| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hiroto Ueba, Masashi Shiomi, Michael Brines, Michael Yamin, Tsutomu Kobayashi, Junya Ako, Shin-Ichi Momomura, Anthony Cerami, Masanobu Kawakam. Suppression of coronary atherosclerosis by helix B surface Peptide, a nonerythropoietic, tissue-protective compound derived from erythropoietin. Molecular medicine (Cambridge, Mass.). vol 19. 2013-12-24. PMID:23648638. |
by using a small interfering rna approach, akt was shown to be a key molecule in hbsp-mediated prevention of apoptosis. |
2013-12-24 |
2023-08-12 |
human |
| Hiroto Ueba, Masashi Shiomi, Michael Brines, Michael Yamin, Tsutomu Kobayashi, Junya Ako, Shin-Ichi Momomura, Anthony Cerami, Masanobu Kawakam. Suppression of coronary atherosclerosis by helix B surface Peptide, a nonerythropoietic, tissue-protective compound derived from erythropoietin. Molecular medicine (Cambridge, Mass.). vol 19. 2013-12-24. PMID:23648638. |
in the whhlmi rabbit, hbsp significantly suppressed progression of coronary atherosclerotic lesions as assessed by mean cross-sectional stenosis (hbsp 21.3 ± 2.2% versus control peptide 38.0 ± 2.7%) and inhibited coronary artery endothelial cell apoptosis with increased activation of akt. |
2013-12-24 |
2023-08-12 |
human |
| Hiroto Ueba, Masashi Shiomi, Michael Brines, Michael Yamin, Tsutomu Kobayashi, Junya Ako, Shin-Ichi Momomura, Anthony Cerami, Masanobu Kawakam. Suppression of coronary atherosclerosis by helix B surface Peptide, a nonerythropoietic, tissue-protective compound derived from erythropoietin. Molecular medicine (Cambridge, Mass.). vol 19. 2013-12-24. PMID:23648638. |
in conclusion, these data demonstrate that hbsp suppresses coronary atherosclerosis, in part by inhibiting endothelial cell apoptosis through activation of akt and in association with decreased tnf-α production and modified macrophage polarization in coronary atherosclerotic lesions. |
2013-12-24 |
2023-08-12 |
human |
| Xiaohua Yang, Gengyin Zhou, Tao Ren, Hui Li, Yanjun Zhang, Deling Yin, Haixin Qian, Qinchuan L. β-Arrestin prevents cell apoptosis through pro-apoptotic ERK1/2 and p38 MAPKs and anti-apoptotic Akt pathways. Apoptosis : an international journal on programmed cell death. vol 17. issue 9. 2013-12-23. PMID:22699970. |
β-arrestin prevents cell apoptosis through pro-apoptotic erk1/2 and p38 mapks and anti-apoptotic akt pathways. |
2013-12-23 |
2023-08-12 |
Not clear |
| Xiaohua Yang, Gengyin Zhou, Tao Ren, Hui Li, Yanjun Zhang, Deling Yin, Haixin Qian, Qinchuan L. β-Arrestin prevents cell apoptosis through pro-apoptotic ERK1/2 and p38 MAPKs and anti-apoptotic Akt pathways. Apoptosis : an international journal on programmed cell death. vol 17. issue 9. 2013-12-23. PMID:22699970. |
our study thus demonstrates that β-arrestin inhibits cell apoptosis through pro-apoptotic erk1/2 and p38 mapks and anti-apoptotic akt signaling pathways. |
2013-12-23 |
2023-08-12 |
Not clear |
| Hou-Guang Zhou, Ling Liu, Yu Zhang, Yan-Yan Huang, Ying-Hong Tao, Shuo Zhang, Jing-Jing Su, Yu-Ping Tang, Zhuang-Li Guo, Ren-Ming Hu, Qiang Don. Glutathione prevents free fatty acids-induced oxidative stress and apoptosis in human brain vascular endothelial cells through Akt pathway. CNS neuroscience & therapeutics. vol 19. issue 4. 2013-12-23. PMID:23521913. |
glutathione prevents free fatty acids-induced oxidative stress and apoptosis in human brain vascular endothelial cells through akt pathway. |
2013-12-23 |
2023-08-12 |
human |
| Jiwon Ahn, Misun Won, Jeong-Hae Choi, Yong Sung Kim, Cho-Rock Jung, Dong-Su Im, Mi-Lang Kyun, Kyeong Lee, Kyung-Bin Song, Kyung-Sook Chun. Reactive oxygen species-mediated activation of the Akt/ASK1/p38 signaling cascade and p21(Cip1) downregulation are required for shikonin-induced apoptosis. Apoptosis : an international journal on programmed cell death. vol 18. issue 7. 2013-12-23. PMID:23546866. |
in the presence of shikonin, inactivation of akt caused apoptosis signal-regulating kinase 1 (ask1) dephosphorylation at ser83, which is associated with ask1 activation. |
2013-12-23 |
2023-08-12 |
Not clear |
| Jiwon Ahn, Misun Won, Jeong-Hae Choi, Yong Sung Kim, Cho-Rock Jung, Dong-Su Im, Mi-Lang Kyun, Kyeong Lee, Kyung-Bin Song, Kyung-Sook Chun. Reactive oxygen species-mediated activation of the Akt/ASK1/p38 signaling cascade and p21(Cip1) downregulation are required for shikonin-induced apoptosis. Apoptosis : an international journal on programmed cell death. vol 18. issue 7. 2013-12-23. PMID:23546866. |
shikonin-induced apoptosis was enhanced by inhibition of akt, whereas overexpression of constitutively active akt prevented apoptosis through modulating ask1 phosphorylation. |
2013-12-23 |
2023-08-12 |
Not clear |
| Bit Na Seo, Jung Min Ryu, Seung Pil Yun, Ji Hoon Jeon, Su Shin Park, Keon Bong Oh, Jin-Ki Park, Ho Jae Ha. Delphinidin prevents hypoxia-induced mouse embryonic stem cell apoptosis through reduction of intracellular reactive oxygen species-mediated activation of JNK and NF-κB, and Akt inhibition. Apoptosis : an international journal on programmed cell death. vol 18. issue 7. 2013-12-23. PMID:23584725. |
delphinidin prevents hypoxia-induced mouse embryonic stem cell apoptosis through reduction of intracellular reactive oxygen species-mediated activation of jnk and nf-κb, and akt inhibition. |
2013-12-23 |
2023-08-12 |
mouse |
| Bit Na Seo, Jung Min Ryu, Seung Pil Yun, Ji Hoon Jeon, Su Shin Park, Keon Bong Oh, Jin-Ki Park, Ho Jae Ha. Delphinidin prevents hypoxia-induced mouse embryonic stem cell apoptosis through reduction of intracellular reactive oxygen species-mediated activation of JNK and NF-κB, and Akt inhibition. Apoptosis : an international journal on programmed cell death. vol 18. issue 7. 2013-12-23. PMID:23584725. |
moreover, inhibition of jnk and nf-κb abolished hypoxia-induced es cell apoptosis and inhibition of akt attenuated delphinidin-induced blockage of apoptosis. |
2013-12-23 |
2023-08-12 |
mouse |
| Bit Na Seo, Jung Min Ryu, Seung Pil Yun, Ji Hoon Jeon, Su Shin Park, Keon Bong Oh, Jin-Ki Park, Ho Jae Ha. Delphinidin prevents hypoxia-induced mouse embryonic stem cell apoptosis through reduction of intracellular reactive oxygen species-mediated activation of JNK and NF-κB, and Akt inhibition. Apoptosis : an international journal on programmed cell death. vol 18. issue 7. 2013-12-23. PMID:23584725. |
the results indicate that delphinidin can prevent hypoxia-induced apoptosis of es cells through the inhibition of jnk and nf-κb phosphorylation, and restoration of akt phosphorylation. |
2013-12-23 |
2023-08-12 |
mouse |
| Li-Yuan Bai, Jing-Ru Weng, Chang-Fang Chiu, Chia-Yung Wu, Su-Peng Yeh, Aaron M Sargeant, Po-Han Lin, Yu-Min Lia. OSU-A9, an indole-3-carbinol derivative, induces cytotoxicity in acute myeloid leukemia through reactive oxygen species-mediated apoptosis. Biochemical pharmacology. vol 86. issue 10. 2013-12-23. PMID:24041743. |
interestingly, pretreatment of aml cell lines and primary aml cells with n-acetylcysteine or glutathione rescues them from apoptosis (and concomitant parp cleavage) and akt hypophosphorylation, implicating a key role of reactive oxygen species (ros) in osu-a9-related cytotoxicity. |
2013-12-23 |
2023-08-12 |
mouse |
| Jaikrit Bhutani, Asfandyar Sheikh, Asfandyar Khan Niaz. Akt inhibitors: mechanism of action and implications for anticancer therapeutics. Infectious agents and cancer. vol 8. issue 1. 2013-12-19. PMID:24330834. |
akt, better known as protein kinase b (pkb), is a serine/threonine-specific protein kinase which acts as mediator via pi3k/akt pathway in many biological processes like glucose metabolism, apoptosis, cell differentiation and transcription. |
2013-12-19 |
2023-08-12 |
Not clear |
| Zhennan Gu, Jiansheng Wu, Shihua Wang, Janel Suburu, Haiqin Chen, Michael J Thomas, Lihong Shi, Iris J Edwards, Isabelle M Berquin, Yong Q Che. Polyunsaturated fatty acids affect the localization and signaling of PIP3/AKT in prostate cancer cells. Carcinogenesis. vol 34. issue 9. 2013-12-17. PMID:23633519. |
akt is a serine-threonine protein kinase that plays important roles in cell growth, proliferation and apoptosis. |
2013-12-17 |
2023-08-12 |
Not clear |
| Kartick C Pramanik, Shashi K Kudugunti, Neel M Fofaria, Majid Y Moridani, Sanjay K Srivastav. Caffeic acid phenethyl ester suppresses melanoma tumor growth by inhibiting PI3K/AKT/XIAP pathway. Carcinogenesis. vol 34. issue 9. 2013-12-17. PMID:23640046. |
tumors from cape-treated mice showed reduced phosphorylation of phosphoinositide 3-kinase, akt, mammalian target of rapamycin and protein level of x-linked inhibitor of apoptosis protein (xiap) and enhanced the cleavage of caspase-3 and poly (adp ribose) polymerase. |
2013-12-17 |
2023-08-12 |
mouse |
| Kartick C Pramanik, Shashi K Kudugunti, Neel M Fofaria, Majid Y Moridani, Sanjay K Srivastav. Caffeic acid phenethyl ester suppresses melanoma tumor growth by inhibiting PI3K/AKT/XIAP pathway. Carcinogenesis. vol 34. issue 9. 2013-12-17. PMID:23640046. |
our results revealed that akt overexpression attenuated the decrease in xiap and significantly blocked cape-mediated apoptosis. |
2013-12-17 |
2023-08-12 |
mouse |
| Sachin Thakur, Neha Garg, Martin L Adam. Deficiency of insulin-like growth factor-1 receptor confers resistance to oxidative stress in C2C12 myoblasts. PloS one. vol 8. issue 5. 2013-12-17. PMID:23675509. |
however, in nih-3t3 fibroblasts and mc3t3-e1 osteoblasts, the loss of igf-1r by sirna directed knockdown was associated with reduced levels of phosphorylated akt on treatment with h2o2 or uv as compared to control cells and these cells showed more apoptosis. |
2013-12-17 |
2023-08-12 |
mouse |
| Qiu-Hua Liang, Yuan Liu, Shan-Shan Wu, Rong-Rong Cui, Ling-Qing Yuan, Er-Yuan Lia. Ghrelin inhibits the apoptosis of MC3T3-E1 cells through ERK and AKT signaling pathway. Toxicology and applied pharmacology. vol 272. issue 3. 2013-12-10. PMID:23921150. |
ghrelin inhibits the apoptosis of mc3t3-e1 cells through erk and akt signaling pathway. |
2013-12-10 |
2023-08-12 |
Not clear |
| Hwang Gyun Jeon, Cheol Yong Yoon, Ji Hyeong Yu, Mi Jeong Park, Jung Eun Lee, Seong Jin Jeong, Sung Kyu Hong, Seok-Soo Byun, Sang Eun Le. Induction of caspase mediated apoptosis and down-regulation of nuclear factor-κB and Akt signaling are involved in the synergistic antitumor effect of gemcitabine and the histone deacetylase inhibitor trichostatin A in human bladder cancer cells. The Journal of urology. vol 186. issue 5. 2013-12-09. PMID:21944112. |
induction of caspase mediated apoptosis and down-regulation of nuclear factor-κb and akt signaling are involved in the synergistic antitumor effect of gemcitabine and the histone deacetylase inhibitor trichostatin a in human bladder cancer cells. |
2013-12-09 |
2023-08-12 |
human |
| Shu-Qiang Yin, Min Shi, Ting-Ting Kong, Cheng-Mei Zhang, Kunkun Han, Biyin Cao, Zubin Zhang, Xiaolin Du, Long-Qian Tang, Xinliang Mao, Zhao-Peng Li. Preparation of S14161 and its analogues and the discovery of 6-bromo-8-ethoxy-3-nitro-2H-chromene as a more potent antitumor agent in vitro. Bioorganic & medicinal chemistry letters. vol 23. issue 11. 2013-12-09. PMID:23601711. |
compared with s14161, benc-511 was more potent in blocking the akt phosphorylation and inducing cancer cell apoptosis. |
2013-12-09 |
2023-08-12 |
human |