| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Toshimitsu Yamaoka, Fang Yan, Hanwei Cao, Stuart S Hobbs, Rebecca S Dise, Wei Tong, D Brent Pol. Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 33. 2008-09-16. PMID:18701712. |
activation of egfr, erbb2, akt, src, and apoptosis were determined in vivo and in vitro. |
2008-09-16 |
2023-08-12 |
mouse |
| Konstantinos J Mavrakis, Hong Zhu, Ricardo L A Silva, John R Mills, Julie Teruya-Feldstein, Scott W Lowe, Wayne Tam, Jerry Pelletier, Hans-Guido Wende. Tumorigenic activity and therapeutic inhibition of Rheb GTPase. Genes & development. vol 22. issue 16. 2008-09-16. PMID:18708578. |
rheb causes mtorc1-dependent effects on apoptosis, senescence, and treatment responses that resemble those of akt. |
2008-09-16 |
2023-08-12 |
human |
| Elzbieta Pluskota, Dmitry A Soloviev, Dorota Szpak, Christian Weber, Edward F Plo. Neutrophil apoptosis: selective regulation by different ligands of integrin alphaMbeta2. Journal of immunology (Baltimore, Md. : 1950). vol 181. issue 5. 2008-09-15. PMID:18714035. |
plasminogen, fibrinogen, and p2-c suppressed apoptosis via activation of akt and erk1/2 kinases, while angiostatin and p1 failed to activate these prosurvival pathways and did not prevent neutrophil apoptosis. |
2008-09-15 |
2023-08-12 |
Not clear |
| Hoe Suk Kim, Patricia A Loughran, Jayashree Rao, Timothy R Billiar, Brian S Zuckerbrau. Carbon monoxide activates NF-kappaB via ROS generation and Akt pathways to protect against cell death of hepatocytes. American journal of physiology. Gastrointestinal and liver physiology. vol 295. issue 1. 2008-09-09. PMID:18497334. |
we found that co treatment of hepatocytes prevents spontaneous apoptosis and leads to an increase in ros production in association with akt phosphorylation and ikappab degradation. |
2008-09-09 |
2023-08-12 |
mouse |
| Mahmoud Toulany, Rainer Kehlbach, Urszula Florczak, Ali Sak, Shaomeng Wang, Jianyong Chen, Markus Lobrich, H Peter Rodeman. Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair. Molecular cancer therapeutics. vol 7. issue 7. 2008-09-08. PMID:18644989. |
thus, targeting of akt enhances radiation sensitivity of lung cancer cell lines a549 and h460 most likely through specific inhibition of dna-pkcs-dependent dna-dsb repair but not through enhancement of radiation-induced apoptosis. |
2008-09-08 |
2023-08-12 |
human |
| Young-Hee Kim, Yoon-Sook Kim, Chang-Hwan Park, In-Yong Chung, Ji-Myong Yoo, Jae-Geun Kim, Byung-Ju Lee, Sang-Soo Kang, Gyeong-Jae Cho, Wan-Sung Cho. Protein kinase C-delta mediates neuronal apoptosis in the retinas of diabetic rats via the Akt signaling pathway. Diabetes. vol 57. issue 8. 2008-09-04. PMID:18443201. |
protein kinase c-delta mediates neuronal apoptosis in the retinas of diabetic rats via the akt signaling pathway. |
2008-09-04 |
2023-08-12 |
rat |
| Young-Hee Kim, Yoon-Sook Kim, Chang-Hwan Park, In-Yong Chung, Ji-Myong Yoo, Jae-Geun Kim, Byung-Ju Lee, Sang-Soo Kang, Gyeong-Jae Cho, Wan-Sung Cho. Protein kinase C-delta mediates neuronal apoptosis in the retinas of diabetic rats via the Akt signaling pathway. Diabetes. vol 57. issue 8. 2008-09-04. PMID:18443201. |
herein, we examined the role of pkc-delta in neuronal apoptosis through akt in the retinas of diabetic rats. |
2008-09-04 |
2023-08-12 |
rat |
| Ricardo Boland, Andrea Vasconsuelo, Lorena Milanesi, Ana C Ronda, Ana R de Bolan. 17beta-estradiol signaling in skeletal muscle cells and its relationship to apoptosis. Steroids. vol 73. issue 9-10. 2008-09-03. PMID:18272190. |
erbeta plays a major role in the inhibition of apoptosis by 17beta-estradiol at the level of mitochondria, whereas eralpha and erbeta mediate the activation of akt to the same extent, suggesting differential involvement of er isoforms depending on the step of the apoptotic/survival pathway involved. |
2008-09-03 |
2023-08-12 |
Not clear |
| Pin Ling, Te-Jung Lu, Chiun-Jye Yuan, Ming-Derg La. Biosignaling of mammalian Ste20-related kinases. Cellular signalling. vol 20. issue 7. 2008-09-02. PMID:18255267. |
mst1 and mst2 kinases play an important role in cell growth and apoptosis, and the signal pathways involves many important molecules including ras, akt, and foxo3. |
2008-09-02 |
2023-08-12 |
Not clear |
| David Allard, Nichola Figg, Martin R Bennett, Trevor D Littlewoo. Akt regulates the survival of vascular smooth muscle cells via inhibition of FoxO3a and GSK3. The Journal of biological chemistry. vol 283. issue 28. 2008-08-28. PMID:18458087. |
we conclude that akt and its downstream targets foxo3a and gsk3 regulate a survival pathway in vsmcs and that their deregulation due to a reduction of igf1r signaling may promote apoptosis in atherosclerosis. |
2008-08-28 |
2023-08-12 |
human |
| Jiang Shujia, Husnain Khawaja Haider, Niagara Muhammad Idris, Gang Lu, Muhammad Ashra. Stable therapeutic effects of mesenchymal stem cell-based multiple gene delivery for cardiac repair. Cardiovascular research. vol 77. issue 3. 2008-08-26. PMID:18032392. |
we have previously shown that transplantation of mesenchymal stem cells (mscs) co-overexpressing angiopoietin-1 (ang-1) and akt prevented cell apoptosis, enhanced angiogenesis, and improved left ventricular heart function. |
2008-08-26 |
2023-08-12 |
Not clear |
| Céline Van Themsche, Lyne Lafontaine, Eric Asseli. X-linked inhibitor of apoptosis protein levels and protein kinase C activity regulate the sensitivity of human endometrial carcinoma cells to tumor necrosis factor alpha-induced apoptosis. Endocrinology. vol 149. issue 8. 2008-08-26. PMID:18467439. |
exposure to tnfalpha triggered tnf-r1-dependent activation of caspases-8, -9, and -3, down-regulated akt and xiap proteins and induced dose-dependent and time-dependent apoptosis in ishikawa cells. |
2008-08-26 |
2023-08-12 |
human |
| Keiko Kawauchi, Kei Tobiume, Kimi Iwashita, Hiroko Inagaki, Tetsunori Morikawa, Yukinao Shibukawa, Yoshinori Moriyama, Hajime Hirata, Hideaki Kamat. Cycloprodigiosin hydrochloride activates the Ras-PI3K-Akt pathway and suppresses protein synthesis inhibition-induced apoptosis in PC12 cells. Bioscience, biotechnology, and biochemistry. vol 72. issue 6. 2008-08-25. PMID:18540098. |
in this study, we found a novel function of cprg-hcl; to suppress cell death in pc12 cells, which is caused by protein synthesis inhibitors cycloheximide and actinomycin d. cprg-hcl activated akt and suppressed apoptosis, and this was accompanied by inhibition of caspase-3 activity and dna fragmentation independently of its h(+)/cl(-) symporter activity. |
2008-08-25 |
2023-08-12 |
Not clear |
| Ching-Feng Cheng, Shu-Hui Juan, Jin-Jer Chen, Ying-Chi Chao, His-Hsien Chen, Wei-Shiung Lian, Chun-Yi Lu, Chung-I Chang, Ted-H Chiu, Heng Li. Pravastatin attenuates carboplatin-induced cardiotoxicity via inhibition of oxidative stress associated apoptosis. Apoptosis : an international journal on programmed cell death. vol 13. issue 7. 2008-08-20. PMID:18483861. |
lastly, mice pre-treated with pravastatin before carboplatin treatment showed improved survival rate and cardiac function, with reduced cardiomyocyte apoptosis via activating akt and restoring normal mitochondrial hax-1 in heart tissue. |
2008-08-20 |
2023-08-12 |
mouse |
| Leri S Faried, Ahmad Faried, Tatsuya Kanuma, Hiroshi Aoki, Takaaki Sano, Tomoko Nakazato, Tomohiro Tamura, Hiroyuki Kuwano, Takashi Minegish. Expression of an activated mammalian target of rapamycin in adenocarcinoma of the cervix: A potential biomarker and molecular target therapy. Molecular carcinogenesis. vol 47. issue 6. 2008-08-19. PMID:18058806. |
in the in vitro study, cisplatin at cpi(50) targets both the apoptosis and survival pathway by activating the caspase-cascade; inhibiting akt, mtor, p70s6k, and 4ebp1. |
2008-08-19 |
2023-08-12 |
Not clear |
| Ji Yeon Jung, Kwang Hoon Roh, Yeon Jin Jeong, Sun Hun Kim, Eun Ju Lee, Min Seok Kim, Won Mann Oh, Hee Kyun Oh, Won Jae Ki. Estradiol protects PC12 cells against CoCl2-induced apoptosis. Brain research bulletin. vol 76. issue 6. 2008-08-19. PMID:18598848. |
in addition, estradiol increased the phosphorylation of akt in cocl(2)-treated cells, demonstrating that estradiol has no affect on upstream signaling through the pi3k/akt in inhibition of cocl(2)-induced apoptosis in pc12 cells. |
2008-08-19 |
2023-08-12 |
Not clear |
| Frank Hilberg, Gerald J Roth, Martin Krssak, Susanna Kautschitsch, Wolfgang Sommergruber, Ulrike Tontsch-Grunt, Pilar Garin-Chesa, Gerd Bader, Andreas Zoephel, Jens Quant, Armin Heckel, Wolfgang J Retti. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer research. vol 68. issue 12. 2008-08-18. PMID:18559524. |
bibf 1120 inhibits mitogen-activated protein kinase and akt signaling pathways in three cell types contributing to angiogenesis, endothelial cells, pericytes, and smooth muscle cells, resulting in inhibition of cell proliferation (ec(50), 10-80 nmol/l) and apoptosis. |
2008-08-18 |
2023-08-12 |
mouse |
| Catherine C Park, Hui J Zhang, Evelyn S Yao, Chong J Park, Mina J Bissel. Beta1 integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts. Cancer research. vol 68. issue 11. 2008-08-15. PMID:18519702. |
we report that aiib2 increased apoptosis optimally post-ir by down-regulating akt in breast cancer colonies in three-dimensional lrecm. |
2008-08-15 |
2023-08-12 |
mouse |
| Ralf J Braun, Hans Zischk. Mechanisms of Cdc48/VCP-mediated cell death: from yeast apoptosis to human disease. Biochimica et biophysica acta. vol 1783. issue 7. 2008-08-13. PMID:18284922. |
finally, cdc48/vcp protects cells from apoptosis through mediating and activating pro-survival signaling pathways, namely akt and nfkappab signaling. |
2008-08-13 |
2023-08-12 |
human |
| Zhengli Hu, Fumin Zhang, Zhijian Yang, Naiquan Yang, Dingguo Zhang, Jinying Zhang, Kejiang Ca. Combination of simvastatin administration and EPC transplantation enhances angiogenesis and protects against apoptosis for hindlimb ischemia. Journal of biomedical science. vol 15. issue 4. 2008-08-08. PMID:18327656. |
the combination therapy not only inhibites apoptosis of ischemic skeletal muscle cells partially via downregulation of bax and upregulation of bcl-2, but also activates akt phosphorylation significantly. |
2008-08-08 |
2023-08-12 |
mouse |