| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sujeewa Ranatunga, Juan R Del Vall. Synthesis of GSK3β mimetic inhibitors of Akt featuring a novel extended dipeptide surrogate. Bioorganic & medicinal chemistry letters. vol 21. issue 23. 2012-04-18. PMID:22001093. |
akt is a cardinal nodal point in pi3k signaling pathway and confers resistance to apoptosis through inactivation of regulatory substrates such as gsk3β. |
2012-04-18 |
2023-08-12 |
Not clear |
| Ling Chu, Hong Hao, Min Luo, Yu Huang, Zhenyu Chen, Tiewei Lu, Xue Zhao, Catherine M Verfaillie, Jay L Zweier, Zhenguo Li. Ox-LDL modifies the behaviour of bone marrow stem cells and impairs their endothelial differentiation via inhibition of Akt phosphorylation. Journal of cellular and molecular medicine. vol 15. issue 2. 2012-04-16. PMID:19863696. |
ox-ldl-induced apoptosis and inhibition of oct-4 expression, cell proliferation and endothelial differentiation of mapcs were associated with significant inhibition of akt phosphorylation. |
2012-04-16 |
2023-08-12 |
rat |
| Ling Chu, Hong Hao, Min Luo, Yu Huang, Zhenyu Chen, Tiewei Lu, Xue Zhao, Catherine M Verfaillie, Jay L Zweier, Zhenguo Li. Ox-LDL modifies the behaviour of bone marrow stem cells and impairs their endothelial differentiation via inhibition of Akt phosphorylation. Journal of cellular and molecular medicine. vol 15. issue 2. 2012-04-16. PMID:19863696. |
akt overexpression in mapcs transfected with a constitutively active akt completely reversed the effects of ox-ldl on mapcs including enhanced apoptosis, decreased cell proliferation, suppressed oct-4 expression and endothelial differentiation as well as in vitro vascular structure formation. |
2012-04-16 |
2023-08-12 |
rat |
| Ling Chu, Hong Hao, Min Luo, Yu Huang, Zhenyu Chen, Tiewei Lu, Xue Zhao, Catherine M Verfaillie, Jay L Zweier, Zhenguo Li. Ox-LDL modifies the behaviour of bone marrow stem cells and impairs their endothelial differentiation via inhibition of Akt phosphorylation. Journal of cellular and molecular medicine. vol 15. issue 2. 2012-04-16. PMID:19863696. |
in conclusion, ox-ldl promotes apoptosis and inhibits oct-4 expression and self-renewal of mapcs, and impairs their endothelial differentiation via suppression of akt signalling. |
2012-04-16 |
2023-08-12 |
rat |
| Ya-Ling Chio. The supplementation of zinc increased the apoptosis of airway smooth muscle cells by increasing p38 phosphorylation. Environmental toxicology and pharmacology. vol 33. issue 1. 2012-04-16. PMID:22134001. |
zinc supplementation may reduce proliferation of pdgf-treated asmcs through the activation of p38 mitogen-activated protein kinase (map kinase) and suppression of akt phosphorylation, which both drive the induction of cellular apoptosis, subsequently reducing the proliferation of asmcs. |
2012-04-16 |
2023-08-12 |
Not clear |
| Sonia Ramos, Ildefonso Rodríguez-Ramiro, María Angeles Martín, Luis Goya, Laura Brav. Dietary flavanols exert different effects on antioxidant defenses and apoptosis/proliferation in Caco-2 and SW480 colon cancer cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 25. issue 8. 2012-04-13. PMID:21945981. |
exposure of sw480 cells to ecg led to apoptosis as determined by caspase-3 activity, imbalance among bcl-2 anti- and pro-apoptotic protein levels, erk activation and akt inhibition, whereas pb2 treatment enhanced phospho-akt and phospho-erk levels. |
2012-04-13 |
2023-08-12 |
Not clear |
| Shi-Sheng Li, Qing-Lai Tang, Shu-hui Wang, Yue-Hong Chen, Jia-Jia Liu, Xin-Ming Yan. Simultaneously targeting Bcl-2 and Akt pathways reverses resistance of nasopharyngeal carcinoma to TRAIL synergistically. Tumori. vol 97. issue 6. 2012-04-11. PMID:22322844. |
given the antiapoptotic functions of bcl-2 and akt, we examined the effects of targeting these pathways alone or simultaneously on trail apoptosis in npc cell lines. |
2012-04-11 |
2023-08-12 |
Not clear |
| Jei-Ming Peng, Yee-Hsiung Chen, Shao-Wen Hung, Ching-Feng Chiu, Ming-Yi Ho, Yi-Jen Lee, Tsung-Ching Lai, Michael Hsiao, Chi-Ming Liang, Shu-Mei Lian. Recombinant viral protein promotes apoptosis and suppresses invasion of ovarian adenocarcinoma cells by targeting α5β1 integrin to down-regulate Akt and MMP-2. British journal of pharmacology. vol 165. issue 2. 2012-04-10. PMID:21740408. |
recombinant viral protein promotes apoptosis and suppresses invasion of ovarian adenocarcinoma cells by targeting α5β1 integrin to down-regulate akt and mmp-2. |
2012-04-10 |
2023-08-12 |
Not clear |
| S Sun, F Li, X Gao, Y Zhu, J Chen, X Zhu, H Yuan, D Ga. Calbindin-D28K inhibits apoptosis in dopaminergic neurons by activation of the PI3-kinase-Akt signaling pathway. Neuroscience. vol 199. 2012-04-06. PMID:22020319. |
after treating with 6-ohda, a significant decrease in the apoptosis rate of the transfected mn9d cells was noted, as well as an obvious increase in the expression of phosphorylation of akt (p-akt); however, no significant change in the expression of total akt or phospho-p100 (p-p100) occurred after this treatment. |
2012-04-06 |
2023-08-12 |
Not clear |
| Huan Zhang, Shinghung Mak, Wei Cui, Wenming Li, Renwen Han, Shengquan Hu, Minzhong Ye, Rongbiao Pi, Yifan Ha. Tacrine(2)-ferulic acid, a novel multifunctional dimer, attenuates 6-hydroxydopamine-induced apoptosis in PC12 cells by activating Akt pathway. Neurochemistry international. vol 59. issue 7. 2012-04-03. PMID:21939707. |
tacrine(2)-ferulic acid, a novel multifunctional dimer, attenuates 6-hydroxydopamine-induced apoptosis in pc12 cells by activating akt pathway. |
2012-04-03 |
2023-08-12 |
Not clear |
| Huan Zhang, Shinghung Mak, Wei Cui, Wenming Li, Renwen Han, Shengquan Hu, Minzhong Ye, Rongbiao Pi, Yifan Ha. Tacrine(2)-ferulic acid, a novel multifunctional dimer, attenuates 6-hydroxydopamine-induced apoptosis in PC12 cells by activating Akt pathway. Neurochemistry international. vol 59. issue 7. 2012-04-03. PMID:21939707. |
collectively, these results suggest that t2fa prevents 6-ohda-induced apoptosis possibly by activating the akt pathway in pc12 cells. |
2012-04-03 |
2023-08-12 |
Not clear |
| Hong-Bo Chen, Lan-Zhen Zhou, Lin Mei, Xiao-Jun Shi, Xiao-Shan Wang, Qing-Lin Li, Laiqiang Huan. Gambogenic acid-induced time- and dose-dependent growth inhibition and apoptosis involving Akt pathway inactivation in U251 glioblastoma cells. Journal of natural medicines. vol 66. issue 1. 2012-04-02. PMID:21879332. |
gambogenic acid-induced time- and dose-dependent growth inhibition and apoptosis involving akt pathway inactivation in u251 glioblastoma cells. |
2012-04-02 |
2023-08-12 |
Not clear |
| Hui Luo, Yang Yang, Fang Huang, Feng Li, Qian Jiang, Kejian Shi, Caimin X. Selenite induces apoptosis in colorectal cancer cells via AKT-mediated inhibition of β-catenin survival axis. Cancer letters. vol 315. issue 1. 2012-04-02. PMID:22074856. |
further experiments by transient expression of akt and β-catenin revealed that inhibition of akt/β-catenin was closely correlated with selenite-triggered apoptosis. |
2012-04-02 |
2023-08-12 |
Not clear |
| Kwang-Beom Lee, Hyun-Jung Byun, Sung Ho Park, Chan-Yong Park, Seung-Hoon Lee, Seung Bae Rh. CYR61 controls p53 and NF-κB expression through PI3K/Akt/mTOR pathways in carboplatin-induced ovarian cancer cells. Cancer letters. vol 315. issue 1. 2012-04-02. PMID:22078465. |
in parallel, cyr61-expressing cells, during carboplatin-induced apoptosis, resulted in an increase of akt phosphorylation, while rapamycin-treated cells were not affected. |
2012-04-02 |
2023-08-12 |
Not clear |
| Yan Wang, Yanlei Hao, Stephen E Alwa. Suppression of GSK-3β activation by M-cadherin protects myoblasts against mitochondria-associated apoptosis during myogenic differentiation. Journal of cell science. vol 124. issue Pt 22. 2012-04-02. PMID:22114306. |
overexpression of wild-type gsk-3β in confluent c2c12 myoblasts exacerbated the apoptosis, whereas chemical inhibition of gsk-3β using tdzd-8, or forced expression of constitutively active akt (myrakt), or a kinase-deficient gsk-3β mutant [gsk-3β(k85r)], attenuated apoptosis and rescued the impaired myogenic differentiation that is caused by m-cadherin rna interference. |
2012-04-02 |
2023-08-12 |
Not clear |
| Euan A Stronach, Michelle Chen, Elaina N Maginn, Roshan Agarwal, Gordon B Mills, Harpreet Wasan, Hani Gabr. DNA-PK mediates AKT activation and apoptosis inhibition in clinically acquired platinum resistance. Neoplasia (New York, N.Y.). vol 13. issue 11. 2012-04-02. PMID:22131882. |
dna-pk mediates akt activation and apoptosis inhibition in clinically acquired platinum resistance. |
2012-04-02 |
2023-08-12 |
Not clear |
| Euan A Stronach, Michelle Chen, Elaina N Maginn, Roshan Agarwal, Gordon B Mills, Harpreet Wasan, Hani Gabr. DNA-PK mediates AKT activation and apoptosis inhibition in clinically acquired platinum resistance. Neoplasia (New York, N.Y.). vol 13. issue 11. 2012-04-02. PMID:22131882. |
akt relocates to the nucleus of resistant cells where it is phosphorylated specifically on s473 by dna-dependent protein kinase (dna-pk), and this activation inhibits cisplatin-mediated apoptosis. |
2012-04-02 |
2023-08-12 |
Not clear |
| Euan A Stronach, Michelle Chen, Elaina N Maginn, Roshan Agarwal, Gordon B Mills, Harpreet Wasan, Hani Gabr. DNA-PK mediates AKT activation and apoptosis inhibition in clinically acquired platinum resistance. Neoplasia (New York, N.Y.). vol 13. issue 11. 2012-04-02. PMID:22131882. |
strikingly, in patient-matched sensitive cells, we do not see enhanced apoptosis on combining cisplatin with akt or dna-pk inhibition. |
2012-04-02 |
2023-08-12 |
Not clear |
| Qi-Wen Fan, William A Weis. Autophagy and Akt promote survival in glioma. Autophagy. vol 7. issue 5. 2012-03-27. PMID:21266843. |
the allosteric mtorc1 inhibitor rapamycin fails to induce apoptosis in conjunction with blockade of autophagy, due to feedback-activation of akt. |
2012-03-27 |
2023-08-12 |
Not clear |
| Leila Seddik, Thierno Madjou Bah, Abdelkader Aoues, Miloud Slimani, Mohamed Benderdou. Elucidation of mechanisms underlying the protective effects of olive leaf extract against lead-induced neurotoxicity in Wistar rats. The Journal of toxicological sciences. vol 36. issue 6. 2012-03-27. PMID:22129743. |
upon examination of signaling pathways involved in apoptosis process, we found that pb induced p38 mitogen activated protein kinase (mapk) and akt phosphorylation, but in contrast, inhibited that of erk(1/2). |
2012-03-27 |
2023-08-12 |
rat |