| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yazhen Huo, Lihong Fan, Shutao Yin, Yinhui Dong, Xiao Guo, Hanchun Yang, Hongbo H. Involvement of unfolded protein response, p53 and Akt in modulation of porcine reproductive and respiratory syndrome virus-mediated JNK activation. Virology. vol 444. issue 1-2. 2013-11-06. PMID:23850458. |
furthermore, induction of upr, p53 and akt was not only involved in modulation of prrsv-mediated apoptosis, but also contributed to the virus replication. |
2013-11-06 |
2023-08-12 |
Not clear |
| Giuliana Cassinelli, Valentina Zuco, Laura Gatti, Cinzia Lanzi, Nadia Zaffaroni, Diego Colombo, Paola Pereg. Targeting the Akt kinase to modulate survival, invasiveness and drug resistance of cancer cells. Current medicinal chemistry. vol 20. issue 15. 2013-11-04. PMID:23410153. |
inhibition of akt signalling results in apoptosis and growth inhibition of tumour cells with elevated akt activity. |
2013-11-04 |
2023-08-12 |
human |
| Jun Ma, Lei Zhang, Jianguo Zhang, Mengmeng Liu, Liuping Wei, Tingting Shen, Cui Ma, Yanyan Wang, Yingli Chen, Daling Zh. 15-lipoxygenase-1/15-hydroxyeicosatetraenoic acid promotes hepatocellular cancer cells growth through protein kinase B and heat shock protein 90 complex activation. The international journal of biochemistry & cell biology. vol 45. issue 6. 2013-11-01. PMID:23474367. |
meanwhile, 15-hete strengthened the expression of phosphor-akt and heat shock protein 90, and inhibited apoptosis induced by serum deprivation via promoting the interaction of akt with heat shock protein 90. |
2013-11-01 |
2023-08-12 |
human |
| Jun Ma, Lei Zhang, Jianguo Zhang, Mengmeng Liu, Liuping Wei, Tingting Shen, Cui Ma, Yanyan Wang, Yingli Chen, Daling Zh. 15-lipoxygenase-1/15-hydroxyeicosatetraenoic acid promotes hepatocellular cancer cells growth through protein kinase B and heat shock protein 90 complex activation. The international journal of biochemistry & cell biology. vol 45. issue 6. 2013-11-01. PMID:23474367. |
these results indicate that the 15-lo-1/15-hete pathway prevents hepatocellular carcinoma cells from apoptosis and promotes hepatocellular carcinoma progression via a specific intracellular signaling pathway centered by the interaction of akt with heat shock protein 90, and suggest a new therapeutic target for hepatocellular carcinoma. |
2013-11-01 |
2023-08-12 |
human |
| Ersilia Nigro, Olga Scudiero, Daniela Sarnataro, Gennaro Mazzarella, Matteo Sofia, Andrea Bianco, Aurora Daniel. Adiponectin affects lung epithelial A549 cell viability counteracting TNFα and IL-1ß toxicity through AdipoR1. The international journal of biochemistry & cell biology. vol 45. issue 6. 2013-11-01. PMID:23500159. |
here, we investigated the effects of acrp30 on a549, a human alveolar epithelial cell line, showing how, in a time and dose-dependent manner, it decreases cell viability and increases apoptosis through erk1/2 and akt. |
2013-11-01 |
2023-08-12 |
human |
| Yan Zhang, Xiao Wang, Hui Yang, Huanrong Liu, Yun Lu, Limei Han, Guangwei Li. Kinase AKT controls innate immune cell development and function. Immunology. vol 140. issue 2. 2013-10-29. PMID:23692658. |
the critical roles of kinase akt in tumour cell proliferation, apoptosis and protein synthesis have been widely recognized. |
2013-10-29 |
2023-08-12 |
Not clear |
| Guo-Qing Bao, Bai-Yong Shen, Chun-Peng Pan, Ya-Jing Zhang, Min-Min Shi, Cheng-Hong Pen. Andrographolide causes apoptosis via inactivation of STAT3 and Akt and potentiates antitumor activity of gemcitabine in pancreatic cancer. Toxicology letters. vol 222. issue 1. 2013-10-29. PMID:23845849. |
andrographolide causes apoptosis via inactivation of stat3 and akt and potentiates antitumor activity of gemcitabine in pancreatic cancer. |
2013-10-29 |
2023-08-12 |
human |
| Guo-Qing Bao, Bai-Yong Shen, Chun-Peng Pan, Ya-Jing Zhang, Min-Min Shi, Cheng-Hong Pen. Andrographolide causes apoptosis via inactivation of STAT3 and Akt and potentiates antitumor activity of gemcitabine in pancreatic cancer. Toxicology letters. vol 222. issue 1. 2013-10-29. PMID:23845849. |
interestingly, andro induces cell cycle arrest and apoptosis of pancreatic cancer cells by inhibiting stat3 and akt activation, upregulating the expression of p21(waf1) and bax, and downregulating the expression of cyclind1, cycline, survivin, x-iap and bcl-2. |
2013-10-29 |
2023-08-12 |
human |
| Guo-Qing Bao, Bai-Yong Shen, Chun-Peng Pan, Ya-Jing Zhang, Min-Min Shi, Cheng-Hong Pen. Andrographolide causes apoptosis via inactivation of STAT3 and Akt and potentiates antitumor activity of gemcitabine in pancreatic cancer. Toxicology letters. vol 222. issue 1. 2013-10-29. PMID:23845849. |
the mechanistic study demonstrates that this synergistic effect is also dependent on the inhibition of stat3 and akt activations which subsequently regulates the pathways involved in the apoptosis and cell cycle arrest. |
2013-10-29 |
2023-08-12 |
human |
| Ming-Yue Li, Nian Ci Liang, George G Che. Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid induces apoptosis of human malignant cancer cells. Current drug targets. vol 13. issue 14. 2013-10-25. PMID:23140284. |
mapk kinases and akt are also involved in process of 5f inducing cancer cell apoptosis. |
2013-10-25 |
2023-08-12 |
human |
| Jen-Yang Tang, Hsueh-Wei Chang, Jan-Gowth Chan. Modulating roles of amiloride in irradiation-induced antiproliferative effects in glioblastoma multiforme cells involving Akt phosphorylation and the alternative splicing of apoptotic genes. DNA and cell biology. vol 32. issue 9. 2013-10-24. PMID:23822711. |
studies suggest that akt signaling may play a role in apoptosis and radioresistance. |
2013-10-24 |
2023-08-12 |
human |
| Qiao Qiao, Yuanjun Jiang, Guang L. Inhibition of the PI3K/AKT-NF-κB pathway with curcumin enhanced radiation-induced apoptosis in human Burkitt's lymphoma. Journal of pharmacological sciences. vol 121. issue 4. 2013-10-23. PMID:23603894. |
we further demonstrated that the blockage of radiation-induced activation of the pi3k/akt pathway and its downstream regulator nf-κb by either curcumin or specific pi3/akt inhibitors (ly294002 for pi3k or sh-5 for akt) enhance apoptosis in three human burkitt's lymphoma cell lines (namalwa, ramos, and raji) that were treated with ionizing radiation. |
2013-10-23 |
2023-08-12 |
human |
| Fei Hao, Nan-Nan Zhang, Dong-Mei Zhang, Hui-Yu Bai, Hua Piao, Bo Yuan, Hao-Yue Zhu, Huan Yu, Cong-Shu Xiao, Ai-Ping L. Chemokine fractalkine attenuates overactivation and apoptosis of BV-2 microglial cells induced by extracellular ATP. Neurochemical research. vol 38. issue 5. 2013-10-22. PMID:23456675. |
prolonged exposure to a high atp concentration (3 mm for 2 h) transformed ramified (quiescent) bv-2 cells to the amoebic state, induced apoptosis, and reduced akt phosphorylation. |
2013-10-22 |
2023-08-12 |
Not clear |
| Munehisa Shimamura, Ping Zhou, Barbara Casolla, Liping Qian, Carmen Capone, Hitomi Kurinami, Costantino Iadecola, Josef Anrathe. Prostaglandin E2 type 1 receptors contribute to neuronal apoptosis after transient forebrain ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 33. issue 8. 2013-10-22. PMID:23632967. |
these data implicate ep1r in postischemic neuronal apoptosis possibly by facilitating akt inhibition. |
2013-10-22 |
2023-08-12 |
mouse |
| Alfredo Q Antoniazzi, Brett T Webb, Jared J Romero, Ryan L Ashley, Natalia P Smirnova, Luiz E Henkes, Rebecca C Bott, João F Oliveira, Gordon D Niswender, Fuller W Bazer, Thomas R Hanse. Endocrine delivery of interferon tau protects the corpus luteum from prostaglandin F2 alpha-induced luteolysis in ewes. Biology of reproduction. vol 88. issue 6. 2013-10-21. PMID:23616594. |
infusion of 200 μg of ifnt over 24 h induced greater mrna concentrations for cell survival genes, such as bcl2-like 1 (bcl2l1 or bcl-xl), serine/threonine kinase (akt), and x-linked inhibitor of apoptosis (xiap) and decreased prostaglandin f receptor (ptgfr) mrna concentrations, when compared to controls. |
2013-10-21 |
2023-08-12 |
cattle |
| Mahandranauth A Chetram, Danaya A Bethea, Valerie A Odero-Marah, Ayesha S Don-Salu-Hewage, Kia J Jones, Cimona V Hinto. ROS-mediated activation of AKT induces apoptosis via pVHL in prostate cancer cells. Molecular and cellular biochemistry. vol 376. issue 1-2. 2013-10-17. PMID:23315288. |
ros-mediated activation of akt induces apoptosis via pvhl in prostate cancer cells. |
2013-10-17 |
2023-08-12 |
human |
| Ghayda M Mirzaa, Jean-Baptiste Rivière, William B Dobyn. Megalencephaly syndromes and activating mutations in the PI3K-AKT pathway: MPPH and MCAP. American journal of medical genetics. Part C, Seminars in medical genetics. vol 163C. issue 2. 2013-10-17. PMID:23592320. |
pik3r2, akt3, and pik3ca are members of the critical phosphatidylinositol-3-kinase (pi3k)-vakt murine thymoma viral oncogene homolog (akt) pathway that is well implicated in cell growth, proliferation, survival, apoptosis, among other diverse cellular functions. |
2013-10-17 |
2023-08-12 |
Not clear |
| Matthew Riopel, William Stuart, Rennian Wan. Fibrin improves beta (INS-1) cell function, proliferation and survival through integrin αvβ3. Acta biomaterialia. vol 9. issue 9. 2013-10-17. PMID:23747317. |
a significant increase in integrin αvβ3 protein and phosphorylated fak, erk1/2 and akt levels was observed in fibrin-cultured ins-1 cells, which was associated with significantly increased cell proliferation and decreased cell apoptosis. |
2013-10-17 |
2023-08-12 |
rat |
| Andrew J Wilson, Annie Y Liu, Joseph Roland, Oluwafunmilayo B Adebayo, Sarah A Fletcher, James C Slaughter, Jeanette Saskowski, Marta A Crispens, Howard W Jones, Samuel James, Oluwole Fadare, Dineo Khabel. TR3 modulates platinum resistance in ovarian cancer. Cancer research. vol 73. issue 15. 2013-09-30. PMID:23720056. |
mechanistic studies showed that the cisplatin-induced cytoplasmic tr3 translocation required for apoptosis induction was regulated by jnk activation and inhibition of akt. |
2013-09-30 |
2023-08-12 |
Not clear |
| Lin-xi Wang, Yan-ping Wang, Xiao-ying Liu, Liang Liu, Li-jing Wang, Wen-jia Chen, Xiao-hong Liu, Li-bin Li. [Dexamethasone-induced apoptosis of murine MIN6 pancreatic beta-cells and its effect on AKT phosphorylation]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 44. issue 11. 2013-09-26. PMID:21355321. |
[dexamethasone-induced apoptosis of murine min6 pancreatic beta-cells and its effect on akt phosphorylation]. |
2013-09-26 |
2023-08-12 |
Not clear |