| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elizabeth S Yeh, George K Belka, Ann E Vernon, Chien-Chung Chen, Jason J Jung, Lewis A Chodos. Hunk negatively regulates c-myc to promote Akt-mediated cell survival and mammary tumorigenesis induced by loss of Pten. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 15. 2013-07-12. PMID:23520049. |
consequently, akt pathway activation in the mammary glands of hunk(-/-) mice results in induction of c-myc expression to levels that induce apoptosis. |
2013-07-12 |
2023-08-12 |
mouse |
| Elizabeth S Yeh, George K Belka, Ann E Vernon, Chien-Chung Chen, Jason J Jung, Lewis A Chodos. Hunk negatively regulates c-myc to promote Akt-mediated cell survival and mammary tumorigenesis induced by loss of Pten. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 15. 2013-07-12. PMID:23520049. |
c-myc knockdown rescues the increase in apoptosis induced by hunk deletion in cells in which akt has been activated, indicating that repression of c-myc is a principal mechanism by which hunk mediates the prosurvival effects of akt. |
2013-07-12 |
2023-08-12 |
mouse |
| Elizabeth S Yeh, George K Belka, Ann E Vernon, Chien-Chung Chen, Jason J Jung, Lewis A Chodos. Hunk negatively regulates c-myc to promote Akt-mediated cell survival and mammary tumorigenesis induced by loss of Pten. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 15. 2013-07-12. PMID:23520049. |
together, our findings establish a prosurvival function for hunk in tumorigenesis, define an essential mechanism by which akt suppresses c-myc-induced apoptosis, and identify hunk as a previously unrecognized link between the akt and c-myc oncogenic pathways. |
2013-07-12 |
2023-08-12 |
mouse |
| Jianhua Wu, Jianzhe Li, Hankun Hu, Ping Liu, Yunxiang Fang, Dongfang W. Rho-kinase inhibitor, fasudil, prevents neuronal apoptosis via the Akt activation and PTEN inactivation in the ischemic penumbra of rat brain. Cellular and molecular neurobiology. vol 32. issue 7. 2013-07-10. PMID:22552888. |
rho-kinase inhibitor, fasudil, prevents neuronal apoptosis via the akt activation and pten inactivation in the ischemic penumbra of rat brain. |
2013-07-10 |
2023-08-12 |
rat |
| Mingzhe Zheng, Hongda Zhu, Ye Gong, Daijun Wang, Qing Xie, Hailiang Tang, Zhihong Yang, Bin Lu, Xiancheng Chen, Xuanchun Wan. Involvement of GMRP1, a novel mediator of Akt pathway, in brain damage after intracerebral hemorrhage. International journal of clinical and experimental pathology. vol 6. issue 2. 2013-07-09. PMID:23330007. |
gmrp1, also known as btbd10, has been reported to inhibit apoptosis of neuronal and islet beta cells via akt pathway. |
2013-07-09 |
2023-08-12 |
rat |
| Mingzhe Zheng, Hongda Zhu, Ye Gong, Daijun Wang, Qing Xie, Hailiang Tang, Zhihong Yang, Bin Lu, Xiancheng Chen, Xuanchun Wan. Involvement of GMRP1, a novel mediator of Akt pathway, in brain damage after intracerebral hemorrhage. International journal of clinical and experimental pathology. vol 6. issue 2. 2013-07-09. PMID:23330007. |
we presented here evidence that decreased gmrp1-mediated akt pathway contributed to cell apoptosis in hemorrhagic side, suggesting that gmrp1 played an important role in brain damage after ich. |
2013-07-09 |
2023-08-12 |
rat |
| Eun-Seok Park, Jun Chul Kang, Do-Hyun Kang, Yong Chang Jang, Kyu Yang Yi, Hun-Jong Chung, Jong Seok Park, Bokyung Kim, Zhong-Ping Feng, Hwa-Sup Shi. 5-AIQ inhibits H2O2-induced apoptosis through reactive oxygen species scavenging and Akt/GSK-3β signaling pathway in H9c2 cardiomyocytes. Toxicology and applied pharmacology. vol 268. issue 1. 2013-07-05. PMID:23352507. |
our data also showed that 5-aiq pretreatment protected h9c2 cells from h2o2-induced apoptosis by triggering activation of akt and glycogen synthase kinase-3β (gsk-3β), and that the protective effect of 5-aiq was diminished by the pi3k inhibitor ly294002 at a concentration that effectively abolished 5-aiq-induced akt and gsk-3β activation. |
2013-07-05 |
2023-08-12 |
Not clear |
| Shanshan Li, Yajuan Ran, Dandan Zhang, Jianguo Chen, Shuzhen Li, Daling Zh. MicroRNA-138 plays a role in hypoxic pulmonary vascular remodelling by targeting Mst1. The Biochemical journal. vol 452. issue 2. 2013-07-05. PMID:23485012. |
the serine/threonine kinase mst1, an amplifier of cell apoptosis, seemed to be a target of mir-138, and the activation of the akt pathway was necessary for the anti-apoptotic effect of mir-138. |
2013-07-05 |
2023-08-12 |
Not clear |
| Lucy Liu, Marina Kritsanida, Prokopios Magiatis, Nicolas Gaboriaud, Yan Wang, Jun Wu, Ralf Buettner, Fan Yang, Sangkil Nam, Leandros Skaltsounis, Richard Jov. A novel 7-bromoindirubin with potent anticancer activity suppresses survival of human melanoma cells associated with inhibition of STAT3 and Akt signaling. Cancer biology & therapy. vol 13. issue 13. 2013-07-03. PMID:22895078. |
here, we show that mls-2438 inhibits viability and induces apoptosis of human melanoma cells associated with inhibition of stat3 and akt signaling. |
2013-07-03 |
2023-08-12 |
mouse |
| Chaoran Liu, Zhong Liu, Meng Li, Xiaoling Li, Yum-Shing Wong, Sai-Ming Ngai, Wenjie Zheng, Yibo Zhang, Tianfeng Che. Enhancement of auranofin-induced apoptosis in MCF-7 human breast cells by selenocystine, a synergistic inhibitor of thioredoxin reductase. PloS one. vol 8. issue 1. 2013-07-03. PMID:23342042. |
dna damage-mediated p53 phosphorylation and down-regulation of phosphorylated akt and erk also contributed to cell apoptosis. |
2013-07-03 |
2023-08-12 |
human |
| Thomas Tawadros, Florian Alonso, Patrice Jichlinski, Noel Clarke, Thierry Calandra, Jacques-Antoine Haefliger, Thierry Roge. Release of macrophage migration inhibitory factor by neuroendocrine-differentiated LNCaP cells sustains the proliferation and survival of prostate cancer cells. Endocrine-related cancer. vol 20. issue 1. 2013-07-02. PMID:23207293. |
addition of exogenous recombinant mif to lncap and pc-3 cells stimulated the akt and erk1/2 signalling pathways, the expression of genes involved in pca, as well as proliferation and resistance to paclitaxel and thapsigargin-induced apoptosis. |
2013-07-02 |
2023-08-12 |
Not clear |
| Poyil Pratheeshkumar, Young-Ok Son, Amit Budhraja, Xin Wang, Songze Ding, Lei Wang, Andrew Hitron, Jeong-Chae Lee, Donghern Kim, Sasidharan Padmaja Divya, Gang Chen, Zhuo Zhang, Jia Luo, Xianglin Sh. Luteolin inhibits human prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis. PloS one. vol 7. issue 12. 2013-07-02. PMID:23300633. |
moreover, luteolin reduced cell viability and induced apoptosis in prostate cancer cells, which were correlated with the downregulation of akt, erk, mtor, p70s6k, mmp-2, and mmp-9 expressions. |
2013-07-02 |
2023-08-12 |
mouse |
| Raúl Vivar, Claudio Humeres, Pedro Ayala, Ivonne Olmedo, Mabel Catalán, Lorena García, Sergio Lavandero, Guillermo Díaz-Aray. TGF-β1 prevents simulated ischemia/reperfusion-induced cardiac fibroblast apoptosis by activation of both canonical and non-canonical signaling pathways. Biochimica et biophysica acta. vol 1832. issue 6. 2013-07-01. PMID:23416528. |
the inhibition of erk1/2, akt and smad3 also blocked the preventive effects of tgf-β1 on cardiac fibroblast apoptosis induced by simulated ischemia/reperfusion. |
2013-07-01 |
2023-08-12 |
rat |
| Raúl Vivar, Claudio Humeres, Pedro Ayala, Ivonne Olmedo, Mabel Catalán, Lorena García, Sergio Lavandero, Guillermo Díaz-Aray. TGF-β1 prevents simulated ischemia/reperfusion-induced cardiac fibroblast apoptosis by activation of both canonical and non-canonical signaling pathways. Biochimica et biophysica acta. vol 1832. issue 6. 2013-07-01. PMID:23416528. |
overall, our data suggest that tgf-β1 prevents cardiac fibroblast apoptosis induced by simulated ischemia-reperfusion through the canonical (smad3) and non canonical (erk1/2 and akt) signaling pathways. |
2013-07-01 |
2023-08-12 |
rat |
| Maolong Dong, Nan Hu, Yinan Hua, Xihui Xu, Machender R Kandadi, Rui Guo, Shasha Jiang, Sreejayan Nair, Dahai Hu, Jun Re. Chronic Akt activation attenuated lipopolysaccharide-induced cardiac dysfunction via Akt/GSK3β-dependent inhibition of apoptosis and ER stress. Biochimica et biophysica acta. vol 1832. issue 6. 2013-07-01. PMID:23474308. |
chronic akt activation attenuated lipopolysaccharide-induced cardiac dysfunction via akt/gsk3β-dependent inhibition of apoptosis and er stress. |
2013-07-01 |
2023-08-12 |
mouse |
| Maolong Dong, Nan Hu, Yinan Hua, Xihui Xu, Machender R Kandadi, Rui Guo, Shasha Jiang, Sreejayan Nair, Dahai Hu, Jun Re. Chronic Akt activation attenuated lipopolysaccharide-induced cardiac dysfunction via Akt/GSK3β-dependent inhibition of apoptosis and ER stress. Biochimica et biophysica acta. vol 1832. issue 6. 2013-07-01. PMID:23474308. |
akt activation itself did not affect cardiac contractile and intracellular ca²⁺ properties, ros production, oxidative stress, apoptosis and er stress. |
2013-07-01 |
2023-08-12 |
mouse |
| Maolong Dong, Nan Hu, Yinan Hua, Xihui Xu, Machender R Kandadi, Rui Guo, Shasha Jiang, Sreejayan Nair, Dahai Hu, Jun Re. Chronic Akt activation attenuated lipopolysaccharide-induced cardiac dysfunction via Akt/GSK3β-dependent inhibition of apoptosis and ER stress. Biochimica et biophysica acta. vol 1832. issue 6. 2013-07-01. PMID:23474308. |
taken together, these data showed that akt activation ameliorated lps-induced cardiac contractile and intracellular ca²⁺ anomalies through inhibition of apoptosis and er stress, possibly involving an akt/gsk3β-dependent mechanism. |
2013-07-01 |
2023-08-12 |
mouse |
| Jake Shortt, Benjamin P Martin, Andrea Newbold, Katherine M Hannan, Jennifer R Devlin, Adele J Baker, Rachael Ralli, Carleen Cullinane, Clemens A Schmitt, Maurice Reimann, Michael N Hall, Meaghan Wall, Ross D Hannan, Richard B Pearson, Grant A McArthur, Ricky W Johnston. Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas. Blood. vol 121. issue 15. 2013-06-28. PMID:23403624. |
moreover, apoptosis was initiated at drug concentrations insufficient to antagonize pi3k/mtorc2-regulated akt phosphorylation. |
2013-06-28 |
2023-08-12 |
human |
| Evan E Santo, Peter Stroeken, Peter V Sluis, Jan Koster, Rogier Versteeg, Ellen M Westerhou. FOXO3a is a major target of inactivation by PI3K/AKT signaling in aggressive neuroblastoma. Cancer research. vol 73. issue 7. 2013-06-25. PMID:23378341. |
conversely, apoptosis induced by pi-103 or the akt inhibitor mk-2206 was potentiated by foxo3a overexpression. |
2013-06-25 |
2023-08-12 |
Not clear |
| Liang-Cheng Li, Shankara Jayarama, Tania Pilli, Lixia Qian, Furio Pacini, Bellur S Prabhaka. Down-modulation of expression, or dephosphorylation, of IG20/MADD in tumor necrosis factor-related apoptosis-inducing ligand-resistant thyroid cancer cells makes them susceptible to treatment with this ligand. Thyroid : official journal of the American Thyroid Association. vol 23. issue 1. 2013-06-24. PMID:22998497. |
the ability of the madd protein to resist trail-induced apoptosis is dependent upon its phosphorylation by akt. |
2013-06-24 |
2023-08-12 |
Not clear |