| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Min Wang, Gui-bo Sun, Xiao Sun, Hong-wei Wang, Xiang-bao Meng, Meng Qin, Jing Sun, Yun Luo, Xiao-bo Su. Cardioprotective effect of salvianolic acid B against arsenic trioxide-induced injury in cardiac H9c2 cells via the PI3K/Akt signal pathway. Toxicology letters. vol 216. issue 2-3. 2013-05-03. PMID:23201927. |
conversely, blocking akt activation with the pi3k inhibitor ly294002 effectively suppressed the protective effect of sal b against ato-induced cell apoptosis. |
2013-05-03 |
2023-08-12 |
Not clear |
| Christopher A Pettigrew, John S Clerkin, Thomas G Cotte. DUOX enzyme activity promotes AKT signalling in prostate cancer cells. Anticancer research. vol 32. issue 12. 2013-05-02. PMID:23225414. |
inhibition of duox by diphenylene iodium (dpi), intracellular calcium chelation and small-interfering rna (sirna) resulted in lower ros levels, lower akt and glycogen synthase kinase 3β (gsk3β) phosphorylation, as well as reduced cell viability and increased susceptibility to apoptosis stimulating fragment (fas) induced apoptosis. |
2013-05-02 |
2023-08-12 |
Not clear |
| Christopher A Pettigrew, John S Clerkin, Thomas G Cotte. DUOX enzyme activity promotes AKT signalling in prostate cancer cells. Anticancer research. vol 32. issue 12. 2013-05-02. PMID:23225414. |
this report shows that ros levels in pc3 cells are constitutively maintained by duox enzymes, and these ros positively regulate akt signalling through inactivating phosphatases, leading to increased resistance to apoptosis. |
2013-05-02 |
2023-08-12 |
Not clear |
| Tanusree Sen, Nilkantha Sen, Maartje G Noordhuis, Rajani Ravi, T-C Wu, Patrick K Ha, David Sidransky, Mohammad Obaidul Hoqu. OGDHL is a modifier of AKT-dependent signaling and NF-κB function. PloS one. vol 7. issue 11. 2013-05-01. PMID:23152800. |
forced expression of ogdhl increased the production of reactive oxygen species (ros) leading to apoptosis through caspase 3 mediated down-regulation of the akt signaling cascade and decreased nf-κb phosphorylation. |
2013-05-01 |
2023-08-12 |
Not clear |
| Ling-Huei Yih, Nai-Chi Hsu, Yi-Chen Wu, Wen-Yen Yen, Hsiao-Hui Ku. Inhibition of AKT enhances mitotic cell apoptosis induced by arsenic trioxide. Toxicology and applied pharmacology. vol 267. issue 3. 2013-04-30. PMID:23352504. |
inhibition of akt enhances mitotic cell apoptosis induced by arsenic trioxide. |
2013-04-30 |
2023-08-12 |
Not clear |
| Ling-Huei Yih, Nai-Chi Hsu, Yi-Chen Wu, Wen-Yen Yen, Hsiao-Hui Ku. Inhibition of AKT enhances mitotic cell apoptosis induced by arsenic trioxide. Toxicology and applied pharmacology. vol 267. issue 3. 2013-04-30. PMID:23352504. |
akt, a serine/threonine kinase frequently over-activated in diverse tumors, plays critical roles in stimulating cell cycle progression, abrogating cell cycle checkpoints, suppressing apoptosis, and regulating mitotic spindle assembly. |
2013-04-30 |
2023-08-12 |
Not clear |
| Ling-Huei Yih, Nai-Chi Hsu, Yi-Chen Wu, Wen-Yen Yen, Hsiao-Hui Ku. Inhibition of AKT enhances mitotic cell apoptosis induced by arsenic trioxide. Toxicology and applied pharmacology. vol 267. issue 3. 2013-04-30. PMID:23352504. |
inhibition of akt by inhibitors of the phosphatidyl inositol 3-kinase/akt pathway significantly enhanced cell sensitivity to ato by elevating mitotic cell apoptosis. |
2013-04-30 |
2023-08-12 |
Not clear |
| Ling-Huei Yih, Nai-Chi Hsu, Yi-Chen Wu, Wen-Yen Yen, Hsiao-Hui Ku. Inhibition of AKT enhances mitotic cell apoptosis induced by arsenic trioxide. Toxicology and applied pharmacology. vol 267. issue 3. 2013-04-30. PMID:23352504. |
inhibition of akt therefore effectively sensitizes cancer cells to ato by enhancing mitotic cell apoptosis. |
2013-04-30 |
2023-08-12 |
Not clear |
| Kaamar Azijli, Saravanan Yuvaraj, Maikel P Peppelenbosch, Thomas Würdinger, Henk Dekker, Jos Joore, Evert van Dijk, Wim J Quax, Godefridus J Peters, Steven de Jong, Frank A E Kruy. Kinome profiling of non-canonical TRAIL signaling reveals RIP1-Src-STAT3-dependent invasion in resistant non-small cell lung cancer cells. Journal of cell science. vol 125. issue Pt 19. 2013-04-26. PMID:22797920. |
fak, akt and erk were activated in a rip1-independent way and inhibition of akt sensitized a549 cells to trail-induced apoptosis. |
2013-04-26 |
2023-08-12 |
human |
| Peng Xiu, Xuesong Dong, Xiaofeng Dong, Zongzhen Xu, Huaqiang Zhu, Feng Liu, Zheng Wei, Bo Zhai, Jagat R Kanwar, Hongchi Jiang, Jie Li, Xueying Su. Secretory clusterin contributes to oxaliplatin resistance by activating Akt pathway in hepatocellular carcinoma. Cancer science. vol 104. issue 3. 2013-04-25. PMID:23279642. |
overexpression of sclu abrogated oxa-induced inhibition of cell growth and cell apoptosis, but depletion of sclu synergized with oxa to inhibit cell growth and enhance cell apoptosis, by regulating proteins involved in mitochondrial apoptosis pathways, such as bcl-2, bax, bcl-xl and caspase-9, and affecting phosphorylation of akt and gsk-3β. |
2013-04-25 |
2023-08-12 |
mouse |
| Hongtu Chao, Li Wang, Jingli Hao, Jie Ni, Lei Chang, Peter H Graham, John H Kearsley, Yong L. Low dose histone deacetylase inhibitor, LBH589, potentiates anticancer effect of docetaxel in epithelial ovarian cancer via PI3K/Akt pathway in vitro. Cancer letters. vol 329. issue 1. 2013-04-24. PMID:22995071. |
the effect of lbh589 alone or in combination with dtx on four eoc cell lines (ovcar-3, igrov-1, a2780 and skov-3) was studied by mtt and clonogenic assays, acridine orange (ao)/ethidium bromide (eb) staining for apoptosis, western blotting for apoptosis-related proteins, histone h3 and h4 proteins, dna double strand break (dsb) repair marker and phosphorylation of akt. |
2013-04-24 |
2023-08-12 |
human |
| Atul Bedi, Xiaofei Chang, Kimberly Noonan, Vui Pham, Rishi Bedi, Elana J Fertig, Michael Considine, Joseph A Califano, Ivan Borrello, Christine H Chung, David Sidransky, Rajani Rav. Inhibition of TGF-β enhances the in vivo antitumor efficacy of EGF receptor-targeted therapy. Molecular cancer therapeutics. vol 11. issue 11. 2013-04-23. PMID:22927667. |
in addition to exerting an extrinsic inhibition of the cytotoxic function of immune effectors, tgf-β-mediated activation of akt provides an intrinsic egfr-independent survival signal that protects tumor cells from immune cell-mediated apoptosis. |
2013-04-23 |
2023-08-12 |
mouse |
| J M Ou, M-K Qui, Y-X Dai, Q Dong, J Shen, P Dong, X-F Wang, Y-B Liu, Z-W Fe. Combined blockade of AKT/mTOR pathway inhibits growth of human hemangioma via downregulation of proliferating cell nuclear antigen. International journal of immunopathology and pharmacology. vol 25. issue 4. 2013-04-23. PMID:23298485. |
combined blockade of akt/mtor pathway by rad5-am diminished cell proliferative activities, and induced cell apoptosis and cycle arrest with the decreased expression of akt, mtor and pcna in proliferative phase hdec. |
2013-04-23 |
2023-08-12 |
human |
| Fan Yang, Veronica Jove, Shirley Chang, Michael Hedvat, Lucy Liu, Ralf Buettner, Yan Tian, Anna Scuto, Wei Wen, M L Richard Yip, Timothy Van Meter, Yun Yen, Richard Jov. Bortezomib induces apoptosis and growth suppression in human medulloblastoma cells, associated with inhibition of AKT and NF-ĸB signaling, and synergizes with an ERK inhibitor. Cancer biology & therapy. vol 13. issue 6. 2013-04-19. PMID:22313636. |
bortezomib induces apoptosis and growth suppression in human medulloblastoma cells, associated with inhibition of akt and nf-ĸb signaling, and synergizes with an erk inhibitor. |
2013-04-19 |
2023-08-12 |
mouse |
| Gokulakrishnan Seshadri, Pao Lin Che, Archana V Boopathy, Michael E Davi. Characterization of superoxide dismutases in cardiac progenitor cells demonstrates a critical role for manganese superoxide dismutase. Stem cells and development. vol 21. issue 17. 2013-04-19. PMID:22758933. |
finally, we found xxo activated akt within 10 min, and this regulated both sod2 gene expression and protection against apoptosis. |
2013-04-19 |
2023-08-12 |
rat |
| Sivalokanathan Sarveswaran, Subhash C Gautam, Jagadananda Ghos. Wedelolactone, a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. International journal of oncology. vol 41. issue 6. 2013-04-19. PMID:23076676. |
wedelolactone, a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of pkcε without inhibiting akt. |
2013-04-19 |
2023-08-12 |
human |
| Sivalokanathan Sarveswaran, Subhash C Gautam, Jagadananda Ghos. Wedelolactone, a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. International journal of oncology. vol 41. issue 6. 2013-04-19. PMID:23076676. |
interestingly, wdl triggers apoptosis in prostate cancer cells via downregulation of protein kinase cε (pkcε), but without inhibition of akt. |
2013-04-19 |
2023-08-12 |
human |
| Sivalokanathan Sarveswaran, Subhash C Gautam, Jagadananda Ghos. Wedelolactone, a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. International journal of oncology. vol 41. issue 6. 2013-04-19. PMID:23076676. |
these findings indicate that wdl selectivity induces caspase-dependent apoptosis in prostate cancer cells via a novel mechanism involving inhibition of pkcε without affecting akt and suggest that wdl may emerge as a novel therapeutic agent against clinical prostate cancer in human. |
2013-04-19 |
2023-08-12 |
human |
| He Zhu, Feriyl Bhaijee, Nivin Ishaq, Dominique J Pepper, Kandis Backus, Alexandra S Brown, Xinchun Zhou, Lucio Miel. Correlation of Notch1, pAKT and nuclear NF-κB expression in triple negative breast cancer. American journal of cancer research. vol 3. issue 2. 2013-04-18. PMID:23593544. |
recent publications suggest that inhibition of cell growth, migration, invasion, and induction of apoptosis caused by notch1 or jagged1 inhibition may be attributed in part to inactivation of the akt signaling pathway. |
2013-04-18 |
2023-08-12 |
human |
| Sara Mongiorgi, Matilde Y Follo, Cristina Clissa, Roberto Giardino, Milena Fini, Lucia Manzoli, Giulia Ramazzotti, Roberta Fiume, Carlo Finelli, Lucio Cocc. Nuclear PI-PLC β1 and Myelodysplastic syndromes: from bench to clinics. Current topics in microbiology and immunology. vol 362. 2013-04-17. PMID:23086421. |
the molecular mechanisms underlying the mds evolution to aml are still unclear, even though it is now clear that the nuclear signaling elicited by pi-plc β1, cyclin d3, and akt plays an important role in the control of the balance between cell cycle progression and apoptosis in both normal and pathologic conditions. |
2013-04-17 |
2023-08-12 |
Not clear |