| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Irene Barinaga-Rementeria Ramirez, Grzegorz Pietka, David R Jones, Nullin Divecha, A Alia, Scott C Baraban, Adam F L Hurlstone, Martin Low. Impaired neural development in a zebrafish model for Lowe syndrome. Human molecular genetics. vol 21. issue 8. 2012-06-18. PMID:22210625. |
in ocrl1-deficient embryos, akt signalling is reduced and there is both increased apoptosis and reduced proliferation, most strikingly in the neural tissue. |
2012-06-18 |
2023-08-12 |
zebrafish |
| Devalingam Mahalingam, Corina N A M Oldenhuis, Eva Szegezdi, Francis J Giles, Elisabeth G E de Vries, Steven de Jong, Steffan T Nawrock. Targeting TRAIL towards the clinic. Current drug targets. vol 12. issue 14. 2012-06-11. PMID:21777191. |
trail induces apoptosis via the extrinsic death receptor apoptotic pathway and activates the jnk, erk, akt and nf-κb signaling cascades. |
2012-06-11 |
2023-08-12 |
Not clear |
| Papa Alioune Ndour, Guillaume Brocqueville, Tan-Sothéa Ouk, Gautier Goormachtigh, Olivier Morales, Alexandra Mougel, Julie Bertout, Oleg Melnyk, Véronique Fafeur, Jean Feuillard, Jean Coll, Eric Adriaenssen. Inhibition of latent membrane protein 1 impairs the growth and tumorigenesis of latency II Epstein-Barr virus-transformed T cells. Journal of virology. vol 86. issue 7. 2012-06-11. PMID:22258264. |
these dns inhibit nf-κb and akt pathways, resulting in the impairment of survival processes and increased apoptosis in these cell lines. |
2012-06-11 |
2023-08-12 |
human |
| Lifeng Zhang, Eric Pang, Rachel R Ogorzalek Loo, Jianyu Rao, Vay-Liang W Go, Joseph A Loo, Qing-Yi L. Concomitant inhibition of HSP90, its mitochondrial localized homologue TRAP1 and HSP27 by green tea in pancreatic cancer HPAF-II cells. Proteomics. vol 11. issue 24. 2012-06-01. PMID:22116673. |
furthermore, we showed that gte inhibited akt activation and the levels of mutant p53 protein, and induced apoptosis and growth suppression of the cells. |
2012-06-01 |
2023-08-12 |
human |
| Shuhui Hong, Xiaoyan Li, Ying Zhao, Qifeng Yang, Beihua Kon. 53BP1 suppresses tumor growth and promotes susceptibility to apoptosis of ovarian cancer cells through modulation of the Akt pathway. Oncology reports. vol 27. issue 4. 2012-05-30. PMID:22266878. |
53bp1 suppresses tumor growth and promotes susceptibility to apoptosis of ovarian cancer cells through modulation of the akt pathway. |
2012-05-30 |
2023-08-12 |
Not clear |
| Dong-Sub Jung, Sun Ha Lee, Seung-Jae Kwak, Jin Ji Li, Do Hee Kim, Bo-Young Nam, Hye Young Kang, Tae Ik Chang, Jung Tak Park, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kan. Apoptosis occurs differentially according to glomerular size in diabetic kidney disease. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. vol 27. issue 1. 2012-05-29. PMID:21652547. |
apoptosis, which is involved in the process of mesangial cell and podocyte loss in diabetic nephropathy, is known to be regulated by protein kinase b/akt (akt). |
2012-05-29 |
2023-08-12 |
Not clear |
| Dong-Sub Jung, Sun Ha Lee, Seung-Jae Kwak, Jin Ji Li, Do Hee Kim, Bo-Young Nam, Hye Young Kang, Tae Ik Chang, Jung Tak Park, Seung Hyeok Han, Tae-Hyun Yoo, Shin-Wook Kan. Apoptosis occurs differentially according to glomerular size in diabetic kidney disease. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. vol 27. issue 1. 2012-05-29. PMID:21652547. |
in this study, we hypothesized that apoptosis may occur differentially and that akt may be differentially activated according to glomerular size in diabetic kidney disease. |
2012-05-29 |
2023-08-12 |
Not clear |
| Fuquan Lin, Wen Xu, Cuiping Guan, Miaoni Zhou, Weisong Hong, Lifang Fu, Dongyin Liu, Aie X. Niacin protects against UVB radiation-induced apoptosis in cultured human skin keratinocytes. International journal of molecular medicine. vol 29. issue 4. 2012-05-29. PMID:22246168. |
the pi3k/akt inhibitor, ly294002, and the mtor inhibitor, rapamycin, largely neutralized the protective effects of niacin, suggesting that akt and downstream signaling mtor/s6 activation are necessary for the niacin-induced protective effects against uv-induced cell death and cell apoptosis. |
2012-05-29 |
2023-08-12 |
human |
| Woo-Kwang Jeon, Hey-Young Hong, Won-Chan Seo, Kyu-Hyoung Lim, Hui-Young Lee, Woo-Jin Kim, Seo-Young Song, Byung-Chul Ki. Smad7 sensitizes A549 lung cancer cells to cisplatin-induced apoptosis through heme oxygenase-1 inhibition. Biochemical and biophysical research communications. vol 420. issue 2. 2012-05-25. PMID:22421218. |
consistently, smad7 sensitized a549 cells to cisplatin-induced apoptosis and these effects were dependent on ho-1 and akt inhibition. |
2012-05-25 |
2023-08-12 |
human |
| W-F Hu, L Gong, Z Cao, H Ma, W Ji, M Deng, M Liu, X-H Hu, P Chen, Q Yan, H-G Chen, J Liu, S Sun, L Zhang, J-P Liu, E Wawrousek, D W-C L. αA- and αB-crystallins interact with caspase-3 and Bax to guard mouse lens development. Current molecular medicine. vol 12. issue 2. 2012-05-24. PMID:22280356. |
while αa-crystallin regulates activation of the akt signaling pathway, αb negatively regulates the mapk pathway to suppress apoptosis induced by uv and oxidative stress. |
2012-05-24 |
2023-08-12 |
mouse |
| G Zhang, Y Wang, Y Zhang, X Wan, J Li, K Liu, F Wang, K Liu, Q Liu, C Yang, P Yu, Y Huang, S Wang, P Jiang, Z Qu, J Luan, H Duan, L Zhang, A Hou, S Jin, T-C Hsieh, E W. Anti-cancer activities of tea epigallocatechin-3-gallate in breast cancer patients under radiotherapy. Current molecular medicine. vol 12. issue 2. 2012-05-24. PMID:22280355. |
mda-mb-231 cells exposed to 5-10 µm egcg also showed significant augmentation of the apoptosis inducing effects of γ-radiation, concomitant with reduced nf-κb protein level and akt phosphorylation. |
2012-05-24 |
2023-08-12 |
human |
| Jessica Dal Col, Katy Mastorci, Damiana Antonia Faè, Elena Muraro, Debora Martorelli, Giorgio Inghirami, Riccardo Dolcett. Retinoic acid/alpha-interferon combination inhibits growth and promotes apoptosis in mantle cell lymphoma through Akt-dependent modulation of critical targets. Cancer research. vol 72. issue 7. 2012-05-24. PMID:22311672. |
pharmacologic suppression of akt, but not of torc1, increases noxa protein levels and downregulates bfl-1 protein supporting the conclusion that the inhibition of the akt pathway, the resulting foxo3a activation and noxa upregulation are critical molecular mechanisms underlying ra/ifn-α-dependent mcl cell apoptosis. |
2012-05-24 |
2023-08-12 |
Not clear |
| Kelli A McDowell, Gregory J Riggins, Gary L Galli. Targeting the AKT pathway in glioblastoma. Current pharmaceutical design. vol 17. issue 23. 2012-05-22. PMID:21827416. |
this rtk/pten/pi3k pathway leads to activated akt and phospho-akt levels are elevated in the majority of gbm tumor samples and cell lines, which studies show help glioma cells grow uncontrolled, evade apoptosis, and enhance tumor invasion. |
2012-05-22 |
2023-08-12 |
Not clear |
| Ali R Jazirehi, Peter B Wenn, Mohsen Damavan. Therapeutic implications of targeting the PI3Kinase/AKT/mTOR signaling module in melanoma therapy. American journal of cancer research. vol 2. issue 2. 2012-05-22. PMID:22485197. |
aberrant expression of akt is observed in nearly 60% of melanomas culminating in apoptosis resistance via deactivation of apoptotic molecules bad and cas-pase-9. |
2012-05-22 |
2023-08-12 |
Not clear |
| Alexandre Rouette, Sophie Parent, Julie Girouard, Valérie Leblanc, Eric Asseli. Cisplatin increases B-cell-lymphoma-2 expression via activation of protein kinase C and Akt2 in endometrial cancer cells. International journal of cancer. vol 130. issue 8. 2012-05-21. PMID:21618512. |
cells stably expressing shrna for akt isoforms revealed that akt2 was involved in cisplatin-dependant increase in bcl-2 and apoptosis. |
2012-05-21 |
2023-08-12 |
human |
| Ke Gong, Wenhua L. Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma. Free radical biology & medicine. vol 51. issue 12. 2012-05-18. PMID:22011623. |
however, downregulation of akt and rip1/nf-κb activity was found to be involved in shikonin-induced apoptosis. |
2012-05-18 |
2023-08-12 |
mouse |
| Ke Gong, Wenhua L. Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma. Free radical biology & medicine. vol 51. issue 12. 2012-05-18. PMID:22011623. |
ectopic expression of akt or rip1 partly abrogated the effects of shikonin, and akt inhibitor and rip1 inhibitor synergistically induced apoptosis in conjunction with shikonin treatment. |
2012-05-18 |
2023-08-12 |
mouse |
| Masatoshi Abe, Yoko Yokoyama, Osamu Ishikaw. A possible mechanism of basic fibroblast growth factor-promoted scarless wound healing: the induction of myofibroblast apoptosis. European journal of dermatology : EJD. vol 22. issue 1. 2012-05-18. PMID:22370167. |
bfgf promoted apoptosis of the myofibroblasts but not of the fibroblasts, even in the presence of two different inhibitors, either ly294002 or an akt inhibitor. |
2012-05-18 |
2023-08-12 |
Not clear |
| Masatoshi Abe, Yoko Yokoyama, Osamu Ishikaw. A possible mechanism of basic fibroblast growth factor-promoted scarless wound healing: the induction of myofibroblast apoptosis. European journal of dermatology : EJD. vol 22. issue 1. 2012-05-18. PMID:22370167. |
the present study suggests that the phosphatidylinositol-3-kinase to akt as well as the rho to rho kinase signaling pathway is involved in bfgf-promoted myofibroblast apoptosis, and bfgf can promote the scarless wound healing upon the induction of apoptosis of myofibroblasts, but not fibroblasts. |
2012-05-18 |
2023-08-12 |
Not clear |
| Shailendra Kumar Maurya, Asit Rai, Nagendra Kumar Rai, Shreekant Deshpande, Rajeev Jain, Mohana Krishna Reddy Mudiam, Yenamandra S Prabhakar, Sanghamitra Bandyopadhya. Cypermethrin induces astrocyte apoptosis by the disruption of the autocrine/paracrine mode of epidermal growth factor receptor signaling. Toxicological sciences : an official journal of the Society of Toxicology. vol 125. issue 2. 2012-05-17. PMID:22048644. |
hb-egf activated the extracellular signal-regulated kinases and akt pathways that protected against apoptosis. |
2012-05-17 |
2023-08-12 |
rat |