| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Cai, Qidi Wang, Zhidong Ling, Daniel Pipeleers, Paul McDermott, Mario Pende, Harry Heimberg, Mark Van de Casteel. Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR. Biochemical pharmacology. vol 75. issue 10. 2008-05-16. PMID:18377870. |
it is unknown whether akt activation can counteract ampk-mediated apoptosis, nor whether mtor activation downstream of akt mediates any survival signal in these conditions. |
2008-05-16 |
2023-08-12 |
Not clear |
| Ying Cai, Qidi Wang, Zhidong Ling, Daniel Pipeleers, Paul McDermott, Mario Pende, Harry Heimberg, Mark Van de Casteel. Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR. Biochemical pharmacology. vol 75. issue 10. 2008-05-16. PMID:18377870. |
we report that expression of a constitutively active form of akt increases mtor activity and prevents apoptosis upon ampk activation. |
2008-05-16 |
2023-08-12 |
Not clear |
| Ying Cai, Qidi Wang, Zhidong Ling, Daniel Pipeleers, Paul McDermott, Mario Pende, Harry Heimberg, Mark Van de Casteel. Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR. Biochemical pharmacology. vol 75. issue 10. 2008-05-16. PMID:18377870. |
expression of a constitutively active form of the mtor target ribosomal protein s6 kinase (s6k) or of translation factor eif4e reduced apoptosis by glucose limitation, and co-expression of s6k and eif4e protected beta cells to the same extent as active akt. |
2008-05-16 |
2023-08-12 |
Not clear |
| Ellen Weisberg, Lolita Banerji, Renee D Wright, Rosemary Barrett, Arghya Ray, Daisy Moreno, Laurence Catley, Jingrui Jiang, Elizabeth Hall-Meyers, Maira Sauveur-Michel, Richard Stone, Ilene Galinsky, Edward Fox, Andrew L Kung, James D Griffi. Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL- and mutant FLT3-expressing cells. Blood. vol 111. issue 7. 2008-05-15. PMID:18184863. |
bag956 was shown to block akt phosphorylation induced by bcr-abl-, and induce apoptosis of bcr-abl-expressing cell lines and patient bone marrow cells at concentrations that also inhibit pi3k signaling. |
2008-05-15 |
2023-08-12 |
Not clear |
| N Zhang, J Li, R Luo, J Jiang, J-A Wan. Bone marrow mesenchymal stem cells induce angiogenesis and attenuate the remodeling of diabetic cardiomyopathy. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 116. issue 2. 2008-05-15. PMID:18286426. |
studies have demonstrated mscs transplantation can prevent apoptosis of ischemic heart via upregulation of akt and enos and inhibit myocardial fibrosis of dilated cardiomyopathy by decreasing the expression of matrix metalloproteinase (mmp) in rat models. |
2008-05-15 |
2023-08-12 |
rat |
| Yanbin Zhao, Xuesong Chen, Li Cai, Yanmei Yang, Guangjie Sui, Jin W. Angiotensin II suppresses adriamycin-induced apoptosis through activation of phosphatidylinositol 3-kinase/Akt signaling in human breast cancer cells. Acta biochimica et biophysica Sinica. vol 40. issue 4. 2008-05-14. PMID:18401528. |
in addition, ang ii significantly prevented apoptosis through inhibiting the cleavage of procaspase-9, a major downstream effector of akt. |
2008-05-14 |
2023-08-12 |
human |
| Cristina Montiel-Duarte, Lucia Cordeu, Xabier Agirre, José Román-Gómez, Antonio Jiménez-Velasco, Edurne San José-Eneriz, Leire Gárate, Enrique J Andreu, Maria José Calasanz, Anabel Heiniger, Antonio Torres, Felipe Próspe. Resistance to Imatinib Mesylate-induced apoptosis in acute lymphoblastic leukemia is associated with PTEN down-regulation due to promoter hypermethylation. Leukemia research. vol 32. issue 5. 2008-05-13. PMID:17942153. |
resistance of ph+ all cells to imatinib-induced apoptosis was associated with lack of inhibition of akt phosphorylation. |
2008-05-13 |
2023-08-12 |
Not clear |
| Klaus Jürgen Schmitz, Friedrich Otterbach, Rainer Callies, Bodo Levkau, Melanie Hölscher, Oliver Hoffmann, Florian Grabellus, Rainer Kimmig, Kurt Werner Schmid, Hideo Andreas Bab. Prognostic relevance of activated Akt kinase in node-negative breast cancer: a clinicopathological study of 99 cases. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. vol 17. issue 1. 2008-05-09. PMID:14631376. |
for this purpose, we examined the activation state of two kinases important in the regulation of cell proliferation and apoptosis in a series of 99 node-negative breast cancer cases with a mean follow-up of 10 years: akt and extracellular regulated kinase (erk1/2). |
2008-05-09 |
2023-08-12 |
Not clear |
| Klaus Jürgen Schmitz, Friedrich Otterbach, Rainer Callies, Bodo Levkau, Melanie Hölscher, Oliver Hoffmann, Florian Grabellus, Rainer Kimmig, Kurt Werner Schmid, Hideo Andreas Bab. Prognostic relevance of activated Akt kinase in node-negative breast cancer: a clinicopathological study of 99 cases. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. vol 17. issue 1. 2008-05-09. PMID:14631376. |
activation of akt (pakt) but not activation of erk1/2 (perk1/2) correlated with her-2/neu overexpression (p<0.05) and was related to reduced tumor apoptosis (p<0.05). |
2008-05-09 |
2023-08-12 |
Not clear |
| Shintaro Fukushima, Seiya Kato, Mitsuhide Maeda, Minoru Shigemor. Caspase-9 pathway activation by inhibiting endogenous fibroblast growth factor signaling in human glioma cells. International journal of oncology. vol 32. issue 2. 2008-05-08. PMID:18202770. |
the infection with addnfgfr (multiplicity of infection of 200) induced marked apoptosis, along with a down-regulation of akt phosphorylation, and activation of caspase-9 and -3, but not -8. |
2008-05-08 |
2023-08-12 |
human |
| Christian Freund, Dorien Ward-van Oostwaard, Jantine Monshouwer-Kloots, Stieneke van den Brink, Marga van Rooijen, Xiuqin Xu, Robert Zweigerdt, Christine Mummery, Robert Passie. Insulin redirects differentiation from cardiogenic mesoderm and endoderm to neuroectoderm in differentiating human embryonic stem cells. Stem cells (Dayton, Ohio). vol 26. issue 3. 2008-05-07. PMID:18096723. |
insulin/insulin-like growth factors and their intracellular downstream target protein kinase akt are known to protect many cell types from apoptosis and to promote proliferation, including hesc-derived cardiomyocytes. |
2008-05-07 |
2023-08-12 |
human |
| Yasunari Takada, Gautam Sethi, Bokyung Sung, Bharat B Aggarwa. Flavopiridol suppresses tumor necrosis factor-induced activation of activator protein-1, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase (MAPK), p44/p42 MAPK, and Akt, inhibits expression of antiapoptotic gene products, and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells. Molecular pharmacology. vol 73. issue 5. 2008-05-06. PMID:18287248. |
flavopiridol suppresses tumor necrosis factor-induced activation of activator protein-1, c-jun n-terminal kinase, p38 mitogen-activated protein kinase (mapk), p44/p42 mapk, and akt, inhibits expression of antiapoptotic gene products, and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells. |
2008-05-06 |
2023-08-12 |
human |
| Tae-Jin Lee, Jung-Tae Lee, Sang Hyun Kim, Yung Hyun Choi, Kyoung Seob Song, Jong-Wook Park, Taeg Kyu Kwo. Overexpression of Par-4 enhances thapsigargin-induced apoptosis via down-regulation of XIAP and inactivation of Akt in human renal cancer cells. Journal of cellular biochemistry. vol 103. issue 2. 2008-05-01. PMID:18041764. |
overexpression of par-4 enhances thapsigargin-induced apoptosis via down-regulation of xiap and inactivation of akt in human renal cancer cells. |
2008-05-01 |
2023-08-12 |
human |
| Martina B Schaefer, Alice Wenzel, Tobias Fischer, Ruediger C Braun-Dullaeus, Fabrice Renner, Hartmut Dietrich, Christian A Schaefer, Werner Seeger, Konstantin Maye. Fatty acids differentially influence phosphatidylinositol 3-kinase signal transduction in endothelial cells: impact on adhesion and apoptosis. Atherosclerosis. vol 197. issue 2. 2008-04-29. PMID:17950294. |
pi3-kinase driven phosphorylation of akt and apoptosis of huvec as contribution to the resolution of inflammation is differentially modulated by dha versus aa. |
2008-04-29 |
2023-08-12 |
human |
| Chen-Tzu Kuo, Ming-Jen Hsu, Bing-Chang Chen, Chien-Chih Chen, Che-Ming Teng, Shiow-Lin Pan, Chien-Huang Li. Denbinobin induces apoptosis in human lung adenocarcinoma cells via Akt inactivation, Bad activation, and mitochondrial dysfunction. Toxicology letters. vol 177. issue 1. 2008-04-29. PMID:18262737. |
denbinobin induces apoptosis in human lung adenocarcinoma cells via akt inactivation, bad activation, and mitochondrial dysfunction. |
2008-04-29 |
2023-08-12 |
human |
| Chen-Tzu Kuo, Ming-Jen Hsu, Bing-Chang Chen, Chien-Chih Chen, Che-Ming Teng, Shiow-Lin Pan, Chien-Huang Li. Denbinobin induces apoptosis in human lung adenocarcinoma cells via Akt inactivation, Bad activation, and mitochondrial dysfunction. Toxicology letters. vol 177. issue 1. 2008-04-29. PMID:18262737. |
transfection of a549 cells with both wild-type and constitutively active akt significantly suppressed denbinobin-induced bad activation and cell apoptosis. |
2008-04-29 |
2023-08-12 |
human |
| Chen-Tzu Kuo, Ming-Jen Hsu, Bing-Chang Chen, Chien-Chih Chen, Che-Ming Teng, Shiow-Lin Pan, Chien-Huang Li. Denbinobin induces apoptosis in human lung adenocarcinoma cells via Akt inactivation, Bad activation, and mitochondrial dysfunction. Toxicology letters. vol 177. issue 1. 2008-04-29. PMID:18262737. |
these results suggest that akt inactivation, followed by bad activation, mitochondrial dysfunction, caspase 3 activation, and aif release, contributes to denbinobin-induced cell apoptosis. |
2008-04-29 |
2023-08-12 |
human |
| Nelson Rhodes, Dirk A Heerding, Derek R Duckett, Derek J Eberwein, Victoria B Knick, Timothy J Lansing, Randy T McConnell, Tona M Gilmer, Shu-Yun Zhang, Kimberly Robell, Jason A Kahana, Robert S Geske, Elena V Kleymenova, Anthony E Choudhry, Zhihong Lai, Jack D Leber, Elisabeth A Minthorn, Susan L Strum, Edgar R Wood, Pearl S Huang, Robert A Copeland, Rakesh Kuma. Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity. Cancer research. vol 68. issue 7. 2008-04-25. PMID:18381444. |
gsk690693 inhibited proliferation and induced apoptosis in a subset of tumor cells with potency consistent with intracellular inhibition of akt kinase activity. |
2008-04-25 |
2023-08-12 |
mouse |
| Xuehuo Zeng, Timothy J Kinsell. Mammalian target of rapamycin and S6 kinase 1 positively regulate 6-thioguanine-induced autophagy. Cancer research. vol 68. issue 7. 2008-04-25. PMID:18381446. |
furthermore, we show that inhibition of mtor by rapamycin induces the activation of akt as shown by increased akt phosphorylation at ser(473) and the inhibition of 6-tg-induced apoptosis and cell death. |
2008-04-25 |
2023-08-12 |
human |
| S K Radhakrishnan, M Halasi, U G Bhat, R T Kurmasheva, P J Houghton, A L Garte. Proapoptotic compound ARC targets Akt and N-myc in neuroblastoma cells. Oncogene. vol 27. issue 5. 2008-04-22. PMID:17724478. |
furthermore, we found that while arc inhibited the phosphorylation of akt ser-473 in multiple cancer cell lines, forced expression of myristoylated akt promoted resistance to arc-induced apoptosis in neuroblastoma cells. |
2008-04-22 |
2023-08-12 |
Not clear |