| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michela Garofalo, Cristina Quintavalle, Ciro Zanca, Assunta De Rienzo, Giulia Romano, Mario Acunzo, Loredana Puca, Mariarosaria Incoronato, Carlo M Croce, Gerolama Condorell. Akt regulates drug-induced cell death through Bcl-w downregulation. PloS one. vol 3. issue 12. 2009-02-05. PMID:19114998. |
we have found that inhibition of akt activity may promote apoptosis through the downregulation of bcl-w protein and the consequential reduction in interaction of bcl-w with pro-apoptotic members of the bcl-2 family. |
2009-02-05 |
2023-08-12 |
human |
| Jingmei Zhang, Opal Kamdar, Wei Le, Glenn D Rosen, Daya Upadhya. Nicotine induces resistance to chemotherapy by modulating mitochondrial signaling in lung cancer. American journal of respiratory cell and molecular biology. vol 40. issue 2. 2009-02-03. PMID:18676776. |
inhibition of mitogen-activated protein kinase (mapk) and akt prevented the antiapoptotic effects of nicotine and decreased chemotherapy-induced apoptosis. |
2009-02-03 |
2023-08-12 |
Not clear |
| Annesofie Faurschou, Robert Gniadecki, Hans Christian Wul. Infliximab inhibits DNA repair in ultraviolet B-irradiated premalignant keratinocytes. Experimental dermatology. vol 17. issue 11. 2009-02-02. PMID:18557931. |
in conclusion, despite the fact that infliximab blocks akt and stimulates the g2/m checkpoint and apoptosis in uvb-irradiated keratinocytes, the repair of cpd is impaired. |
2009-02-02 |
2023-08-12 |
human |
| Irene Ortín, Juan Francisco González, Elena de la Cuesta, Cristina Manguan-García, Rosario Perona, Carmen Avendañ. Pyrazino[1,2-b]isoquinolines: synthesis and study of their cytostatic and cytotoxic properties. Bioorganic & medicinal chemistry. vol 16. issue 19. 2009-01-30. PMID:18799316. |
furthermore, the apoptosis induction of 3a is not mediated by activation of pro-apoptotic kinases jnk and p38 or by activation of akt. |
2009-01-30 |
2023-08-12 |
human |
| Youqing Liu, Hui Xing, Danhui Weng, Xiaohong Song, Xiaomin Qin, Xi Xia, Yanjie Weng, Fengqi Liang, Gang Chen, Xiaobing Han, Xiaoli Ma, Shixuan Wang, Jianfeng Zhou, Gang Xu, Li Meng, Ding M. Inhibition of Akt signaling by SN-38 induces apoptosis in cervical cancer. Cancer letters. vol 274. issue 1. 2009-01-30. PMID:18929442. |
inhibition of akt signaling by sn-38 induces apoptosis in cervical cancer. |
2009-01-30 |
2023-08-12 |
Not clear |
| Youqing Liu, Hui Xing, Danhui Weng, Xiaohong Song, Xiaomin Qin, Xi Xia, Yanjie Weng, Fengqi Liang, Gang Chen, Xiaobing Han, Xiaoli Ma, Shixuan Wang, Jianfeng Zhou, Gang Xu, Li Meng, Ding M. Inhibition of Akt signaling by SN-38 induces apoptosis in cervical cancer. Cancer letters. vol 274. issue 1. 2009-01-30. PMID:18929442. |
transfection of the full-length akt cdna into hela and siha cells resulted in the reduction of apoptosis induced by sn-38, and akt kinase activity regulated the p53 pathway, indicating that inhibition of the akt pathway played an important role in exhibition of sn-38-mediated cytotoxic effect. |
2009-01-30 |
2023-08-12 |
Not clear |
| Youqing Liu, Hui Xing, Danhui Weng, Xiaohong Song, Xiaomin Qin, Xi Xia, Yanjie Weng, Fengqi Liang, Gang Chen, Xiaobing Han, Xiaoli Ma, Shixuan Wang, Jianfeng Zhou, Gang Xu, Li Meng, Ding M. Inhibition of Akt signaling by SN-38 induces apoptosis in cervical cancer. Cancer letters. vol 274. issue 1. 2009-01-30. PMID:18929442. |
our data suggested that sn-38 could induce apoptosis through a p53 pathway and that activation of p53 in response to s-38 is governed by akt. |
2009-01-30 |
2023-08-12 |
Not clear |
| Jia Yu, David G Ryan, Spiro Getsios, Michelle Oliveira-Fernandes, Anees Fatima, Robert M Lavke. MicroRNA-184 antagonizes microRNA-205 to maintain SHIP2 levels in epithelia. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 49. 2009-01-30. PMID:19033458. |
partial knockdown of endogenous mir-205 in sccs markedly decreased phosphorylated akt and phosphorylated bad levels and increased apoptosis. |
2009-01-30 |
2023-08-12 |
Not clear |
| Venkata Ramesh Dasari, Krishna Kumar Veeravalli, Kay L Saving, Meena Gujrati, Dan Fassett, Jeffrey D Klopfenstein, Dzung H Dinh, Jasti S Ra. Neuroprotection by cord blood stem cells against glutamate-induced apoptosis is mediated by Akt pathway. Neurobiology of disease. vol 32. issue 3. 2009-01-28. PMID:18930139. |
neuroprotection by cord blood stem cells against glutamate-induced apoptosis is mediated by akt pathway. |
2009-01-28 |
2023-08-12 |
human |
| Jan-Paul Flacke, Sanjeev Kumar, Sawa Kostin, H Peter Reusch, Yury Ladilo. Acidic preconditioning protects endothelial cells against apoptosis through p38- and Akt-dependent Bcl-xL overexpression. Apoptosis : an international journal on programmed cell death. vol 14. issue 1. 2009-01-28. PMID:19082728. |
therefore, apc leads to protection of ec against ischemic apoptosis by activation of akt and p38 followed by overexpression of bcl-xl, which is a key anti-apoptotic mechanism of apc. |
2009-01-28 |
2023-08-12 |
rat |
| Pei-Hsuan Chen, Chia-Ron Yan. Decoy receptor 3 expression in AsPC-1 human pancreatic adenocarcinoma cells via the phosphatidylinositol 3-kinase-, Akt-, and NF-kappa B-dependent pathway. Journal of immunology (Baltimore, Md. : 1950). vol 181. issue 12. 2009-01-27. PMID:19050262. |
in addition, panc-1 cell incubation with conditioned medium from aspc-1 cells transfected with dominant-negative akt or ikappabalpha plasmids or dcr3 small interfering rna showed increased soluble fasl-mediated apoptosis compared with the control group. |
2009-01-27 |
2023-08-12 |
human |
| M A Scheper, R Chaisuparat, N G Nikitakis, J J Sau. Expression and alterations of the PTEN / AKT / mTOR pathway in ameloblastomas. Oral diseases. vol 14. issue 6. 2009-01-26. PMID:18826385. |
in carcinogenesis, loss of pten allows for overactivity of the phosphatidylinositol-3-kinase/protein kinase b (pi3k / akt) pathway inducing an upregulation of mammalian-target of rapamycin (mtor) and its downstream effector ribosomal-subunit-6 kinase (s6k); allowing for uncontrolled cell proliferation, apoptosis inhibition and cell cycle deregulation. |
2009-01-26 |
2023-08-12 |
Not clear |
| Joon Hee Park, Cheng-Yun Jin, Bok Kyu Lee, Gi-Young Kim, Yung Hyun Choi, Yong Kee Jeon. Naringenin induces apoptosis through downregulation of Akt and caspase-3 activation in human leukemia THP-1 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 46. issue 12. 2009-01-26. PMID:18930780. |
naringenin induces apoptosis through downregulation of akt and caspase-3 activation in human leukemia thp-1 cells. |
2009-01-26 |
2023-08-12 |
human |
| Rachel Rogers, Gregory Ouellet, Caitlin Brown, Ben Moyer, Teresa Rasoulpour, Mary Hixo. Cross-talk between the Akt and NF-kappaB signaling pathways inhibits MEHP-induced germ cell apoptosis. Toxicological sciences : an official journal of the Society of Toxicology. vol 106. issue 2. 2009-01-22. PMID:18755736. |
cross-talk between the akt and nf-kappab signaling pathways inhibits mehp-induced germ cell apoptosis. |
2009-01-22 |
2023-08-12 |
mouse |
| Rachel Rogers, Gregory Ouellet, Caitlin Brown, Ben Moyer, Teresa Rasoulpour, Mary Hixo. Cross-talk between the Akt and NF-kappaB signaling pathways inhibits MEHP-induced germ cell apoptosis. Toxicological sciences : an official journal of the Society of Toxicology. vol 106. issue 2. 2009-01-22. PMID:18755736. |
here we observe that akt kinase activity increases in the testes of postnatal day 28 wild-type mice following exposure to 500 mg/kg mono-(2-ethylhexyl) phthalate (mehp), and that loss of akt1 results in the premature onset of germ cell apoptosis. |
2009-01-22 |
2023-08-12 |
mouse |
| Gang Song, Yanlin Ming, Yubin Mao, Shideng Bao, Gaoliang Ouyan. Osteopontin prevents curcumin-induced apoptosis and promotes survival through Akt activation via alpha v beta 3 integrins in human gastric cancer cells. Experimental biology and medicine (Maywood, N.J.). vol 233. issue 12. 2009-01-22. PMID:18849546. |
osteopontin prevents curcumin-induced apoptosis and promotes survival through akt activation via alpha v beta 3 integrins in human gastric cancer cells. |
2009-01-22 |
2023-08-12 |
human |
| S McKenzie, S Sakamoto, N Kypriano. Maspin modulates prostate cancer cell apoptotic and angiogenic response to hypoxia via targeting AKT. Oncogene. vol 27. issue 57. 2009-01-22. PMID:18931702. |
this enhanced sensitivity to hypoxia-induced apoptosis leads to a significant suppression of tumor growth and tumor vascularity in vivo by targeting akt and focal adhesion kinase activation. |
2009-01-22 |
2023-08-12 |
human |
| Natalie E Freeman-Anderson, Theresa G Pickle, Courtney D Netherland, Alicia Bales, Nancy E Buckley, Douglas P Thewk. Cannabinoid (CB2) receptor deficiency reduces the susceptibility of macrophages to oxidized LDL/oxysterol-induced apoptosis. Journal of lipid research. vol 49. issue 11. 2009-01-14. PMID:18614816. |
these results suggest that cb2 expression increases the susceptibility of macrophages to oxldl-induced apoptosis, in part, by modulating the effect of oxysterols on the akt survival pathway and that cb2 may influence atherosclerosis by modulating lesional macrophage apoptosis. |
2009-01-14 |
2023-08-12 |
Not clear |
| Shin Kim, Tae-Jin Lee, Jong-Wook Park, Taeg Kyu Kwo. Overexpression of cFLIPs inhibits oxaliplatin-mediated apoptosis through enhanced XIAP stability and Akt activation in human renal cancer cells. Journal of cellular biochemistry. vol 105. issue 4. 2009-01-12. PMID:18767116. |
overexpression of cflips inhibits oxaliplatin-mediated apoptosis through enhanced xiap stability and akt activation in human renal cancer cells. |
2009-01-12 |
2023-08-12 |
human |
| Shin Kim, Tae-Jin Lee, Jong-Wook Park, Taeg Kyu Kwo. Overexpression of cFLIPs inhibits oxaliplatin-mediated apoptosis through enhanced XIAP stability and Akt activation in human renal cancer cells. Journal of cellular biochemistry. vol 105. issue 4. 2009-01-12. PMID:18767116. |
thus, our findings imply that the anti-apoptotic functions of cflips may be attributed to inhibit oxaliplatin-induced apoptosis through the sustained xiap protein level and akt activation. |
2009-01-12 |
2023-08-12 |
human |