| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Venkatabalasubramanian Sivaramakrishnan, Sivasitambaram Niranjali Devara. Morin fosters apoptosis in experimental hepatocellular carcinogenesis model. Chemico-biological interactions. vol 183. issue 2. 2010-02-25. PMID:19931519. |
further, morin caused the up-regulation of tumor suppressor pten, an important negative regulator of akt, thus initiating apoptosis. |
2010-02-25 |
2023-08-12 |
Not clear |
| Mariola Kulawiec, Kjerstin M Owens, Keshav K Sing. mtDNA G10398A variant in African-American women with breast cancer provides resistance to apoptosis and promotes metastasis in mice. Journal of human genetics. vol 54. issue 11. 2010-02-24. PMID:19763141. |
resistance to apoptosis was mediated by akt activation. |
2010-02-24 |
2023-08-12 |
mouse |
| Mei Hua Gao, Tong Tang, Atsushi Miyanohara, James R Feramisco, H Kirk Hammon. beta(1)-Adrenergic receptor vs adenylyl cyclase 6 expression in cardiac myocytes: differences in transgene localization and intracellular signaling. Cellular signalling. vol 22. issue 4. 2010-02-24. PMID:19932173. |
in contrast, increased ac6, but not beta(1)ar, inhibited phlpp2 activity, activated pi3k and akt, and increased p70s6 kinase phosphorylation and bcl-2 expression; apoptosis was unchanged. |
2010-02-24 |
2023-08-12 |
rat |
| Han Jin Cho, Gyoo Taik Kwon, Jung Han Yoon Par. trans-10,cis-12 Conjugated linoleic acid induces depolarization of mitochondrial membranes in HT-29 human colon cancer cells: a possible mechanism for induction of apoptosis. Journal of medicinal food. vol 12. issue 5. 2010-02-23. PMID:19857056. |
these findings indicate that physiological levels of t10c12 induce apoptosis in ht-29 colon cancer cells, which is mediated via mitochondrion-mediated events associated with a decline in akt activity, an increase in the translocation of the pro-apototic bad and bax to the mitochondria, and the subsequent disruption of normal mitochondrial membrane potential. |
2010-02-23 |
2023-08-12 |
human |
| Chi-Yuan Chen, Shih-Hwa Chiou, Chih-Yang Huang, Chia-Ing Jan, Shu-Chun Lin, Wen-Yuan Hu, Shiu-Huey Chou, Chung-Ji Liu, Jeng-Fan L. Tid1 functions as a tumour suppressor in head and neck squamous cell carcinoma. The Journal of pathology. vol 219. issue 3. 2010-02-22. PMID:19681071. |
on the other hand, ectopic expression of constitutively active akt greatly reduced apoptosis induced by tid1 overexpression. |
2010-02-22 |
2023-08-12 |
human |
| Yu-Xiong Feng, Jiang-Sha Zhao, Jing-Jing Li, Tao Wang, Shu-Qun Cheng, Yunfei Yuan, Fudi Wang, Xiao-Fan Wang, Dong Xi. Liver cancer: EphrinA2 promotes tumorigenicity through Rac1/Akt/NF-kappaB signaling pathway. Hepatology (Baltimore, Md.). vol 51. issue 2. 2010-02-22. PMID:19918976. |
furthermore, we disclosed a novel ephrina2/ras-related c3 botulinum toxin substrate 1 (rac1)/v-akt murine thymoma viral oncogene homolog (akt)/nuclear factor-kappa b (nf-kappab) pathway contributing to the inhibitory effect on apoptosis in hcc cells. |
2010-02-22 |
2023-08-12 |
Not clear |
| Cho Hee Kim, A Ra Ko, Su Yeon Lee, Hyun Min Jeon, Sun Mi Kim, Hye Gyeong Park, Song Iy Han, Ho Sung Kan. Hypoxia switches glucose depletion-induced necrosis to phosphoinositide 3-kinase/Akt-dependent apoptosis in A549 lung adenocarcinoma cells. International journal of oncology. vol 36. issue 1. 2010-02-22. PMID:19956840. |
we also found that during ogd-induced apoptosis the prosurvival protein kinase akt is activated and inhibition of akt by the phosphoinositide 3-kinase (pi3k) inhibitors ly294002 and wortmannin prevent ogd-induced apoptosis, caspase-3 and -9 activation, and nuclear translocation of aif and endog. |
2010-02-22 |
2023-08-12 |
Not clear |
| Hao Zhang, Bin Li, Shu-wei Bai, Hui-juan Wan. Constitutively active Akt contributes to vincristine resistance in human retinoblastoma cells. Cancer investigation. vol 28. issue 2. 2010-02-22. PMID:19968493. |
akt mediates survival signals which preserve various cancer cells from apoptosis. |
2010-02-22 |
2023-08-12 |
human |
| Hao Zhang, Bin Li, Shu-wei Bai, Hui-juan Wan. Constitutively active Akt contributes to vincristine resistance in human retinoblastoma cells. Cancer investigation. vol 28. issue 2. 2010-02-22. PMID:19968493. |
inhibition of akt can decrease the survival of both sensitive and vincristine-resistant so-rb50 cells and increase the sensitivity of both cell lines to vincristine by enhancing the cell apoptosis and increasing the cellular accumulation of the drug. |
2010-02-22 |
2023-08-12 |
human |
| Xiao-Mei Li, Yi-Tong Ma, Yi-Ning Yang, Fen Liu, Bang-Dang Chen, Wei Han, Jian-Fa Zhang, Xiao-Ming Ga. Downregulation of survival signalling pathways and increased apoptosis in the transition of pressure overload-induced cardiac hypertrophy to heart failure. Clinical and experimental pharmacology & physiology. vol 36. issue 11. 2010-02-18. PMID:19566828. |
downregulation of erk1/2, akt and gsk3beta and enhanced cardiomyocyte apoptosis are implicated as important mechanisms in the transition from compensated hypertrophy to heart failure. |
2010-02-18 |
2023-08-12 |
mouse |
| Mercè de Frias, Daniel Iglesias-Serret, Ana M Cosialls, Llorenç Coll-Mulet, Antonio F Santidrián, Diana M González-Gironès, Esmeralda de la Banda, Gabriel Pons, Joan Gi. Akt inhibitors induce apoptosis in chronic lymphocytic leukemia cells. Haematologica. vol 94. issue 12. 2010-02-18. PMID:19815839. |
akt inhibitors induce apoptosis in chronic lymphocytic leukemia cells. |
2010-02-18 |
2023-08-12 |
Not clear |
| Daniele Torella, Cosimo Gasparri, Georgina M Ellison, Antonio Curcio, Angelo Leone, Carla Vicinanza, Valentina Galuppo, Isabella Mendicino, Walter Sacco, Iolanda Aquila, Francesca Chiara Surace, Maria Luposella, Gilda Stillo, Valter Agosti, Claudia Cosentino, Enrico V Avvedimento, Ciro Indolf. Differential regulation of vascular smooth muscle and endothelial cell proliferation in vitro and in vivo by cAMP/PKA-activated p85alphaPI3K. American journal of physiology. Heart and circulatory physiology. vol 297. issue 6. 2010-02-17. PMID:19783773. |
accordingly, pka-activated p85alpha triggered akt activation, reducing both vsmc and ec apoptosis in vitro. |
2010-02-17 |
2023-08-12 |
rat |
| Eun J Choi, Gun-Hee Ki. 5-Fluorouracil combined with apigenin enhances anticancer activity through induction of apoptosis in human breast cancer MDA-MB-453 cells. Oncology reports. vol 22. issue 6. 2010-02-17. PMID:19885610. |
taken together, our results suggest that 5-fluorouracil acts synergistically with apigenin inhibiting cell growth and inducing apoptosis via the down-regulation of erbb2 expression and akt signaling. |
2010-02-17 |
2023-08-12 |
human |
| Céline Van Themsche, Sophie Parent, Valérie Leblanc, Caroline Descôteaux, Anne-Marie Simard, Gervais Bérubé, Eric Asseli. VP-128, a novel oestradiol-platinum(II) hybrid with selective anti-tumour activity towards hormone-dependent breast cancer cells in vivo. Endocrine-related cancer. vol 16. issue 4. 2010-02-16. PMID:19661132. |
in these cells, only the hybrid induced apoptosis in an eralpha-dependent manner, inactivated both x-linked inhibitor of apoptosis protein and akt, and induced selective nuclear accumulation of eralpha and the expression of er-regulated genes c-myc and tff1, which was blocked by eralpha-specific antagonist ici 282 780. |
2010-02-16 |
2023-08-12 |
mouse |
| Arpad Boronkai, Szabolcs Bellyei, Andras Szigeti, Eva Pozsgai, Zita Bognar, Balazs Sumegi, Ferenc Gallya. Potentiation of paclitaxel-induced apoptosis by galectin-13 overexpression via activation of Ask-1-p38-MAP kinase and JNK/SAPK pathways and suppression of Akt and ERK1/2 activation in U-937 human macrophage cells. European journal of cell biology. vol 88. issue 12. 2010-02-12. PMID:19717209. |
potentiation of paclitaxel-induced apoptosis by galectin-13 overexpression via activation of ask-1-p38-map kinase and jnk/sapk pathways and suppression of akt and erk1/2 activation in u-937 human macrophage cells. |
2010-02-12 |
2023-08-12 |
human |
| S Chandarlapaty, M Scaltriti, P Angelini, Q Ye, M Guzman, C A Hudis, L Norton, D B Solit, J Arribas, J Baselga, N Rose. Inhibitors of HSP90 block p95-HER2 signaling in Trastuzumab-resistant tumors and suppress their growth. Oncogene. vol 29. issue 3. 2010-02-12. PMID:19855434. |
chronic administration of hsp90 inhibitors in vivo results in sustained loss of her2 and p95-her2 expression and inhibition of akt activation, together with induction of apoptosis and complete inhibition of tumor growth in trastuzumab-resistant, p95-her2-overexpressing models. |
2010-02-12 |
2023-08-12 |
Not clear |
| Yoshitaka Nakamura, Shingo Yogosawa, Yasuyuki Izutani, Hirotsuna Watanabe, Eigo Otsuji, Tosiyuki Saka. A combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagy. Molecular cancer. vol 8. 2010-02-05. PMID:19909554. |
a combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer ht-29 cells by inhibiting akt phosphorylation and progression of autophagy. |
2010-02-05 |
2023-08-12 |
human |
| Paola Palozza, Rossella Simone, Assunta Catalano, Alma Boninsegna, Volker Böhm, Kati Fröhlich, Maria Cristina Mele, Giovanni Monego, Franco O Ranellett. Lycopene prevents 7-ketocholesterol-induced oxidative stress, cell cycle arrest and apoptosis in human macrophages. The Journal of nutritional biochemistry. vol 21. issue 1. 2010-02-01. PMID:19157829. |
concomitantly, it inhibited 7-kc-induced apoptosis, by limiting caspase-3 activation and the modulatory effects of 7-kc on akt, bcl-2, bcl-xl and bax. |
2010-02-01 |
2023-08-12 |
human |
| Jane L Watson, Anna Greenshields, Richard Hill, Ashley Hilchie, Patrick W Lee, Carman A Giacomantonio, David W Hoski. Curcumin-induced apoptosis in ovarian carcinoma cells is p53-independent and involves p38 mitogen-activated protein kinase activation and downregulation of Bcl-2 and survivin expression and Akt signaling. Molecular carcinogenesis. vol 49. issue 1. 2010-02-01. PMID:19676105. |
curcumin-induced apoptosis in ovarian carcinoma cells is p53-independent and involves p38 mitogen-activated protein kinase activation and downregulation of bcl-2 and survivin expression and akt signaling. |
2010-02-01 |
2023-08-12 |
Not clear |
| Jane L Watson, Anna Greenshields, Richard Hill, Ashley Hilchie, Patrick W Lee, Carman A Giacomantonio, David W Hoski. Curcumin-induced apoptosis in ovarian carcinoma cells is p53-independent and involves p38 mitogen-activated protein kinase activation and downregulation of Bcl-2 and survivin expression and Akt signaling. Molecular carcinogenesis. vol 49. issue 1. 2010-02-01. PMID:19676105. |
we conclude that p53-independent curcumin-induced apoptosis in ovarian carcinoma cells involves p38 mapk activation, ablation of prosurvival akt signaling, and reduced expression of the antiapoptotic proteins bcl-2 and survivin. |
2010-02-01 |
2023-08-12 |
Not clear |