| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jing Sun, Guibo Sun, Xiangbao Meng, Hongwei Wang, Min Wang, Meng Qin, Bo Ma, Yun Luo, Yingli Yu, Rongchang Chen, Qidi Ai, Xiaobo Su. Ginsenoside RK3 Prevents Hypoxia-Reoxygenation Induced Apoptosis in H9c2 Cardiomyocytes via AKT and MAPK Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-08-12. PMID:23935671. |
ginsenoside rk3 prevents hypoxia-reoxygenation induced apoptosis in h9c2 cardiomyocytes via akt and mapk pathway. |
2013-08-12 |
2023-08-12 |
Not clear |
| M J Stankiewicz, J D Crispin. AKT collaborates with ERG and Gata1s to dysregulate megakaryopoiesis and promote AMKL. Leukemia. vol 27. issue 6. 2013-08-09. PMID:23380710. |
we discovered that constitutive akt signaling is associated with a dramatic increase in apoptosis of wt megakaryocytes (mks), but that overexpression of erg blocks akt-induced death. |
2013-08-09 |
2023-08-12 |
Not clear |
| Shuai Zhang, Yong Sun, Zhiqiang Yuan, Ying Li, Xiaolu Li, Zhenyu Gong, Yizhi Pen. Heat shock protein 90β inhibits apoptosis of intestinal epithelial cells induced by hypoxia through stabilizing phosphorylated Akt. BMB reports. vol 46. issue 1. 2013-08-07. PMID:23351384. |
heat shock protein 90β inhibits apoptosis of intestinal epithelial cells induced by hypoxia through stabilizing phosphorylated akt. |
2013-08-07 |
2023-08-12 |
Not clear |
| Shuai Zhang, Yong Sun, Zhiqiang Yuan, Ying Li, Xiaolu Li, Zhenyu Gong, Yizhi Pen. Heat shock protein 90β inhibits apoptosis of intestinal epithelial cells induced by hypoxia through stabilizing phosphorylated Akt. BMB reports. vol 46. issue 1. 2013-08-07. PMID:23351384. |
however, the specific role of akt and hsp90β in iec apoptosis induced by hypoxia has not been explored. |
2013-08-07 |
2023-08-12 |
Not clear |
| Shuai Zhang, Yong Sun, Zhiqiang Yuan, Ying Li, Xiaolu Li, Zhenyu Gong, Yizhi Pen. Heat shock protein 90β inhibits apoptosis of intestinal epithelial cells induced by hypoxia through stabilizing phosphorylated Akt. BMB reports. vol 46. issue 1. 2013-08-07. PMID:23351384. |
the protective effect of hsp90β against apoptosis was negated by ly294002, an akt inhibitor. |
2013-08-07 |
2023-08-12 |
Not clear |
| Hideki Nakamura, Yoshiro Horai, Takahisa Suzuki, Akitomo Okada, Kunihiro Ichinose, Satoshi Yamasaki, Takehiko Koji, Atsushi Kawakam. TLR3-mediated apoptosis and activation of phosphorylated Akt in the salivary gland epithelial cells of primary Sjögren's syndrome patients. Rheumatology international. vol 33. issue 2. 2013-08-05. PMID:22457005. |
tlr3-mediated apoptosis and activation of phosphorylated akt in the salivary gland epithelial cells of primary sjögren's syndrome patients. |
2013-08-05 |
2023-08-12 |
human |
| Shishir Shishodi. Molecular mechanisms of curcumin action: gene expression. BioFactors (Oxford, England). vol 39. issue 1. 2013-08-05. PMID:22996381. |
curcumin regulates the expression of inflammatory cytokines (e.g., tnf, il-1), growth factors (e.g., vegf, egf, fgf), growth factor receptors (e.g., egfr, her-2, ar), enzymes (e.g., cox-2, lox, mmp9, mapk, mtor, akt), adhesion molecules (e.g., elam-1, icam-1, vcam-1), apoptosis related proteins (e.g., bcl-2, caspases, dr, fas), and cell cycle proteins (e.g., cyclin d1). |
2013-08-05 |
2023-08-12 |
Not clear |
| Chunhua Liu, Wei Guo, Stefanie Maerz, Xianfeng Gu, Yizhun Zh. 3,5-Dimethoxy-4-(3-(2-carbonyl-ethyldisulfanyl)-propionyl)-benzoic acid 4-guanidino-butyl ester: a novel twin drug that prevents primary cardiac myocytes from hypoxia-induced apoptosis. European journal of pharmacology. vol 700. issue 1-3. 2013-08-05. PMID:23305837. |
compound 2 inhibited apoptosis by reducing the ratio of bcl-2/bax, decreasing cleaved-caspase-3 expression and enhancing the phosphorylation of akt. |
2013-08-05 |
2023-08-12 |
Not clear |
| Jin Sun Lee, In Sang Yoon, Myung Sun Lee, Eun Young Cha, Phuong Thien Thuong, Trinh Thi Diep, Je Ryong Ki. Anticancer activity of pristimerin in epidermal growth factor receptor 2-positive SKBR3 human breast cancer cells. Biological & pharmaceutical bulletin. vol 36. issue 2. 2013-08-05. PMID:23370361. |
these results suggest that pristimerin is a novel her2-downregulated compound that is able to decrease fatty acid synthase and modulate the akt, mapk, and mtor signaling pathways to influence metastasis and apoptosis. |
2013-08-05 |
2023-08-12 |
human |
| Yan Ye, Qun Li, Wang Lai Hu, Hsin-Yi Tseng, Lei Jin, Xu Dong Zhang, Lin Jie Zhang, Sen Yan. Loss of PI(4,5)P2 5-Phosphatase A Contributes to Resistance of Human Melanoma Cells to RAF/MEK Inhibitors. Translational oncology. vol 6. issue 4. 2013-08-05. PMID:23908690. |
this was due to inhibition of pi3k/akt, as co-introduction of an active form of akt (myr-akt) abolished the effect of overexpression of pib5pa on apoptosis induced by plx4720 or u0126. |
2013-08-05 |
2023-08-12 |
human |
| Yuyu Yao, Zulong Sheng, Yefei Li, Fengdi Yan, Cong Fu, Yongjun Li, Genshan Ma, Naifeng Liu, Julie Chao, Lee Cha. Tissue kallikrein promotes cardiac neovascularization by enhancing endothelial progenitor cell functional capacity. Human gene therapy. vol 23. issue 8. 2013-08-01. PMID:22435954. |
apoptosis was evaluated by flow-cytometry analysis using annexin v-fitc/pi staining, as well as western-blot analysis of akt phosphorylation and cleaved caspase-3. |
2013-08-01 |
2023-08-12 |
mouse |
| Yuyu Yao, Zulong Sheng, Yefei Li, Fengdi Yan, Cong Fu, Yongjun Li, Genshan Ma, Naifeng Liu, Julie Chao, Lee Cha. Tissue kallikrein promotes cardiac neovascularization by enhancing endothelial progenitor cell functional capacity. Human gene therapy. vol 23. issue 8. 2013-08-01. PMID:22435954. |
transduction of tk in cultured epcs attenuated apoptosis induced by hypoxia and led to an increase in akt phosphorylation and a decrease in cleaved caspase-3 levels. |
2013-08-01 |
2023-08-12 |
mouse |
| Fumi Shima, Yoko Yoshikawa, Min Ye, Mitsugu Araki, Shigeyuki Matsumoto, Jingling Liao, Lizhi Hu, Takeshi Sugimoto, Yuichi Ijiri, Azusa Takeda, Yuko Nishiyama, Chie Sato, Shin Muraoka, Atsuo Tamura, Tsutomu Osoda, Ken-ichiro Tsuda, Tomoya Miyakawa, Hiroaki Fukunishi, Jiro Shimada, Takashi Kumasaka, Masaki Yamamoto, Tohru Kataok. In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 20. 2013-07-25. PMID:23630290. |
they effectively inhibit both anchorage-dependent and -independent growth and induce apoptosis of h-ras(g12v)-transformed nih 3t3 cells, which is accompanied by down-regulation of downstream molecules such as mek/erk, akt, and rala as well as an upstream molecule, son of sevenless. |
2013-07-25 |
2023-08-12 |
human |
| E Giovannetti, M Labots, H Dekker, E Galvani, J S W Lind, R Sciarrillo, R Honeywell, E F Smit, H M Verheul, G J Peter. Molecular mechanisms and modulation of key pathways underlying the synergistic interaction of sorafenib with erlotinib in non-small-cell-lung cancer (NSCLC) cells. Current pharmaceutical design. vol 19. issue 5. 2013-07-22. PMID:22973961. |
pharmacologic interaction was studied using mtt/srb assays and the combination index (ci) method, while effects on egfr, erk1/2 and akt phosphorylation, cell cycle and apoptosis were studied with western-blot, elisa, and flow cytometry. |
2013-07-22 |
2023-08-12 |
Not clear |
| J Huo, S Xu, B Lin, W-J Chng, K-P La. Fas apoptosis inhibitory molecule is upregulated by IGF-1 signaling and modulates Akt activation and IRF4 expression in multiple myeloma. Leukemia. vol 27. issue 5. 2013-07-19. PMID:23138182. |
fas apoptosis inhibitory molecule is upregulated by igf-1 signaling and modulates akt activation and irf4 expression in multiple myeloma. |
2013-07-19 |
2023-08-12 |
Not clear |
| Jiaxing Song, Qun Chen, Da Xin. Enhanced apoptotic effects by downregulating Mcl-1: evidence for the improvement of photodynamic therapy with Celecoxib. Experimental cell research. vol 319. issue 10. 2013-07-19. PMID:23524145. |
inhibition of akt by wortmannin or sirna significantly reduces the levels of mcl-1 mrna and protein and enhances pdt-induced apoptosis. |
2013-07-19 |
2023-08-12 |
Not clear |
| Jiaxing Song, Qun Chen, Da Xin. Enhanced apoptotic effects by downregulating Mcl-1: evidence for the improvement of photodynamic therapy with Celecoxib. Experimental cell research. vol 319. issue 10. 2013-07-19. PMID:23524145. |
a loss in mcl-1 by inhibiting akt promotes pdt-induced apoptosis through the mitochondrial pathway. |
2013-07-19 |
2023-08-12 |
Not clear |
| Yannick D Benoit, Mavee S Witherspoon, Kristian B Laursen, Amel Guezguez, Marco Beauséjour, Jean-Francois Beaulieu, Steven M Lipkin, Lorraine J Guda. Pharmacological inhibition of polycomb repressive complex-2 activity induces apoptosis in human colon cancer stem cells. Experimental cell research. vol 319. issue 10. 2013-07-19. PMID:23588203. |
using colon cancer stem cells (ccsc) isolated from human primary colorectal tumors, we demonstrate that suz12 knockdown and treatment with dznep, one of the most potent ezh2 inhibitors, increase apoptosis levels, marked by decreased akt phosphorylation, in ccscs, while embryonic stem (es) cell survival is not affected. |
2013-07-19 |
2023-08-12 |
human |
| Yoshimi Shionome, Li Yan, Song Liu, Toshiaki Saeki, Toru Ouch. Integrity of p53 associated pathways determines induction of apoptosis of tumor cells resistant to Aurora-A kinase inhibitors. PloS one. vol 8. issue 1. 2013-07-17. PMID:23383195. |
when further treated with inhibitors of both mtor and akt, those cells undergo apoptosis. |
2013-07-17 |
2023-08-12 |
mouse |
| Iain Brown, Maria G Cascio, Dino Rotondo, Roger G Pertwee, Steven D Heys, Klaus W J Wahl. Cannabinoids and omega-3/6 endocannabinoids as cell death and anticancer modulators. Progress in lipid research. vol 52. issue 1. 2013-07-12. PMID:23103355. |
they signal through p38, mapk, jun, pi3, akt, ceramide, caspases, mmps, ppars, vegf, nf-κb, p8, chop, trb3 and pro-apoptotic oncogenes (p53,p21 waf1/cip1) to induce cell cycle arrest, autophagy, apoptosis and tumour inhibition. |
2013-07-12 |
2023-08-12 |
Not clear |