| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K-H Lee, Y-L Chen, S-D Yeh, M Hsiao, J-T Lin, Y-G Goan, P-J L. MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation. Oncogene. vol 28. issue 38. 2009-10-06. PMID:19597470. |
after overexpressing of mir-330 in pc-3 cells, cell growth was suppressed by reducing e2f1-mediated akt phosphorylation and thereby inducing apoptosis. |
2009-10-06 |
2023-08-12 |
human |
| K-H Lee, Y-L Chen, S-D Yeh, M Hsiao, J-T Lin, Y-G Goan, P-J L. MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation. Oncogene. vol 28. issue 38. 2009-10-06. PMID:19597470. |
collectively, this is the first study to show that e2f1 is negatively regulated by mir-330 and also show that mir-330 induces apoptosis in prostate cancer cells through e2f1-mediated suppression of akt phosphorylation. |
2009-10-06 |
2023-08-12 |
human |
| Zheng-Guang Li, Ying-Lan Zhao, Xiaohua Wu, Hao-Yu Ye, Aihua Peng, Zhi-Xing Cao, Yong-Qiu Mao, Yu-Zhu Zheng, Pei-Du Jiang, Xia Zhao, Li-Juan Chen, Yu-Quan We. Barbigerone, a natural isoflavone, induces apoptosis in murine lung-cancer cells via the mitochondrial apoptotic pathway. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 24. issue 1-2. 2009-10-05. PMID:19590197. |
in conclusion, our results indicated that barbigerone can inhibit murine lung cancer cell proliferation by inducing apoptosis via mitochondrial apoptotic pathway and by decreasing phosphorylated p42/44 mapk and akt. |
2009-10-05 |
2023-08-12 |
Not clear |
| Sung-Wuk Jang, Xia Liu, Haian Fu, Howard Rees, Manuel Yepes, Allan Levey, Keqiang Y. Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons. The Journal of biological chemistry. vol 284. issue 36. 2009-10-05. PMID:19592491. |
akt phosphorylates srpk2 on thr-492 and promotes its nuclear translocation leading to cyclin d1 up-regulation, cell cycle reentry, and neuronal apoptosis. |
2009-10-05 |
2023-08-12 |
Not clear |
| Andreas Antonsson, Jenny L Persso. Induction of apoptosis by staurosporine involves the inhibition of expression of the major cell cycle proteins at the G(2)/m checkpoint accompanied by alterations in Erk and Akt kinase activities. Anticancer research. vol 29. issue 8. 2009-09-30. PMID:19661292. |
induction of apoptosis by staurosporine involves the inhibition of expression of the major cell cycle proteins at the g(2)/m checkpoint accompanied by alterations in erk and akt kinase activities. |
2009-09-30 |
2023-08-12 |
Not clear |
| Alexander Persson, Robert Blomgran-Julinder, Daniel Eklund, Charlotte Lundström, Olle Stendah. Induction of apoptosis in human neutrophils by Mycobacterium tuberculosis is dependent on mature bacterial lipoproteins. Microbial pathogenesis. vol 47. issue 3. 2009-09-28. PMID:19501642. |
opsonized mtb were readily phagocytosed, and the immuno-mediated phagocytosis triggered early activation of anti-apoptotic akt in the neutrophils but the bacteria still induced apoptosis to the same extent as non-phagocytosed mtb. |
2009-09-28 |
2023-08-12 |
human |
| Yongxin Zhou, Huiling Zhen, Yunqing Mei, Yongwu Wang, Jing Feng, Shuchang Xu, Xiaoying F. PI3K/AKT mediated p53 down-regulation participates in CpG DNA inhibition of spontaneous B cell apoptosis. Cellular & molecular immunology. vol 6. issue 3. 2009-09-28. PMID:19567200. |
treatment of cpg dna could reduce the expression of caspase 3, increase iap and bcl-xl expressions, and inhibit p53 protein expression which level was increased in b cell spontaneous apoptosis at 24 h. akt kinase activity was increased with the incubation of cpg dna. |
2009-09-28 |
2023-08-12 |
Not clear |
| Fang Gao, Hao Li, Ya-Dong Chen, Xiao-Ning Yu, Ran Wang, Xue-Liang Che. Upregulation of PTEN involved in scorpion venom-induced apoptosis in a lymphoma cell line. Leukemia & lymphoma. vol 50. issue 4. 2009-09-25. PMID:19373662. |
treatment with bmk venom and ly294002 (an inhibitor of akt) synergistically enhanced apoptosis. |
2009-09-25 |
2023-08-12 |
human |
| Judy T T Zhu, Roy C Y Choi, Heidi Q Xie, Ken Y Z Zheng, Ava J Y Guo, Cathy W C Bi, David T W Lau, Jun Li, Tina T X Dong, Brad W C Lau, Ji J Chen, Karl W K Tsi. Hibifolin, a flavonol glycoside, prevents beta-amyloid-induced neurotoxicity in cultured cortical neurons. Neuroscience letters. vol 461. issue 2. 2009-09-23. PMID:19539722. |
these results therefore provided the first evidence that hibifolin protected neurons against a beta-induced apoptosis and stimulated akt activation, which would be useful in developing potential drugs or food supplements for treating ad. |
2009-09-23 |
2023-08-12 |
Not clear |
| M Yeste-Velasco, J Folch, G Casadesús, M A Smith, M Pallàs, A Camin. Neuroprotection by c-Jun NH2-terminal kinase inhibitor SP600125 against potassium deprivation-induced apoptosis involves the Akt pathway and inhibition of cell cycle reentry. Neuroscience. vol 159. issue 3. 2009-09-21. PMID:19356694. |
neuroprotection by c-jun nh2-terminal kinase inhibitor sp600125 against potassium deprivation-induced apoptosis involves the akt pathway and inhibition of cell cycle reentry. |
2009-09-21 |
2023-08-12 |
rat |
| Lucia Gaddini, Marika Villa, Andrea Matteucci, Cinzia Mallozzi, Tamara C Petrucci, Anna Maria M Di Stasi, Lanfranco Leo, Fiorella Malchiodi-Albedi, Flavia Pricc. Early effects of high glucose in retinal tissue cultures Renin-Angiotensin system-dependent and -independent signaling. Neurobiology of disease. vol 35. issue 2. 2009-09-21. PMID:19481149. |
in line with akt activation, no apoptosis or synapse degeneration was found. |
2009-09-21 |
2023-08-12 |
rat |
| Prashanth T Bhaskar, Veronique Nogueira, Krushna C Patra, Sang-Min Jeon, Youngkyu Park, R Brooks Robey, Nissim Ha. mTORC1 hyperactivity inhibits serum deprivation-induced apoptosis via increased hexokinase II and GLUT1 expression, sustained Mcl-1 expression, and glycogen synthase kinase 3beta inhibition. Molecular and cellular biology. vol 29. issue 18. 2009-09-15. PMID:19620286. |
the current concept is that tsc-deficient cells are sensitized to apoptosis due to the inhibition of akt activity by the negative feedback mechanism induced by the hyperactive mtorc1. |
2009-09-15 |
2023-08-12 |
Not clear |
| Prashanth T Bhaskar, Veronique Nogueira, Krushna C Patra, Sang-Min Jeon, Youngkyu Park, R Brooks Robey, Nissim Ha. mTORC1 hyperactivity inhibits serum deprivation-induced apoptosis via increased hexokinase II and GLUT1 expression, sustained Mcl-1 expression, and glycogen synthase kinase 3beta inhibition. Molecular and cellular biology. vol 29. issue 18. 2009-09-15. PMID:19620286. |
the inhibition of mtorc1 activity by either rapamycin or raptor knockdown cannot resensitize these cells to serum deprivation-induced apoptosis because of elevated akt activity that is an indirect consequence of mtorc1 inhibition. |
2009-09-15 |
2023-08-12 |
Not clear |
| Fahad Shuja, Malek Tabbara, Yongqing Li, Baoling Liu, Muhammad Umar Butt, George C Velmahos, Marc DeMoya, Hasan B Ala. Profound hypothermia decreases cardiac apoptosis through Akt survival pathway. Journal of the American College of Surgeons. vol 209. issue 1. 2009-09-15. PMID:19651068. |
profound hypothermia decreases cardiac apoptosis through akt survival pathway. |
2009-09-15 |
2023-08-12 |
Not clear |
| Yu-Ying Chen, Zhan-Xiang Wang, Ping-An Chang, Jian-Jun Li, Feng Pan, Li Yang, Zhi-Heng Bian, Lan Zou, Jian-Ming He, Hou-Jie Lian. Knockdown of focal adhesion kinase reverses colon carcinoma multicellular resistance. Cancer science. vol 100. issue 9. 2009-09-10. PMID:19500106. |
however, silencing of fak combined with 5-fu treatment significantly decreased the 50% inhibitory concentration (ic(50)) of 5-fu and markedly increased the population of apoptosis cells, which was associated with the reduction of the levels of akt and nuclear factor-kappa b (nf-kappab). |
2009-09-10 |
2023-08-12 |
mouse |
| Ivana Sirangelo, Clara Iannuzzi, Silvia Vilasi, Gaetano Irace, Gaia Giuberti, Gabriella Misso, Annamaria D'Alessandro, Alberto Abbruzzese, Michele Caragli. W7FW14F apomyoglobin amyloid aggregates-mediated apoptosis is due to oxidative stress and AKT inactivation caused by Ras and Rac. Journal of cellular physiology. vol 221. issue 2. 2009-09-09. PMID:19585524. |
w7fw14f apomyoglobin amyloid aggregates-mediated apoptosis is due to oxidative stress and akt inactivation caused by ras and rac. |
2009-09-09 |
2023-08-12 |
human |
| Wei-Lei Yang, Jing Wang, Chia-Hsin Chan, Szu-Wei Lee, Alejandro D Campos, Betty Lamothe, Lana Hur, Brian C Grabiner, Xin Lin, Bryant G Darnay, Hui-Kuan Li. The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science (New York, N.Y.). vol 325. issue 5944. 2009-09-09. PMID:19713527. |
akt signaling plays a central role in many biological functions, such as cell proliferation and apoptosis. |
2009-09-09 |
2023-08-12 |
human |
| Luisa Pecorari, Oriano Marin, Chiara Silvestri, Olivia Candini, Elena Rossi, Clara Guerzoni, Sara Cattelani, Samanta A Mariani, Francesca Corradini, Giovanna Ferrari-Amorotti, Laura Cortesi, Rita Bussolari, Giuseppe Raschellà, Massimo R Federico, Bruno Calabrett. Elongation Factor 1 alpha interacts with phospho-Akt in breast cancer cells and regulates their proliferation, survival and motility. Molecular cancer. vol 8. 2009-09-03. PMID:19646290. |
activation of akt in breast cancer portends aggressive tumour behaviour, resistance to hormone-, chemo-, and radiotherapy-induced apoptosis and it is correlated with decreased overall survival. |
2009-09-03 |
2023-08-12 |
Not clear |
| Eumorphia G Konstantakou, Gerassimos E Voutsinas, Panagiotis K Karkoulis, Gerasimos Aravantinos, Lukas H Margaritis, Dimitrios J Stravopodi. Human bladder cancer cells undergo cisplatin-induced apoptosis that is associated with p53-dependent and p53-independent responses. International journal of oncology. vol 35. issue 2. 2009-09-01. PMID:19578756. |
the differential resistance of rt4 and t24 cells to cisplatin-induced apoptosis was associated with an rt4-specific phosphorylation (ser15; ser392) pattern of p53, together with structural amputations of the akt and xiap anti-apoptotic regulators. |
2009-09-01 |
2023-08-12 |
human |
| F Puglisi, L Lacitigniola, A Loverre, P Capuano, G Martines, F Staffieri, G Rossi, A Crovac. Activation of PI3-kinase/Akt induced small bowel cell apoptosis during laparoscopic ischaemia-reperfusion of swine jejunum. Acta chirurgica Belgica. vol 109. issue 2. 2009-08-20. PMID:19499684. |
this study aimed to detect small bowel cell apoptosis by evaluating the nuclear activation of transcription factors, nuclear factor-kappab (nf-kappab) and akt pathways as well as detecting apoptotic cells by tunel assay, during ischaemia-reperfusion (i/r) injury by arterio-venous occlusion (avo) of ajejunal loop in swine, using a laparoscopic procedure. |
2009-08-20 |
2023-08-12 |
Not clear |