| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tamara N Fitzgerald, Benjamin R Shepherd, Hidenori Asada, Desarom Teso, Akihito Muto, Tiffany Fancher, Jose M Pimiento, Stephen P Maloney, Alan Dardi. Laminar shear stress stimulates vascular smooth muscle cell apoptosis via the Akt pathway. Journal of cellular physiology. vol 216. issue 2. 2008-07-08. PMID:18247368. |
smc exposed to laminar shear stress have decreased proliferation and increased apoptosis, mediated by the akt pathway. |
2008-07-08 |
2023-08-12 |
cattle |
| Claudio Festuccia, Giovanni Luca Gravina, Paola Muzi, Danilo Millimaggi, Vincenza Dolo, Carlo Vicentini, Mauro Bologn. Akt down-modulation induces apoptosis of human prostate cancer cells and synergizes with EGFR tyrosine kinase inhibitors. The Prostate. vol 68. issue 9. 2008-07-03. PMID:18361408. |
akt down-modulation induces apoptosis of human prostate cancer cells and synergizes with egfr tyrosine kinase inhibitors. |
2008-07-03 |
2023-08-12 |
human |
| Hye-Kyung Na, Young-Joon Sur. The antitumor ether lipid edelfosine (ET-18-O-CH3) induces apoptosis in H-ras transformed human breast epithelial cells: by blocking ERK1/2 and p38 mitogen-activated protein kinases as potential targets. Asia Pacific journal of clinical nutrition. vol 17 Suppl 1. 2008-07-02. PMID:18296338. |
based on these findings, it is likely that et-18-o-ch3 inactivates erk1/2, akt, and nf-kappab signaling via cox-2 induction in mcf10a-ras cells, thereby inducing apoptosis of these cells. |
2008-07-02 |
2023-08-12 |
human |
| Hui Chen, Bianzhi Xing, Xiuheng Liu, Bingyan Zhan, Jiangqiao Zhou, Hengcheng Zhu, Zhiyuan Che. Ischemic postconditioning inhibits apoptosis after renal ischemia/reperfusion injury in rat. Transplant international : official journal of the European Society for Organ Transplantation. vol 21. issue 4. 2008-07-01. PMID:18069925. |
serum urea nitrogen and creatinine levels, phosphorylation of akt and erk1/2 and apoptosis were compared after renal injury. |
2008-07-01 |
2023-08-12 |
rat |
| Hui Chen, Bianzhi Xing, Xiuheng Liu, Bingyan Zhan, Jiangqiao Zhou, Hengcheng Zhu, Zhiyuan Che. Ischemic postconditioning inhibits apoptosis after renal ischemia/reperfusion injury in rat. Transplant international : official journal of the European Society for Organ Transplantation. vol 21. issue 4. 2008-07-01. PMID:18069925. |
our data showed that ischemic postconditioning attenuated the renal dysfunction and cell apoptosis induced by i/r and increased phosphorylation of akt and erk1/2. |
2008-07-01 |
2023-08-12 |
rat |
| Jun Song, Ye-Wei Zhang, Ai-Hua Yao, Yue Yu, Zhi-Yuan Hua, Li-Yong Pu, Guo-Qiang Li, Xiang-Cheng Li, Feng Zhang, Guo-Qing Sheng, Xue-Hao Wan. Adenoviral cardiotrophin-1 transfer improves survival and early graft function after ischemia and reperfusion in rat small-for-size liver transplantation model. Transplant international : official journal of the European Society for Organ Transplantation. vol 21. issue 4. 2008-07-01. PMID:18167151. |
in conclusion, donor liver adenoviral ct-1 transfer ameliorated ischemia/reperfusion injury by decreasing hepatic necrosis and apoptosis in small-for-size liver transplantation, mediated in part by activation of the akt, erk, and stat-3 survival signaling pathways. |
2008-07-01 |
2023-08-12 |
rat |
| F Chiarini, M Del Sole, S Mongiorgi, G C Gaboardi, A Cappellini, I Mantovani, M Y Follo, J A McCubrey, A M Martell. The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism. Leukemia. vol 22. issue 6. 2008-06-26. PMID:18385752. |
the novel akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates p-glycoprotein expression in multidrug-resistant human t-acute leukemia cells by a jnk-dependent mechanism. |
2008-06-26 |
2023-08-12 |
human |
| Hervé Sartelet, Luc-Laurier Oligny, Gilles Vassa. AKT pathway in neuroblastoma and its therapeutic implication. Expert review of anticancer therapy. vol 8. issue 5. 2008-06-26. PMID:18471048. |
akt is a major mediator of survival signals that protect cells from apoptosis and regulate cell proliferation. |
2008-06-26 |
2023-08-12 |
Not clear |
| Hervé Sartelet, Luc-Laurier Oligny, Gilles Vassa. AKT pathway in neuroblastoma and its therapeutic implication. Expert review of anticancer therapy. vol 8. issue 5. 2008-06-26. PMID:18471048. |
in this article, the authors discuss the relation between activators of akt in neuroblastoma, in particular, growth factors such as igf-1, trk, gdnf, vegf and egf, and their effects on tumoral proliferation, differentiation and apoptosis. |
2008-06-26 |
2023-08-12 |
Not clear |
| Hervé Sartelet, Luc-Laurier Oligny, Gilles Vassa. AKT pathway in neuroblastoma and its therapeutic implication. Expert review of anticancer therapy. vol 8. issue 5. 2008-06-26. PMID:18471048. |
specific inhibition of akt has been studied, such as with ly249002, with significant effects on cell progression and apoptosis in tumoral cells. |
2008-06-26 |
2023-08-12 |
Not clear |
| Jun Chen, Fan Deng, Shivendra V Singh, Qiming J Wan. Protein kinase D3 (PKD3) contributes to prostate cancer cell growth and survival through a PKCepsilon/PKD3 pathway downstream of Akt and ERK 1/2. Cancer research. vol 68. issue 10. 2008-06-24. PMID:18483269. |
overexpression of wild-type pkd3 in lncap cells blocked phorbol 12-myristate 13-acetate (pma)-induced apoptosis in association with inhibition of pma-induced down-regulation of akt activity, and prolonged extracellular signal-regulated kinase (erk)1/2 activation. |
2008-06-24 |
2023-08-12 |
human |
| Xin Yan, Hua Shen, Hongjian Jiang, Chengsheng Zhang, Dan Hu, Jun Wang, Xinqi W. External Qi of Yan Xin Qigong induces G2/M arrest and apoptosis of androgen-independent prostate cancer cells by inhibiting Akt and NF-kappa B pathways. Molecular and cellular biochemistry. vol 310. issue 1-2. 2008-06-20. PMID:18080802. |
external qi of yan xin qigong induces g2/m arrest and apoptosis of androgen-independent prostate cancer cells by inhibiting akt and nf-kappa b pathways. |
2008-06-20 |
2023-08-12 |
human |
| Xin Yan, Hua Shen, Hongjian Jiang, Chengsheng Zhang, Dan Hu, Jun Wang, Xinqi W. External Qi of Yan Xin Qigong induces G2/M arrest and apoptosis of androgen-independent prostate cancer cells by inhibiting Akt and NF-kappa B pathways. Molecular and cellular biochemistry. vol 310. issue 1-2. 2008-06-20. PMID:18080802. |
these results indicate that yxqg-eq has profound effects on growth and apoptosis of prostate cancer cells by targeting survival pathways including the akt and nf-kappa b pathways. |
2008-06-20 |
2023-08-12 |
human |
| Andrea Havasi, Zhijian Li, Zhiyong Wang, Jody L Martin, Venugopal Botla, Kathleen Ruchalski, John H Schwartz, Steven C Borka. Hsp27 inhibits Bax activation and apoptosis via a phosphatidylinositol 3-kinase-dependent mechanism. The Journal of biological chemistry. vol 283. issue 18. 2008-06-19. PMID:18299320. |
these data show that hsp27 antagonizes bax-mediated mitochondrial injury and apoptosis by promoting akt activation via a pi3-kinase-dependent mechanism. |
2008-06-19 |
2023-08-12 |
Not clear |
| Ping Song, Zhonglin Xie, Yong Wu, Jian Xu, Yunzhou Dong, Ming-Hui Zo. Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells. The Journal of biological chemistry. vol 283. issue 18. 2008-06-19. PMID:18321849. |
these effects were accompanied by increased activity of the lipid phosphatase pten, decreased activity and phosphorylation (ser(473)) of akt, and induction of apoptosis. |
2008-06-19 |
2023-08-12 |
human |
| Ping Song, Zhonglin Xie, Yong Wu, Jian Xu, Yunzhou Dong, Ming-Hui Zo. Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells. The Journal of biological chemistry. vol 283. issue 18. 2008-06-19. PMID:18321849. |
we conclude that pkczeta mediates lkb1-dependent akt inhibition in response to onoo(-), resulting in endothelial apoptosis. |
2008-06-19 |
2023-08-12 |
human |
| Edward Kyu-Ho Han, Thomas Mcgonigal, Chris Butler, Vincent L Giranda, Yan Lu. Characterization of Akt overexpression in MiaPaCa-2 cells: prohibitin is an Akt substrate both in vitro and in cells. Anticancer research. vol 28. issue 2A. 2008-06-18. PMID:18507042. |
akt (pkb) is a serine/threonine protein kinase that plays an important role in the transduction of signals affecting apoptosis, cell proliferation and survival. |
2008-06-18 |
2023-08-12 |
human |
| Dae-Hee Lee, Miroslaw Szczepanski, Yong J Le. Role of Bax in quercetin-induced apoptosis in human prostate cancer cells. Biochemical pharmacology. vol 75. issue 12. 2008-06-16. PMID:18455702. |
treatment of lncap cells with an apoptosis inducing concentration of quercetin (100 microm) resulted in a rapid decrease in the inhibitory ser473 phosphorylation of akt leading to inhibition of its kinase activity. |
2008-06-16 |
2023-08-12 |
human |
| Kwang Sup So, Ji Eun Oh, Jee Hye Han, Hong Keun Jung, Young Suk Lee, Sang Hee Kim, Young Jin Chun, Mie Young Ki. Induction of apoptosis by a stilbene analog involves Bax translocation regulated by p38 MAPK and Akt. Archives of pharmacal research. vol 31. issue 4. 2008-06-11. PMID:18449500. |
induction of apoptosis by a stilbene analog involves bax translocation regulated by p38 mapk and akt. |
2008-06-11 |
2023-08-12 |
Not clear |
| Kwang Sup So, Ji Eun Oh, Jee Hye Han, Hong Keun Jung, Young Suk Lee, Sang Hee Kim, Young Jin Chun, Mie Young Ki. Induction of apoptosis by a stilbene analog involves Bax translocation regulated by p38 MAPK and Akt. Archives of pharmacal research. vol 31. issue 4. 2008-06-11. PMID:18449500. |
in hl-60 cells, sa induced apoptosis through activation of p38 mapk and inactivation of akt, which in turn activated bad and mitochondrial death signaling pathway, as evidenced by bax translocation and cytochrome c release. |
2008-06-11 |
2023-08-12 |
Not clear |