| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anush Oganesian, Lucas C Armstrong, Mary M Migliorini, Dudley K Strickland, Paul Bornstei. Thrombospondins use the VLDL receptor and a nonapoptotic pathway to inhibit cell division in microvascular endothelial cells. Molecular biology of the cell. vol 19. issue 2. 2008-11-10. PMID:18032585. |
hmvecs, cultured in low serum, responded to vegf with an increase in [(3)h]thymidine incorporation that was inhibited by tsps and was accompanied by decreases in the phosphorylation of akt and mapk, without an increase in apoptosis. |
2008-11-10 |
2023-08-12 |
Not clear |
| Yiwei Li, Zhiwei Wang, Dejuan Kong, Ran Li, Sanila H Sarkar, Fazlul H Sarka. Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by isoflavone in prostate cancer cells. The Journal of biological chemistry. vol 283. issue 41. 2008-11-10. PMID:18687691. |
it is known that foxo3a and gsk-3beta, targets of akt, regulate cell proliferation and apoptosis. |
2008-11-10 |
2023-08-12 |
Not clear |
| Johannes Rieger, Dieter Lemke, Gabriele Maurer, Markus Weiler, Brigitte Frank, Ghazaleh Tabatabai, Michael Weller, Wolfgang Wic. Enzastaurin-induced apoptosis in glioma cells is caspase-dependent and inhibited by BCL-XL. Journal of neurochemistry. vol 106. issue 6. 2008-11-07. PMID:18662322. |
inhibition of the phosphatidylinositol 3 kinase signaling pathway did not restore sensitivity of a172 cells towards enza, and constitutively active akt did not protect lnt-229 and t98g cells from enza-induced apoptosis. |
2008-11-07 |
2023-08-12 |
Not clear |
| Emely Castro-Rivera, Sophia Ran, Rolf A Brekken, John D Minn. Semaphorin 3B inhibits the phosphatidylinositol 3-kinase/Akt pathway through neuropilin-1 in lung and breast cancer cells. Cancer research. vol 68. issue 20. 2008-11-07. PMID:18922901. |
in the current study, treatment of lung and breast cancer cells with picomolar concentrations of soluble sema3b inhibited their growth; induced apoptosis; and was associated with decreased akt phosphorylation, increase in cytochrome c release and caspase-3 cleavage, as well as increased phosphorylation of several proapoptotic proteins, including glycogen synthase kinase-3beta, fkhr, and mdm-2. |
2008-11-07 |
2023-08-12 |
Not clear |
| Emely Castro-Rivera, Sophia Ran, Rolf A Brekken, John D Minn. Semaphorin 3B inhibits the phosphatidylinositol 3-kinase/Akt pathway through neuropilin-1 in lung and breast cancer cells. Cancer research. vol 68. issue 20. 2008-11-07. PMID:18922901. |
sema3b-mediated inhibition of proliferation and induction of apoptosis in cancer cells were blocked by expressing a constitutively active akt mutant and are linked to tumor cell expression of neuropilin-1 (np-1). |
2008-11-07 |
2023-08-12 |
Not clear |
| Emely Castro-Rivera, Sophia Ran, Rolf A Brekken, John D Minn. Semaphorin 3B inhibits the phosphatidylinositol 3-kinase/Akt pathway through neuropilin-1 in lung and breast cancer cells. Cancer research. vol 68. issue 20. 2008-11-07. PMID:18922901. |
we conclude that sema3b is a potential tumor suppressor that induces apoptosis in sema3b-inactivated tumor cells through the np-1 receptor by inactivating the akt signaling pathway. |
2008-11-07 |
2023-08-12 |
Not clear |
| Taiji Tamura, Xing Cui, Nagako Sakaguchi, Makoto Akash. Ginsenoside Rd prevents and rescues rat intestinal epithelial cells from irradiation-induced apoptosis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 46. issue 9. 2008-11-06. PMID:18638517. |
inhibition of akt phosphorylation prevented the reduction of apoptosis by rd following irradiation. |
2008-11-06 |
2023-08-12 |
rat |
| Zhiquan Li, Yunyu Hu, Qingsheng Zhu, Jinyu Zh. Neurotrophin-3 reduces apoptosis induced by 6-OHDA in PC12 cells through Akt signaling pathway. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 26. issue 6. 2008-11-05. PMID:18462913. |
neurotrophin-3 reduces apoptosis induced by 6-ohda in pc12 cells through akt signaling pathway. |
2008-11-05 |
2023-08-12 |
Not clear |
| Zhiquan Li, Yunyu Hu, Qingsheng Zhu, Jinyu Zh. Neurotrophin-3 reduces apoptosis induced by 6-OHDA in PC12 cells through Akt signaling pathway. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 26. issue 6. 2008-11-05. PMID:18462913. |
further study revealed that ly294002, an inhibitor of pi3-kinase (a molecule upstream of akt), enhanced 6-ohda-induced apoptosis. |
2008-11-05 |
2023-08-12 |
Not clear |
| Halvor L Holen, Mohsen Shadidi, Kristina Narvhus, Oddveig Kjøsnes, Anne Tierens, Hans-Christian Aashei. Signaling through ephrin-A ligand leads to activation of Src-family kinases, Akt phosphorylation, and inhibition of antigen receptor-induced apoptosis. Journal of leukocyte biology. vol 84. issue 4. 2008-11-04. PMID:18593733. |
signaling through ephrin-a ligand leads to activation of src-family kinases, akt phosphorylation, and inhibition of antigen receptor-induced apoptosis. |
2008-11-04 |
2023-08-12 |
human |
| Kwanjin Park, Kyong Shin Ryu, Wen Ji Li, Soo Woong Kim, Jae-Seung Paic. Chronic treatment with a type 5 phosphodiesterase inhibitor suppresses apoptosis of corporal smooth muscle by potentiating Akt signalling in a rat model of diabetic erectile dysfunction. European urology. vol 53. issue 6. 2008-11-03. PMID:18243503. |
chronic treatment with a type 5 phosphodiesterase inhibitor suppresses apoptosis of corporal smooth muscle by potentiating akt signalling in a rat model of diabetic erectile dysfunction. |
2008-11-03 |
2023-08-12 |
rat |
| Kwanjin Park, Kyong Shin Ryu, Wen Ji Li, Soo Woong Kim, Jae-Seung Paic. Chronic treatment with a type 5 phosphodiesterase inhibitor suppresses apoptosis of corporal smooth muscle by potentiating Akt signalling in a rat model of diabetic erectile dysfunction. European urology. vol 53. issue 6. 2008-11-03. PMID:18243503. |
to examine whether chronic treatment with a type 5 phosphodiesterase inhibitor (pde5i) could suppress corporal apoptosis via potentiation of akt signalling in diabetic erectile dysfunction. |
2008-11-03 |
2023-08-12 |
rat |
| Mustafa F Ust. Editorial comment on: chronic treatment with a type 5 phosphodiesterase inhibitor suppresses apoptosis of corporal smooth muscle by potentiating Akt signalling in a rat model of diabetic erectile dysfunction. European urology. vol 53. issue 6. 2008-11-03. PMID:18243512. |
editorial comment on: chronic treatment with a type 5 phosphodiesterase inhibitor suppresses apoptosis of corporal smooth muscle by potentiating akt signalling in a rat model of diabetic erectile dysfunction. |
2008-11-03 |
2023-08-12 |
rat |
| Antonino Neri, Sandra Marmiroli, Pierfrancesco Tassone, Luigia Lombardi, Lucia Nobili, Donata Verdelli, Monica Civallero, Maria Cosenza, Jessika Bertacchini, Massimo Federico, Anto De Pol, Giorgio Lambertenghi Deliliers, Stefano Sacch. The oral protein-kinase C beta inhibitor enzastaurin (LY317615) suppresses signalling through the AKT pathway, inhibits proliferation and induces apoptosis in multiple myeloma cell lines. Leukemia & lymphoma. vol 49. issue 7. 2008-10-31. PMID:18452078. |
the oral protein-kinase c beta inhibitor enzastaurin (ly317615) suppresses signalling through the akt pathway, inhibits proliferation and induces apoptosis in multiple myeloma cell lines. |
2008-10-31 |
2023-08-12 |
human |
| Sinéad Lordan, Cora O'Neill, Nora M O'Brie. Effects of apigenin, lycopene and astaxanthin on 7 beta-hydroxycholesterol-induced apoptosis and Akt phosphorylation in U937 cells. The British journal of nutrition. vol 100. issue 2. 2008-10-27. PMID:18186953. |
effects of apigenin, lycopene and astaxanthin on 7 beta-hydroxycholesterol-induced apoptosis and akt phosphorylation in u937 cells. |
2008-10-27 |
2023-08-12 |
Not clear |
| Sinéad Lordan, Cora O'Neill, Nora M O'Brie. Effects of apigenin, lycopene and astaxanthin on 7 beta-hydroxycholesterol-induced apoptosis and Akt phosphorylation in U937 cells. The British journal of nutrition. vol 100. issue 2. 2008-10-27. PMID:18186953. |
our data suggest that apigenin, lycopene and astaxanthin failed to protect against 7 beta-oh-induced apoptosis, and the decrease in cell viability and the increase in apoptotic nuclei induced by the antioxidants appear to be associated with down regulation of akt activity. |
2008-10-27 |
2023-08-12 |
Not clear |
| Yi-Lin Chen, Min-Hui Jian, Chai-Ching Lin, Jung-Cheng Kang, Shee-Ping Chen, Po-Cheng Lin, Putzer-Joseph Hung, Jen-Ren Chen, Wen-Liang Chang, Shinn-Zong Lin, Horng-Jyh Har. The induction of orphan nuclear receptor Nur77 expression by n-butylenephthalide as pharmaceuticals on hepatocellular carcinoma cell therapy. Molecular pharmacology. vol 74. issue 4. 2008-10-27. PMID:18577687. |
n-butylidenephthalide-related tumor apoptosis was associated with phosphatidylinositol 3-kinase/protein kinase b (akt)/glycogen synthase kinase-3beta rather than the mitogen-activated protein kinase or protein kinase c pathway. |
2008-10-27 |
2023-08-12 |
Not clear |
| Saverio Marchi, Alessandro Rimessi, Carlotta Giorgi, Claudio Baldini, Letizia Ferroni, Rosario Rizzuto, Paolo Pinto. Akt kinase reducing endoplasmic reticulum Ca2+ release protects cells from Ca2+-dependent apoptotic stimuli. Biochemical and biophysical research communications. vol 375. issue 4. 2008-10-27. PMID:18723000. |
the proto-oncogene akt is a potent inhibitor of apoptosis, and it is activated in many human cancers. |
2008-10-27 |
2023-08-12 |
human |
| Jun Saegusa, Daniel K Hsu, Wei Liu, Ichiro Kuwabara, Yasuko Kuwabara, Lan Yu, Fu-Tong Li. Galectin-3 protects keratinocytes from UVB-induced apoptosis by enhancing AKT activation and suppressing ERK activation. The Journal of investigative dermatology. vol 128. issue 10. 2008-10-22. PMID:18463681. |
galectin-3 protects keratinocytes from uvb-induced apoptosis by enhancing akt activation and suppressing erk activation. |
2008-10-22 |
2023-08-12 |
mouse |
| Jun Saegusa, Daniel K Hsu, Wei Liu, Ichiro Kuwabara, Yasuko Kuwabara, Lan Yu, Fu-Tong Li. Galectin-3 protects keratinocytes from UVB-induced apoptosis by enhancing AKT activation and suppressing ERK activation. The Journal of investigative dermatology. vol 128. issue 10. 2008-10-22. PMID:18463681. |
moreover, we demonstrated that increased apoptosis in gal3(-/-) keratinocytes was attributable to higher extracellular signal-regulated kinase (erk) activation and lower akt activation after uvb irradiation. |
2008-10-22 |
2023-08-12 |
mouse |