| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria U Rømer, Lise Larsen, Hanne Offenberg, Nils Brünner, Ulrik A Lademan. Plasminogen activator inhibitor 1 protects fibrosarcoma cells from etoposide-induced apoptosis through activation of the PI3K/Akt cell survival pathway. Neoplasia (New York, N.Y.). vol 10. issue 10. 2008-12-04. PMID:18813358. |
altogether, our data suggest that pai-1 influences sensitivity to etoposide-induced apoptosis through the pi3k/akt cell survival pathway by acting upstream of pi3k and akt. |
2008-12-04 |
2023-08-12 |
Not clear |
| Francis Dida, Yufeng Li, Atsushi Iwao, Takao Deguchi, Eiichi Azuma, Yoshihiro Komad. Resistance to TRAIL-induced apoptosis caused by constitutional phosphorylation of Akt and PTEN in acute lymphoblastic leukemia cells. Experimental hematology. vol 36. issue 10. 2008-12-03. PMID:18599181. |
resistance to trail-induced apoptosis caused by constitutional phosphorylation of akt and pten in acute lymphoblastic leukemia cells. |
2008-12-03 |
2023-08-12 |
Not clear |
| Junming Tang, Jianing Wang, Jianye Yang, Xia Kon. Adenovirus-mediated stromal cell-derived- factor-1alpha gene transfer induces cardiac preservation after infarction via angiogenesis of CD133+ stem cells and anti-apoptosis. Interactive cardiovascular and thoracic surgery. vol 7. issue 5. 2008-12-02. PMID:18577527. |
in our study, we found cardiocytes expressed cxcr4, and the number of cardiocytes apoptosis with sdf-1 treatment decreased obviously through sdf-1 induced the up-regulation of phosphorylated akt. |
2008-12-02 |
2023-08-12 |
Not clear |
| Michael Degtyarev, Ann De Mazière, Christine Orr, Jie Lin, Brian B Lee, Janet Y Tien, Wei W Prior, Suzanne van Dijk, Hong Wu, Daniel C Gray, David P Davis, Howard M Stern, Lesley J Murray, Klaus P Hoeflich, Judith Klumperman, Lori S Friedman, Kui Li. Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents. The Journal of cell biology. vol 183. issue 1. 2008-11-28. PMID:18838554. |
although akt is known as a survival kinase, inhibitors of the phosphatidylinositol 3-kinase (pi3k)-akt pathway do not always induce substantial apoptosis. |
2008-11-28 |
2023-08-12 |
human |
| Michael Degtyarev, Ann De Mazière, Christine Orr, Jie Lin, Brian B Lee, Janet Y Tien, Wei W Prior, Suzanne van Dijk, Hong Wu, Daniel C Gray, David P Davis, Howard M Stern, Lesley J Murray, Klaus P Hoeflich, Judith Klumperman, Lori S Friedman, Kui Li. Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents. The Journal of cell biology. vol 183. issue 1. 2008-11-28. PMID:18838554. |
akt knockdown or inactivation with small molecule inhibitors did not induce significant apoptosis but rather markedly increased autophagy. |
2008-11-28 |
2023-08-12 |
human |
| Paola Palozza, Rosanna Sestito, Nevio Picci, Paola Lanza, Giovanni Monego, Franco O Ranellett. The sensitivity to beta-carotene growth-inhibitory and proapoptotic effects is regulated by caveolin-1 expression in human colon and prostate cancer cells. Carcinogenesis. vol 29. issue 11. 2008-11-24. PMID:18635524. |
the results of this study show that (i) beta-carotene acted as a growth-inhibitory agent in cav-1-positive cells, but not in cav-1-negative cells; (ii) in cav-1-positive cells, the carotenoid downregulated in a dose- and time-dependent manner the expression of cav-1 protein and messenger rna levels and inhibited akt phosphorylation which, in turn, stimulated apoptosis by increasing the expression of beta-catenin and c-myc and the activity of caspases-3, -7, -8 and -9; when the carotenoid was removed from culture medium, a progressive increase in cell growth was observed with respect to beta-carotene-treated cells and (iii) the transfection of cav-1 in cav-1-negative cells increased cell sensitivity to beta-carotene by inducing apoptosis. |
2008-11-24 |
2023-08-12 |
human |
| Hang-Zi Chen, Bi-Xing Zhao, Wen-Xiu Zhao, Li Li, Bing Zhang, Qiao W. Akt phosphorylates the TR3 orphan receptor and blocks its targeting to the mitochondria. Carcinogenesis. vol 29. issue 11. 2008-11-24. PMID:18713840. |
acutely transforming retrovirus akt8 in rodent t cell lymphoma (akt) phosphorylates and regulates the function of many cellular proteins involved in processes such as metabolism, apoptosis and proliferation. |
2008-11-24 |
2023-08-12 |
Not clear |
| Hang-Zi Chen, Bi-Xing Zhao, Wen-Xiu Zhao, Li Li, Bing Zhang, Qiao W. Akt phosphorylates the TR3 orphan receptor and blocks its targeting to the mitochondria. Carcinogenesis. vol 29. issue 11. 2008-11-24. PMID:18713840. |
however, the precise mechanisms by which akt promotes cell survival and inhibits apoptosis have been characterized in part only. |
2008-11-24 |
2023-08-12 |
Not clear |
| Hang-Zi Chen, Bi-Xing Zhao, Wen-Xiu Zhao, Li Li, Bing Zhang, Qiao W. Akt phosphorylates the TR3 orphan receptor and blocks its targeting to the mitochondria. Carcinogenesis. vol 29. issue 11. 2008-11-24. PMID:18713840. |
moreover, akt displayed an ability to disrupt the interaction of tr3 with bcl-2, which is thought to be a critical requirement for mitochondrial tr3 to elicit apoptosis. |
2008-11-24 |
2023-08-12 |
Not clear |
| Parminder Kaur, Sanjeev Shukla, Sanjay Gupt. Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study. Carcinogenesis. vol 29. issue 11. 2008-11-24. PMID:18725386. |
plant flavonoid apigenin inactivates akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study. |
2008-11-24 |
2023-08-12 |
human |
| Parminder Kaur, Sanjeev Shukla, Sanjay Gupt. Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study. Carcinogenesis. vol 29. issue 11. 2008-11-24. PMID:18725386. |
in vivo, apigenin intake through gavage resulted in inactivation of akt and induction of apoptosis in pc-3 tumors. |
2008-11-24 |
2023-08-12 |
human |
| Parminder Kaur, Sanjeev Shukla, Sanjay Gupt. Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo study. Carcinogenesis. vol 29. issue 11. 2008-11-24. PMID:18725386. |
these results suggest that akt inactivation and dephosphorylation of bad is a critical event, at least in part, in apigenin-induced decreased cell survival and apoptosis. |
2008-11-24 |
2023-08-12 |
human |
| Lin Cao, De-xiong Cao, Xing-wen Su, Li-jun Chen, Ai-lin Liu, Wei-jian Jian, Yu-ping Wu, Peng-xin Qiu, Guang-mei Ya. Activation of PI3-K/Akt pathway for thermal preconditioning to protect cultured cerebellar granule neurons against low potassium-induced apoptosis. Acta pharmacologica Sinica. vol 28. issue 2. 2008-11-18. PMID:17241518. |
this study was designed to investigate whether the activation of the phosphatidylinositol 3-kinase (pi3-k)/akt pathway is required for thermal preconditioning to protect rat cerebellar granule neurons (cgn) against apoptosis induced by low potassium, and to explore the possibility of a link between the upregulated heat shock protein (hsp)70 expression and akt activation in the acquisition of neuroprotection induced by thermal preconditioning. |
2008-11-18 |
2023-08-12 |
rat |
| b' D Lane, A Cartier, C Rancourt, A Pich\\xc3\\xa. Cell detachment modulates TRAIL resistance in ovarian cancer cells by downregulating the phosphatidylinositol 3-kinase/Akt pathway. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. vol 18. issue 4. 2008-11-18. PMID:17868340.' |
our data indicate that cell detachment enhances trail-induced killing by decreasing akt activity in trail-resistant ovarian carcinoma cells and suggest that akt inhibition primes trail-resistant cells to trail-induced apoptosis. |
2008-11-18 |
2023-08-12 |
Not clear |
| Kevin A Janes, H Christian Reinhardt, Michael B Yaff. Cytokine-induced signaling networks prioritize dynamic range over signal strength. Cell. vol 135. issue 2. 2008-11-14. PMID:18957207. |
we develop a general computational technique, "model-breakpoint analysis," to analyze the mechanism of these failures, identifying new time- and stimulus-specific roles for akt, erk, and mk2 kinase activity in apoptosis, which were experimentally verified. |
2008-11-14 |
2023-08-12 |
Not clear |
| Natalia Scaglia, R Ariel Iga. Inhibition of Stearoyl-CoA Desaturase 1 expression in human lung adenocarcinoma cells impairs tumorigenesis. International journal of oncology. vol 33. issue 4. 2008-11-13. PMID:18813799. |
interestingly, the effects of scd1 blockade on akt activation, cancer cell growth and apoptosis could not be reversed by exogenously added oleic acid. |
2008-11-13 |
2023-08-12 |
mouse |
| Hongtao Wu, Dunyue Lu, Hao Jiang, Ye Xiong, Changsheng Qu, Bo Li, Asim Mahmood, Dong Zhou, Michael Chop. Increase in phosphorylation of Akt and its downstream signaling targets and suppression of apoptosis by simvastatin after traumatic brain injury. Journal of neurosurgery. vol 109. issue 4. 2008-11-13. PMID:18826357. |
increase in phosphorylation of akt and its downstream signaling targets and suppression of apoptosis by simvastatin after traumatic brain injury. |
2008-11-13 |
2023-08-12 |
rat |
| Makoto Hagiwara, Bo Shen, Lee Chao, Julie Cha. Kallikrein-modified mesenchymal stem cell implantation provides enhanced protection against acute ischemic kidney injury by inhibiting apoptosis and inflammation. Human gene therapy. vol 19. issue 8. 2008-11-12. PMID:18554097. |
in addition, tissue kallikrein and kinin significantly inhibited h2o2-induced apoptosis and increased akt phosphorylation and cell viability in cultured proximal tubular cells. |
2008-11-12 |
2023-08-12 |
human |
| C-H Cheng, H-R Chang, C-W Chiang, K-H Shu, M-C Cho. Possible mechanism by which rapamycin increases cyclosporine nephrotoxicity. Transplantation proceedings. vol 40. issue 7. 2008-11-12. PMID:18790238. |
recently, it has been shown that akt phosphorylation activates mammalian target of rapamycin (m-tor) and inhibits programmed cell death including apoptosis and autophagy. |
2008-11-12 |
2023-08-12 |
Not clear |
| C-H Cheng, H-R Chang, C-W Chiang, K-H Shu, M-C Cho. Possible mechanism by which rapamycin increases cyclosporine nephrotoxicity. Transplantation proceedings. vol 40. issue 7. 2008-11-12. PMID:18790238. |
in theory, blockade of the akt pathway through inhibition of m-tor may increase cyclosporine-induced apoptosis. |
2008-11-12 |
2023-08-12 |
Not clear |