| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eloisi Caldas-Lopes, Leandro Cerchietti, James H Ahn, Cristina C Clement, Ana I Robles, Anna Rodina, Kamalika Moulick, Tony Taldone, Alexander Gozman, Yunke Guo, Nian Wu, Elisa de Stanchina, Julie White, Steven S Gross, Yuliang Ma, Lyuba Varticovski, Ari Melnick, Gabriela Chiosi. Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 20. 2009-06-23. PMID:19416831. |
among them, we identify downregulation of components of the ras/raf/mapk pathway and g(2)-m phase to contribute to its anti-proliferative effect, degradation of activated akt and bcl-xl to induce apoptosis, and inhibition of activated nf-kappab, akt, erk2, tyk2, and pkc to reduce tnbc invasive potential. |
2009-06-23 |
2023-08-12 |
Not clear |
| Tobias Sinnberg, Konstantinos Lasithiotakis, Heike Niessner, Birgit Schittek, Keith T Flaherty, Dagmar Kulms, Evelyn Maczey, Minia Campos, Jeannette Gogel, Claus Garbe, Friedegund Meie. Inhibition of PI3K-AKT-mTOR signaling sensitizes melanoma cells to cisplatin and temozolomide. The Journal of investigative dermatology. vol 129. issue 6. 2009-06-22. PMID:19078992. |
cotreatment of melanoma cells with akt pathway inhibitors and chemotherapeutics led to a 2- to 3-fold increase of apoptosis (p<0.05, combination therapy vs monotherapy) and completely suppressed invasive tumor growth in organotypic culture. |
2009-06-22 |
2023-08-12 |
Not clear |
| Shuhua Xia, Zhihong Chen, Lora W Forman, Douglas V Falle. PKCdelta survival signaling in cells containing an activated p21Ras protein requires PDK1. Cellular signalling. vol 21. issue 4. 2009-06-22. PMID:19146951. |
knock-down of pdk1, pkcdelta, or akt forces cells containing activated p21(ras) to undergo apoptosis. |
2009-06-22 |
2023-08-12 |
Not clear |
| Marc J Berna, Jose A Tapia, Veronica Sancho, Michelle Thill, Andrea Pace, K Martin Hoffmann, Lauro Gonzalez-Fernandez, Robert T Jense. Gastrointestinal growth factors and hormones have divergent effects on Akt activation. Cellular signalling. vol 21. issue 4. 2009-06-22. PMID:19166928. |
akt is a central regulator of apoptosis, cell growth and survival. |
2009-06-22 |
2023-08-12 |
rat |
| Marc J Berna, Jose A Tapia, Veronica Sancho, Michelle Thill, Andrea Pace, K Martin Hoffmann, Lauro Gonzalez-Fernandez, Robert T Jense. Gastrointestinal growth factors and hormones have divergent effects on Akt activation. Cellular signalling. vol 21. issue 4. 2009-06-22. PMID:19166928. |
akt inhibition by cck was also found in vivo and in panc-1 cancer cells where it inhibited serum-mediated rescue from apoptosis. |
2009-06-22 |
2023-08-12 |
rat |
| Maria Grandoch, Maider López de Jesús, Paschal A Oude Weernink, Artur-Aron Weber, Karl H Jakobs, Martina Schmid. B cell receptor-induced growth arrest and apoptosis in WEHI-231 immature B lymphoma cells involve cyclic AMP and Epac proteins. Cellular signalling. vol 21. issue 4. 2009-06-22. PMID:19167486. |
in immature b cells, ligation of the bcr promotes growth arrest and apoptosis, and bcr-driven balancing between pro-apoptotic extracellular signal-regulated kinase 1 and 2 (erk1/2) and anti-apoptotic phosphoinositide 3-kinase-dependent akt seems to define the final cellular apoptotic response. |
2009-06-22 |
2023-08-12 |
Not clear |
| Maria Grandoch, Maider López de Jesús, Paschal A Oude Weernink, Artur-Aron Weber, Karl H Jakobs, Martina Schmid. B cell receptor-induced growth arrest and apoptosis in WEHI-231 immature B lymphoma cells involve cyclic AMP and Epac proteins. Cellular signalling. vol 21. issue 4. 2009-06-22. PMID:19167486. |
our data indicate that cyclic amp-dependent epac signals to erk1/2 and akt upon activation of rap1 and h-ras, and is involved in bcr-induced growth arrest and apoptosis in wehi-231 cells. |
2009-06-22 |
2023-08-12 |
Not clear |
| Timothy R Peterson, Mathieu Laplante, Carson C Thoreen, Yasemin Sancak, Seong A Kang, W Michael Kuehl, Nathanael S Gray, David M Sabatin. DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell. vol 137. issue 5. 2009-06-22. PMID:19446321. |
in these cells, high deptor expression is necessary to maintain pi3k and akt activation and a reduction in deptor levels leads to apoptosis. |
2009-06-22 |
2023-08-12 |
human |
| John P Plastaras, Jay F Dorsey, Kristina Carroll, Seok-Hyun Kim, Morris J Birnbaum, Wafik S El-Deir. Role of PI3K/Akt signaling in TRAIL- and radiation-induced gastrointestinal apoptosis. Cancer biology & therapy. vol 7. issue 12. 2009-06-19. PMID:19106634. |
we sought to characterize the effects of physiologic and genetic manipulation of akt signaling on ir-induced gastrointestinal (gi) apoptosis in mice. |
2009-06-19 |
2023-08-12 |
mouse |
| John P Plastaras, Jay F Dorsey, Kristina Carroll, Seok-Hyun Kim, Morris J Birnbaum, Wafik S El-Deir. Role of PI3K/Akt signaling in TRAIL- and radiation-induced gastrointestinal apoptosis. Cancer biology & therapy. vol 7. issue 12. 2009-06-19. PMID:19106634. |
we evaluated the time course of akt stimulation by insulin and found it overlapped with protection from apoptosis induced by trail (tnfalpha related apoptosis inducing ligand) in cell lines. |
2009-06-19 |
2023-08-12 |
mouse |
| Kazuhiro Shiozaki, Kazunori Yamaguchi, Ikuro Sato, Taeko Miyag. Plasma membrane-associated sialidase (NEU3) promotes formation of colonic aberrant crypt foci in azoxymethane-treated transgenic mice. Cancer science. vol 100. issue 4. 2009-06-19. PMID:19215228. |
enhanced phosphorylation of epidermal growth factor (egf) receptor, akt and erk and up-regulation of bcl-xl protein were observed in the transgenic colon mucosa, but no changes were found in cell proliferation, suggesting that the increased acf formation is due to suppression of apoptosis. |
2009-06-19 |
2023-08-12 |
mouse |
| Ahmed Essaghir, Nicolas Dif, Catherine Y Marbehant, Paul J Coffer, Jean-Baptiste Demouli. The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors. The Journal of biological chemistry. vol 284. issue 16. 2009-06-18. PMID:19244250. |
foxo (forkhead box o) transcription factors induce cell growth arrest and apoptosis, which can be prevented by foxo phosphorylation by akt in response to growth factors such as platelet-derived growth factors (pdgf) and insulin-like growth factor i (igf-i). |
2009-06-18 |
2023-08-12 |
human |
| Anna Gates, Simon Hohenester, M Sawkat Anwer, Cynthia R L Webste. cAMP-GEF cytoprotection by Src tyrosine kinase activation of phosphoinositide-3-kinase p110 beta/alpha in rat hepatocytes. American journal of physiology. Gastrointestinal and liver physiology. vol 296. issue 4. 2009-06-17. PMID:19196950. |
maximal camp-gef-mediated akt phosphorylation as well as protection from bile acid-induced apoptosis requires activation of src-tyk and the egfr. |
2009-06-17 |
2023-08-12 |
rat |
| Lifang Yang, Lanbo Xiao, Xiaoqian Ma, Min Tang, Xinxiang Weng, Xue Chen, Lunquan Sun, Ya Ca. Effect of DNAzymes targeting Akt1 on cell proliferation and apoptosis in nasopharyngeal carcinoma. Cancer biology & therapy. vol 8. issue 4. 2009-06-16. PMID:19276680. |
activated pi3k and its downstream target akt are concernful signaling molecules and key survival factors involved in the control of cell proliferation, apoptosis and oncogenesis. |
2009-06-16 |
2023-08-12 |
mouse |
| Jean-Marc Navenot, Nobutaka Fujii, Stephen C Peipe. Activation of Rho and Rho-associated kinase by GPR54 and KiSS1 metastasis suppressor gene product induces changes of cell morphology and contributes to apoptosis. Molecular pharmacology. vol 75. issue 6. 2009-06-15. PMID:19286835. |
we also demonstrated that activation of gpr54 inhibited akt phosphorylation after the activation of epidermal growth factor receptor and the insulin receptor and triggered apoptosis in epithelial and lymphoid cell lines through a mechanism involving extracellular signal-regulated kinase (erk) mitogen-activated protein kinase. |
2009-06-15 |
2023-08-12 |
Not clear |
| Holger Hoff, Karin Knieke, Zulema Cabail, Heike Hirseland, George Vratsanos, Gerd-Rüdiger Burmester, Gerhard Jorch, Steven G Nadler, Barbara Bröker, Katrin Hebel, Monika C Brunner-Weinzier. Surface CD152 (CTLA-4) expression and signaling dictates longevity of CD28null T cells. Journal of immunology (Baltimore, Md. : 1950). vol 182. issue 9. 2009-06-15. PMID:19380781. |
apoptosis protection conferred by cd152 is mediated by phosphatidylinositol 3'-kinase-dependent activation of the kinase akt, resulting in enhanced phosphorylation and thereby inhibition of the proapoptotic molecule bad. |
2009-06-15 |
2023-08-12 |
human |
| Christine E Eyler, Wen-Chi Foo, Katherine M LaFiura, Roger E McLendon, Anita B Hjelmeland, Jeremy N Ric. Brain cancer stem cells display preferential sensitivity to Akt inhibition. Stem cells (Dayton, Ohio). vol 26. issue 12. 2009-06-11. PMID:18802038. |
treatment with an akt inhibitor more potently reduced the numbers of viable brain cancer stem cells relative to matched nonstem cancer cells associated with a preferential induction of apoptosis and a suppression of neurosphere formation. |
2009-06-11 |
2023-08-12 |
mouse |
| V Gama, J A Gomez, L D Mayo, M W Jackson, D Danielpour, K Song, A L Haas, M J Laughlin, S Matsuyam. Hdm2 is a ubiquitin ligase of Ku70-Akt promotes cell survival by inhibiting Hdm2-dependent Ku70 destabilization. Cell death and differentiation. vol 16. issue 5. 2009-06-11. PMID:19247369. |
taken together, we propose that hdm2 is a ku70 ub ligase and that akt inhibits bax-mediated apoptosis, at least in part, by maintaining ku70 levels through the promotion of hdm2 nuclear translocation. |
2009-06-11 |
2023-08-12 |
human |
| Gabriella Marfe, Marco Tafani, Manuela Indelicato, Paola Sinibaldi-Salimei, Valentina Reali, Bruna Pucci, Massimo Fini, Matteo Antonio Russ. Kaempferol induces apoptosis in two different cell lines via Akt inactivation, Bax and SIRT3 activation, and mitochondrial dysfunction. Journal of cellular biochemistry. vol 106. issue 4. 2009-06-10. PMID:19160423. |
kaempferol induces apoptosis in two different cell lines via akt inactivation, bax and sirt3 activation, and mitochondrial dysfunction. |
2009-06-10 |
2023-08-12 |
human |
| X Song, B Kong, D Li, Q Yan. The inhibitory effect of human embryonic germ cells on ovarian cancer. Neoplasma. vol 56. issue 1. 2009-06-09. PMID:19152240. |
we examined the efficacy of hegcs through coculturing skov3 with hegcs, detecting tunel apoptosis and caspase-9 activity by immunocytochemistry, and measuring the expression of akt by real-time pcr and western blot. |
2009-06-09 |
2023-08-12 |
mouse |