| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shu-chi Hsiung, Adrianne Tin, Hadassah Tamir, Thomas F Franke, Kuo-peing Li. Inhibition of 5-HT1A receptor-dependent cell survival by cAMP/protein kinase A: role of protein phosphatase 2A and Bax. Journal of neuroscience research. vol 86. issue 10. 2008-09-30. PMID:18459133. |
stimulation with the 5-ht(1a) receptor agonist 8-oh-dpat and pharmacological agonists of ac induced pka and protein phosphatase 2a (pp2a) activity, which in turn inhibited: akt activity, ikappabalpha degradation, nuclear translocation of nf-kappab, and expression of x-linked inhibitor of apoptosis protein (xiap/birc4). |
2008-09-30 |
2023-08-12 |
Not clear |
| Efstathia Papageorgiou, Nea Pitulis, Menelaos Manoussakis, Peter Lembessis, Michael Koutsilieri. Rosiglitazone attenuates insulin-like growth factor 1 receptor survival signaling in PC-3 cells. Molecular medicine (Cambridge, Mass.). vol 14. issue 7-8. 2008-09-30. PMID:18475308. |
in addition, rosiglitazone attenuated the type i igf receptor (igf-1r) survival signaling on adriamycin-induced apoptosis of pc-3 cells via its nongenomic action on erk1/2 and akt phosphorylation. |
2008-09-30 |
2023-08-12 |
human |
| Yanjie Lu, Jin Zhou, Chaoqian Xu, Huixian Lin, Jiening Xiao, Zhiguo Wang, Baofeng Yan. JAK/STAT and PI3K/AKT pathways form a mutual transactivation loop and afford resistance to oxidative stress-induced apoptosis in cardiomyocytes. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 21. issue 4. 2008-09-29. PMID:18441519. |
we identified a population of cells bearing higher resistance to apoptosis and found that the cells that survived from apoptotic insults had markedly higher levels of akt and stat3. |
2008-09-29 |
2023-08-12 |
rat |
| Takahisa Yan. [Etiology of iodinated radiocontrast nephrotoxicity and its attenuation by beraprost]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 128. issue 7. 2008-09-26. PMID:18591870. |
moreover, we found that cm caused an increase in ceramide content in renal tubular cells, which leads to apoptosis by inhibiting the phosphorylation of akt and camp responsive element binding protein (creb) and the subsequent reduction in bcl-2 expression. |
2008-09-26 |
2023-08-12 |
mouse |
| Dirk Westermann, Olga Lettau, Meike Sobirey, Alexander Riad, Michael Bader, Heinz-Peter Schultheiss, Carsten Tschöp. Doxorubicin cardiomyopathy-induced inflammation and apoptosis are attenuated by gene deletion of the kinin B1 receptor. Biological chemistry. vol 389. issue 6. 2008-09-26. PMID:18627295. |
this was associated with a reduced activation state of akt, as well as an increased bax/bcl2 ratio in western blots, indicating cardiac apoptosis. |
2008-09-26 |
2023-08-12 |
mouse |
| Dinender K Singla, Reetu D Singla, Debbie E McDonal. Factors released from embryonic stem cells inhibit apoptosis in H9c2 cells through PI3K/Akt but not ERK pathway. American journal of physiology. Heart and circulatory physiology. vol 295. issue 2. 2008-09-25. PMID:18552162. |
furthermore, h(2)o(2)-induced apoptosis is associated with decreased levels of phosphorylated (p)akt activity. |
2008-09-25 |
2023-08-12 |
mouse |
| Dinender K Singla, Reetu D Singla, Debbie E McDonal. Factors released from embryonic stem cells inhibit apoptosis in H9c2 cells through PI3K/Akt but not ERK pathway. American journal of physiology. Heart and circulatory physiology. vol 295. issue 2. 2008-09-25. PMID:18552162. |
following treatment with es-cm, we observed a decrease in apoptosis with an increase in pakt, and the increased activity was attenuated with the akt inhibitor, suggesting that the akt pathway is involved in the decreased apoptosis and cell survival provided by es-cm. |
2008-09-25 |
2023-08-12 |
mouse |
| Dinender K Singla, Reetu D Singla, Debbie E McDonal. Factors released from embryonic stem cells inhibit apoptosis in H9c2 cells through PI3K/Akt but not ERK pathway. American journal of physiology. Heart and circulatory physiology. vol 295. issue 2. 2008-09-25. PMID:18552162. |
in conclusion, we suggest that es-cm inhibited apoptosis and is mediated by akt but not the erk pathway. |
2008-09-25 |
2023-08-12 |
mouse |
| Tapas K Makar, David Trisler, Karna T Sura, Shireen Sultana, Niraj Patel, Christopher T Beve. Brain derived neurotrophic factor treatment reduces inflammation and apoptosis in experimental allergic encephalomyelitis. Journal of the neurological sciences. vol 270. issue 1-2. 2008-09-24. PMID:18374360. |
consistent with the known mechanism of action of bdnf on apoptosis, bcl-2 and akt were increased in treated mice. |
2008-09-24 |
2023-08-12 |
mouse |
| Enrica Favaro, Ilaria Miceli, Benedetta Bussolati, Michel Schmitt-Ney, Michel Schimitt-Ney, Paolo Cavallo Perin, Giovanni Camussi, Maria M Zanon. Hyperglycemia induces apoptosis of human pancreatic islet endothelial cells: effects of pravastatin on the Akt survival pathway. The American journal of pathology. vol 173. issue 2. 2008-09-24. PMID:18599614. |
hyperglycemia induces apoptosis of human pancreatic islet endothelial cells: effects of pravastatin on the akt survival pathway. |
2008-09-24 |
2023-08-12 |
human |
| Enrica Favaro, Ilaria Miceli, Benedetta Bussolati, Michel Schmitt-Ney, Michel Schimitt-Ney, Paolo Cavallo Perin, Giovanni Camussi, Maria M Zanon. Hyperglycemia induces apoptosis of human pancreatic islet endothelial cells: effects of pravastatin on the Akt survival pathway. The American journal of pathology. vol 173. issue 2. 2008-09-24. PMID:18599614. |
pravastatin (1 mumol/l) decreased apoptosis induced by high glucose or oxidized ldl and increased akt phosphorylation. |
2008-09-24 |
2023-08-12 |
human |
| Patrizia Portanova, Tiziana Russo, Ornella Pellerito, Giuseppe Calvaruso, Michela Giuliano, Renza Vento, Giovanni Tesorier. The role of oxidative stress in apoptosis induced by the histone deacetylase inhibitor suberoylanilide hydroxamic acid in human colon adenocarcinoma HT-29 cells. International journal of oncology. vol 33. issue 2. 2008-09-23. PMID:18636153. |
furthermore, saha down-regulated flipl and akt, two proteins which exert an inhibitory role in apoptosis. |
2008-09-23 |
2023-08-12 |
human |
| Hanshuang Shao, Xiao-Ming Yi, Alan Well. Epidermal growth factor protects fibroblasts from apoptosis via PI3 kinase and Rac signaling pathways. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 16. issue 4. 2008-09-23. PMID:18638274. |
furthermore, by using kp372-1, a specific akt inhibitor, we found that downstream of akt signaling pathways is absolutely required for the egf rescue from staurosporine-induced apoptosis in nr6wt. |
2008-09-23 |
2023-08-12 |
human |
| Georgina P Coló, María F Rubio, Cecilia V Alvarado, Mónica A Costa. [RAC3 nuclear receptor co-activator has a protective role in the apoptosis induced by different stimuli]. Medicina. vol 67. issue 5. 2008-09-22. PMID:18051230. |
the normal or transfected coactivator over-expression inhibits apoptosis through a diminished caspase activity and aif nuclear translocation, increased nf-kappab, akt and p38, and decreased erk activities. |
2008-09-22 |
2023-08-12 |
human |
| Shin Kim, Tae-Jin Lee, Jaechan Leem, Kyeong Sook Choi, Jong-Wook Park, Taeg Kyu Kwo. Sanguinarine-induced apoptosis: generation of ROS, down-regulation of Bcl-2, c-FLIP, and synergy with TRAIL. Journal of cellular biochemistry. vol 104. issue 3. 2008-09-22. PMID:18189268. |
additionally, we found that sub-lethal doses of sanguinarine remarkably sensitized breast cancer cells to trail-mediated apoptosis, but the cell death induced by sanguinarine and trail in combination was not blocked by overexpression of bcl-2 or akt. |
2008-09-22 |
2023-08-12 |
human |
| Changxue Lu, Mark C Willingham, Fumihiko Furuya, Sheue-Yann Chen. Activation of phosphatidylinositol 3-kinase signaling promotes aberrant pituitary growth in a mouse model of thyroid-stimulating hormone-secreting pituitary tumors. Endocrinology. vol 149. issue 7. 2008-09-22. PMID:18356276. |
in addition, activation of akt led to decreased apoptosis by inhibiting proapoptotic activity of bcl-2-associated death promoter, further contributing to the aberrant cell proliferation. |
2008-09-22 |
2023-08-12 |
mouse |
| Masayasu Iwase, Sayaka Takaoka, Makiko Uchida, Sayaka Yoshiba, Gen Kondo, Hitoshi Watanabe, Masaru Ohashi, Masao Nagum. Epidermal growth factor receptor inhibitors enhance susceptibility to Fas-mediated apoptosis in oral squamous cell carcinoma cells. Oral oncology. vol 44. issue 4. 2008-09-18. PMID:17689285. |
treatment of oscc cells with an anti-egfr monoclonal antibody, c225, and an egfr tyrosine kinase inhibitor, ag1478, which target the extracellular and intracellular domains of the receptor, respectively, inhibited phosphorylation of egfr and its downstream effector molecule akt and amplified the induction of fas-mediated apoptosis. |
2008-09-18 |
2023-08-12 |
Not clear |
| C Tekle, E Giovannetti, J Sigmond, J R Graff, K Smid, G J Peter. Molecular pathways involved in the synergistic interaction of the PKC beta inhibitor enzastaurin with the antifolate pemetrexed in non-small cell lung cancer cells. British journal of cancer. vol 99. issue 5. 2008-09-17. PMID:18728666. |
pharmacologic interaction was studied using the combination-index method, while cell cycle, apoptosis induction, vegf secretion and erk1/2 and akt phosphorylation were studied by flow cytometry and elisas. |
2008-09-17 |
2023-08-12 |
Not clear |
| C Tekle, E Giovannetti, J Sigmond, J R Graff, K Smid, G J Peter. Molecular pathways involved in the synergistic interaction of the PKC beta inhibitor enzastaurin with the antifolate pemetrexed in non-small cell lung cancer cells. British journal of cancer. vol 99. issue 5. 2008-09-17. PMID:18728666. |
enzastaurin reduced both phosphocdc25c, resulting in g2/m checkpoint abrogation and apoptosis induction in pemetrexed-damaged cells, and gsk3 beta and akt phosphorylation, which was additionally reduced by drug combination (-58% in a549). |
2008-09-17 |
2023-08-12 |
Not clear |
| Steven W Paugh, Barbara S Paugh, Mohamed Rahmani, Dmitri Kapitonov, Jorge A Almenara, Tomasz Kordula, Sheldon Milstien, Jeffrey K Adams, Robert E Zipkin, Steven Grant, Sarah Spiege. A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia. Blood. vol 112. issue 4. 2008-09-16. PMID:18511810. |
expression of constitutively active akt protected against sk1-i-induced apoptosis. |
2008-09-16 |
2023-08-12 |
human |