| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Azhar R Hussain, Shahab Uddin, Rong Bu, Omar S Khan, Saeeda O Ahmed, Maqbool Ahmed, Khawla S Al-Kuray. Resveratrol suppresses constitutive activation of AKT via generation of ROS and induces apoptosis in diffuse large B cell lymphoma cell lines. PloS one. vol 6. issue 9. 2012-02-28. PMID:21931821. |
resveratrol suppresses constitutive activation of akt via generation of ros and induces apoptosis in diffuse large b cell lymphoma cell lines. |
2012-02-28 |
2023-08-12 |
Not clear |
| Pramod K Dash, Daniel Johnson, Jordan Clark, Sara A Orsi, Min Zhang, Jing Zhao, Raymond J Grill, Anthony N Moore, Shibani Pat. Involvement of the glycogen synthase kinase-3 signaling pathway in TBI pathology and neurocognitive outcome. PloS one. vol 6. issue 9. 2012-02-28. PMID:21935433. |
growth factors activate akt, which in turn inhibits gsk-3 activity by direct phosphorylation, leading to a reduction in apoptosis. |
2012-02-28 |
2023-08-12 |
Not clear |
| Dan Shu, Yong Qing, Qingyi Tong, Yang He, Zhihua Xing, Yinglan Zhao, Yi Li, Yuquan Wei, Wen Huang, Xiaohua W. Deltonin isolated from Dioscorea zingiberensis inhibits cancer cell growth through inducing mitochondrial apoptosis and suppressing Akt and mitogen activated protein kinase signals. Biological & pharmaceutical bulletin. vol 34. issue 8. 2012-02-27. PMID:21804211. |
deltonin isolated from dioscorea zingiberensis inhibits cancer cell growth through inducing mitochondrial apoptosis and suppressing akt and mitogen activated protein kinase signals. |
2012-02-27 |
2023-08-12 |
Not clear |
| Dan Shu, Yong Qing, Qingyi Tong, Yang He, Zhihua Xing, Yinglan Zhao, Yi Li, Yuquan Wei, Wen Huang, Xiaohua W. Deltonin isolated from Dioscorea zingiberensis inhibits cancer cell growth through inducing mitochondrial apoptosis and suppressing Akt and mitogen activated protein kinase signals. Biological & pharmaceutical bulletin. vol 34. issue 8. 2012-02-27. PMID:21804211. |
these results demonstrate that deltonin mediates the growth inhibition of cancer cells through multiple targets, which include the generation of reactive oxygen species (ros), mitochondrial apoptosis and the inhibition of the mitogen-activated protein kinase (mapk) and akt signaling pathways, suggesting deltonin is a potent cancer preventive and therapeutic agent. |
2012-02-27 |
2023-08-12 |
Not clear |
| Nisha Marathe, Hema Rangaswami, Shunhui Zhuang, Gerry R Boss, Renate B Pil. Pro-survival effects of 17β-estradiol on osteocytes are mediated by nitric oxide/cGMP via differential actions of cGMP-dependent protein kinases I and II. The Journal of biological chemistry. vol 287. issue 2. 2012-02-27. PMID:22117068. |
in conclusion, 17β-estradiol protects osteocytes against apoptosis by activating the no/cgmp/pkg cascade; pkg ii is required for estradiol-induced activation of erk and akt, and pkg iα contributes to pro-survival signaling by directly phosphorylating bad. |
2012-02-27 |
2023-08-12 |
Not clear |
| Nisreen Sherif Alyasiri, Syed Jafar Mehdi, M Shabbir Alam, Asgar Ali, Ashish K Mandal, Sunita Gupta, Ishwar Singh, M Moshahid Alam Rizv. PTEN-mediated AKT activation contributes to the reduced apoptosis among Indian oral squamous cell carcinoma patients. Journal of cancer research and clinical oncology. vol 138. issue 1. 2012-02-24. PMID:22033727. |
pten-mediated akt activation contributes to the reduced apoptosis among indian oral squamous cell carcinoma patients. |
2012-02-24 |
2023-08-12 |
Not clear |
| Nisreen Sherif Alyasiri, Syed Jafar Mehdi, M Shabbir Alam, Asgar Ali, Ashish K Mandal, Sunita Gupta, Ishwar Singh, M Moshahid Alam Rizv. PTEN-mediated AKT activation contributes to the reduced apoptosis among Indian oral squamous cell carcinoma patients. Journal of cancer research and clinical oncology. vol 138. issue 1. 2012-02-24. PMID:22033727. |
several studies have reported the role of pten gene in akt downregulation and apoptosis induction in different cancers and cell lines. |
2012-02-24 |
2023-08-12 |
Not clear |
| Nisreen Sherif Alyasiri, Syed Jafar Mehdi, M Shabbir Alam, Asgar Ali, Ashish K Mandal, Sunita Gupta, Ishwar Singh, M Moshahid Alam Rizv. PTEN-mediated AKT activation contributes to the reduced apoptosis among Indian oral squamous cell carcinoma patients. Journal of cancer research and clinical oncology. vol 138. issue 1. 2012-02-24. PMID:22033727. |
however, the role of loss of pten expression in akt activation and spontaneous apoptosis in oral squamous cell carcinoma clinical specimens is not well established. |
2012-02-24 |
2023-08-12 |
Not clear |
| Fang Fang, Dongye Li, Huanjun Pan, Dan Chen, Lingling Qi, Ruiqu Zhang, Hong Su. Luteolin inhibits apoptosis and improves cardiomyocyte contractile function through the PI3K/Akt pathway in simulated ischemia/reperfusion. Pharmacology. vol 88. issue 3-4. 2012-02-23. PMID:21934351. |
inhibition of akt activity markedly abolished luteolin-induced positive contraction and inhibition of apoptosis in si/r cardiomyocytes. |
2012-02-23 |
2023-08-12 |
rat |
| Bassam G Abu Jawdeh, Shenaz Khan, Isabelle Deschênes, Malcolm Hoshi, Monu Goel, Jeffrey T Lock, Krekwit Shinlapawittayatorn, Gerald Babcock, Sujata Lakhe-Reddy, Garren DeCaro, Satya P Yadav, Maradumane L Mohan, Sathyamangla V Naga Prasad, William P Schilling, Eckhard Ficker, Jeffrey R Schellin. Phosphoinositide binding differentially regulates NHE1 Na+/H+ exchanger-dependent proximal tubule cell survival. The Journal of biological chemistry. vol 286. issue 49. 2012-02-21. PMID:22020933. |
divergent pi(4,5)p(2) and pi(3,4,5)p(3) effects on nhe1-dependent na(+)/h(+) exchange and apoptosis were confirmed by selective phosphoinositide sequestration with pleckstrin homology domain-containing phospholipase cδ and akt peptides, pi 3-kinase, and akt inhibition in wild-type and nhe1-null ptcs. |
2012-02-21 |
2023-08-12 |
Not clear |
| Lin Wang, Xin-Kui Liu, Xiu-Qin Sh. Involvement of Akt in synergistic effects of thermo-chemotherapy on human small cell lung cancer H446 cell apoptosis. Chinese journal of cancer. vol 29. issue 4. 2012-02-13. PMID:20346214. |
involvement of akt in synergistic effects of thermo-chemotherapy on human small cell lung cancer h446 cell apoptosis. |
2012-02-13 |
2023-08-12 |
human |
| Lin Wang, Xin-Kui Liu, Xiu-Qin Sh. Involvement of Akt in synergistic effects of thermo-chemotherapy on human small cell lung cancer H446 cell apoptosis. Chinese journal of cancer. vol 29. issue 4. 2012-02-13. PMID:20346214. |
akt pathway plays an important role in cell growth and apoptosis. |
2012-02-13 |
2023-08-12 |
human |
| Su Jin Park, Jogeswar Gadi, Kyoung-Won Cho, Kwang Joon Kim, Se Hwa Kim, Han-Sung Jung, Sung-Kil Li. The forkhead transcription factor Foxc2 promotes osteoblastogenesis via up-regulation of integrin β1 expression. Bone. vol 49. issue 3. 2012-02-13. PMID:21640215. |
in addition, the resistance to apoptosis induced by serum deprivation and phosphorylation of both akt and erk was significantly reduced after sifoxc2 treatment. |
2012-02-13 |
2023-08-12 |
mouse |
| Shahab Uddin, Azhar R Hussain, Maqbool Ahmed, Nasser Al-Sanea, Alaa Abduljabbar, Luai H Ashari, Samar Alhomoud, Fouad Al-Dayel, Prashant Bavi, Khawla S Al-Kuray. Coexpression of activated c-Met and death receptor 5 predicts better survival in colorectal carcinoma. The American journal of pathology. vol 179. issue 6. 2012-02-09. PMID:21978492. |
pha665752, a selective p-met inhibitor, induced apoptosis in crc cells via inactivation of c-met and akt. |
2012-02-09 |
2023-08-12 |
Not clear |
| Larissa Larsen, Huan-Yuan Chen, Jun Saegusa, Fu-Tong Li. Galectin-3 and the skin. Journal of dermatological science. vol 64. issue 2. 2012-02-06. PMID:21889881. |
galectin-3 may act as a regulator of epithelial tumor progression and development through various signaling pathways, such as inhibiting keratinocyte apoptosis through regulation of the activation status of extracellular signal-regulated kinase (erk) and activated protein kinase b (akt). |
2012-02-06 |
2023-08-12 |
Not clear |
| Sanjiv Dhingra, Ashim K Bagchi, Ana L Ludke, Anita K Sharma, Pawan K Singa. Akt regulates IL-10 mediated suppression of TNFα-induced cardiomyocyte apoptosis by upregulating Stat3 phosphorylation. PloS one. vol 6. issue 9. 2012-02-03. PMID:21949832. |
akt regulates il-10 mediated suppression of tnfα-induced cardiomyocyte apoptosis by upregulating stat3 phosphorylation. |
2012-02-03 |
2023-08-12 |
Not clear |
| Sanjiv Dhingra, Ashim K Bagchi, Ana L Ludke, Anita K Sharma, Pawan K Singa. Akt regulates IL-10 mediated suppression of TNFα-induced cardiomyocyte apoptosis by upregulating Stat3 phosphorylation. PloS one. vol 6. issue 9. 2012-02-03. PMID:21949832. |
present study investigates the role of akt and jak/stat pathway in the il-10 modulation of tnf-α induced cardiomyocyte apoptosis. |
2012-02-03 |
2023-08-12 |
Not clear |
| Ling Yang, Weiwei Guo, Qunling Zhang, Hongyan Li, Xiaoyu Liu, Yunlong Yang, Ji Zuo, Wen Li. Crosstalk between Raf/MEK/ERK and PI3K/AKT in suppression of Bax conformational change by Grp75 under glucose deprivation conditions. Journal of molecular biology. vol 414. issue 5. 2012-02-03. PMID:21964438. |
the activated akt and extracellular signal-regulated protein kinases 1 and 2 by grp75 inhibited the bax conformational change and subsequent apoptosis. |
2012-02-03 |
2023-08-12 |
Not clear |
| Z Liu, C Sun, Y Zhang, Z Ji, G Yan. Phosphatidylinositol 3-kinase-C2β inhibits cisplatin-mediated apoptosis via the Akt pathway in oesophageal squamous cell carcinoma. The Journal of international medical research. vol 39. issue 4. 2012-02-02. PMID:21986133. |
phosphatidylinositol 3-kinase-c2β inhibits cisplatin-mediated apoptosis via the akt pathway in oesophageal squamous cell carcinoma. |
2012-02-02 |
2023-08-12 |
Not clear |
| Wilfred Lieberthal, Leiqing Zhang, Vimal A Patel, Jerrold S Levin. AMPK protects proximal tubular cells from stress-induced apoptosis by an ATP-independent mechanism: potential role of Akt activation. American journal of physiology. Renal physiology. vol 301. issue 6. 2012-02-01. PMID:21957177. |
ampk protects proximal tubular cells from stress-induced apoptosis by an atp-independent mechanism: potential role of akt activation. |
2012-02-01 |
2023-08-12 |
mouse |