| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francis Edwin, Tarun B Pate. A novel role of Sprouty 2 in regulating cellular apoptosis. The Journal of biological chemistry. vol 283. issue 6. 2008-03-31. PMID:18070883. |
inhibiting both the erk1/2 and akt pathways abolished the ability of serum to protect against apoptosis, mimicking the effects of silencing hspry2. |
2008-03-31 |
2023-08-12 |
human |
| Dong-Oh Moon, Sung-Yong Park, Yung Hyun Choi, Nam Deuk Kim, Chan Lee, Gi-Young Ki. Melittin induces Bcl-2 and caspase-3-dependent apoptosis through downregulation of Akt phosphorylation in human leukemic U937 cells. Toxicon : official journal of the International Society on Toxinology. vol 51. issue 1. 2008-03-26. PMID:17936321. |
melittin induces bcl-2 and caspase-3-dependent apoptosis through downregulation of akt phosphorylation in human leukemic u937 cells. |
2008-03-26 |
2023-08-12 |
human |
| Dong-Oh Moon, Sung-Yong Park, Yung Hyun Choi, Nam Deuk Kim, Chan Lee, Gi-Young Ki. Melittin induces Bcl-2 and caspase-3-dependent apoptosis through downregulation of Akt phosphorylation in human leukemic U937 cells. Toxicon : official journal of the International Society on Toxinology. vol 51. issue 1. 2008-03-26. PMID:17936321. |
in the present study, we report that mel induces apoptosis in leukemic u937 cells through downregulating akt signal pathways. |
2008-03-26 |
2023-08-12 |
human |
| Dong-Oh Moon, Sung-Yong Park, Yung Hyun Choi, Nam Deuk Kim, Chan Lee, Gi-Young Ki. Melittin induces Bcl-2 and caspase-3-dependent apoptosis through downregulation of Akt phosphorylation in human leukemic U937 cells. Toxicon : official journal of the International Society on Toxinology. vol 51. issue 1. 2008-03-26. PMID:17936321. |
the results indicated that key regulators in mel-induced apoptosis in human leukemic u937 cells include bcl-2 and caspase-3, which are controlled through the akt signaling pathway. |
2008-03-26 |
2023-08-12 |
human |
| K J Woo, Y H Yoo, J-W Park, T K Kwo. Bcl-2 attenuates anticancer agents-induced apoptosis by sustained activation of Akt/protein kinase B in U937 cells. Apoptosis : an international journal on programmed cell death. vol 10. issue 6. 2008-03-25. PMID:16215670. |
in the present study, we determined the effect of the anti-apoptosis protein bcl-2 on caspase-3 activation, plc-gamma1 degradation and akt activation during the various anticancer agents-induced apoptosis. |
2008-03-25 |
2023-08-12 |
Not clear |
| K J Woo, Y H Yoo, J-W Park, T K Kwo. Bcl-2 attenuates anticancer agents-induced apoptosis by sustained activation of Akt/protein kinase B in U937 cells. Apoptosis : an international journal on programmed cell death. vol 10. issue 6. 2008-03-25. PMID:16215670. |
induction of apoptosis was also accompanied by down-regulation of xiap and inactivation of akt. |
2008-03-25 |
2023-08-12 |
Not clear |
| K J Woo, Y H Yoo, J-W Park, T K Kwo. Bcl-2 attenuates anticancer agents-induced apoptosis by sustained activation of Akt/protein kinase B in U937 cells. Apoptosis : an international journal on programmed cell death. vol 10. issue 6. 2008-03-25. PMID:16215670. |
ectopic expression of bcl-2 appeared to inhibit ceramide-, and akt specific inhibitor (sh-6)-induced apoptosis by sustained akt activation. |
2008-03-25 |
2023-08-12 |
Not clear |
| K J Woo, Y H Yoo, J-W Park, T K Kwo. Bcl-2 attenuates anticancer agents-induced apoptosis by sustained activation of Akt/protein kinase B in U937 cells. Apoptosis : an international journal on programmed cell death. vol 10. issue 6. 2008-03-25. PMID:16215670. |
thus, our findings imply that some of the biological functions of bcl-2 may be attributed to their ability to inhibit anticancer agents-induced apoptosis through the sustained akt activation. |
2008-03-25 |
2023-08-12 |
Not clear |
| P Palozza, A Sheriff, S Serini, A Boninsegna, N Maggiano, F O Ranelletti, G Calviello, A Cittadin. Lycopene induces apoptosis in immortalized fibroblasts exposed to tobacco smoke condensate through arresting cell cycle and down-regulating cyclin D1, pAKT and pBad. Apoptosis : an international journal on programmed cell death. vol 10. issue 6. 2008-03-25. PMID:16215689. |
moreover, the carotenoid up-regulated apoptosis and down-regulated the phosphorylation of akt and bad in cells exposed to tar. |
2008-03-25 |
2023-08-12 |
Not clear |
| G Giannelli, N Napoli, S Antonac. Tyrosine kinase inhibitors: a potential approach to the treatment of hepatocellular carcinoma. Current pharmaceutical design. vol 13. issue 32. 2008-03-24. PMID:18045182. |
in particular, proliferation, invasion, survival, apoptosis, are regulated by erk1/2 and akt pathways, that can be considered for this reason as potential therapeutic targets. |
2008-03-24 |
2023-08-12 |
Not clear |
| Yanhong Zhao, Zhifeng Xiao, Yuan Gao, Bing Chen, Yannan Zhao, Jing Zhang, Jianwu Da. Insulin rescues ES cell-derived neural progenitor cells from apoptosis by differential regulation of Akt and ERK pathways. Neuroscience letters. vol 429. issue 1. 2008-03-21. PMID:17980966. |
insulin rescues es cell-derived neural progenitor cells from apoptosis by differential regulation of akt and erk pathways. |
2008-03-21 |
2023-08-12 |
mouse |
| Yanhong Zhao, Zhifeng Xiao, Yuan Gao, Bing Chen, Yannan Zhao, Jing Zhang, Jianwu Da. Insulin rescues ES cell-derived neural progenitor cells from apoptosis by differential regulation of Akt and ERK pathways. Neuroscience letters. vol 429. issue 1. 2008-03-21. PMID:17980966. |
in summary, our data suggest that insulin prevent apoptosis in es-npcs by activating akt and inhibiting erk through the pi3k pathway. |
2008-03-21 |
2023-08-12 |
mouse |
| Clint Mitchell, Maragret A Park, Guo Zhang, Adly Yacoub, David T Curiel, Paul B Fisher, John D Roberts, Steven Grant, Paul Den. Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells. Molecular cancer therapeutics. vol 6. issue 12 Pt 1. 2008-03-19. PMID:18065490. |
collectively, these data argue that flavopiridol enhances the lethality of vorinostat in breast cancer cells in part through the inhibition of akt and erk1/2 function, leading to reduced expression of multiple inhibitors of the extrinsic and intrinsic apoptosis pathways, as well as activation of cathepsin protease-dependent pathways. |
2008-03-19 |
2023-08-12 |
Not clear |
| Janna Krol, Richard E Francis, André Albergaria, Andrew Sunters, Andreas Polychronis, R Charles Coombes, Eric W-F La. The transcription factor FOXO3a is a crucial cellular target of gefitinib (Iressa) in breast cancer cells. Molecular cancer therapeutics. vol 6. issue 12 Pt 1. 2008-03-19. PMID:18089711. |
in the sensitive cells, gefitinib treatment causes cell cycle arrest predominantly at the g(0)-g(1) phase and apoptosis, which is associated with foxo3a dephosphorylation at akt sites and nuclear translocation, whereas in the resistant cells, foxo3a stays phosphorylated and remains in the cytoplasm. |
2008-03-19 |
2023-08-12 |
human |
| Hanna Mannell, Nicole Hellwig, Torsten Gloe, Christian Plank, Hae-Young Sohn, Leopold Groesser, Barbara Walzog, Ulrich Pohl, Florian Krot. Inhibition of the tyrosine phosphatase SHP-2 suppresses angiogenesis in vitro and in vivo. Journal of vascular research. vol 45. issue 2. 2008-03-17. PMID:17962719. |
the inhibitory effect of shp-2 knock-down on vessel growth was mediated by increased endothelial apoptosis (annexin v staining, p < 0.05, n = 9), which was associated with reduced fgf-2-induced phosphorylation of phosphatidylinositol 3-kinase (pi3-k), akt and extracellular regulated kinase 1/2 (erk1/2) and involved diminished erk1/2 phosphorylation after pi3-k inhibition (n = 3). |
2008-03-17 |
2023-08-12 |
human |
| H Kuwana, Y Terada, T Kobayashi, T Okado, J M Penninger, J Irie-Sasaki, T Sasaki, S Sasak. The phosphoinositide-3 kinase gamma-Akt pathway mediates renal tubular injury in cisplatin nephrotoxicity. Kidney international. vol 73. issue 4. 2008-03-14. PMID:18046317. |
transfection of dominant-active forms of akt and pi3k-gamma ameliorated apoptosis of the tubule epithelial cells derived from the knockout mice. |
2008-03-14 |
2023-08-12 |
mouse |
| Sang Hyub Lee, Ji Kon Ryu, Kyeung-Yeup Lee, Sang Myung Woo, Joo Kyung Park, Ji Won Yoo, Yong-Tae Kim, Yong Bum Yoo. Enhanced anti-tumor effect of combination therapy with gemcitabine and apigenin in pancreatic cancer. Cancer letters. vol 259. issue 1. 2008-03-13. PMID:17967505. |
in vitro, the combination treatment resulted in more growth inhibition and apoptosis through the down-regulation of nf-kappa b activity with suppression of akt activation in pancreatic cancer cell lines (miapaca-2, aspc-1). |
2008-03-13 |
2023-08-12 |
Not clear |
| Sang Hyub Lee, Ji Kon Ryu, Kyeung-Yeup Lee, Sang Myung Woo, Joo Kyung Park, Ji Won Yoo, Yong-Tae Kim, Yong Bum Yoo. Enhanced anti-tumor effect of combination therapy with gemcitabine and apigenin in pancreatic cancer. Cancer letters. vol 259. issue 1. 2008-03-13. PMID:17967505. |
the combination of gemcitabine and apigenin enhanced anti-tumor efficacy through akt and nf-kappa b activity suppression and apoptosis induction. |
2008-03-13 |
2023-08-12 |
Not clear |
| Pablo G Longo, Luca Laurenti, Stefania Gobessi, Simona Sica, Giuseppe Leone, Dimitar G Efremo. The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells. Blood. vol 111. issue 2. 2008-03-11. PMID:17928528. |
sustained activation of akt resulted in increased leukemic cell viability and increased expression of the antiapoptotic proteins mcl-1, bcl-xl, and x-linked inhibitor of apoptosis protein (xiap), thus largely recapitulating the effects of sustained bcr stimulation. |
2008-03-11 |
2023-08-12 |
Not clear |
| Klaus Juergen Schmitz, Jeremias Wohlschlaeger, Hauke Lang, Georgios Charalambos Sotiropoulos, Massimo Malago, Karen Steveling, Henning Reis, Vito Rosario Cicinnati, Kurt Werner Schmid, Hideo Andreas Bab. Activation of the ERK and AKT signalling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection. Journal of hepatology. vol 48. issue 1. 2008-03-11. PMID:17998146. |
the aim of the study was to determine the prognostic relevance of akt and extracellular regulated kinases (erk1/2), which are implied in the regulation of cell proliferation and apoptosis, in hepatocellular carcinoma (hcc). |
2008-03-11 |
2023-08-12 |
Not clear |