jou Shen, Tsung-Ting Tsai, Chi-Chang Shieh, Chiou-Feng Li. Albumin prevents reactive oxygen species-induced mitochondrial damage, autophagy, and apoptosis during serum starvation. Apoptosis : an international journal on programmed cell death. vol 17. issue 11. 2014-01-10. PMID:22983605. |
in addition, activation of glycogen synthase kinase (gsk)-3β by nox/ros-inactivated akt facilitated a decrease in mcl-1, followed by mitochondrial apoptosis as well as autophagy. |
2014-01-10 |
2023-08-12 |
Not clear |
| Yueh-Shan Weng, Wei-Wen Kuo, Yueh-Min Lin, Chia-Hua Kuo, Bor-Show Tzang, Fuu-Jen Tsai, Chang-Hai Tsai, James A Lin, Dennis Jine-Yuan Hsieh, Chih-Yang Huan. Danshen mediates through estrogen receptors to activate Akt and inhibit apoptosis effect of Leu27IGF-II-induced IGF-II receptor signaling activation in cardiomyoblasts. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 56. 2014-01-10. PMID:23419388. |
danshen mediates through estrogen receptors to activate akt and inhibit apoptosis effect of leu27igf-ii-induced igf-ii receptor signaling activation in cardiomyoblasts. |
2014-01-10 |
2023-08-12 |
Not clear |
| Yueh-Shan Weng, Wei-Wen Kuo, Yueh-Min Lin, Chia-Hua Kuo, Bor-Show Tzang, Fuu-Jen Tsai, Chang-Hai Tsai, James A Lin, Dennis Jine-Yuan Hsieh, Chih-Yang Huan. Danshen mediates through estrogen receptors to activate Akt and inhibit apoptosis effect of Leu27IGF-II-induced IGF-II receptor signaling activation in cardiomyoblasts. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 56. 2014-01-10. PMID:23419388. |
we found that danshen extract treatments significantly enhanced phosphorylated akt through estrogen receptor activation to inhibit leu27igf-ii-induced calcineurin activation and block h9c2 cell apoptosis. |
2014-01-10 |
2023-08-12 |
Not clear |
| Shu-Sheng Jia, Guang-Peng Xi, Ming Zhang, Yan-Bo Chen, Bo Lei, Xin-Shu Dong, Yan-Mei Yan. Induction of apoptosis by D-limonene is mediated by inactivation of Akt in LS174T human colon cancer cells. Oncology reports. vol 29. issue 1. 2014-01-09. PMID:23117412. |
induction of apoptosis by d-limonene is mediated by inactivation of akt in ls174t human colon cancer cells. |
2014-01-09 |
2023-08-12 |
human |
| S Scotland, E Saland, N Skuli, F de Toni, H Boutzen, E Micklow, I Sénégas, R Peyraud, L Peyriga, F Théodoro, E Dumon, Y Martineau, G Danet-Desnoyers, F Bono, C Rocher, T Levade, S Manenti, C Junot, J-C Portais, N Alet, C Récher, M A Selak, M Carroll, J-E Sarr. Mitochondrial energetic and AKT status mediate metabolic effects and apoptosis of metformin in human leukemic cells. Leukemia. vol 27. issue 11. 2014-01-09. PMID:23568147. |
mitochondrial energetic and akt status mediate metabolic effects and apoptosis of metformin in human leukemic cells. |
2014-01-09 |
2023-08-12 |
human |
| S Scotland, E Saland, N Skuli, F de Toni, H Boutzen, E Micklow, I Sénégas, R Peyraud, L Peyriga, F Théodoro, E Dumon, Y Martineau, G Danet-Desnoyers, F Bono, C Rocher, T Levade, S Manenti, C Junot, J-C Portais, N Alet, C Récher, M A Selak, M Carroll, J-E Sarr. Mitochondrial energetic and AKT status mediate metabolic effects and apoptosis of metformin in human leukemic cells. Leukemia. vol 27. issue 11. 2014-01-09. PMID:23568147. |
importantly, leukemic cells with high basal akt phosphorylation, glucose consumption or glycolysis exhibit a markedly reduced induction of the pasteur effect in response to metformin and are resistant to metformin-induced apoptosis. |
2014-01-09 |
2023-08-12 |
human |
| S Scotland, E Saland, N Skuli, F de Toni, H Boutzen, E Micklow, I Sénégas, R Peyraud, L Peyriga, F Théodoro, E Dumon, Y Martineau, G Danet-Desnoyers, F Bono, C Rocher, T Levade, S Manenti, C Junot, J-C Portais, N Alet, C Récher, M A Selak, M Carroll, J-E Sarr. Mitochondrial energetic and AKT status mediate metabolic effects and apoptosis of metformin in human leukemic cells. Leukemia. vol 27. issue 11. 2014-01-09. PMID:23568147. |
overall, metformin elicits reprogramming of intermediary metabolism leading to inhibition of cell proliferation in all leukemic cells and apoptosis only in leukemic cells responding to metformin with akt phosphorylation and a strong pasteur effect. |
2014-01-09 |
2023-08-12 |
human |
| Hiroyuki Tanak. [Old or new medicine? Vitamin B12 and peripheral nerve neuropathy]. Brain and nerve = Shinkei kenkyu no shinpo. vol 65. issue 9. 2014-01-09. PMID:24018744. |
in addition, methylcobalamin facilitates neurite outgrowth and inhibits neural apoptosis through the erk1/2 and akt signaling pathways. |
2014-01-09 |
2023-08-12 |
Not clear |
| Hyun-Kyung Lee, Ga Bin Park, Yeong Seok Kim, Hyunkeun Song, V Courtney Broaddus, Dae Young Hu. Ligation of CM1 enhances apoptosis of lung cancer cells through different mechanisms in conformity with EGFR mutation. International journal of oncology. vol 42. issue 2. 2014-01-07. PMID:23232551. |
further studies to investigate the signaling mechanisms identified that ligation of cm1‑induced apoptosis in a549 cell involved fasl expression, caspase-8, erk1/2 and akt kinase, whereas apoptosis of hcc827 cells was induced through caspase-9, jnk and c-jun‑dependent pathways. |
2014-01-07 |
2023-08-12 |
Not clear |
| Wen-jing Liu, Shu-yang Zhu, Yu-ling Chen, Xia Wu, Wen-jing Ni, Yun-feng Chen, Ling Zha. [The effects of leptin on apoptosis of airway smooth muscle cells via the PI3K/Akt signaling pathway]. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases. vol 35. issue 12. 2014-01-07. PMID:23328183. |
to observe the effects of leptin on the expression of akt, pho-akt, bcl-2, bax, caspase-3 and the apoptosis of airway smooth muscle cells (asmcs), and to explore the possible mechanisms. |
2014-01-07 |
2023-08-12 |
Not clear |
| Li Chen, Yuyan Zhao, Delu Zheng, Shujing Ju, Yang Shen, Lei Gu. Orexin A Affects INS-1 Rat Insulinoma Cell Proliferation via Orexin Receptor 1 and the AKT Signaling Pathway. International journal of endocrinology. vol 2013. 2014-01-02. PMID:24382962. |
ins-1 amount of cell proliferation, viability and apoptosis, insulin secretion, ox1r protein expression, caspase-3 activity, and akt protein levels were determined. |
2014-01-02 |
2023-08-12 |
rat |
| Li Chen, Yuyan Zhao, Delu Zheng, Shujing Ju, Yang Shen, Lei Gu. Orexin A Affects INS-1 Rat Insulinoma Cell Proliferation via Orexin Receptor 1 and the AKT Signaling Pathway. International journal of endocrinology. vol 2013. 2014-01-02. PMID:24382962. |
these results suggest that the upregulation of oxa-ox1r mediated by akt activation may inhibit cell apoptosis and promote cell proliferation in ins-1 cells. |
2014-01-02 |
2023-08-12 |
rat |
| Katsuyuki Iida, Rong Zheng, Ruoqian Shen, David M Nanu. Adenoviral neutral endopeptidase gene delivery in combination with paclitaxel for the treatment of prostate cancer. International journal of oncology. vol 41. issue 4. 2013-12-31. PMID:22895534. |
du145 cells were infected with adenovirus expressing nep or lacz, treated with paclitaxel, and assessed for cell viability, akt activation and induction of apoptosis. |
2013-12-31 |
2023-08-12 |
mouse |
| Sehamuddin Galadari, Anees Rahman, Siraj Pallichankandy, Alaa Galadari, Faisal Thayyullathi. Role of ceramide in diabetes mellitus: evidence and mechanisms. Lipids in health and disease. vol 12. 2013-12-31. PMID:23835113. |
ceramide induces β-cell apoptosis by multiple mechanisms namely; activation of extrinsic apoptotic pathway, increasing cytochrome c release, free radical generation, induction of endoplasmic reticulum stress and inhibition of akt. |
2013-12-31 |
2023-08-12 |
human |
| Fang Yan, Liping Liu, Peter J Dempsey, Yu-Hwai Tsai, Elaine W Raines, Carole L Wilson, Hailong Cao, Zheng Cao, LinShu Liu, D Brent Pol. A Lactobacillus rhamnosus GG-derived soluble protein, p40, stimulates ligand release from intestinal epithelial cells to transactivate epidermal growth factor receptor. The Journal of biological chemistry. vol 288. issue 42. 2013-12-31. PMID:24043629. |
knockdown of hb-egf expression by sirna suppresses p40 effects on transactivating egfr and akt, preventing apoptosis, and preserving tight junction function. |
2013-12-31 |
2023-08-12 |
mouse |
| Junxia Zhang, Zhimei Wang, Guangfeng Zuo, Bing Li, Junjie Zhang, Nailiang Tian, Shaoliang Che. Low shear stress induces human vascular endothelial cell apoptosis by activating Akt signal and increasing reactive oxygen species. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 33. issue 3. 2013-12-30. PMID:23529222. |
low shear stress induces human vascular endothelial cell apoptosis by activating akt signal and increasing reactive oxygen species. |
2013-12-30 |
2023-08-12 |
human |
| Elena N Atochina-Vasserman, Dmitry A Goncharov, Alla V Volgina, Megan Milavec, Melane L James, Vera P Krymskay. Statins in lymphangioleiomyomatosis. Simvastatin and atorvastatin induce differential effects on tuberous sclerosis complex 2-null cell growth and signaling. American journal of respiratory cell and molecular biology. vol 49. issue 5. 2013-12-27. PMID:23947572. |
simvastatin, but not atorvastatin, inhibited the activity of prosurvival serine-threonine kinase akt and induced marked up-regulation of cleaved caspase-3, a marker of cell apoptosis. |
2013-12-27 |
2023-08-12 |
mouse |