| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sylvestor A Moses, M Ahad Ali, Song Zuohe, Lei Du-Cuny, Li Li Zhou, Robert Lemos, Nathan Ihle, A Geoffrey Skillman, Shuxing Zhang, Eugene A Mash, Garth Powis, Emmanuelle J Meuille. In vitro and in vivo activity of novel small-molecule inhibitors targeting the pleckstrin homology domain of protein kinase B/AKT. Cancer research. vol 69. issue 12. 2009-07-06. PMID:19491272. |
we identified a novel chemical scaffold in several of the compounds that binds selectively to the ph domain of akt, inducing a decrease in akt activation and causing apoptosis at low micromolar concentrations. |
2009-07-06 |
2023-08-12 |
mouse |
| Olivier Meurette, Spyros Stylianou, Rebecca Rock, Giovanna M Collu, Andrew P Gilmore, Keith Brenna. Notch activation induces Akt signaling via an autocrine loop to prevent apoptosis in breast epithelial cells. Cancer research. vol 69. issue 12. 2009-07-06. PMID:19491273. |
notch activation induces akt signaling via an autocrine loop to prevent apoptosis in breast epithelial cells. |
2009-07-06 |
2023-08-12 |
Not clear |
| Olivier Meurette, Spyros Stylianou, Rebecca Rock, Giovanna M Collu, Andrew P Gilmore, Keith Brenna. Notch activation induces Akt signaling via an autocrine loop to prevent apoptosis in breast epithelial cells. Cancer research. vol 69. issue 12. 2009-07-06. PMID:19491273. |
this activation of akt was necessary for notch-induced protection against apoptosis in the nontransformed breast epithelial cell line mcf10a. |
2009-07-06 |
2023-08-12 |
Not clear |
| Olivier Meurette, Spyros Stylianou, Rebecca Rock, Giovanna M Collu, Andrew P Gilmore, Keith Brenna. Notch activation induces Akt signaling via an autocrine loop to prevent apoptosis in breast epithelial cells. Cancer research. vol 69. issue 12. 2009-07-06. PMID:19491273. |
moreover, inhibiting notch signaling in breast cancer cells induced a decrease in akt activity and an increase in sensitivity to apoptosis. |
2009-07-06 |
2023-08-12 |
Not clear |
| Olivier Meurette, Spyros Stylianou, Rebecca Rock, Giovanna M Collu, Andrew P Gilmore, Keith Brenna. Notch activation induces Akt signaling via an autocrine loop to prevent apoptosis in breast epithelial cells. Cancer research. vol 69. issue 12. 2009-07-06. PMID:19491273. |
finally, the inhibition of ask1 by akt was responsible for the protection from apoptosis induced by dna damage, as it prevented c-jun nh(2)-terminal kinase-mediated phosphorylation and activation of p53. |
2009-07-06 |
2023-08-12 |
Not clear |
| Kohei Ueda, Shuichi Inoue, Ye Zhang, Tomohiko Kutsuna, Sayaka Inoue, Kumiko Noto, Naoya Arai, Makoto Noguch. Heparin induces apoptosis through suppression of AKt in oral squamous cell carcinoma cells. Anticancer research. vol 29. issue 4. 2009-07-02. PMID:19414349. |
heparin induces apoptosis through suppression of akt in oral squamous cell carcinoma cells. |
2009-07-02 |
2023-08-12 |
Not clear |
| June Liu, Courtney Netherland, Theresa Pickle, Michael S Sinensky, Douglas P Thewk. Stimulation of Akt poly-ubiquitination and proteasomal degradation in P388D1 cells by 7-ketocholesterol and 25-hydroxycholesterol. Archives of biochemistry and biophysics. vol 487. issue 1. 2009-07-02. PMID:19464253. |
akt plays a role in protecting macrophages from apoptosis induced by some oxysterols. |
2009-07-02 |
2023-08-12 |
Not clear |
| June Liu, Courtney Netherland, Theresa Pickle, Michael S Sinensky, Douglas P Thewk. Stimulation of Akt poly-ubiquitination and proteasomal degradation in P388D1 cells by 7-ketocholesterol and 25-hydroxycholesterol. Archives of biochemistry and biophysics. vol 487. issue 1. 2009-07-02. PMID:19464253. |
modification of akt by the addition of a gly-ala repeat (gar), a domain known to block ubiquitin-dependent targeting of proteins to the proteasome, resulted in a chimeric protein that is resistant to turn-over induced by 25-oh or 7-kc and provides protection from apoptosis induced by these oxysterols. |
2009-07-02 |
2023-08-12 |
Not clear |
| Patricio Godoy, Jan G Hengstler, Iryna Ilkavets, Christoph Meyer, Anastasia Bachmann, Alexandra Müller, Gregor Tuschl, Stefan O Mueller, Steven Doole. Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor beta-induced apoptosis. Hepatology (Baltimore, Md.). vol 49. issue 6. 2009-07-01. PMID:19274752. |
akt causes resistance to transforming growth factor beta (tgf-beta)-induced apoptosis by antagonizing p38, whereas erk1/2 signaling opens the route to epithelial-mesenchymal transition (emt). |
2009-07-01 |
2023-08-12 |
Not clear |
| Patricio Godoy, Jan G Hengstler, Iryna Ilkavets, Christoph Meyer, Anastasia Bachmann, Alexandra Müller, Gregor Tuschl, Stefan O Mueller, Steven Doole. Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor beta-induced apoptosis. Hepatology (Baltimore, Md.). vol 49. issue 6. 2009-07-01. PMID:19274752. |
apoptosis resistance is reversible by inhibiting akt or src, and emt can be abrogated by blocking the erk1/2 pathway. |
2009-07-01 |
2023-08-12 |
Not clear |
| Patricio Godoy, Jan G Hengstler, Iryna Ilkavets, Christoph Meyer, Anastasia Bachmann, Alexandra Müller, Gregor Tuschl, Stefan O Mueller, Steven Doole. Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor beta-induced apoptosis. Hepatology (Baltimore, Md.). vol 49. issue 6. 2009-07-01. PMID:19274752. |
in this culture system, inhibition of p38 as well as overexpression of constitutively active akt causes apoptosis resistance, whereas constitutively active ras induces emt. |
2009-07-01 |
2023-08-12 |
Not clear |
| Rui Zhao, Nong Xiang, Fredrick E Domann, Weixiong Zhon. Effects of selenite and genistein on G2/M cell cycle arrest and apoptosis in human prostate cancer cells. Nutrition and cancer. vol 61. issue 3. 2009-06-30. PMID:19373614. |
downregulation of akt by sirna caused apoptosis and g2/m cell cycle arrest and masked the effects of genistein. |
2009-06-30 |
2023-08-12 |
human |
| John Brognard, Matthew Niederst, Gloria Reyes, Noel Warfel, Alexandra C Newto. Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C. The Journal of biological chemistry. vol 284. issue 22. 2009-06-29. PMID:19324870. |
here we identify a polymorphism that results in an amino acid change from a leu to ser at codon 1016 in the phosphatase domain of phlpp2, which reduces phosphatase activity toward akt both in vitro and in cells, in turn resulting in reduced apoptosis. |
2009-06-29 |
2023-08-12 |
Not clear |
| Xian-Bao Liu, Jian-An Wang, Molly E Ogle, Ling We. Prolyl hydroxylase inhibitor dimethyloxalylglycine enhances mesenchymal stem cell survival. Journal of cellular biochemistry. vol 106. issue 5. 2009-06-25. PMID:19229863. |
dmog treatment reduced mitochondrial cytochrome c release, nuclear translocation of apoptosis inducing factor (aif), and promoted akt phosphorylation. |
2009-06-25 |
2023-08-12 |
Not clear |
| Jun Ren, Sara A Babcock, Qun Li, Anna F Huff, Shi-Yan Li, Thomas A Dose. Aldehyde dehydrogenase-2 transgene ameliorates chronic alcohol ingestion-induced apoptosis in cerebral cortex. Toxicology letters. vol 187. issue 3. 2009-06-25. PMID:19429258. |
western blot was performed to examine expression (or its activation) of aldh2, the pro- and anti-apoptotic proteins caspase-8, bax, bcl-2, omi/htra2, apoptosis repressor with caspase recruitment domain (arc), flice-like inhibitory protein (flip), x-linked inhibitor of apoptosis protein (xiap), akt, glycogen synthase kinase-3beta (gsk-3beta), p38, c-jun n-terminal kinase (jnk) and extracellular signal-regulated kinase (erk). |
2009-06-25 |
2023-08-12 |
mouse |
| Joydeep Das, Jyotirmoy Ghosh, Prasenjit Manna, Mahua Sinha, Parames C Si. Taurine protects rat testes against NaAsO(2)-induced oxidative stress and apoptosis via mitochondrial dependent and independent pathways. Toxicology letters. vol 187. issue 3. 2009-06-25. PMID:19429265. |
in this study, we report that as administration (in the form of naaso(2) at a dose of 10mg/kg body weight for 2 days, orally) induces apoptosis in testicular tissue of the experimental rats by the activation of caspase-3 and reciprocal regulation of bcl-2/bad with the concomitant reduction of mitochondrial membrane potential and increased level of cytosolic cytochrome c. arsenite has also been shown to induce activation of mitogen-activated protein kinases (mapks), akt as well as nf-kappab (p65) in testicular tissue. |
2009-06-25 |
2023-08-12 |
rat |
| Joseph E Aslan, Huihong You, Danielle M Williamson, Jessica Endig, Robert T Youker, Laurel Thomas, Hongjun Shu, Yuhong Du, Robert L Milewski, Matthew H Brush, Anthony Possemato, Kam Sprott, Haian Fu, Kenneth D Greis, Douglas N Runckel, Arndt Vogel, Gary Thoma. Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis. Molecular cell. vol 34. issue 4. 2009-06-25. PMID:19481529. |
akt and 14-3-3 control a pacs-2 homeostatic switch that integrates membrane traffic with trail-induced apoptosis. |
2009-06-25 |
2023-08-12 |
Not clear |
| Christine M Coticchia, Chetana M Revankar, Tushar B Deb, Robert B Dickson, Michael D Johnso. Calmodulin modulates Akt activity in human breast cancer cell lines. Breast cancer research and treatment. vol 115. issue 3. 2009-06-23. PMID:18587642. |
growth factor-induced activation of akt occurs in the majority of human breast cancer cell lines resulting in a variety of cellular outcomes, including suppression of apoptosis and enhanced survival. |
2009-06-23 |
2023-08-12 |
mouse |
| Raju V S Rajala, Ivana Ivanovic, Ashok Kumar Dill. Retinal insulin receptor signaling in hyperosmotic stress. Vitamins and hormones. vol 80. 2009-06-23. PMID:19251051. |
insulin receptor (ir) activation has been shown to rescue retinal neurons from apoptosis through a phosphoinositide 3-kinase and protein kinase b (akt) survival cascade. |
2009-06-23 |
2023-08-12 |
human |
| Sanjeev Kumar, Christopher S Bryant, Sreedhar Chamala, Aamer Qazi, Shelly Seward, Jagannath Pal, Christopher P Steffes, Donald W Weaver, Robert Morris, John M Malone, Masood A Shammas, Madhu Prasad, Ramesh B Batch. Ritonavir blocks AKT signaling, activates apoptosis and inhibits migration and invasion in ovarian cancer cells. Molecular cancer. vol 8. 2009-06-23. PMID:19386116. |
ritonavir blocks akt signaling, activates apoptosis and inhibits migration and invasion in ovarian cancer cells. |
2009-06-23 |
2023-08-12 |
human |