| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei-Tao Cong, Jin Ling, Hai-Shan Tian, Ren Ling, Yang Wang, Bin-Bin Huang, Ting Zhao, Yuan-Meng Duan, Li-Tai Jin, Xiao Kun L. Proteomic study on the protective mechanism of fibroblast growth factor 21 to ischemia-reperfusion injury. Canadian journal of physiology and pharmacology. vol 91. issue 11. 2014-05-15. PMID:24117266. |
the results showed that fgf-21 treatment prevented the oxidative stress and apoptosis associated with i/r damage by reducing the levels of superoxide anions, inhibiting glycogen synthase kinase (gsk) 3β by activating akt phosphorylation, and recovering the levels of atp synthase pyruvate kinase isozymes m1 and protein kinase c, thereby improving energy supply. |
2014-05-15 |
2023-08-12 |
rat |
| Miliana Vojvodic, Loen M Hansford, Olena Morozova, Kim M Blakely, Paul Taylor, Kelly E Fathers, Jason Moffat, Marco Marra, Kristen M Smith, Michael F Moran, David R Kapla. A phosphoproteomics approach to identify candidate kinase inhibitor pathway targets in lymphoma-like primary cell lines. Current drug discovery technologies. vol 10. issue 4. 2014-05-12. PMID:23701117. |
both sfk inhibitors reduced erk1/2 and akt phosphorylation and induced apoptosis. |
2014-05-12 |
2023-08-12 |
human |
| Wenjing Wu, Shuwan Zhang, Xu Li, Mei Xue, Sancheng Cao, Wei Che. Ets-2 regulates cell apoptosis via the Akt pathway, through the regulation of urothelial cancer associated 1, a long non-coding RNA, in bladder cancer cells. PloS one. vol 8. issue 9. 2014-05-08. PMID:24069250. |
ets-2 regulates cell apoptosis via the akt pathway, through the regulation of urothelial cancer associated 1, a long non-coding rna, in bladder cancer cells. |
2014-05-08 |
2023-08-12 |
human |
| Wenjing Wu, Shuwan Zhang, Xu Li, Mei Xue, Sancheng Cao, Wei Che. Ets-2 regulates cell apoptosis via the Akt pathway, through the regulation of urothelial cancer associated 1, a long non-coding RNA, in bladder cancer cells. PloS one. vol 8. issue 9. 2014-05-08. PMID:24069250. |
taking into account the anti-apoptosis function of ets-2, our data suggested that ets-2 regulates apoptosis process by regulating the expression of uca1, moreover uca1 may be involved in the activation of akt signaling pathway by ets-2 in bladder cancer cells. |
2014-05-08 |
2023-08-12 |
human |
| Zhenwei Zhang, Lei Miao, Xin Wu, Guangze Liu, Yuting Peng, Xiaoming Xin, Binghua Jiao, Xiangping Kon. Carnosine Inhibits the Proliferation of Human Gastric Carcinoma Cells by Retarding Akt/mTOR/p70S6K Signaling. Journal of Cancer. vol 5. issue 5. 2014-05-06. PMID:24799956. |
the results showed that treatment with carnosine led to proliferation inhibition, cell cycle arrest in the g0/g1 phase, apoptosis increase, and inhibition of mtor signaling activation by decreasing the phosphorylation of akt, mtor and p70s6k, suggesting that proliferation inhibition of carnosine in human gastric carcinoma was through the inhibition of akt/mtor/p70s6k pathway, and carnosine would be a mimic of rapamycin. |
2014-05-06 |
2023-08-13 |
human |
| Yung-Ho Hsu, Tso-Hsiao Chen, Yen-Cheng Chen, Chung-Yi Cheng, Yuh-Mou Sue, Jia-Rung Chen, Cheng-Hsien Che. Urotensin II exerts antiapoptotic effect on NRK-52E cells through prostacyclin-mediated peroxisome proliferator-activated receptor alpha and Akt activation. Molecular and cellular endocrinology. vol 381. issue 1-2. 2014-05-01. PMID:23933501. |
our results suggest that uii can protect renal tubular cells from gentamicin-induced apoptosis through pgi2-mediated pparα and akt activation. |
2014-05-01 |
2023-08-12 |
mouse |
| Kazufumi Wakao, Tadashi Watanabe, Tadatoshi Takadama, Sadaharu Ui, Zenpei Shigemi, Hiroki Kagawa, Chizuka Higashi, Rie Ohga, Takahiro Taira, Masahiro Fujimur. Sangivamycin induces apoptosis by suppressing Erk signaling in primary effusion lymphoma cells. Biochemical and biophysical research communications. vol 444. issue 2. 2014-04-30. PMID:24434142. |
it is known that activation of erk and akt signaling inhibits apoptosis and promotes proliferation in pel cells. |
2014-04-30 |
2023-08-12 |
Not clear |
| Kazufumi Wakao, Tadashi Watanabe, Tadatoshi Takadama, Sadaharu Ui, Zenpei Shigemi, Hiroki Kagawa, Chizuka Higashi, Rie Ohga, Takahiro Taira, Masahiro Fujimur. Sangivamycin induces apoptosis by suppressing Erk signaling in primary effusion lymphoma cells. Biochemical and biophysical research communications. vol 444. issue 2. 2014-04-30. PMID:24434142. |
our data therefore suggest that sangivamycin induces apoptosis by inhibiting erk and akt signaling in such cells. |
2014-04-30 |
2023-08-12 |
Not clear |
| Libin Wang, Qilun Liu, Fang Li, Jing Qiu, Heng Fan, Haibin Ma, Yongzhao Zhu, Ligang Wu, Xuebo Han, Zhihong Yang, Haifeng Jiang, Jun Wei, Haibin Xi. Apoptosis induced by PGC-1β in breast cancer cells is mediated by the mTOR pathway. Oncology reports. vol 30. issue 4. 2014-04-29. PMID:23877360. |
however, akt phosphorylation on ser473 was upregulated and cell apoptosis occurred. |
2014-04-29 |
2023-08-12 |
Not clear |
| Hua Qin, Xiaoyan Du, Yan Zhang, Ru Wan. Platycodin D, a triterpenoid saponin from Platycodon grandiflorum, induces G2/M arrest and apoptosis in human hepatoma HepG2 cells by modulating the PI3K/Akt pathway. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 2. 2014-04-28. PMID:24048756. |
in addition, the inhibitors of z-devd-fmk (a specific caspase-3 inhibitor) and z-lehd-fmk (a specific caspase-9 inhibitor), but not z-ietd-fmk (a specific caspase-8 inhibitor), could significantly block pd-triggered apoptosis, whereas ly294002 (akt inhibitor) could significantly enhance pd-induced apoptosis in hepg2 cells. |
2014-04-28 |
2023-08-12 |
human |
| Daniela N Petrusca, Mary Van Demark, Yuan Gu, Matthew J Justice, Adriana Rogozea, Walter C Hubbard, Irina Petrach. Smoking exposure induces human lung endothelial cell adaptation to apoptotic stress. American journal of respiratory cell and molecular biology. vol 50. issue 3. 2014-04-24. PMID:24079644. |
in cells from smokers, the prominent up-regulation of akt pathways inhibited ceramide-triggered apoptosis, and was associated with elevated sphingosine and high-mobility group box 1, skewing the cell's response toward autophagy and survival. |
2014-04-24 |
2023-08-12 |
human |
| T-I Hsu, C-H Hsu, K-H Lee, J-T Lin, C-S Chen, K-C Chang, C-Yj Su, M Hsiao, P-J L. MicroRNA-18a is elevated in prostate cancer and promotes tumorigenesis through suppressing STK4 in vitro and in vivo. Oncogenesis. vol 3. 2014-04-22. PMID:24752237. |
interestingly, mir-18a knockdown decreased cell growth in prostate cancer cells and significantly decreased prostate tumor growth in in vivo nude mice experiments through stk4-mediated dephosphorylation of akt and thereby inducing apoptosis. |
2014-04-22 |
2023-08-13 |
mouse |
| Shi-Yun Cui, Jia-Yuan Huang, Yi-Tian Chen, Hai-Zhu Song, Bing Feng, Gui-Chun Huang, Rui Wang, Long-Bang Chen, Wei D. Let-7c governs the acquisition of chemo- or radioresistance and epithelial-to-mesenchymal transition phenotypes in docetaxel-resistant lung adenocarcinoma. Molecular cancer research : MCR. vol 11. issue 7. 2014-04-21. PMID:23562878. |
ectopic let-7c expression increased the in vitro and in vivo chemo- or radiosensitivity of dtx-resistant lad cells through enhanced apoptosis, reversal of epithelial-to-mesenchymal phenotypes, and inhibition of in vivo metastatic potential via inactivation of akt phosphorylation, whereas a let-7c inhibitor decreased the chemo- or radiosensitivity of parental cells. |
2014-04-21 |
2023-08-12 |
Not clear |
| Giulia Federici, Xi Gao, Janusz Slawek, Tomasz Arodz, Amanuel Shitaye, Julia D Wulfkuhle, Ruggero De Maria, Lance A Liotta, Emanuel F Petricoi. Systems analysis of the NCI-60 cancer cell lines by alignment of protein pathway activation modules with "-OMIC" data fields and therapeutic response signatures. Molecular cancer research : MCR. vol 11. issue 6. 2014-04-17. PMID:23635402. |
we aggregated the signaling data into biochemical modules of interconnected kinase substrates for 6 key cancer signaling pathways: akt, mtor, egf receptor (egfr), insulin-like growth factor-1 receptor (igf-1r), integrin, and apoptosis signaling. |
2014-04-17 |
2023-08-12 |
human |
| Yu-Chen Lee, Jung-Kang Jin, Chien-Jui Cheng, Chih-Fen Huang, Jian H Song, Miao Huang, Wells S Brown, Sui Zhang, Li-Yuan Yu-Lee, Edward T Yeh, Bradley W McIntyre, Christopher J Logothetis, Gary E Gallick, Sue-Hwa Li. Targeting constitutively activated β1 integrins inhibits prostate cancer metastasis. Molecular cancer research : MCR. vol 11. issue 4. 2014-04-15. PMID:23339185. |
mab 33b6 also inhibited the phosphorylation of β1 integrin downstream effectors, focal adhesion kinase (fak) and akt, leading to a 3-fold increase in pc3-mm2 apoptosis. |
2014-04-15 |
2023-08-12 |
human |
| Joseph C Loftus, Harshil Dhruv, Serdar Tuncali, Jean Kloss, Zhongbo Yang, Cassie A Schumacher, Brian Cao, Bart O Williams, Jennifer M Eschbacher, Julianna T D Ross, Nhan L Tra. TROY (TNFRSF19) promotes glioblastoma survival signaling and therapeutic resistance. Molecular cancer research : MCR. vol 11. issue 8. 2014-04-15. PMID:23699535. |
moreover, troy expression significantly increased resistance of glioblastoma cells to both ir- and tmz-induced apoptosis via activation of akt and nf-κb. |
2014-04-15 |
2023-08-12 |
mouse |
| Tatsushi Miyazaki, Satsuki Miyazaki, Masafumi Ashida, Tomofumi Tanaka, Fumi Tashiro, Jun-ichi Miyazak. Functional analysis of Tcl1 using Tcl1-deficient mouse embryonic stem cells. PloS one. vol 8. issue 8. 2014-04-14. PMID:23940776. |
we found that tcl1 expression levels correlated positively with the proliferation rate and negatively with the apoptosis of es cells, but did not affect akt phosphorylation. |
2014-04-14 |
2023-08-12 |
mouse |
| Ping Cheng, Weiqi Dai, Fan Wang, Jie Lu, Miao Shen, Kan Chen, Jingjing Li, Yan Zhang, Chengfen Wang, Jing Yang, Rong Zhu, Huawei Zhang, Yuanyuan Zheng, Chuan-Yong Guo, Ling X. Ethyl pyruvate inhibits proliferation and induces apoptosis of hepatocellular carcinoma via regulation of the HMGB1-RAGE and AKT pathways. Biochemical and biophysical research communications. vol 443. issue 4. 2014-04-14. PMID:24361892. |
ethyl pyruvate inhibits proliferation and induces apoptosis of hepatocellular carcinoma via regulation of the hmgb1-rage and akt pathways. |
2014-04-14 |
2023-08-12 |
Not clear |
| Yasushi Sawai, Hiroaki Murata, Motoyuki Horii, Kazutaka Koto, Takaaki Matsui, Naoyuki Horie, Yoshiro Tsuji, Eishi Ashihara, Taira Maekawa, Toshikazu Kubo, Shinji Fushik. Effectiveness of sulforaphane as a radiosensitizer for murine osteosarcoma cells. Oncology reports. vol 29. issue 3. 2014-04-11. PMID:23254561. |
we found that sfn enhanced the radiosensitivity of lm8 murine osteosarcoma cells by inducing apoptosis through g2/m-phase arrest and by inhibiting erk and akt activation. |
2014-04-11 |
2023-08-12 |
Not clear |
| Hyun-Gwan Lee, Na Zhao, Bridget K Campion, Michelle M Nguyen, Scott B Sellec. Akt regulates glutamate receptor trafficking and postsynaptic membrane elaboration at the Drosophila neuromuscular junction. Developmental neurobiology. vol 73. issue 10. 2014-04-11. PMID:23592328. |
the akt family of serine-threonine kinases integrates a myriad of signals governing cell proliferation, apoptosis, glucose metabolism, and cytoskeletal organization. |
2014-04-11 |
2023-08-12 |
drosophila_melanogaster |