| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hitesh Peshavariya, Gregory J Dusting, Fan Jiang, Lesley R Halmos, Christopher G Sobey, Grant R Drummond, Stavros Selemidi. NADPH oxidase isoform selective regulation of endothelial cell proliferation and survival. Naunyn-Schmiedeberg's archives of pharmacology. vol 380. issue 2. 2009-08-19. PMID:19337723. |
in the present study, we investigated the roles of the ros-generating nox4- and nox2-containing reduced nicotinamide adenine dinucleotide phosphate (nadph) oxidases in proliferation of human endothelial cells by examining the impact of these enzyme systems on (1) specific proliferative and tumorigenic kinases, extracellular regulated kinase1/2 (erk1/2) and akt, (2) cytoskeletal organization, and (3) the mechanisms that influence cellular apoptosis. |
2009-08-19 |
2023-08-12 |
human |
| Chun Shi, Lina Zhao, Bilian Zhu, Qianxi Li, David T Yew, Zhibin Yao, Jie X. Protective effects of Ginkgo biloba extract (EGb761) and its constituents quercetin and ginkgolide B against beta-amyloid peptide-induced toxicity in SH-SY5Y cells. Chemico-biological interactions. vol 181. issue 1. 2009-08-18. PMID:19464278. |
we found that egb761 was able to block abeta (1-42)-induced cell apoptosis, reactive oxygen species (ros) accumulation, mitochondrial dysfunction and activation of c-jun n-terminal kinase (jnk), extracellular signal-regulated kinase 1/2 (erk1/2) and akt signaling pathways. |
2009-08-18 |
2023-08-12 |
human |
| Raj Kumar, Sowmyalakshmi Srinivasan, Srinivas Koduru, Pallab Pahari, Jürgen Rohr, Natasha Kyprianou, Chendil Damodara. Psoralidin, an herbal molecule, inhibits phosphatidylinositol 3-kinase-mediated Akt signaling in androgen-independent prostate cancer cells. Cancer prevention research (Philadelphia, Pa.). vol 2. issue 3. 2009-08-14. PMID:19223576. |
furthermore, ectopic expression of akt renders aipc cells resistant to chemotherapy; however, psoralidin overcomes akt-mediated resistance and induces apoptosis in aipc cells. |
2009-08-14 |
2023-08-12 |
mouse |
| Takayo Maekawa, Yoshimasa Maniwa, Takefumi Doi, Wataru Nishio, Masahiro Yoshimura, Chiho Ohbayashi, Yoshitake Hayashi, Yutaka Okit. Expression and localization of FOXO1 in non-small cell lung cancer. Oncology reports. vol 22. issue 1. 2009-08-14. PMID:19513505. |
significant correlations between these data were assessed in order to discern the relationship between akt and apoptosis. |
2009-08-14 |
2023-08-12 |
cattle |
| Takayo Maekawa, Yoshimasa Maniwa, Takefumi Doi, Wataru Nishio, Masahiro Yoshimura, Chiho Ohbayashi, Yoshitake Hayashi, Yutaka Okit. Expression and localization of FOXO1 in non-small cell lung cancer. Oncology reports. vol 22. issue 1. 2009-08-14. PMID:19513505. |
inhibition of akt using rna interference resulted in the accumulation of foxo1 in a549 and ebc1 cell nuclei, and in accelerated apoptosis induction. |
2009-08-14 |
2023-08-12 |
cattle |
| Takayo Maekawa, Yoshimasa Maniwa, Takefumi Doi, Wataru Nishio, Masahiro Yoshimura, Chiho Ohbayashi, Yoshitake Hayashi, Yutaka Okit. Expression and localization of FOXO1 in non-small cell lung cancer. Oncology reports. vol 22. issue 1. 2009-08-14. PMID:19513505. |
in nsclc cells, where foxo1 was present in the cytoplasm constitutively, inhibition of akt led to foxo1 translocation to the nucleus and initiation of apoptosis. |
2009-08-14 |
2023-08-12 |
cattle |
| Nauman Ahmad, Yigang Wang, Ailia K Ali, Muhammad Ashra. Long-acting phosphodiesterase-5 inhibitor, tadalafil, induces sustained cardioprotection against lethal ischemic injury. American journal of physiology. Heart and circulatory physiology. vol 297. issue 1. 2009-08-12. PMID:19429825. |
the readministration of tadalafil at 36 and 72 h restored the protection till 108 h. tadalafil treatment accelerated akt phosphorylation in cardiac tissue and decreased myocyte apoptosis. |
2009-08-12 |
2023-08-12 |
mouse |
| Nauman Ahmad, Yigang Wang, Ailia K Ali, Muhammad Ashra. Long-acting phosphodiesterase-5 inhibitor, tadalafil, induces sustained cardioprotection against lethal ischemic injury. American journal of physiology. Heart and circulatory physiology. vol 297. issue 1. 2009-08-12. PMID:19429825. |
the administration of wortmannin abolished the beneficial effects of tadalafil on hemodynamic parameters and myocyte apoptosis, together with significantly reduced akt phosphorylation. |
2009-08-12 |
2023-08-12 |
mouse |
| b' He-yong Zheng, Jian-da Hu, Zhi-hong Zheng, L\\xc3\\xbc-ye Huang, Ying-yu Chen, Jing Zheng, Xin-ji Chen, Lian-huang L\\xc3\\xb. [Emodin induces leukemic HL-60 cells apoptosis probably by inhibiting Akt signal pathway]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 42. issue 11. 2009-08-06. PMID:18300468.' |
[emodin induces leukemic hl-60 cells apoptosis probably by inhibiting akt signal pathway]. |
2009-08-06 |
2023-08-12 |
human |
| b' He-yong Zheng, Jian-da Hu, Zhi-hong Zheng, L\\xc3\\xbc-ye Huang, Ying-yu Chen, Jing Zheng, Xin-ji Chen, Lian-huang L\\xc3\\xb. [Emodin induces leukemic HL-60 cells apoptosis probably by inhibiting Akt signal pathway]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 42. issue 11. 2009-08-06. PMID:18300468.' |
this study is to investigate the effect of emodin on inducing human myeloid leukemia cell line hl-60 apoptosis and the role of akt signal pathway in the apoptosis. |
2009-08-06 |
2023-08-12 |
human |
| Alessandro Bellis, Diletta Castaldo, Valentina Trimarco, Maria Gaia Monti, Pierpaolo Chivasso, Junichi Sadoshima, Bruno Trimarco, Carmine Morisc. Cross-talk between PKA and Akt protects endothelial cells from apoptosis in the late ischemic preconditioning. Arteriosclerosis, thrombosis, and vascular biology. vol 29. issue 8. 2009-08-06. PMID:19461052. |
cross-talk between pka and akt protects endothelial cells from apoptosis in the late ischemic preconditioning. |
2009-08-06 |
2023-08-12 |
Not clear |
| Seung Chan Park, Hwa Seung Yoo, Cheol Park, Chong Kwan Cho, Gi-Young Kim, Wun-Jae Kim, Yeon-Weol Lee, Yung Hyun Cho. Induction of apoptosis in human lung carcinoma cells by the water extract of Panax notoginseng is associated with the activation of caspase-3 through downregulation of Akt. International journal of oncology. vol 35. issue 1. 2009-08-06. PMID:19513559. |
induction of apoptosis in human lung carcinoma cells by the water extract of panax notoginseng is associated with the activation of caspase-3 through downregulation of akt. |
2009-08-06 |
2023-08-12 |
human |
| Seung Chan Park, Hwa Seung Yoo, Cheol Park, Chong Kwan Cho, Gi-Young Kim, Wun-Jae Kim, Yeon-Weol Lee, Yung Hyun Cho. Induction of apoptosis in human lung carcinoma cells by the water extract of Panax notoginseng is associated with the activation of caspase-3 through downregulation of Akt. International journal of oncology. vol 35. issue 1. 2009-08-06. PMID:19513559. |
moreover, the activity of akt was downregulated in wepn-treated cells and the phosphatidylinositol-3 kinase (pi3k)/akt inhibitor ly294002 sensitized the cells to wepn-induced apoptosis through enhancing the activation of caspase-3 and loss of mmp. |
2009-08-06 |
2023-08-12 |
human |
| Seung Chan Park, Hwa Seung Yoo, Cheol Park, Chong Kwan Cho, Gi-Young Kim, Wun-Jae Kim, Yeon-Weol Lee, Yung Hyun Cho. Induction of apoptosis in human lung carcinoma cells by the water extract of Panax notoginseng is associated with the activation of caspase-3 through downregulation of Akt. International journal of oncology. vol 35. issue 1. 2009-08-06. PMID:19513559. |
the results indicated that the major regulators of wepn-induced apoptosis in human lung carcinoma cells are the bcl-2 family and caspase-3, which are associated with mitochondrial dysfunction and dephosphorylation of the akt signaling pathway. |
2009-08-06 |
2023-08-12 |
human |
| Bhumsoo Kim, Eva L Feldma. Insulin receptor substrate (IRS)-2, not IRS-1, protects human neuroblastoma cells against apoptosis. Apoptosis : an international journal on programmed cell death. vol 14. issue 5. 2009-08-05. PMID:19259821. |
in the presence of high glucose, irs-1 underwent caspase-mediated degradation, followed by focal adhesion kinase (fak) and akt degradation and apoptosis. |
2009-08-05 |
2023-08-12 |
human |
| Mi-Hyun Kang, Do-Yeon Kim, Jae Youn Yi, Youngsook So. Substance P accelerates intestinal tissue regeneration after gamma-irradiation-induced damage. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 17. issue 2. 2009-08-05. PMID:19320890. |
the proliferation of cells exposed to gamma-irradiation is also stimulated by exposure to sp, a phenomenon that may result from inhibition of apoptosis because sp activates akt and inhibits the cleavage of caspase-3. |
2009-08-05 |
2023-08-12 |
mouse |
| Alexandra Dieterle, Ronald Orth, Merle Daubrawa, Antje Grotemeier, Sebastian Alers, Susanne Ullrich, Reiner Lammers, Sebastian Wesselborg, Björn Stor. The Akt inhibitor triciribine sensitizes prostate carcinoma cells to TRAIL-induced apoptosis. International journal of cancer. vol 125. issue 4. 2009-08-04. PMID:19422047. |
the akt inhibitor triciribine sensitizes prostate carcinoma cells to trail-induced apoptosis. |
2009-08-04 |
2023-08-12 |
human |
| Lee Lee Wong, Chan Fong Chang, Evelyn S C Koay, Daohai Zhan. Tyrosine phosphorylation of PP2A is regulated by HER-2 signalling and correlates with breast cancer progression. International journal of oncology. vol 34. issue 5. 2009-08-03. PMID:19360341. |
these phosphoproteins included many known her-2/neu-regulated molecules (e.g., shc, akt, syk and stat1) and proteins that had not been previously linked to her-2/neu signalling, such as fas-associated death domain protein (fadd), apoptosis repressor with card domain (arc), and the tumour suppressor, protein phosphatase type 2a (pp2a). |
2009-08-03 |
2023-08-12 |
Not clear |
| Eun-Kyung Park, Mi Jung Park, Seong-Hee Lee, Ying Chun Li, Jungeun Kim, Jae-Seon Lee, Jung Weon Lee, Sang-Kyu Ye, Jong-Wan Park, Chul-Woo Kim, Byung-Kiu Park, Yong-Nyun Ki. Cholesterol depletion induces anoikis-like apoptosis via FAK down-regulation and caveolae internalization. The Journal of pathology. vol 218. issue 3. 2009-07-31. PMID:19288501. |
the expression of dominant-active fak was able to delay caveolae internalization and apoptosis and attenuated akt inactivation by mbetacd, whereas dominant-negative fak expression resulted in enhanced apoptosis. |
2009-07-31 |
2023-08-12 |
Not clear |
| Rui Li, Yan Chen, Ling-Lan Zeng, Wen-Xiu Shu, Fei Zhao, Lu Wen, Yuan Li. Gambogic acid induces G0/G1 arrest and apoptosis involving inhibition of SRC-3 and inactivation of Akt pathway in K562 leukemia cells. Toxicology. vol 262. issue 2. 2009-07-28. PMID:19433130. |
gambogic acid induces g0/g1 arrest and apoptosis involving inhibition of src-3 and inactivation of akt pathway in k562 leukemia cells. |
2009-07-28 |
2023-08-12 |
human |